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P24920 (TRPC_PHYPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan biosynthesis protein TRP1

Including the following 2 domains:

  1. Indole-3-glycerol phosphate synthase
    Short name=IGPS
    EC=4.1.1.48
  2. N-(5'-phospho-ribosyl)anthranilate isomerase
    Short name=PRAI
    EC=5.3.1.24
Gene names
Name:TRP1
OrganismPhytophthora parasitica (Potato buckeye rot agent)
Taxonomic identifier4792 [NCBI]
Taxonomic lineageEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. HAMAP-Rule MF_00135

Catalytic activity

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00135

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.

Sequence similarities

In the N-terminal section; belongs to the TrpC family.

In the C-terminal section; belongs to the TrpF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531Tryptophan biosynthesis protein TRP1 HAMAP-Rule MF_00135
PRO_0000154306

Regions

Region1 – 254254Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00135
Region255 – 531277N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135

Sequences

Sequence LengthMass (Da)Tools
P24920 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: C154137A6A419ED1

FASTA53157,375
        10         20         30         40         50         60 
MGNILEEIAA QRRLDVAAAK QVVSTDDLAK KIEHTESVYG PALPVLERLN APAEQVQAYA 

        70         80         90        100        110        120 
NAGASMISVL TEPKWFKGSL DDMMEAREVV EGMSQRPAIL RKDFIIDVYQ LLEARAYGAD 

       130        140        150        160        170        180 
CVLLIVTLLS KEQLIELIDA THNLGMCALV EVNSVQELDI ALAAKARLIG VNNRDLRTFK 

       190        200        210        220        230        240 
VDMNTTARVA DAIRERGLSL GRDGVALFAL SGIRSHTDVV KYEKCGARGI LVGEYLMKSG 

       250        260        270        280        290        300 
DIATTVKDLL QNVTRHSESG EFALLPPLAK VCGITTVEYA LAALRNGANM IGIIMAEHSP 

       310        320        330        340        350        360 
RYVEKEEAKA IAKAVREYGE RTGPILSDIL ESHLDDKSDW FHRNVLALRE ACSRAPLVVG 

       370        380        390        400        410        420 
VFVNKTATEM NAAAEEIGLD LVQLHGDEGF EICKDIKYPT IRALHLPDTA QCDGVDAEAV 

       430        440        450        460        470        480 
LQQVSEGLAN YILLDTTVKG QQGGTGVAFD WKIAAIFTQA RLPCLMAGGL TPENVVKALS 

       490        500        510        520        530 
VGHPVGVDVS SGVEVKGSPG VKDLDKVAAF LKAVKDHLSV ATLKIDEETE N 

« Hide

References

[1]"The TRP1 gene of Phytophthora parasitica encoding indole-3-glycerolphosphate synthase-N-(5'-phosphoribosyl)anthranilate isomerase: structure and evolutionary distance from homologous fungal genes."
Karlovsky P., Prell H.H.
Gene 109:161-165(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64473 Genomic DNA. Translation: AAA33751.1.

3D structure databases

ProteinModelPortalP24920.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA5.3.1.24. 4813.
UniPathwayUPA00035; UER00042.
UPA00035; UER00043.

Family and domain databases

Gene3D3.20.20.70. 3 hits.
HAMAPMF_00135. PRAI.
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 3 hits.
ProtoNetSearch...

Entry information

Entry nameTRPC_PHYPR
AccessionPrimary (citable) accession number: P24920
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways