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P25001

- COX1_PISOC

UniProt

P25001 - COX1_PISOC

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Pisaster ochraceus (Ochre sea star) (Asterias ochracea)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Iron (heme A axial ligand)Curated
    Metal bindingi240 – 2401Copper BCurated
    Metal bindingi244 – 2441Copper BCurated
    Metal bindingi290 – 2901Copper BCurated
    Metal bindingi291 – 2911Copper BCurated
    Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
    Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiPisaster ochraceus (Ochre sea star) (Asterias ochracea)
    Taxonomic identifieri7612 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaAsterozoaAsteroideaForcipulataceaForcipulatidaAsteriidaePisaster

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Cytochrome c oxidase subunit 1PRO_0000183392Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP25001.
    SMRiP25001. Positions 3-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLSRWLFST NHKDIGTLYL IFGAWAGMIG TAMSVIIRTE LAQPGSLLQD    50
    DQIYNVIVTA HALVMIFFMV MPIMIGGFGN WLIPLMIGAP DMAFPRMNNM 100
    SFWLIPPSFL LLLASAGVES GTGTGWTIYP PLSSGLAHAG GSVDLAIFSL 150
    HLAGASSILA SINFITTIIN MRTPGMSFDR LPLFVWSVFV TAFLLLLSLP 200
    VLAGAITMLL TDRNINTTFF DPAGGGDPIL FQHLFWFFGH PEVYILILPG 250
    FGMISHVIAH YAGKNEPFGY LGMVYAIISI GILGFLVWAH HMFTVGMDVD 300
    TRAYFTAATM IIAVPTGIKV FSWMATLQGS NLRWDTPLLW ALGFVFLFTI 350
    GGLTGVVLAN SSIDIILHDT HYVVAHFHYV LSMGAVFAIF AGFTHWFPLF 400
    SGVSLHPLWS KVHFAVMFIG VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW 450
    NTVSSIGSTI SLIRTLIFLF LIWEAFSTKR TPIHPEFSSS SLEWQYPSFP 500
    PSHHTFDETP SAVYLIK 517
    Length:517
    Mass (Da):57,238
    Last modified:March 1, 1992 - v1
    Checksum:i92E10740FC03DAED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16888 Genomic DNA. Translation: CAA34768.1.
    X55514 Genomic DNA. Translation: CAA39124.1.
    PIRiS14205.
    RefSeqiNP_803159.1. NC_004610.1.

    Genome annotation databases

    GeneIDi806799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16888 Genomic DNA. Translation: CAA34768.1 .
    X55514 Genomic DNA. Translation: CAA39124.1 .
    PIRi S14205.
    RefSeqi NP_803159.1. NC_004610.1.

    3D structure databases

    ProteinModelPortali P25001.
    SMRi P25001. Positions 3-508.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 806799.

    Organism-specific databases

    CTDi 4512.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of nine protein-coding genes and 22 tRNAs in the mitochondrial DNA of the sea star Pisaster ochraceus."
      Smith M.J., Banfield D.K., Doteval K., Gorski S., Kowbel D.J.
      J. Mol. Evol. 31:195-204(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Conserved tRNA gene cluster in starfish mitochondrial DNA."
      Jacobs H.T., Asakawa S., Araki T., Miura K., Smith M.J., Watanabe K.
      Curr. Genet. 15:193-206(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.

    Entry informationi

    Entry nameiCOX1_PISOC
    AccessioniPrimary (citable) accession number: P25001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3