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Protein

Tryptophan biosynthesis protein TRP1

Gene

TRP1

Organism
Phytophthora parasitica (Potato buckeye rot agent)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway.

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Tryptophan biosynthesis protein TRP1 (TRP1)
  4. Tryptophan biosynthesis protein TRP1 (TRP1)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BRENDAi5.3.1.24. 4813.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TRP1
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiPhytophthora parasitica (Potato buckeye rot agent)
Taxonomic identifieri4792 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesPeronosporalesPhytophthora

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543061 – 531Tryptophan biosynthesis protein TRP1Add BLAST531

Structurei

3D structure databases

ProteinModelPortaliP24920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 254Indole-3-glycerol phosphate synthaseAdd BLAST254
Regioni255 – 531N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST277

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Family and domain databases

CDDicd00331. IGPS. 1 hit.
cd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 3 hits.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 3 hits.

Sequencei

Sequence statusi: Complete.

P24920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNILEEIAA QRRLDVAAAK QVVSTDDLAK KIEHTESVYG PALPVLERLN
60 70 80 90 100
APAEQVQAYA NAGASMISVL TEPKWFKGSL DDMMEAREVV EGMSQRPAIL
110 120 130 140 150
RKDFIIDVYQ LLEARAYGAD CVLLIVTLLS KEQLIELIDA THNLGMCALV
160 170 180 190 200
EVNSVQELDI ALAAKARLIG VNNRDLRTFK VDMNTTARVA DAIRERGLSL
210 220 230 240 250
GRDGVALFAL SGIRSHTDVV KYEKCGARGI LVGEYLMKSG DIATTVKDLL
260 270 280 290 300
QNVTRHSESG EFALLPPLAK VCGITTVEYA LAALRNGANM IGIIMAEHSP
310 320 330 340 350
RYVEKEEAKA IAKAVREYGE RTGPILSDIL ESHLDDKSDW FHRNVLALRE
360 370 380 390 400
ACSRAPLVVG VFVNKTATEM NAAAEEIGLD LVQLHGDEGF EICKDIKYPT
410 420 430 440 450
IRALHLPDTA QCDGVDAEAV LQQVSEGLAN YILLDTTVKG QQGGTGVAFD
460 470 480 490 500
WKIAAIFTQA RLPCLMAGGL TPENVVKALS VGHPVGVDVS SGVEVKGSPG
510 520 530
VKDLDKVAAF LKAVKDHLSV ATLKIDEETE N
Length:531
Mass (Da):57,375
Last modified:March 1, 1992 - v1
Checksum:iC154137A6A419ED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64473 Genomic DNA. Translation: AAA33751.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64473 Genomic DNA. Translation: AAA33751.1.

3D structure databases

ProteinModelPortaliP24920.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.
BRENDAi5.3.1.24. 4813.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
cd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 3 hits.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC_PHYPR
AccessioniPrimary (citable) accession number: P24920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.