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P24920

- TRPC_PHYPR

UniProt

P24920 - TRPC_PHYPR

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Protein
Tryptophan biosynthesis protein TRP1
Gene
TRP1
Organism
Phytophthora parasitica (Potato buckeye rot agent)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway.UniRule annotation

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
  2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BRENDAi5.3.1.24. 4813.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TRP1
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiPhytophthora parasitica (Potato buckeye rot agent)
Taxonomic identifieri4792 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Tryptophan biosynthesis protein TRP1UniRule annotation
PRO_0000154306Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP24920.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 254254Indole-3-glycerol phosphate synthaseUniRule annotation
Add
BLAST
Regioni255 – 531277N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.
In the C-terminal section; belongs to the TrpF family.

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 3 hits.

Sequencei

Sequence statusi: Complete.

P24920-1 [UniParc]FASTAAdd to Basket

« Hide

MGNILEEIAA QRRLDVAAAK QVVSTDDLAK KIEHTESVYG PALPVLERLN    50
APAEQVQAYA NAGASMISVL TEPKWFKGSL DDMMEAREVV EGMSQRPAIL 100
RKDFIIDVYQ LLEARAYGAD CVLLIVTLLS KEQLIELIDA THNLGMCALV 150
EVNSVQELDI ALAAKARLIG VNNRDLRTFK VDMNTTARVA DAIRERGLSL 200
GRDGVALFAL SGIRSHTDVV KYEKCGARGI LVGEYLMKSG DIATTVKDLL 250
QNVTRHSESG EFALLPPLAK VCGITTVEYA LAALRNGANM IGIIMAEHSP 300
RYVEKEEAKA IAKAVREYGE RTGPILSDIL ESHLDDKSDW FHRNVLALRE 350
ACSRAPLVVG VFVNKTATEM NAAAEEIGLD LVQLHGDEGF EICKDIKYPT 400
IRALHLPDTA QCDGVDAEAV LQQVSEGLAN YILLDTTVKG QQGGTGVAFD 450
WKIAAIFTQA RLPCLMAGGL TPENVVKALS VGHPVGVDVS SGVEVKGSPG 500
VKDLDKVAAF LKAVKDHLSV ATLKIDEETE N 531
Length:531
Mass (Da):57,375
Last modified:March 1, 1992 - v1
Checksum:iC154137A6A419ED1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64473 Genomic DNA. Translation: AAA33751.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64473 Genomic DNA. Translation: AAA33751.1 .

3D structure databases

ProteinModelPortali P24920.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .
BRENDAi 5.3.1.24. 4813.

Family and domain databases

Gene3Di 3.20.20.70. 3 hits.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "The TRP1 gene of Phytophthora parasitica encoding indole-3-glycerolphosphate synthase-N-(5'-phosphoribosyl)anthranilate isomerase: structure and evolutionary distance from homologous fungal genes."
    Karlovsky P., Prell H.H.
    Gene 109:161-165(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTRPC_PHYPR
AccessioniPrimary (citable) accession number: P24920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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