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P25003 (COX3_PISOC) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COIII
Encoded onMitochondrion
OrganismPisaster ochraceus (Ochre sea star) (Asterias ochracea)
Taxonomic identifier7612 [NCBI]
Taxonomic lineageEukaryotaMetazoaEchinodermataEleutherozoaAsterozoaAsteroideaForcipulataceaForcipulatidaAsteriidaePisaster

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Cytochrome c oxidase subunit 3
PRO_0000183833

Regions

Transmembrane30 – 5021Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P25003 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 2A3BD9B47188841E

FASTA26029,648
        10         20         30         40         50         60 
MTHQHPYHLV DQSPWPLTGA ISALMMTSGL ILWFHINSTI LFILGTVLLV LTIINWWRDI 

        70         80         90        100        110        120 
IREATFQGFH TLSVSNGLRY GMILFITSEV CLFFAFFWAF FHSSLAPTIE LGVSWPPTGI 

       130        140        150        160        170        180 
TPINPFLVPL LNTAVLLSSG VTVTWAHHSI LSGNRVEAIQ SLTLTVFLGV YFTILQAWEY 

       190        200        210        220        230        240 
FDSPFTIADS VYGSTFFVAT GFHGLHVLIG TAFLAVCLLR LYNFHFSNHH HFGFEAASWY 

       250        260 
WHFVDVVWLF LYICIYWWGS 

« Hide

References

[1]"Nucleotide sequence of nine protein-coding genes and 22 tRNAs in the mitochondrial DNA of the sea star Pisaster ochraceus."
Smith M.J., Banfield D.K., Doteval K., Gorski S., Kowbel D.J.
J. Mol. Evol. 31:195-204(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55514 Genomic DNA. Translation: CAA39129.1.
PIRS14210.
RefSeqNP_803164.1. NC_004610.1.

3D structure databases

ProteinModelPortalP25003.
SMRP25003. Positions 1-260.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID806806.

Organism-specific databases

CTD4514.

Phylogenomic databases

ProtClustDBMTH00039.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_PISOC
AccessionPrimary (citable) accession number: P25003
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families