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Protein

Transcription factor jun-B

Gene

Junb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: RGD
  • female pregnancy Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • positive regulation of cell differentiation Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • regulation of cell cycle Source: GO_Central
  • regulation of cell death Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to cAMP Source: RGD
  • response to corticosterone Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to light stimulus Source: RGD
  • response to lipopolysaccharide Source: GO_Central
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to progesterone Source: RGD
  • transcription from RNA polymerase II promoter Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Gene namesi
Name:Junb
Synonyms:Jun-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2944. Junb.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: GO_Central
  • nucleus Source: RGD
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Transcription factor jun-BPRO_0000076440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki4 – 4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki33 – 33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki36 – 36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei102 – 1021PhosphothreonineBy similarity
Modified residuei104 – 1041PhosphothreonineBy similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei237 – 2371N6-acetyllysine; alternateBy similarity
Cross-linki237 – 237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki237 – 237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei252 – 2521PhosphothreonineCombined sources
Modified residuei256 – 2561PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP24898.
PRIDEiP24898.

PTM databases

iPTMnetiP24898.
PhosphoSiteiP24898.

Expressioni

Inductioni

By growth factors.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061729.

Structurei

3D structure databases

ProteinModelPortaliP24898.
SMRiP24898. Positions 269-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 32864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 29228Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni293 – 32129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP24898.
KOiK09028.
OrthoDBiEOG75MVXV.
PhylomeDBiP24898.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF37. PTHR11462:SF37. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL
60 70 80 90 100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT
160 170 180 190 200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG
210 220 230 240 250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD
260 270 280 290 300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL
310 320 330 340
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF
Length:344
Mass (Da):35,765
Last modified:September 27, 2004 - v2
Checksum:i6F52D4FECC32E234
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81P → A in CAA38500 (PubMed:1542584).Curated
Sequence conflicti144 – 1441H → Q in CAA38500 (PubMed:1542584).Curated
Sequence conflicti310 – 3101A → T in AAH61862 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54686 Genomic DNA. Translation: CAA38500.1.
BC061862 mRNA. Translation: AAH61862.1.
PIRiS21063.
RefSeqiNP_068608.2. NM_021836.2.
UniGeneiRn.15806.

Genome annotation databases

GeneIDi24517.
KEGGirno:24517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54686 Genomic DNA. Translation: CAA38500.1.
BC061862 mRNA. Translation: AAH61862.1.
PIRiS21063.
RefSeqiNP_068608.2. NM_021836.2.
UniGeneiRn.15806.

3D structure databases

ProteinModelPortaliP24898.
SMRiP24898. Positions 269-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061729.

PTM databases

iPTMnetiP24898.
PhosphoSiteiP24898.

Proteomic databases

PaxDbiP24898.
PRIDEiP24898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24517.
KEGGirno:24517.

Organism-specific databases

CTDi3726.
RGDi2944. Junb.

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP24898.
KOiK09028.
OrthoDBiEOG75MVXV.
PhylomeDBiP24898.

Miscellaneous databases

PROiP24898.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF37. PTHR11462:SF37. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Fischer.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-252 AND SER-256, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiJUNB_RAT
AccessioniPrimary (citable) accession number: P24898
Secondary accession number(s): Q6P733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 27, 2004
Last modified: July 6, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.