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Protein

Cytochrome c oxidase subunit 2

Gene

ctc-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164Copper ACurated1
Metal bindingi199Copper ACurated1
Metal bindingi203Copper ACurated1
Metal bindingi207Copper ACurated1

GO - Molecular functioni

  • copper ion binding Source: InterPro
  • cytochrome-c oxidase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctc-2Imported
Synonyms:coIIImported, cox-2Imported
ORF Names:MTCE.31Imported
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Mitochondrion

Organism-specific databases

WormBaseiMTCE.31; CE35351; WBGene00010965; ctc-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30Mitochondrial intermembraneSequence analysisAdd BLAST30
Transmembranei31 – 52HelicalSequence analysisAdd BLAST22
Topological domaini53 – 69Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei70 – 89HelicalSequence analysisAdd BLAST20
Topological domaini90 – 231Mitochondrial intermembraneSequence analysisAdd BLAST142

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835261 – 231Cytochrome c oxidase subunit 2Add BLAST231

Proteomic databases

EPDiP24894.
PaxDbiP24894.
PRIDEiP24894.

Expressioni

Gene expression databases

BgeeiWBGene00010965.
ExpressionAtlasiP24894. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.MTCE.31.

Structurei

3D structure databases

ProteinModelPortaliP24894.
SMRiP24894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
HOGENOMiHOG000264988.
InParanoidiP24894.
KOiK02261.
OrthoDBiEOG091G0IO9.
PhylomeDBiP24894.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFFQGYNL LFQHSLFASY MDWFHSFNCS LLLGVLVFVT LLFGYLIFGT
60 70 80 90 100
FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV
110 120 130 140 150
KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LSLGEPRLLE VDNRCVIPCD
160 170 180 190 200
TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS
210 220 230
EICGANHSFM PIALEVTLLD NFKSWCFGTM E
Length:231
Mass (Da):26,549
Last modified:November 1, 1995 - v2
Checksum:iFCD8D458D1B0DDAA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti132S → N in strain: PB303. 1 Publication1
Natural varianti143N → I in strain: CB4857. 1 Publication1
Natural varianti186S → N in strain: AB2, CB4852, CB4853, CB4855, CB4858 and PB306. 1 Publication1
Natural varianti216V → M in strain: AB1 and KR314. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171193 Genomic DNA. Translation: AAO16253.1.
AY171194 Genomic DNA. Translation: AAO16257.1.
AY171195 Genomic DNA. Translation: AAO16261.1.
AY171196 Genomic DNA. Translation: AAO16265.1.
AY171197 Genomic DNA. Translation: AAO16269.1.
AY171198 Genomic DNA. Translation: AAO16273.1.
AY171199 Genomic DNA. Translation: AAO16277.1.
AY171200 Genomic DNA. Translation: AAO16281.1.
AY171201 Genomic DNA. Translation: AAO16285.1.
AY171202 Genomic DNA. Translation: AAO16289.1.
AY171203 Genomic DNA. Translation: AAO16293.1.
AY171204 Genomic DNA. Translation: AAO16297.1.
AY171205 Genomic DNA. Translation: AAO16301.1.
AY171206 Genomic DNA. Translation: AAO16305.1.
AY171207 Genomic DNA. Translation: AAO16309.1.
X54252 Genomic DNA. Translation: CAA38160.1.
PIRiS26035.
RefSeqiNP_006962.1. NC_001328.1.

Genome annotation databases

GeneIDi2565697.
KEGGicel:COX2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171193 Genomic DNA. Translation: AAO16253.1.
AY171194 Genomic DNA. Translation: AAO16257.1.
AY171195 Genomic DNA. Translation: AAO16261.1.
AY171196 Genomic DNA. Translation: AAO16265.1.
AY171197 Genomic DNA. Translation: AAO16269.1.
AY171198 Genomic DNA. Translation: AAO16273.1.
AY171199 Genomic DNA. Translation: AAO16277.1.
AY171200 Genomic DNA. Translation: AAO16281.1.
AY171201 Genomic DNA. Translation: AAO16285.1.
AY171202 Genomic DNA. Translation: AAO16289.1.
AY171203 Genomic DNA. Translation: AAO16293.1.
AY171204 Genomic DNA. Translation: AAO16297.1.
AY171205 Genomic DNA. Translation: AAO16301.1.
AY171206 Genomic DNA. Translation: AAO16305.1.
AY171207 Genomic DNA. Translation: AAO16309.1.
X54252 Genomic DNA. Translation: CAA38160.1.
PIRiS26035.
RefSeqiNP_006962.1. NC_001328.1.

3D structure databases

ProteinModelPortaliP24894.
SMRiP24894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.MTCE.31.

Proteomic databases

EPDiP24894.
PaxDbiP24894.
PRIDEiP24894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2565697.
KEGGicel:COX2.

Organism-specific databases

CTDi4513.
WormBaseiMTCE.31; CE35351; WBGene00010965; ctc-2.

Phylogenomic databases

eggNOGiKOG4767. Eukaryota.
COG1622. LUCA.
HOGENOMiHOG000264988.
InParanoidiP24894.
KOiK02261.
OrthoDBiEOG091G0IO9.
PhylomeDBiP24894.

Miscellaneous databases

PROiP24894.

Gene expression databases

BgeeiWBGene00010965.
ExpressionAtlasiP24894. differential.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_CAEEL
AccessioniPrimary (citable) accession number: P24894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.