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P24894

- COX2_CAEEL

UniProt

P24894 - COX2_CAEEL

Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi164 – 1641Copper ACurated
    Metal bindingi199 – 1991Copper ACurated
    Metal bindingi203 – 2031Copper ACurated
    Metal bindingi207 – 2071Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC
    2. mitochondrial electron transport, cytochrome c to oxygen Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:cox-2
    Synonyms:coII
    ORF Names:MTCE.31
    Encoded oniMitochondrion
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Mitochondrion

    Organism-specific databases

    WormBaseiMTCE.31; CE35351; WBGene00010965; cox-2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Cytochrome c oxidase subunit 2PRO_0000183526Add
    BLAST

    Proteomic databases

    PaxDbiP24894.

    Structurei

    3D structure databases

    ProteinModelPortaliP24894.
    SMRiP24894. Positions 15-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6917Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini90 – 231142Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 8920HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000264988.
    KOiK02261.
    OrthoDBiEOG7TJ3JX.
    PhylomeDBiP24894.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24894-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFFQGYNL LFQHSLFASY MDWFHSFNCS LLLGVLVFVT LLFGYLIFGT    50
    FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV 100
    KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LSLGEPRLLE VDNRCVIPCD 150
    TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS 200
    EICGANHSFM PIALEVTLLD NFKSWCFGTM E 231
    Length:231
    Mass (Da):26,549
    Last modified:November 1, 1995 - v2
    Checksum:iFCD8D458D1B0DDAA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti132 – 1321S → N in strain: PB303. 1 Publication
    Natural varianti143 – 1431N → I in strain: CB4857. 1 Publication
    Natural varianti186 – 1861S → N in strain: AB2, CB4852, CB4853, CB4855, CB4858 and PB306. 1 Publication
    Natural varianti216 – 2161V → M in strain: AB1 and KR314. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY171193 Genomic DNA. Translation: AAO16253.1.
    AY171194 Genomic DNA. Translation: AAO16257.1.
    AY171195 Genomic DNA. Translation: AAO16261.1.
    AY171196 Genomic DNA. Translation: AAO16265.1.
    AY171197 Genomic DNA. Translation: AAO16269.1.
    AY171198 Genomic DNA. Translation: AAO16273.1.
    AY171199 Genomic DNA. Translation: AAO16277.1.
    AY171200 Genomic DNA. Translation: AAO16281.1.
    AY171201 Genomic DNA. Translation: AAO16285.1.
    AY171202 Genomic DNA. Translation: AAO16289.1.
    AY171203 Genomic DNA. Translation: AAO16293.1.
    AY171204 Genomic DNA. Translation: AAO16297.1.
    AY171205 Genomic DNA. Translation: AAO16301.1.
    AY171206 Genomic DNA. Translation: AAO16305.1.
    AY171207 Genomic DNA. Translation: AAO16309.1.
    X54252 Genomic DNA. Translation: CAA38160.1.
    PIRiS26035.
    RefSeqiNP_006962.1. NC_001328.1.

    Genome annotation databases

    GeneIDi2565697.
    KEGGicel:COX2.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY171193 Genomic DNA. Translation: AAO16253.1 .
    AY171194 Genomic DNA. Translation: AAO16257.1 .
    AY171195 Genomic DNA. Translation: AAO16261.1 .
    AY171196 Genomic DNA. Translation: AAO16265.1 .
    AY171197 Genomic DNA. Translation: AAO16269.1 .
    AY171198 Genomic DNA. Translation: AAO16273.1 .
    AY171199 Genomic DNA. Translation: AAO16277.1 .
    AY171200 Genomic DNA. Translation: AAO16281.1 .
    AY171201 Genomic DNA. Translation: AAO16285.1 .
    AY171202 Genomic DNA. Translation: AAO16289.1 .
    AY171203 Genomic DNA. Translation: AAO16293.1 .
    AY171204 Genomic DNA. Translation: AAO16297.1 .
    AY171205 Genomic DNA. Translation: AAO16301.1 .
    AY171206 Genomic DNA. Translation: AAO16305.1 .
    AY171207 Genomic DNA. Translation: AAO16309.1 .
    X54252 Genomic DNA. Translation: CAA38160.1 .
    PIRi S26035.
    RefSeqi NP_006962.1. NC_001328.1.

    3D structure databases

    ProteinModelPortali P24894.
    SMRi P24894. Positions 15-225.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P24894.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2565697.
    KEGGi cel:COX2.

    Organism-specific databases

    CTDi 4513.
    WormBasei MTCE.31 ; CE35351 ; WBGene00010965 ; cox-2.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000264988.
    KOi K02261.
    OrthoDBi EOG7TJ3JX.
    PhylomeDBi P24894.

    Miscellaneous databases

    NextBioi 953869.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
      Denver D.R., Morris K., Thomas W.K.
      Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-132; ILE-143; ASN-186 AND MET-216.
      Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
    2. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
      Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
      Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
      Okimoto R., Macfarlane J.L., Wolstenholme D.R.
      Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

    Entry informationi

    Entry nameiCOX2_CAEEL
    AccessioniPrimary (citable) accession number: P24894
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3