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P24891

- COX3_CAEEL

UniProt

P24891 - COX3_CAEEL

Protein

Cytochrome c oxidase subunit 3

Gene

cox-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:cox-3
    Synonyms:coIII
    ORF Names:MTCE.23
    Encoded oniMitochondrion
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Cytochrome c oxidase subunit 3PRO_0000183750Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.MTCE.23.

    Structurei

    3D structure databases

    ProteinModelPortaliP24891.
    SMRiP24891. Positions 3-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    HOGENOMiHOG000264954.
    KOiK02262.
    PhylomeDBiP24891.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24891-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFHNFHILSL SSYAYNLFFA SAGMLSSLVM FFKFGLYELF IFTLFSVLFI    50
    SFAWGKDIAM EGLSGYHNFF VMDGFKFGVI LFVFSEFMFF FCIFCTFFDA 100
    ALVPVHELGE TWSPFGMHLV NPFGVPLLNT IILLSSGVTV TWAHHSLLSN 150
    KSCTNSMILT CLLAAYFTGI QLMEYMEASF SIADGVFGSI FYLSTGFHGI 200
    HVLCGGLFLA FNFLRLLKNH FNYNHHLGLE FAILYWHFVD VVWLFLFVFV 250
    YWWSY 255
    Length:255
    Mass (Da):29,387
    Last modified:April 11, 2003 - v3
    Checksum:i064200C7300696CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951C → W in CAA38157. (PubMed:1551572)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti185 – 1851G → W in strain: PB306. 1 Publication
    Natural varianti187 – 1871F → L in strain: PB306. 1 Publication
    Natural varianti222 – 2221N → S in strain: CB4854. 1 Publication
    Natural varianti235 – 2351Y → N in strain: CB4856. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54252 Genomic DNA. Translation: CAA38157.1.
    AY171178 Genomic DNA. Translation: AAO16431.1.
    AY171179 Genomic DNA. Translation: AAO16433.1.
    AY171180 Genomic DNA. Translation: AAO16435.1.
    AY171181 Genomic DNA. Translation: AAO16437.1.
    AY171182 Genomic DNA. Translation: AAO16439.1.
    AY171183 Genomic DNA. Translation: AAO16441.1.
    AY171184 Genomic DNA. Translation: AAO16443.1.
    AY171185 Genomic DNA. Translation: AAO16445.1.
    AY171186 Genomic DNA. Translation: AAO16447.1.
    AY171187 Genomic DNA. Translation: AAO16449.1.
    AY171188 Genomic DNA. Translation: AAO16451.1.
    AY171189 Genomic DNA. Translation: AAO16453.1.
    AY171190 Genomic DNA. Translation: AAO16455.1.
    AY171191 Genomic DNA. Translation: AAO16457.1.
    AY171192 Genomic DNA. Translation: AAO16459.1.
    AY171193 Genomic DNA. Translation: AAO16250.1.
    AY171194 Genomic DNA. Translation: AAO16254.1.
    AY171195 Genomic DNA. Translation: AAO16258.1.
    AY171196 Genomic DNA. Translation: AAO16262.1.
    AY171197 Genomic DNA. Translation: AAO16266.1.
    AY171198 Genomic DNA. Translation: AAO16270.1.
    AY171199 Genomic DNA. Translation: AAO16274.1.
    AY171200 Genomic DNA. Translation: AAO16278.1.
    AY171201 Genomic DNA. Translation: AAO16282.1.
    AY171202 Genomic DNA. Translation: AAO16286.1.
    AY171203 Genomic DNA. Translation: AAO16290.1.
    AY171204 Genomic DNA. Translation: AAO16294.1.
    AY171205 Genomic DNA. Translation: AAO16298.1.
    AY171206 Genomic DNA. Translation: AAO16302.1.
    AY171207 Genomic DNA. Translation: AAO16306.1.
    PIRiS26032.
    RefSeqiNP_006959.1. NC_001328.1.

    Genome annotation databases

    GeneIDi2565701.
    KEGGicel:COX3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54252 Genomic DNA. Translation: CAA38157.1 .
    AY171178 Genomic DNA. Translation: AAO16431.1 .
    AY171179 Genomic DNA. Translation: AAO16433.1 .
    AY171180 Genomic DNA. Translation: AAO16435.1 .
    AY171181 Genomic DNA. Translation: AAO16437.1 .
    AY171182 Genomic DNA. Translation: AAO16439.1 .
    AY171183 Genomic DNA. Translation: AAO16441.1 .
    AY171184 Genomic DNA. Translation: AAO16443.1 .
    AY171185 Genomic DNA. Translation: AAO16445.1 .
    AY171186 Genomic DNA. Translation: AAO16447.1 .
    AY171187 Genomic DNA. Translation: AAO16449.1 .
    AY171188 Genomic DNA. Translation: AAO16451.1 .
    AY171189 Genomic DNA. Translation: AAO16453.1 .
    AY171190 Genomic DNA. Translation: AAO16455.1 .
    AY171191 Genomic DNA. Translation: AAO16457.1 .
    AY171192 Genomic DNA. Translation: AAO16459.1 .
    AY171193 Genomic DNA. Translation: AAO16250.1 .
    AY171194 Genomic DNA. Translation: AAO16254.1 .
    AY171195 Genomic DNA. Translation: AAO16258.1 .
    AY171196 Genomic DNA. Translation: AAO16262.1 .
    AY171197 Genomic DNA. Translation: AAO16266.1 .
    AY171198 Genomic DNA. Translation: AAO16270.1 .
    AY171199 Genomic DNA. Translation: AAO16274.1 .
    AY171200 Genomic DNA. Translation: AAO16278.1 .
    AY171201 Genomic DNA. Translation: AAO16282.1 .
    AY171202 Genomic DNA. Translation: AAO16286.1 .
    AY171203 Genomic DNA. Translation: AAO16290.1 .
    AY171204 Genomic DNA. Translation: AAO16294.1 .
    AY171205 Genomic DNA. Translation: AAO16298.1 .
    AY171206 Genomic DNA. Translation: AAO16302.1 .
    AY171207 Genomic DNA. Translation: AAO16306.1 .
    PIRi S26032.
    RefSeqi NP_006959.1. NC_001328.1.

    3D structure databases

    ProteinModelPortali P24891.
    SMRi P24891. Positions 3-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.MTCE.23.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2565701.
    KEGGi cel:COX3.

    Organism-specific databases

    CTDi 4514.

    Phylogenomic databases

    eggNOGi COG1845.
    HOGENOMi HOG000264954.
    KOi K02262.
    PhylomeDBi P24891.

    Miscellaneous databases

    NextBioi 953877.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
      Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
      Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
      Denver D.R., Morris K., Thomas W.K.
      Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96 AND 119-255, VARIANTS TRP-185; LEU-187; SER-222 AND ASN-235.
      Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
    3. "Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
      Okimoto R., Macfarlane J.L., Wolstenholme D.R.
      Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

    Entry informationi

    Entry nameiCOX3_CAEEL
    AccessioniPrimary (citable) accession number: P24891
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3