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Protein

Cytochrome c oxidase subunit 1

Gene

cox-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Iron (heme A axial ligand)Curated1
Metal bindingi247Copper BCurated1
Metal bindingi251Copper BCurated1
Metal bindingi297Copper BCurated1
Metal bindingi298Copper BCurated1
Metal bindingi383Iron (heme A3 axial ligand)Curated1
Metal bindingi385Iron (heme A axial ligand)Curated1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: UniProtKB
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

  • aerobic respiration Source: InterPro
  • mitochondrial electron transport, cytochrome c to oxygen Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:cox-1
Synonyms:coI
ORF Names:MTCE.26
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
  • respiratory chain complex IV Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832981 – 525Cytochrome c oxidase subunit 1Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP24893.
PRIDEiP24893.

Expressioni

Gene expression databases

BgeeiWBGene00010964.
ExpressionAtlasiP24893. differential.

Interactioni

Protein-protein interaction databases

IntActiP24893. 1 interactor.
STRINGi6239.MTCE.26.

Structurei

3D structure databases

ProteinModelPortaliP24893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4769. Eukaryota.
COG0843. LUCA.
HOGENOMiHOG000085274.
InParanoidiP24893.
KOiK02256.
OrthoDBiEOG091G035B.
PhylomeDBiP24893.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLYKKYQGG LAVWLESSNH KDIGTLYFIF GLWSGMVGTS FSLLIRLELA
60 70 80 90 100
KPGFFLSNGQ LYNSVITAHA ILMIFFMVMP TMIGGFGNWL LPLMLGAPDM
110 120 130 140 150
SFPRLNNLSF WLLPTSMLLI LDACFVDMGC GTSWTVYPPL STMGHPGSSV
160 170 180 190 200
DLAIFSLHAA GLSSILGGIN FMCTTKNLRS SSISLEHMTL FVWTVFVTVF
210 220 230 240 250
LLVLSLPVLA GAITMLLTDR NLNTSFFDPS TGGNPLIYQH LFWFFGHPEV
260 270 280 290 300
YILILPAFGI VSQSTLYLTG KKEVFGALGM VYAILSIGLI GCVVWAHHMY
310 320 330 340 350
TVGMDLDSRA YFSAATMVIA VPTGVKVFSW LATLFGMKMV FNPLLLWVLG
360 370 380 390 400
FIFLFTLGGL TGVVLSNSSL DIILHDTYYV VSHFHYVLSL GAVFGIFTGV
410 420 430 440 450
TLWWSFITGY VLDKLMMSAV FILLFIGVNL TFFPLHFAGL HGFPRKYLDY
460 470 480 490 500
PDVYSVWNII ASYGSIISTA GLFLFIYVLL ESFFSYRLVI SDYYSNSSPE
510 520
YCMSNYVFGH SYQSEIYFST TSLKN
Length:525
Mass (Da):58,464
Last modified:November 1, 1995 - v2
Checksum:iE3D051208B09396F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti12A → S in strain: CB4856 and CB4857. 1 Publication1
Natural varianti466I → M in strain: AB1, AB2, CB4852, CB4853, CB4855, CB4857, CB4858, KR314 and PB306. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171193 Genomic DNA. Translation: AAO16252.1.
AY171194 Genomic DNA. Translation: AAO16256.1.
AY171195 Genomic DNA. Translation: AAO16260.1.
AY171196 Genomic DNA. Translation: AAO16264.1.
AY171197 Genomic DNA. Translation: AAO16268.1.
AY171198 Genomic DNA. Translation: AAO16272.1.
AY171199 Genomic DNA. Translation: AAO16276.1.
AY171200 Genomic DNA. Translation: AAO16280.1.
AY171201 Genomic DNA. Translation: AAO16284.1.
AY171202 Genomic DNA. Translation: AAO16288.1.
AY171203 Genomic DNA. Translation: AAO16292.1.
AY171204 Genomic DNA. Translation: AAO16296.1.
AY171205 Genomic DNA. Translation: AAO16300.1.
AY171206 Genomic DNA. Translation: AAO16304.1.
AY171207 Genomic DNA. Translation: AAO16308.1.
X54252 Genomic DNA. Translation: CAA38159.1.
PIRiS26034.
RefSeqiNP_006961.1. NC_001328.1.

Genome annotation databases

GeneIDi2565700.
KEGGicel:COX1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171193 Genomic DNA. Translation: AAO16252.1.
AY171194 Genomic DNA. Translation: AAO16256.1.
AY171195 Genomic DNA. Translation: AAO16260.1.
AY171196 Genomic DNA. Translation: AAO16264.1.
AY171197 Genomic DNA. Translation: AAO16268.1.
AY171198 Genomic DNA. Translation: AAO16272.1.
AY171199 Genomic DNA. Translation: AAO16276.1.
AY171200 Genomic DNA. Translation: AAO16280.1.
AY171201 Genomic DNA. Translation: AAO16284.1.
AY171202 Genomic DNA. Translation: AAO16288.1.
AY171203 Genomic DNA. Translation: AAO16292.1.
AY171204 Genomic DNA. Translation: AAO16296.1.
AY171205 Genomic DNA. Translation: AAO16300.1.
AY171206 Genomic DNA. Translation: AAO16304.1.
AY171207 Genomic DNA. Translation: AAO16308.1.
X54252 Genomic DNA. Translation: CAA38159.1.
PIRiS26034.
RefSeqiNP_006961.1. NC_001328.1.

3D structure databases

ProteinModelPortaliP24893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP24893. 1 interactor.
STRINGi6239.MTCE.26.

Proteomic databases

PaxDbiP24893.
PRIDEiP24893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2565700.
KEGGicel:COX1.

Organism-specific databases

CTDi4512.

Phylogenomic databases

eggNOGiKOG4769. Eukaryota.
COG0843. LUCA.
HOGENOMiHOG000085274.
InParanoidiP24893.
KOiK02256.
OrthoDBiEOG091G035B.
PhylomeDBiP24893.

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

PROiP24893.

Gene expression databases

BgeeiWBGene00010964.
ExpressionAtlasiP24893. differential.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_CAEEL
AccessioniPrimary (citable) accession number: P24893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.