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P25017 (TR2M2_AGRVI) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan 2-monooxygenase
EC=1.13.12.3
Gene names
Name:iaaM
Encoded onPlasmid pTiTM4
OrganismAgrobacterium vitis (Rhizobium vitis)
Taxonomic identifier373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length755 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O.

Pathway

Plant hormone metabolism; auxin biosynthesis.

Sequence similarities

Belongs to the tryptophan 2-monooxygenase family.

Caution

The plasmid pTiTM4 carries two T-regions, the TA and TB region, both of which have a functional iaaM gene, with low homology between them.

Ontologies

Keywords
   Biological processAuxin biosynthesis
   DiseaseCrown gall tumor
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termPlasmid
Gene Ontology (GO)
   Biological processauxin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiontryptophan 2-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 755755Tryptophan 2-monooxygenase
PRO_0000065591

Sequences

Sequence LengthMass (Da)Tools
P25017 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 6FA63E502343136F

FASTA75583,973
        10         20         30         40         50         60 
MSASSLLDKQ CDHFSTKIVD LIMVDKADEL DRRVAAAFSE REASRERRIS QISGECNAGL 

        70         80         90        100        110        120 
ACKRLADGRF PEISAGQRVA VLSAYIYVGE EILRWILEPE ASVRTRVSGL VAIDLAPSCM 

       130        140        150        160        170        180 
DISRAQLLQT MNLLSGKRCA PSDLSHFVAI SISETARSRT LQMAPYEEGS LKSVTGFTVI 

       190        200        210        220        230        240 
IEEAVPFDMV AYGRNLMLKA SAGSFPTIDL LYDYRLFLDK CSDSGRIGFF PEDVPRPKVA 

       250        260        270        280        290        300 
VIGAGISGLV VASELLHAGV DDVTIYEAGD RVGGKLWSHA FKDAPGVVAE MGAMRFPPAA 

       310        320        330        340        350        360 
SCLFFFLERY GLSSMRPFPN PGTVDTDLVY EGCRYMWKAG QQPPKLFHRV YSGWHAFLKD 

       370        380        390        400        410        420 
GFLEGDIVLA SPDAITEALK SGDIRRAHDS WQIWLNRFGR ESFSSAIERI FLGTHPPGGE 

       430        440        450        460        470        480 
TWSFPHDWDL FKLMGIGSGG FGPVFESGFT EILRLVINGY EENQRMCSEG ISELPRRIAS 

       490        500        510        520        530        540 
QVVNGVSVSQ RIRHVQVRAI EKEKTKIKIR LKSGISELYD KVVVTSGLAN IQLRHCLTCD 

       550        560        570        580        590        600 
TTIFRAPVNQ AVDNSHMTGS SKLFLLTERK FWFDHMLPSC VLMDGFAKAV YCLDYEPQDP 

       610        620        630        640        650        660 
NGKGLVLISY TWEDDSHKLL AVPDKKERLC LLRDAISKSF PVFAQHLVPA CADYDQNVVQ 

       670        680        690        700        710        720 
HDWLTDENAG GRFKLNRRGE DFYSEELFFQ ALDTTNDTGV YLAGCSCSFT GGWVEGAIQT 

       730        740        750 
ACNAVCAIIH NCGGILAKDN PLKHPWKRYN YRNRN

« Hide

References

[1]"Sequence of Agrobacterium tumefaciens biotype III auxin genes."
Bonnard G., Vincent F., Otten L.
Plant Mol. Biol. 16:733-738(1991) [PubMed: 1868204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: TM4.
[2]Otten L., de Ruffray P.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CG474.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X56185 Genomic DNA. Translation: CAA39646.1.
U83987 Genomic DNA. Translation: AAB41874.1.

3D structure databases

ProteinModelPortalP25017.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR006064. Glycosidase.
IPR012142. Trp_2-mOase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
PF02027. RolB_RolC. 1 hit.
[Graphical view]
PIRSFPIRSF000319. Trp_2-mono_O2ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTR2M2_AGRVI
AccessionPrimary (citable) accession number: P25017
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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