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P24894 (COX2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox-2
Synonyms:coII
ORF Names:MTCE.31
Encoded onMitochondrion
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Cytochrome c oxidase subunit 2
PRO_0000183526

Regions

Topological domain1 – 3030Mitochondrial intermembrane Potential
Transmembrane31 – 5222Helical; Potential
Topological domain53 – 6917Mitochondrial matrix Potential
Transmembrane70 – 8920Helical; Potential
Topological domain90 – 231142Mitochondrial intermembrane Potential

Sites

Metal binding1641Copper A Probable
Metal binding1991Copper A Probable
Metal binding2031Copper A Probable
Metal binding2071Copper A Probable

Natural variations

Natural variant1321S → N in strain: PB303. Ref.1
Natural variant1431N → I in strain: CB4857. Ref.1
Natural variant1861S → N in strain: AB2, CB4852, CB4853, CB4855, CB4858 and PB306. Ref.1
Natural variant2161V → M in strain: AB1 and KR314. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24894 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: FCD8D458D1B0DDAA

FASTA23126,549
        10         20         30         40         50         60 
MNNFFQGYNL LFQHSLFASY MDWFHSFNCS LLLGVLVFVT LLFGYLIFGT FYFKSKKIEY 

        70         80         90        100        110        120 
QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV KVTGHQWYWS YEYSDIPGLE 

       130        140        150        160        170        180 
FDSYMKSLDQ LSLGEPRLLE VDNRCVIPCD TNIRFCITSA DVIHAWALNS LSVKLDAMSG 

       190        200        210        220        230 
ILSTFSYSFP MVGVFYGQCS EICGANHSFM PIALEVTLLD NFKSWCFGTM E 

« Hide

References

« Hide 'large scale' references
[1]"Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
Denver D.R., Morris K., Thomas W.K.
Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-132; ILE-143; ASN-186 AND MET-216.
Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
[2]"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
Okimoto R., Macfarlane J.L., Wolstenholme D.R.
Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY171193 Genomic DNA. Translation: AAO16253.1.
AY171194 Genomic DNA. Translation: AAO16257.1.
AY171195 Genomic DNA. Translation: AAO16261.1.
AY171196 Genomic DNA. Translation: AAO16265.1.
AY171197 Genomic DNA. Translation: AAO16269.1.
AY171198 Genomic DNA. Translation: AAO16273.1.
AY171199 Genomic DNA. Translation: AAO16277.1.
AY171200 Genomic DNA. Translation: AAO16281.1.
AY171201 Genomic DNA. Translation: AAO16285.1.
AY171202 Genomic DNA. Translation: AAO16289.1.
AY171203 Genomic DNA. Translation: AAO16293.1.
AY171204 Genomic DNA. Translation: AAO16297.1.
AY171205 Genomic DNA. Translation: AAO16301.1.
AY171206 Genomic DNA. Translation: AAO16305.1.
AY171207 Genomic DNA. Translation: AAO16309.1.
X54252 Genomic DNA. Translation: CAA38160.1.
PIRS26035.
RefSeqNP_006962.1. NC_001328.1.

3D structure databases

ProteinModelPortalP24894.
SMRP24894. Positions 15-225.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP24894.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2565697.
KEGGcel:COX2.

Organism-specific databases

CTD4513.
WormBaseMTCE.31; CE35351; WBGene00010965; cox-2.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02261.
OrthoDBEOG7TJ3JX.
PhylomeDBP24894.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio953869.

Entry information

Entry nameCOX2_CAEEL
AccessionPrimary (citable) accession number: P24894
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase