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Protein

Transcription factor jun-B

Gene

Junb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: RGD
  • female pregnancy Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • positive regulation of cell differentiation Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • regulation of cell cycle Source: GO_Central
  • regulation of cell death Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to cAMP Source: RGD
  • response to corticosterone Source: RGD
  • response to cytokine Source: RGD
  • response to drug Source: RGD
  • response to light stimulus Source: RGD
  • response to lipopolysaccharide Source: GO_Central
  • response to mechanical stimulus Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to progesterone Source: RGD
  • transcription from RNA polymerase II promoter Source: RGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Gene namesi
Name:Junb
Synonyms:Jun-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2944. Junb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764401 – 344Transcription factor jun-BAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei102PhosphothreonineBy similarity1
Modified residuei104PhosphothreonineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei237N6-acetyllysine; alternateBy similarity1
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei248PhosphoserineBy similarity1
Modified residuei252PhosphothreonineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP24898.
PRIDEiP24898.

PTM databases

iPTMnetiP24898.
PhosphoSitePlusiP24898.

Expressioni

Inductioni

By growth factors.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246672. 1 interactor.
CORUMiP24898.
STRINGi10116.ENSRNOP00000061729.

Structurei

3D structure databases

ProteinModelPortaliP24898.
SMRiP24898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 328bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 292Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni293 – 321Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837. Eukaryota.
ENOG410XRWH. LUCA.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP24898.
KOiK09028.
PhylomeDBiP24898.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
IPR005643. JNK.
IPR029822. JunB.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
PANTHERiPTHR11462:SF47. PTHR11462:SF47. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P24898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL
60 70 80 90 100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT
160 170 180 190 200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG
210 220 230 240 250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD
260 270 280 290 300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL
310 320 330 340
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF
Length:344
Mass (Da):35,765
Last modified:September 27, 2004 - v2
Checksum:i6F52D4FECC32E234
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8P → A in CAA38500 (PubMed:1542584).Curated1
Sequence conflicti144H → Q in CAA38500 (PubMed:1542584).Curated1
Sequence conflicti310A → T in AAH61862 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54686 Genomic DNA. Translation: CAA38500.1.
BC061862 mRNA. Translation: AAH61862.1.
PIRiS21063.
RefSeqiNP_068608.2. NM_021836.2.
UniGeneiRn.15806.

Genome annotation databases

GeneIDi24517.
KEGGirno:24517.

Similar proteinsi

Entry informationi

Entry nameiJUNB_RAT
AccessioniPrimary (citable) accession number: P24898
Secondary accession number(s): Q6P733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 27, 2004
Last modified: September 27, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families