P24987 (COX2_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	mt-co2
Synonyms:	coii, coxii, mtco2

Encoded on

Mitochondrion

Organism

Cyprinus carpio (Common carp)

Taxonomic identifier

7962 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Cyprinus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Cytochrome c oxidase subunit 2		PRO_0000183564
Regions
	Topological domain	1 – 26	26	Mitochondrial intermembrane Potential
	Transmembrane	27 – 48	22	Helical; Potential
	Topological domain	49 – 62	14	Mitochondrial matrix Potential
	Transmembrane	63 – 82	20	Helical; Potential
	Topological domain	83 – 230	148	Mitochondrial intermembrane Potential
Sites
	Metal binding	161	1	Copper A Probable
	Metal binding	196	1	Copper A Probable
	Metal binding	200	1	Copper A Probable
	Metal binding	204	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P24987 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 237E10E13DBDDFED	FASTA	230	25,999
	10 20 30 40 50 60 MAHPTQLGFK DAAMPVMEEL LHFHDHALMI VLLISTLVLY IITAMVSTKL TNKYILDSQE 70 80 90 100 110 120 IEIVWTILPA VILVLIALPS LRILYLMDEI NDPHLTIKAM GHQWYWSYEY TDYENLGFDS 130 140 150 160 170 180 YMVPTQDLAP GQFRLLETDH RMVVPMESPV RVLVSAEDVL HSWAVPSLGV KMDAVPGRLN 190 200 210 220 230 QAAFIASRPG VFYGQCSEIC GANHSFMPIV VEAVPLEHFE NWSSLMLEDA

References

[1]	"The complete nucleotide sequence and gene organization of carp (Cyprinus carpio) mitochondrial genome." Chang Y.S., Huang F.L., Lo T.B. J. Mol. Evol. 38:138-155(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61010 Genomic DNA. Translation: CAA43340.1.
PIR	S36009.
RefSeq	NP_007085.1. NC_001606.1.
3D structure databases
ProteinModelPortal	P24987.
SMR	P24987. Positions 1-227.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	807772.
Organism-specific databases
CTD	4513.
Phylogenomic databases
HOVERGEN	HBG012727.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_CYPCA

Accession

Primary (citable) accession number: P24987

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program