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Protein

Cyclin-C

Gene

CycC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase Cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation.4 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: FlyBase
  • RNA polymerase II transcription cofactor activity Source: UniProtKB

GO - Biological processi

  • chaeta development Source: FlyBase
  • imaginal disc-derived leg segmentation Source: FlyBase
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: UniProtKB
  • sex comb development Source: FlyBase
  • snRNA 3'-end processing Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionCyclin, Developmental protein, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-212436 Generic Transcription Pathway
R-DME-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SignaLinkiP25008

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-C
Gene namesi
Name:CycC
Synonyms:CLND
ORF Names:CG7281
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0004597 CycC

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804241 – 267Cyclin-CAdd BLAST267

Proteomic databases

PaxDbiP25008
PRIDEiP25008

Expressioni

Developmental stagei

Expressed both maternally and zygotically during developmental periods of maximal cell division; most abundant in early embryos and low levels in larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiFBgn0004597
GenevisibleiP25008 DM

Interactioni

Subunit structurei

Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi66871, 35 interactors
DIPiDIP-17706N
IntActiP25008, 27 interactors
MINTiP25008
STRINGi7227.FBpp0082469

Structurei

3D structure databases

ProteinModelPortaliP25008
SMRiP25008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 151Cyclin N-terminalAdd BLAST104

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG0794 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
InParanoidiP25008
KOiK15161
OMAiSSHHQQW
OrthoDBiEOG091G0FSG
PhylomeDBiP25008

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR028367 CyclinC/Ssn8
PANTHERiPTHR10026:SF7 PTHR10026:SF7, 1 hit
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SUPFAMiSSF47954 SSF47954, 2 hits

Sequencei

Sequence statusi: Complete.

P25008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNFWQSSH SQQWILDKPD LLRERQHDLL ALNEDEYQKV FIFFANVIQV
60 70 80 90 100
LGEQLKLRQQ VIATATVYFK RFYARNSLKN IDPLLLAPTC ILLASKVEEF
110 120 130 140 150
GVISNSRLIS ICQSAIKTKF SYAYAQEFPY RTNHILECEF YLLENLDCCL
160 170 180 190 200
IVYQPYRPLL QLVQDMGQED QLLTLSWRIV NDSLRTDVCL LYPPYQIAIA
210 220 230 240 250
CLQIACVILQ KDATKQWFAE LNVDLDKVQE IVRAIVNLYE LWKDWKEKDE
260
IQMLLSKIPK PKPPPQR
Length:267
Mass (Da):31,292
Last modified:March 1, 1992 - v1
Checksum:iDA73CB7EA89149FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62948 mRNA Translation: CAA44720.1
M74906 mRNA No translation available.
AE014297 Genomic DNA Translation: AAF55109.1
AY061425 mRNA Translation: AAL28973.1
PIRiA40269
RefSeqiNP_476848.1, NM_057500.4
UniGeneiDm.20187

Genome annotation databases

EnsemblMetazoaiFBtr0083010; FBpp0082469; FBgn0004597
GeneIDi41801
KEGGidme:Dmel_CG7281

Similar proteinsi

Entry informationi

Entry nameiCCNC_DROME
AccessioniPrimary (citable) accession number: P25008
Secondary accession number(s): Q9VFF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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