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P24894

- COX2_CAEEL

UniProt

P24894 - COX2_CAEEL

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Protein

Cytochrome c oxidase subunit 2

Gene
cox-2, coII, MTCE.31
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641Copper A Inferred
Metal bindingi199 – 1991Copper A Inferred
Metal bindingi203 – 2031Copper A Inferred
Metal bindingi207 – 2071Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. mitochondrial electron transport, cytochrome c to oxygen Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
ORF Names:MTCE.31
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Mitochondrion

Organism-specific databases

WormBaseiMTCE.31; CE35351; WBGene00010965; cox-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei31 – 5222Helical; Reviewed predictionAdd
BLAST
Topological domaini53 – 6917Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei70 – 8920Helical; Reviewed predictionAdd
BLAST
Topological domaini90 – 231142Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Cytochrome c oxidase subunit 2PRO_0000183526Add
BLAST

Proteomic databases

PaxDbiP24894.

Structurei

3D structure databases

ProteinModelPortaliP24894.
SMRiP24894. Positions 15-225.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
KOiK02261.
OrthoDBiEOG7TJ3JX.
PhylomeDBiP24894.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24894-1 [UniParc]FASTAAdd to Basket

« Hide

MNNFFQGYNL LFQHSLFASY MDWFHSFNCS LLLGVLVFVT LLFGYLIFGT    50
FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV 100
KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LSLGEPRLLE VDNRCVIPCD 150
TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS 200
EICGANHSFM PIALEVTLLD NFKSWCFGTM E 231
Length:231
Mass (Da):26,549
Last modified:November 1, 1995 - v2
Checksum:iFCD8D458D1B0DDAA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321S → N in strain: PB303. 1 Publication
Natural varianti143 – 1431N → I in strain: CB4857. 1 Publication
Natural varianti186 – 1861S → N in strain: AB2, CB4852, CB4853, CB4855, CB4858 and PB306. 1 Publication
Natural varianti216 – 2161V → M in strain: AB1 and KR314. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY171193 Genomic DNA. Translation: AAO16253.1.
AY171194 Genomic DNA. Translation: AAO16257.1.
AY171195 Genomic DNA. Translation: AAO16261.1.
AY171196 Genomic DNA. Translation: AAO16265.1.
AY171197 Genomic DNA. Translation: AAO16269.1.
AY171198 Genomic DNA. Translation: AAO16273.1.
AY171199 Genomic DNA. Translation: AAO16277.1.
AY171200 Genomic DNA. Translation: AAO16281.1.
AY171201 Genomic DNA. Translation: AAO16285.1.
AY171202 Genomic DNA. Translation: AAO16289.1.
AY171203 Genomic DNA. Translation: AAO16293.1.
AY171204 Genomic DNA. Translation: AAO16297.1.
AY171205 Genomic DNA. Translation: AAO16301.1.
AY171206 Genomic DNA. Translation: AAO16305.1.
AY171207 Genomic DNA. Translation: AAO16309.1.
X54252 Genomic DNA. Translation: CAA38160.1.
PIRiS26035.
RefSeqiNP_006962.1. NC_001328.1.

Genome annotation databases

GeneIDi2565697.
KEGGicel:COX2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY171193 Genomic DNA. Translation: AAO16253.1 .
AY171194 Genomic DNA. Translation: AAO16257.1 .
AY171195 Genomic DNA. Translation: AAO16261.1 .
AY171196 Genomic DNA. Translation: AAO16265.1 .
AY171197 Genomic DNA. Translation: AAO16269.1 .
AY171198 Genomic DNA. Translation: AAO16273.1 .
AY171199 Genomic DNA. Translation: AAO16277.1 .
AY171200 Genomic DNA. Translation: AAO16281.1 .
AY171201 Genomic DNA. Translation: AAO16285.1 .
AY171202 Genomic DNA. Translation: AAO16289.1 .
AY171203 Genomic DNA. Translation: AAO16293.1 .
AY171204 Genomic DNA. Translation: AAO16297.1 .
AY171205 Genomic DNA. Translation: AAO16301.1 .
AY171206 Genomic DNA. Translation: AAO16305.1 .
AY171207 Genomic DNA. Translation: AAO16309.1 .
X54252 Genomic DNA. Translation: CAA38160.1 .
PIRi S26035.
RefSeqi NP_006962.1. NC_001328.1.

3D structure databases

ProteinModelPortali P24894.
SMRi P24894. Positions 15-225.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P24894.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2565697.
KEGGi cel:COX2.

Organism-specific databases

CTDi 4513.
WormBasei MTCE.31 ; CE35351 ; WBGene00010965 ; cox-2.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
KOi K02261.
OrthoDBi EOG7TJ3JX.
PhylomeDBi P24894.

Miscellaneous databases

NextBioi 953869.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
    Denver D.R., Morris K., Thomas W.K.
    Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-132; ILE-143; ASN-186 AND MET-216.
    Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
  2. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
    Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
    Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
    Okimoto R., Macfarlane J.L., Wolstenholme D.R.
    Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

Entry informationi

Entry nameiCOX2_CAEEL
AccessioniPrimary (citable) accession number: P24894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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