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P24984

- COX1_COTJA

UniProt

P24984 - COX1_COTJA

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Protein
Cytochrome c oxidase subunit 1
Gene
MT-CO1, COI, COXI, MTCO1
Organism
Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron (heme A axial ligand) Inferred
Metal bindingi241 – 2411Copper B Inferred
Metal bindingi245 – 2451Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi292 – 2921Copper B Inferred
Metal bindingi377 – 3771Iron (heme A3 axial ligand) Inferred
Metal bindingi379 – 3791Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifieri93934 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Transmembranei57 – 7721Helical; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei235 – 25521Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Transmembranei339 – 35921Helical; Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Transmembranei415 – 43521Helical; Reviewed prediction
Add
BLAST
Transmembranei457 – 47721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Cytochrome c oxidase subunit 1
PRO_0000183316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP24984.
SMRiP24984. Positions 3-515.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24984-1 [UniParc]FASTAAdd to Basket

« Hide

MTFINRWLFS TNHKDIGTLY LIFGTWAGMA GTALSLLIRA ELGQPGTLLG    50
DDQIYNVIVT AHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN 100
MSFWLLPPSF LLLLASSTVE AGAGTGWTVY PPLAGNLAHA GASVDLAIFS 150
LHLAGVSSIL GAINFITTII NMKPPALSQY QTPLFVWSVL ITAILLLLSL 200
PVLAAGITML LTDRNLNTTF FDPAGGGDPI LYQHLFWFFG HPEVYILILP 250
GFGIISHVVA YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV 300
DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDPPML WALGFIFLFT 350
IGGLTGIVLA NSSLDIALHD TYYVVAHFHY VLSMGAVFAI LAGFTHWFPL 400
FTGFTLHPTW TKAHFGVMFT GVNLTFFPQH FLGLAGMPRR YSDYPDAYTL 450
WNTLSSIGSL ISMTAVIMLM FIVWEAFSAK RKVLQPELTA TNIEWIHGCP 500
PPYHTFEEPA FVQVQE 516
Length:516
Mass (Da):56,985
Last modified:September 26, 2003 - v3
Checksum:i34779829B535B2B6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti474 – 4741W → L in AAA76729. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003195 Genomic DNA. Translation: BAB62917.1.
X57246 Genomic DNA. Translation: CAA40524.1.
U36794 Genomic DNA. Translation: AAA76729.1.
PIRiS25424.
RefSeqiNP_572016.1. NC_003408.1.

Genome annotation databases

GeneIDi804670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003195 Genomic DNA. Translation: BAB62917.1 .
X57246 Genomic DNA. Translation: CAA40524.1 .
U36794 Genomic DNA. Translation: AAA76729.1 .
PIRi S25424.
RefSeqi NP_572016.1. NC_003408.1.

3D structure databases

ProteinModelPortali P24984.
SMRi P24984. Positions 3-515.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 804670.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species."
    Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.
    Anim. Genet. 32:380-385(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  2. "Nucleotide sequence and evolution of coding and noncoding regions of a quail mitochondrial genome."
    Desjardins P., Morais R.
    J. Mol. Evol. 32:153-161(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-102.
    Tissue: Liver.
  3. "Nucleotide sequence of mitochondrial genes for COI, tRNAs Lys, Asp, Ser (UCN), COII and ATPases 8 and 6 of the quail Coturnix japonica."
    Ramirez V., Morais R.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 463-516.
    Tissue: Liver.

Entry informationi

Entry nameiCOX1_COTJA
AccessioniPrimary (citable) accession number: P24984
Secondary accession number(s): Q8SEX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 26, 2003
Last modified: September 3, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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