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Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron (heme A axial ligand)Curated
Metal bindingi241 – 2411Copper BCurated
Metal bindingi245 – 2451Copper BCurated
Metal bindingi291 – 2911Copper BCurated
Metal bindingi292 – 2921Copper BCurated
Metal bindingi377 – 3771Iron (heme A3 axial ligand)Curated
Metal bindingi379 – 3791Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifieri93934 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Transmembranei457 – 47721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Cytochrome c oxidase subunit 1PRO_0000183316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP24984.
SMRiP24984. Positions 3-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFINRWLFS TNHKDIGTLY LIFGTWAGMA GTALSLLIRA ELGQPGTLLG
60 70 80 90 100
DDQIYNVIVT AHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN
110 120 130 140 150
MSFWLLPPSF LLLLASSTVE AGAGTGWTVY PPLAGNLAHA GASVDLAIFS
160 170 180 190 200
LHLAGVSSIL GAINFITTII NMKPPALSQY QTPLFVWSVL ITAILLLLSL
210 220 230 240 250
PVLAAGITML LTDRNLNTTF FDPAGGGDPI LYQHLFWFFG HPEVYILILP
260 270 280 290 300
GFGIISHVVA YYAGKKEPFG YMGMVWAMLS IGFLGFIVWA HHMFTVGMDV
310 320 330 340 350
DTRAYFTSAT MIIAIPTGIK VFSWLATLHG GTIKWDPPML WALGFIFLFT
360 370 380 390 400
IGGLTGIVLA NSSLDIALHD TYYVVAHFHY VLSMGAVFAI LAGFTHWFPL
410 420 430 440 450
FTGFTLHPTW TKAHFGVMFT GVNLTFFPQH FLGLAGMPRR YSDYPDAYTL
460 470 480 490 500
WNTLSSIGSL ISMTAVIMLM FIVWEAFSAK RKVLQPELTA TNIEWIHGCP
510
PPYHTFEEPA FVQVQE
Length:516
Mass (Da):56,985
Last modified:September 25, 2003 - v3
Checksum:i34779829B535B2B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti474 – 4741W → L in AAA76729 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003195 Genomic DNA. Translation: BAB62917.1.
X57246 Genomic DNA. Translation: CAA40524.1.
U36794 Genomic DNA. Translation: AAA76729.1.
PIRiS25424.
RefSeqiNP_572016.1. NC_003408.1.

Genome annotation databases

GeneIDi804670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003195 Genomic DNA. Translation: BAB62917.1.
X57246 Genomic DNA. Translation: CAA40524.1.
U36794 Genomic DNA. Translation: AAA76729.1.
PIRiS25424.
RefSeqiNP_572016.1. NC_003408.1.

3D structure databases

ProteinModelPortaliP24984.
SMRiP24984. Positions 3-515.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi804670.

Organism-specific databases

CTDi4512.

Phylogenomic databases

HOVERGENiHBG003841.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species."
    Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.
    Anim. Genet. 32:380-385(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  2. "Nucleotide sequence and evolution of coding and noncoding regions of a quail mitochondrial genome."
    Desjardins P., Morais R.
    J. Mol. Evol. 32:153-161(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-102.
    Tissue: Liver.
  3. "Nucleotide sequence of mitochondrial genes for COI, tRNAs Lys, Asp, Ser (UCN), COII and ATPases 8 and 6 of the quail Coturnix japonica."
    Ramirez V., Morais R.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 463-516.
    Tissue: Liver.

Entry informationi

Entry nameiCOX1_COTJA
AccessioniPrimary (citable) accession number: P24984
Secondary accession number(s): Q8SEX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 29, 1992
Last sequence update: September 25, 2003
Last modified: February 3, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.