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P24923 (CDC21_MEDSA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog 1

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:CDC2A
OrganismMedicago sativa (Alfalfa)
Taxonomic identifier3879 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Protein attributes

Sequence length291 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-11 or Tyr-12 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Tissue specificity

Found in most organs including root, young leaf, stem, vegetative meristem and flower bud.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 291›291Cell division control protein 2 homolog 1
PRO_0000085753

Regions

Domain1 – 284284Protein kinase
Nucleotide binding7 – 159ATP By similarity

Sites

Active site1241Proton acceptor By similarity
Binding site301ATP By similarity

Amino acid modifications

Modified residue111Phosphothreonine By similarity
Modified residue121Phosphotyrosine By similarity
Modified residue1581Phosphothreonine; by CAK By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P24923 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: E5D4F43E592D22B5

FASTA29133,481
        10         20         30         40         50         60 
GENVEKIGEG TYGVVYKARD RVTNETIALK KIRLEQEDEG VPSTAIREIS LLKEMQHRNI 

        70         80         90        100        110        120 
VRLQDVVHSD KRLYLVFEYL DLDLKKHMDS SPEFIKDPRQ VKMFLYQMLC GIAYCHSHRV 

       130        140        150        160        170        180 
LHRDLKPQNL LIDRRTNSLK LADFGLARAF GIPVRTFTHE VVTLWYRAPE ILLGSRHYST 

       190        200        210        220        230        240 
PVDVWSVGCI FAEMANRRPL SPGDSEIDEL FKIFRILGTP NEDTWPGVTS LPDFKSTFPR 

       250        260        270        280        290 
WPSKDLATVV PNLEPAGLDL LNSMLCLDPT KRITARSAVE HEYFKDIKFV P 

« Hide

References

[1]"Complementation of a yeast cell cycle mutant by an alfalfa cDNA encoding a protein kinase homologous to p34cdc2."
Hirt H., Pay A., Gyoergyey J., Bako L., Nemeth K., Boegre L., Schweyen R.J., Heberle-Bors E., Dudits D.
Proc. Natl. Acad. Sci. U.S.A. 88:1636-1640(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58365 mRNA. Translation: AAB41817.1.
PIRA39107.

3D structure databases

ProteinModelPortalP24923.
SMRP24923. Positions 2-287.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP24923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC21_MEDSA
AccessionPrimary (citable) accession number: P24923
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families