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P24893

- COX1_CAEEL

UniProt

P24893 - COX1_CAEEL

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Protein

Cytochrome c oxidase subunit 1

Gene

cox-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Iron (heme A axial ligand)Curated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi251 – 2511Copper BCurated
Metal bindingi297 – 2971Copper BCurated
Metal bindingi298 – 2981Copper BCurated
Metal bindingi383 – 3831Iron (heme A3 axial ligand)Curated
Metal bindingi385 – 3851Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox-1
Synonyms:coI
ORF Names:MTCE.26
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence AnalysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Cytochrome c oxidase subunit 1PRO_0000183298Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP24893.

Expressioni

Gene expression databases

ExpressionAtlasiP24893. baseline.

Interactioni

Protein-protein interaction databases

IntActiP24893. 1 interaction.
STRINGi6239.MTCE.26.

Structurei

3D structure databases

ProteinModelPortaliP24893.
SMRiP24893. Positions 14-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
InParanoidiP24893.
KOiK02256.
PhylomeDBiP24893.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24893-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLYKKYQGG LAVWLESSNH KDIGTLYFIF GLWSGMVGTS FSLLIRLELA
60 70 80 90 100
KPGFFLSNGQ LYNSVITAHA ILMIFFMVMP TMIGGFGNWL LPLMLGAPDM
110 120 130 140 150
SFPRLNNLSF WLLPTSMLLI LDACFVDMGC GTSWTVYPPL STMGHPGSSV
160 170 180 190 200
DLAIFSLHAA GLSSILGGIN FMCTTKNLRS SSISLEHMTL FVWTVFVTVF
210 220 230 240 250
LLVLSLPVLA GAITMLLTDR NLNTSFFDPS TGGNPLIYQH LFWFFGHPEV
260 270 280 290 300
YILILPAFGI VSQSTLYLTG KKEVFGALGM VYAILSIGLI GCVVWAHHMY
310 320 330 340 350
TVGMDLDSRA YFSAATMVIA VPTGVKVFSW LATLFGMKMV FNPLLLWVLG
360 370 380 390 400
FIFLFTLGGL TGVVLSNSSL DIILHDTYYV VSHFHYVLSL GAVFGIFTGV
410 420 430 440 450
TLWWSFITGY VLDKLMMSAV FILLFIGVNL TFFPLHFAGL HGFPRKYLDY
460 470 480 490 500
PDVYSVWNII ASYGSIISTA GLFLFIYVLL ESFFSYRLVI SDYYSNSSPE
510 520
YCMSNYVFGH SYQSEIYFST TSLKN
Length:525
Mass (Da):58,464
Last modified:November 1, 1995 - v2
Checksum:iE3D051208B09396F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121A → S in strain: CB4856 and CB4857. 1 Publication
Natural varianti466 – 4661I → M in strain: AB1, AB2, CB4852, CB4853, CB4855, CB4857, CB4858, KR314 and PB306. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171193 Genomic DNA. Translation: AAO16252.1.
AY171194 Genomic DNA. Translation: AAO16256.1.
AY171195 Genomic DNA. Translation: AAO16260.1.
AY171196 Genomic DNA. Translation: AAO16264.1.
AY171197 Genomic DNA. Translation: AAO16268.1.
AY171198 Genomic DNA. Translation: AAO16272.1.
AY171199 Genomic DNA. Translation: AAO16276.1.
AY171200 Genomic DNA. Translation: AAO16280.1.
AY171201 Genomic DNA. Translation: AAO16284.1.
AY171202 Genomic DNA. Translation: AAO16288.1.
AY171203 Genomic DNA. Translation: AAO16292.1.
AY171204 Genomic DNA. Translation: AAO16296.1.
AY171205 Genomic DNA. Translation: AAO16300.1.
AY171206 Genomic DNA. Translation: AAO16304.1.
AY171207 Genomic DNA. Translation: AAO16308.1.
X54252 Genomic DNA. Translation: CAA38159.1.
PIRiS26034.
RefSeqiNP_006961.1. NC_001328.1.

Genome annotation databases

GeneIDi2565700.
KEGGicel:COX1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171193 Genomic DNA. Translation: AAO16252.1 .
AY171194 Genomic DNA. Translation: AAO16256.1 .
AY171195 Genomic DNA. Translation: AAO16260.1 .
AY171196 Genomic DNA. Translation: AAO16264.1 .
AY171197 Genomic DNA. Translation: AAO16268.1 .
AY171198 Genomic DNA. Translation: AAO16272.1 .
AY171199 Genomic DNA. Translation: AAO16276.1 .
AY171200 Genomic DNA. Translation: AAO16280.1 .
AY171201 Genomic DNA. Translation: AAO16284.1 .
AY171202 Genomic DNA. Translation: AAO16288.1 .
AY171203 Genomic DNA. Translation: AAO16292.1 .
AY171204 Genomic DNA. Translation: AAO16296.1 .
AY171205 Genomic DNA. Translation: AAO16300.1 .
AY171206 Genomic DNA. Translation: AAO16304.1 .
AY171207 Genomic DNA. Translation: AAO16308.1 .
X54252 Genomic DNA. Translation: CAA38159.1 .
PIRi S26034.
RefSeqi NP_006961.1. NC_001328.1.

3D structure databases

ProteinModelPortali P24893.
SMRi P24893. Positions 14-501.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P24893. 1 interaction.
STRINGi 6239.MTCE.26.

Proteomic databases

PaxDbi P24893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2565700.
KEGGi cel:COX1.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
InParanoidi P24893.
KOi K02256.
PhylomeDBi P24893.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

NextBioi 953875.

Gene expression databases

ExpressionAtlasi P24893. baseline.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
    Denver D.R., Morris K., Thomas W.K.
    Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-12 AND MET-466.
    Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
  2. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
    Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
    Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
    Okimoto R., Macfarlane J.L., Wolstenholme D.R.
    Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

Entry informationi

Entry nameiCOX1_CAEEL
AccessioniPrimary (citable) accession number: P24893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3