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P24893

- COX1_CAEEL

UniProt

P24893 - COX1_CAEEL

Protein

Cytochrome c oxidase subunit 1

Gene

cox-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi69 – 691Iron (heme A axial ligand)Curated
    Metal bindingi247 – 2471Copper BCurated
    Metal bindingi251 – 2511Copper BCurated
    Metal bindingi297 – 2971Copper BCurated
    Metal bindingi298 – 2981Copper BCurated
    Metal bindingi383 – 3831Iron (heme A3 axial ligand)Curated
    Metal bindingi385 – 3851Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. hydrogen ion transmembrane transport Source: GOC
    3. mitochondrial electron transport, cytochrome c to oxygen Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:cox-1
    Synonyms:coI
    ORF Names:MTCE.26
    Encoded oniMitochondrion
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Cytochrome c oxidase subunit 1PRO_0000183298Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Proteomic databases

    PaxDbiP24893.

    Interactioni

    Protein-protein interaction databases

    IntActiP24893. 1 interaction.
    STRINGi6239.MTCE.26.

    Structurei

    3D structure databases

    ProteinModelPortaliP24893.
    SMRiP24893. Positions 14-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei459 – 47921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02256.
    PhylomeDBiP24893.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24893-1 [UniParc]FASTAAdd to Basket

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    MNLYKKYQGG LAVWLESSNH KDIGTLYFIF GLWSGMVGTS FSLLIRLELA    50
    KPGFFLSNGQ LYNSVITAHA ILMIFFMVMP TMIGGFGNWL LPLMLGAPDM 100
    SFPRLNNLSF WLLPTSMLLI LDACFVDMGC GTSWTVYPPL STMGHPGSSV 150
    DLAIFSLHAA GLSSILGGIN FMCTTKNLRS SSISLEHMTL FVWTVFVTVF 200
    LLVLSLPVLA GAITMLLTDR NLNTSFFDPS TGGNPLIYQH LFWFFGHPEV 250
    YILILPAFGI VSQSTLYLTG KKEVFGALGM VYAILSIGLI GCVVWAHHMY 300
    TVGMDLDSRA YFSAATMVIA VPTGVKVFSW LATLFGMKMV FNPLLLWVLG 350
    FIFLFTLGGL TGVVLSNSSL DIILHDTYYV VSHFHYVLSL GAVFGIFTGV 400
    TLWWSFITGY VLDKLMMSAV FILLFIGVNL TFFPLHFAGL HGFPRKYLDY 450
    PDVYSVWNII ASYGSIISTA GLFLFIYVLL ESFFSYRLVI SDYYSNSSPE 500
    YCMSNYVFGH SYQSEIYFST TSLKN 525
    Length:525
    Mass (Da):58,464
    Last modified:November 1, 1995 - v2
    Checksum:iE3D051208B09396F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121A → S in strain: CB4856 and CB4857. 1 Publication
    Natural varianti466 – 4661I → M in strain: AB1, AB2, CB4852, CB4853, CB4855, CB4857, CB4858, KR314 and PB306. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY171193 Genomic DNA. Translation: AAO16252.1.
    AY171194 Genomic DNA. Translation: AAO16256.1.
    AY171195 Genomic DNA. Translation: AAO16260.1.
    AY171196 Genomic DNA. Translation: AAO16264.1.
    AY171197 Genomic DNA. Translation: AAO16268.1.
    AY171198 Genomic DNA. Translation: AAO16272.1.
    AY171199 Genomic DNA. Translation: AAO16276.1.
    AY171200 Genomic DNA. Translation: AAO16280.1.
    AY171201 Genomic DNA. Translation: AAO16284.1.
    AY171202 Genomic DNA. Translation: AAO16288.1.
    AY171203 Genomic DNA. Translation: AAO16292.1.
    AY171204 Genomic DNA. Translation: AAO16296.1.
    AY171205 Genomic DNA. Translation: AAO16300.1.
    AY171206 Genomic DNA. Translation: AAO16304.1.
    AY171207 Genomic DNA. Translation: AAO16308.1.
    X54252 Genomic DNA. Translation: CAA38159.1.
    PIRiS26034.
    RefSeqiNP_006961.1. NC_001328.1.

    Genome annotation databases

    GeneIDi2565700.
    KEGGicel:COX1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY171193 Genomic DNA. Translation: AAO16252.1 .
    AY171194 Genomic DNA. Translation: AAO16256.1 .
    AY171195 Genomic DNA. Translation: AAO16260.1 .
    AY171196 Genomic DNA. Translation: AAO16264.1 .
    AY171197 Genomic DNA. Translation: AAO16268.1 .
    AY171198 Genomic DNA. Translation: AAO16272.1 .
    AY171199 Genomic DNA. Translation: AAO16276.1 .
    AY171200 Genomic DNA. Translation: AAO16280.1 .
    AY171201 Genomic DNA. Translation: AAO16284.1 .
    AY171202 Genomic DNA. Translation: AAO16288.1 .
    AY171203 Genomic DNA. Translation: AAO16292.1 .
    AY171204 Genomic DNA. Translation: AAO16296.1 .
    AY171205 Genomic DNA. Translation: AAO16300.1 .
    AY171206 Genomic DNA. Translation: AAO16304.1 .
    AY171207 Genomic DNA. Translation: AAO16308.1 .
    X54252 Genomic DNA. Translation: CAA38159.1 .
    PIRi S26034.
    RefSeqi NP_006961.1. NC_001328.1.

    3D structure databases

    ProteinModelPortali P24893.
    SMRi P24893. Positions 14-501.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P24893. 1 interaction.
    STRINGi 6239.MTCE.26.

    Proteomic databases

    PaxDbi P24893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2565700.
    KEGGi cel:COX1.

    Organism-specific databases

    CTDi 4512.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02256.
    PhylomeDBi P24893.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Miscellaneous databases

    NextBioi 953875.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
      Denver D.R., Morris K., Thomas W.K.
      Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-12 AND MET-466.
      Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
    2. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
      Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
      Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
      Okimoto R., Macfarlane J.L., Wolstenholme D.R.
      Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

    Entry informationi

    Entry nameiCOX1_CAEEL
    AccessioniPrimary (citable) accession number: P24893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3