##gff-version 3 P24928 UniProtKB Chain 1 1970 . . . ID=PRO_0000073940;Note=DNA-directed RNA polymerase II subunit RPB1 P24928 UniProtKB Repeat 1593 1599 . . . Note=1;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1600 1606 . . . Note=2%3B approximate;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1608 1614 . . . Note=3;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1615 1621 . . . Note=4;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1622 1628 . . . Note=5;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1629 1635 . . . Note=6;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1636 1642 . . . Note=7;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1643 1649 . . . Note=8;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1650 1656 . . . Note=9;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1657 1663 . . . Note=10;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1664 1670 . . . Note=11;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1671 1677 . . . Note=12;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1678 1684 . . . Note=13;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1685 1691 . . . Note=14;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1692 1698 . . . Note=15;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1699 1705 . . . Note=16;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1706 1712 . . . Note=17;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1713 1719 . . . Note=18;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1720 1726 . . . Note=19;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1727 1733 . . . Note=20;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1734 1740 . . . Note=21;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1741 1747 . . . Note=22;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1748 1754 . . . Note=23;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1755 1761 . . . Note=24;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1762 1768 . . . Note=25;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1769 1775 . . . Note=26;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1776 1782 . . . Note=27;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1783 1789 . . . Note=28;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1790 1796 . . . Note=29;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1797 1803 . . . Note=30;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1804 1810 . . . Note=31;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1811 1817 . . . Note=32;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1818 1824 . . . Note=33;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1825 1831 . . . Note=34;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1832 1838 . . . Note=35;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1839 1845 . . . Note=36;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1846 1852 . . . Note=37;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1853 1859 . . . Note=38;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1860 1866 . . . Note=39;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1867 1873 . . . Note=40;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1874 1880 . . . Note=41;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1881 1887 . . . Note=42;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1888 1894 . . . Note=43;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1895 1901 . . . Note=44;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1902 1908 . . . Note=45;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1909 1915 . . . Note=46;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1916 1922 . . . Note=47;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1923 1929 . . . Note=48;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1930 1936 . . . Note=49;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1940 1946 . . . Note=50;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1947 1953 . . . Note=51%3B approximate;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Repeat 1954 1960 . . . Note=52%3B approximate;Ontology_term=ECO:0000255;evidence=ECO:0000255 P24928 UniProtKB Region 832 873 . . . Note=Bridging helix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Region 1083 1124 . . . Note=Trigger loop;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Region 1546 1970 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24928 UniProtKB Region 1593 1960 . . . Note=C-terminal domain (CTD)%3B 52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN] P24928 UniProtKB Compositional bias 1565 1584 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24928 UniProtKB Compositional bias 1607 1963 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P24928 UniProtKB Binding site 67 67 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 71 71 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 74 74 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 81 81 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 84 84 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 111 111 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 114 114 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 154 154 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 184 184 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 346 346 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 358 358 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 460 460 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 493 493 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 495 495 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 495 495 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 497 497 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 497 497 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04050 P24928 UniProtKB Binding site 499 499 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27193682,ECO:0007744|PDB:5IY6;Dbxref=PMID:27193682 P24928 UniProtKB Binding site 499 499 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 1416 1416 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Binding site 1421 1421 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:G3MZY8 P24928 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 P24928 UniProtKB Modified residue 27 27 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P24928 UniProtKB Modified residue 217 217 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P24928 UniProtKB Modified residue 1603 1603 . . . Note=Omega-N-methylated arginine%3B by CARM1%3B in vitro;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26700805;Dbxref=PMID:26700805 P24928 UniProtKB Modified residue 1810 1810 . . . Note=Asymmetric dimethylarginine%3B alternate%3B by CARM1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21454787,ECO:0000269|PubMed:26700805;Dbxref=PMID:21454787,PMID:26700805 P24928 UniProtKB Modified residue 1810 1810 . . . Note=Symmetric dimethylarginine%3B alternate%3B by PRMT5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26700805;Dbxref=PMID:26700805 P24928 UniProtKB Modified residue 1838 1838 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1838 1838 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1840 1840 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1843 1843 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332,PMID:26566685 P24928 UniProtKB Modified residue 1845 1845 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1847 1847 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1849 1849 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648,PMID:26566685 P24928 UniProtKB Modified residue 1850 1850 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1854 1854 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 P24928 UniProtKB Modified residue 1857 1857 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1859 1859 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1859 1859 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1860 1860 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1861 1861 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1863 1863 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1864 1864 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1866 1866 . . . Note=N6%2CN6%2CN6-trimethyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1866 1866 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1866 1866 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1866 1866 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1867 1867 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1868 1868 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P24928 UniProtKB Modified residue 1870 1870 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1873 1873 . . . Note=N6%2CN6%2CN6-trimethyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1873 1873 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1873 1873 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1874 1874 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569,PMID:26566685 P24928 UniProtKB Modified residue 1875 1875 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1877 1877 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1878 1878 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1881 1881 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1882 1882 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1885 1885 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P24928 UniProtKB Modified residue 1887 1887 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1887 1887 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1887 1887 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1894 1894 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1896 1896 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P24928 UniProtKB Modified residue 1899 1899 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163 P24928 UniProtKB Modified residue 1906 1906 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 P24928 UniProtKB Modified residue 1908 1908 . . . Note=N6%2CN6-dimethyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1909 1909 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:24275569,PMID:26566685 P24928 UniProtKB Modified residue 1912 1912 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1913 1913 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1915 1915 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1916 1916 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1917 1917 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692;Dbxref=PMID:19690332,PMID:21406692,PMID:26566685 P24928 UniProtKB Modified residue 1919 1919 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1920 1920 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1922 1922 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1922 1922 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1922 1922 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1923 1923 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:24275569;Dbxref=PMID:16964243,PMID:18669648,PMID:24275569,PMID:26566685 P24928 UniProtKB Modified residue 1926 1926 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1927 1927 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163,PMID:26566685 P24928 UniProtKB Modified residue 1929 1929 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1930 1930 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1931 1931 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26566685,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692;Dbxref=PMID:19690332,PMID:21406692,PMID:26566685 P24928 UniProtKB Modified residue 1933 1933 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1934 1934 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163 P24928 UniProtKB Modified residue 1936 1936 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P08775 P24928 UniProtKB Modified residue 1936 1936 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Modified residue 1936 1936 . . . Note=N6-methyllysine%3B alternate;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:26566685;Dbxref=PMID:26566685 P24928 UniProtKB Cross-link 1268 1268 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B by NEDD4;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:32142649,ECO:0000305|PubMed:32142654;Dbxref=PMID:32142649,PMID:32142654 P24928 UniProtKB Alternative sequence 558 566 . . . ID=VSP_056184;Note=In isoform 2. GEVMNLLMF->VCGPNGNLA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P24928 UniProtKB Alternative sequence 567 1970 . . . ID=VSP_056185;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P24928 UniProtKB Natural variant 292 292 . . . ID=VAR_051872;Note=R->C;Dbxref=dbSNP:rs2229198 P24928 UniProtKB Natural variant 371 371 . . . ID=VAR_082988;Note=In NEDHIB%3B uncertain significance%3B mild. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 457 457 . . . ID=VAR_082989;Note=In NEDHIB%3B uncertain significance%3B severe%3B no effect on cell viability. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 531 531 . . . ID=VAR_082990;Note=In NEDHIB%3B uncertain significance%3B no effect on cell viability. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 669 669 . . . ID=VAR_082991;Note=In NEDHIB%3B moderate. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 700 1970 . . . ID=VAR_082992;Note=In NEDHIB%3B mild. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 735 1970 . . . ID=VAR_082993;Note=In NEDHIB%3B mild. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 736 736 . . . ID=VAR_082994;Note=In NEDHIB%3B profound%3B decreased cell viability. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 755 755 . . . ID=VAR_082995;Note=In NEDHIB%3B uncertain significance%3B mild%3B decreased cell viability. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 769 769 . . . ID=VAR_082996;Note=In NEDHIB%3B uncertain significance%3B severe. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 848 848 . . . ID=VAR_082997;Note=In NEDHIB%3B uncertain significance%3B moderate. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 1109 1109 . . . ID=VAR_082998;Note=In NEDHIB%3B uncertain significance%3B moderate. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 1124 1124 . . . ID=VAR_082999;Note=In NEDHIB%3B mild%3B decreased cell viability. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 1125 1125 . . . ID=VAR_083000;Note=In NEDHIB%3B uncertain significance%3B mild. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 1251 1251 . . . ID=VAR_083001;Note=In NEDHIB%3B uncertain significance%3B severe%3B no effect on cell viability. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Natural variant 1603 1603 . . . ID=VAR_083002;Note=In NEDHIB%3B uncertain significance%3B moderate%3B no effect on cell viability. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Mutagenesis 812 1970 . . . Note=Decreases cell viability. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31353023;Dbxref=PMID:31353023 P24928 UniProtKB Mutagenesis 1268 1268 . . . Note=Impairs ubiquitination%2C interaction with the TFIIH complex%2C and its degradation during transcription stress. K->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:32142649,ECO:0000269|PubMed:32142654;Dbxref=PMID:32142649,PMID:32142654 P24928 UniProtKB Mutagenesis 1810 1810 . . . Note=Misexpression of a variety of small nuclear RNAs and small nucleolar RNAs. Loss of interaction with TDRD3 and SMN1/SMN2. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21454787,ECO:0000269|PubMed:26700805;Dbxref=PMID:21454787,PMID:26700805 P24928 UniProtKB Mutagenesis 1838 1838 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1859%3B R-1866%3B R-1873%3B R-1887%3B R-1908%3B R-1922 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1859 1859 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1838%3B R-1866%3B R-1873%3B R-1887%3B R-1908%3B R-1922 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1866 1866 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1859%3B R-1859%3B R-1873%3B R-1887%3B R-1908%3B R-1922 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1873 1873 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1838%3B R-1859%3B R-1866%3B R-1887%3B R-1908%3B R-1922 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1887 1887 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1838%3B R-1859%3B R-1866%3B R-1873%3B R-1908%3B R-1922 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1908 1908 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R.1838%3B R-1859%3B R-1866%3B R-1873%3B R-1887%3B R-1922 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1922 1922 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1838%3B R-1859%3B R-1866%3B R-1873%3B R-1887%3B R-1908 and R-1936. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Mutagenesis 1936 1936 . . . Note=Loss of acetylation and loss of regulation of growth-factor-induced gene expression%3B when associated with R-1838%3B R-1859%3B R-1866%3B R-1873%3B R-1887%3B R-1908 and R-1922. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24207025;Dbxref=PMID:24207025 P24928 UniProtKB Sequence conflict 1067 1067 . . . Note=W->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24928 UniProtKB Sequence conflict 1449 1449 . . . Note=D->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24928 UniProtKB Sequence conflict 1835 1835 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P24928 UniProtKB Helix 1718 1720 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7Z42 P24928 UniProtKB Beta strand 1722 1724 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M3H