Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24920

- TRPC_PHYPR

UniProt

P24920 - TRPC_PHYPR

Protein

Tryptophan biosynthesis protein TRP1

Gene

TRP1

Organism
Phytophthora parasitica (Potato buckeye rot agent)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway.

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    2. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BRENDAi5.3.1.24. 4813.
    UniPathwayiUPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan biosynthesis protein TRP1
    Including the following 2 domains:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:TRP1
    OrganismiPhytophthora parasitica (Potato buckeye rot agent)
    Taxonomic identifieri4792 [NCBI]
    Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Tryptophan biosynthesis protein TRP1PRO_0000154306Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP24920.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 254254Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni255 – 531277N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpC family.Curated
    In the C-terminal section; belongs to the TrpF family.Curated

    Family and domain databases

    Gene3Di3.20.20.70. 3 hits.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    P24920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNILEEIAA QRRLDVAAAK QVVSTDDLAK KIEHTESVYG PALPVLERLN    50
    APAEQVQAYA NAGASMISVL TEPKWFKGSL DDMMEAREVV EGMSQRPAIL 100
    RKDFIIDVYQ LLEARAYGAD CVLLIVTLLS KEQLIELIDA THNLGMCALV 150
    EVNSVQELDI ALAAKARLIG VNNRDLRTFK VDMNTTARVA DAIRERGLSL 200
    GRDGVALFAL SGIRSHTDVV KYEKCGARGI LVGEYLMKSG DIATTVKDLL 250
    QNVTRHSESG EFALLPPLAK VCGITTVEYA LAALRNGANM IGIIMAEHSP 300
    RYVEKEEAKA IAKAVREYGE RTGPILSDIL ESHLDDKSDW FHRNVLALRE 350
    ACSRAPLVVG VFVNKTATEM NAAAEEIGLD LVQLHGDEGF EICKDIKYPT 400
    IRALHLPDTA QCDGVDAEAV LQQVSEGLAN YILLDTTVKG QQGGTGVAFD 450
    WKIAAIFTQA RLPCLMAGGL TPENVVKALS VGHPVGVDVS SGVEVKGSPG 500
    VKDLDKVAAF LKAVKDHLSV ATLKIDEETE N 531
    Length:531
    Mass (Da):57,375
    Last modified:March 1, 1992 - v1
    Checksum:iC154137A6A419ED1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64473 Genomic DNA. Translation: AAA33751.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64473 Genomic DNA. Translation: AAA33751.1 .

    3D structure databases

    ProteinModelPortali P24920.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .
    BRENDAi 5.3.1.24. 4813.

    Family and domain databases

    Gene3Di 3.20.20.70. 3 hits.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The TRP1 gene of Phytophthora parasitica encoding indole-3-glycerolphosphate synthase-N-(5'-phosphoribosyl)anthranilate isomerase: structure and evolutionary distance from homologous fungal genes."
      Karlovsky P., Prell H.H.
      Gene 109:161-165(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTRPC_PHYPR
    AccessioniPrimary (citable) accession number: P24920
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3