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Reviewed, UniProtKB/Swiss-Prot P24983 (COX1_BALPH)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I
Gene names
Name: MT-CO1
Synonyms: COI, COXI, MTCO1
Encoded onMitochondrion
OrganismBalaenoptera physalus (Finback whale) (Common rorqual)
Taxonomic identifier9770 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Cetacea › Mysticeti › Balaenopteridae › Balaenoptera

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Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Cytochrome c oxidase subunit 1
PRO_0000183292

Regions

Transmembrane17 – 3721 Potential
Transmembrane63 – 8321 Potential
Transmembrane102 – 12221 Potential
Transmembrane145 – 16521 Potential
Transmembrane183 – 20321 Potential
Transmembrane234 – 25421 Potential
Transmembrane268 – 28821 Potential
Transmembrane310 – 33021 Potential
Transmembrane338 – 35821 Potential
Transmembrane380 – 40021 Potential
Transmembrane412 – 43221 Potential
Transmembrane456 – 47621 Potential

Sites

Metal binding611Iron (heme A axial ligand) Probable
Metal binding2401Copper B Probable
Metal binding2441Copper B Probable
Metal binding2901Copper B Probable
Metal binding2911Copper B Probable
Metal binding3761Iron (heme A3 axial ligand) Probable
Metal binding3781Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

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Sequences

Sequence LengthMass (Da)Tools
P24983-1 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 7CA93F1440BE3CFD

FASTA51657,209
        10         20         30         40         50         60 
MFMNRWLFST NHKDIGTLYL LFGAWAGMVG TGLSLLIRAE LGQPGTLIGD DQVYNVLVTA 

        70         80         90        100        110        120 
HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLMASSMIEA 

       130        140        150        160        170        180 
GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ 

       190        200        210        220        230        240 
TPLFVWSVLV TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMVSI GFLGFIVWAH HMFTVGMDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPALMW ALGFIFLFTV GGLTGIVLAN 

       370        380        390        400        410        420 
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF SGYTLNTTWA KIHFMIMFVG 

       430        440        450        460        470        480 
VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NTISSMGSFI SLTAVMLMIF IIWEAFTSKR 

       490        500        510 
EVLAVDLTST NLEWLNGCPP PYHTFEEPAF VNPKWS

« Hide

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References

[1]"The complete nucleotide sequence of the mitochondrial DNA of the fin whale, Balaenoptera physalus."
Arnason U., Gullberg A., Widegren B.
J. Mol. Evol. 33:556-568(1991) [PubMed: 1779436] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate No. 27 / Anno 1987.
Tissue: Liver.

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Cross-references

Sequence databases

X61145 Genomic DNA. Translation: CAA43451.1.
PIRC58850.
RefSeqNP_006891.1.

3D structure databases

HSSPHSSP built from PDB template 2OCC based on UniProtKB P00396.
SMRP24983. Positions 1-514.
ModBaseSearch...

Genome annotation databases

GeneID807613.

Phylogenomic databases

HOVERGENP24983.

Enzyme and pathway databases

BRENDA1.9.3.1. 142536.

Family and domain databases

InterProIPR000883. Cyt_c_oxidase_su1.
[Graphical view]
Gene3DG3DSA:1.20.210.10. COX1. 1 hit.
PANTHERPTHR10422. COX1. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCOX1_BALPH
AccessionPrimary (citable) accession number: P24983
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents