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Protein

Cyclin-C

Gene

CycC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation.4 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: FlyBase
  • RNA polymerase II transcription cofactor activity Source: UniProtKB

GO - Biological processi

  • chaeta development Source: FlyBase
  • G1/S transition of mitotic cell cycle Source: FlyBase
  • imaginal disc-derived leg segmentation Source: FlyBase
  • mitotic G2 DNA damage checkpoint Source: FlyBase
  • regulation of protein kinase activity Source: GOC
  • regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • sex comb development Source: FlyBase
  • snRNA 3'-end processing Source: FlyBase
  • transcription initiation from RNA polymerase II promoter Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Cyclin, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-212436. Generic Transcription Pathway.
R-DME-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
SignaLinkiP25008.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-C
Gene namesi
Name:CycC
Synonyms:CLND
ORF Names:CG7281
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004597. CycC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Cyclin-CPRO_0000080424Add
BLAST

Proteomic databases

PaxDbiP25008.
PRIDEiP25008.

Expressioni

Developmental stagei

Expressed both maternally and zygotically during developmental periods of maximal cell division; most abundant in early embryos and low levels in larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiP25008.
GenevisibleiP25008. DM.

Interactioni

Subunit structurei

Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdk1P235724EBI-195485,EBI-108689
Cdk5P486094EBI-195485,EBI-94216
Cdk8Q9VT572EBI-195485,EBI-163640
ktoQ9VW472EBI-195485,EBI-139710
skdQ7KTX82EBI-195485,EBI-110730

Protein-protein interaction databases

BioGridi66871. 29 interactions.
DIPiDIP-17706N.
IntActiP25008. 27 interactions.
MINTiMINT-280784.
STRINGi7227.FBpp0082469.

Structurei

3D structure databases

ProteinModelPortaliP25008.
SMRiP25008. Positions 1-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 151104Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0794. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
InParanoidiP25008.
KOiK15161.
OMAiHPPYMIA.
OrthoDBiEOG7WX08X.
PhylomeDBiP25008.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

P25008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNFWQSSH SQQWILDKPD LLRERQHDLL ALNEDEYQKV FIFFANVIQV
60 70 80 90 100
LGEQLKLRQQ VIATATVYFK RFYARNSLKN IDPLLLAPTC ILLASKVEEF
110 120 130 140 150
GVISNSRLIS ICQSAIKTKF SYAYAQEFPY RTNHILECEF YLLENLDCCL
160 170 180 190 200
IVYQPYRPLL QLVQDMGQED QLLTLSWRIV NDSLRTDVCL LYPPYQIAIA
210 220 230 240 250
CLQIACVILQ KDATKQWFAE LNVDLDKVQE IVRAIVNLYE LWKDWKEKDE
260
IQMLLSKIPK PKPPPQR
Length:267
Mass (Da):31,292
Last modified:March 1, 1992 - v1
Checksum:iDA73CB7EA89149FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62948 mRNA. Translation: CAA44720.1.
M74906 mRNA. No translation available.
AE014297 Genomic DNA. Translation: AAF55109.1.
AY061425 mRNA. Translation: AAL28973.1.
PIRiA40269.
RefSeqiNP_476848.1. NM_057500.4.
UniGeneiDm.20187.

Genome annotation databases

EnsemblMetazoaiFBtr0083010; FBpp0082469; FBgn0004597.
GeneIDi41801.
KEGGidme:Dmel_CG7281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62948 mRNA. Translation: CAA44720.1.
M74906 mRNA. No translation available.
AE014297 Genomic DNA. Translation: AAF55109.1.
AY061425 mRNA. Translation: AAL28973.1.
PIRiA40269.
RefSeqiNP_476848.1. NM_057500.4.
UniGeneiDm.20187.

3D structure databases

ProteinModelPortaliP25008.
SMRiP25008. Positions 1-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66871. 29 interactions.
DIPiDIP-17706N.
IntActiP25008. 27 interactions.
MINTiMINT-280784.
STRINGi7227.FBpp0082469.

Proteomic databases

PaxDbiP25008.
PRIDEiP25008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083010; FBpp0082469; FBgn0004597.
GeneIDi41801.
KEGGidme:Dmel_CG7281.

Organism-specific databases

CTDi41801.
FlyBaseiFBgn0004597. CycC.

Phylogenomic databases

eggNOGiKOG0794. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
InParanoidiP25008.
KOiK15161.
OMAiHPPYMIA.
OrthoDBiEOG7WX08X.
PhylomeDBiP25008.

Enzyme and pathway databases

ReactomeiR-DME-212436. Generic Transcription Pathway.
R-DME-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
SignaLinkiP25008.

Miscellaneous databases

GenomeRNAii41801.
PROiP25008.

Gene expression databases

BgeeiP25008.
GenevisibleiP25008. DM.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel cyclin gene from Drosophila complements CLN function in yeast."
    Lahue E.E., Smith A.V., Orr-Weaver T.L.
    Genes Dev. 5:2166-2175(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins."
    Leopold P., O'Farrell P.H.
    Cell 66:1207-1216(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II."
    Leclerc V., Tassan J.-P., O'Farrell P.H., Nigg E.A., Leopold P.
    Mol. Biol. Cell 7:505-513(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION, SUBCELLULAR LOCATION.
  7. "Distinct roles for Mediator Cdk8 module subunits in Drosophila development."
    Loncle N., Boube M., Joulia L., Boschiero C., Werner M., Cribbs D.L., Bourbon H.-M.
    EMBO J. 26:1045-1054(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CYCC; KTO AND SKD.

Entry informationi

Entry nameiCCNC_DROME
AccessioniPrimary (citable) accession number: P25008
Secondary accession number(s): Q9VFF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 8, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.