Cytochrome b - Loxodonta africana (African elephant)

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P24958 (CYB_LOXAF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome b

Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit

Gene names

Name:	MT-CYB
Synonyms:	COB, CYTB, MTCYB

Encoded on

Mitochondrion

Organism

Loxodonta africana (African elephant) [Reference proteome]

Taxonomic identifier

9785 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Afrotheria › Proboscidea › Elephantidae › Loxodonta

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.
Cofactor	Binds 2 heme groups non-covalently By similarity.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.
Sequence similarities	Belongs to the cytochrome b family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 378

378

Cytochrome b

PRO_0000061136

Regions

Transmembrane

33 – 53

Helical; Potential

Transmembrane

76 – 98

Helical; Potential

Transmembrane

116 – 136

Helical; Potential

Transmembrane

140 – 158

Helical; Potential

Transmembrane

178 – 198

Helical; Potential

Transmembrane

229 – 249

Helical; Potential

Transmembrane

288 – 308

Helical; Potential

Transmembrane

323 – 343

Helical; Potential

Transmembrane

348 – 368

Helical; Potential

Sites

Metal binding

Iron 1 (heme b562 axial ligand)

Metal binding

Iron 2 (heme b566 axial ligand)

Metal binding

182

Iron 1 (heme b562 axial ligand)

Metal binding

196

Iron 2 (heme b566 axial ligand)

Experimental info

Sequence conflict

H → D in CAA39732. Ref.1

Sequence conflict

I → M in CAA39732. Ref.1

Sequence conflict

150

F → L in CAA39732. Ref.1

Sequence conflict

155

Y → C in BAA25012. Ref.2

Sequence conflict

155

Y → C in BAA25013. Ref.2

Sequence conflict

212

T → I in BAA25012. Ref.2

Sequence conflict

212

T → I in BAA25013. Ref.2

Sequence conflict

249

M → H in CAA39732. Ref.1

Sequence conflict

257 – 260

MPAD → TLAN in CAA39732. Ref.1

Sequence conflict

264 – 266

TPL → NPP in CAA39732. Ref.1

Sequence conflict

322 – 325

QVLF → LCAYC in CAA39732. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P24958 [UniParc].

Last modified January 27, 2003. Version 2.
Checksum: 05E75F539C8F9D6F
Show »

FASTA

378

42,740

        10         20         30         40         50         60 
MTHIRKSHPL LKIINKSFID LPTPSNISTW WNFGSLLGAC LITQILTGLF LAMHYTPDTM 

        70         80         90        100        110        120 
TAFSSMSHIC RDVNYGWIIR QLHSNGASIF FLCLYTHIGR NIYYGSYLYS ETWNTGIMLL 

       130        140        150        160        170        180 
LITMATAFMG YVLPWGQMSF WGATVITNLF SAIPYIGTNL VEWIWGGFSV DKATLNRFFA 

       190        200        210        220        230        240 
LHFILPFTMI ALAGVHLTFL HETGSNNPLG LTSDSDKIPF HPYYTIKDFL GLLILILLLL 

       250        260        270        280        290        300 
LLALLSPDML GDPDNYMPAD PLNTPLHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI 

       310        320        330        340        350        360 
LGLMPLLHTS KHRSMMLRPL SQVLFWTLTM DLLTLTWIGS QPVEYPYIII GQMASILYFS 

       370 
IILAFLPIAG VIENYLIK

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References

[1]	"Evolution of the cytochrome b gene of mammals." Irwin D.M., Kocher T.D., Wilson A.C. J. Mol. Evol. 32:128-144(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular phylogenetic inference of the woolly mammoth Mammuthus primigenius, based on complete sequences of mitochondrial cytochrome b and 12S ribosomal RNA genes." Noro M., Masuda R., Dubrovo I.A., Yoshida M.C., Kato M. J. Mol. Evol. 46:314-326(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The complete mitochondrial genome sequence of the African elephant (Loxodonta africana), phylogenetic relationships of Proboscidea to other mammals and D-loop heteroplasmy." Hauf J., Waddell P.J., Chalwatzis N., Joger U., Zimmermann F.K. Zoology 102:184-195(2000) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[4]	"Molecular phylogeny of Elephantidae. Extreme divergence of the extant forest African elephant." Barriel V., Thuet E., Tassy P. C. R. Acad. Sci. III, Sci. Vie 322:447-454(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-376.
[5]	"Phylogenetic resolution within the Elephantidae using fossil DNA sequence from the American mastodon (Mammut americanum) as an outgroup." Yang H., Golenberg E.M., Shoshani J. Proc. Natl. Acad. Sci. U.S.A. 93:1190-1194(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-106.
[6]	Mueller S., Steinborn R., Mueller M. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 339-378.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56285 Genomic DNA. Translation: CAA39732.1. D84150 Genomic DNA. Translation: BAA25011.1. D84151 Genomic DNA. Translation: BAA25012.1. D84152 Genomic DNA. Translation: BAA25013.1. AJ224821 Genomic DNA. Translation: CAA12150.1. AF132528 Genomic DNA. Translation: AAD44171.1. U23741 Genomic DNA. Translation: AAA73784.1. AF219242 Genomic DNA. Translation: AAG44238.1.
PIR	S17412. T45562.
RefSeq	NP_009291.1. NC_000934.1.
3D structure databases
ProteinModelPortal	P24958.
SMR	P24958. Positions 1-378.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSLAFT00000038069; ENSLAFP00000029503; ENSLAFG00000033303.
GeneID	808783.
Organism-specific databases
CTD	4519.
Phylogenomic databases
HOVERGEN	HBG017694.
ProtClustDB	MTH00100.
Family and domain databases
InterPro	IPR016175. Cyt_b/b6. IPR005798. Cyt_b/b6_C. IPR005797. Cyt_b/b6_N. IPR016174. Di-haem_cyt_TM. [Graphical view]
PANTHER	PTHR19271. PTHR19271. 1 hit.
Pfam	PF00032. Cytochrom_B_C. 1 hit. PF13631. Cytochrom_B_N_2. 1 hit. [Graphical view]
SUPFAM	SSF81648. Cytochrome_b/b6_C. 1 hit. SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITE	PS51003. CYTB_CTER. 1 hit. PS51002. CYTB_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYB_LOXAF

Accession

Primary (citable) accession number: P24958
Secondary accession number(s): O47887

Q9XNF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	January 27, 2003
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents