Cytochrome c oxidase subunit 3 - Caenorhabditis elegans

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P24891 (COX3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	cox-3
Synonyms:	coIII
ORF Names:	MTCE.23

Encoded on

Mitochondrion

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 255

255

Cytochrome c oxidase subunit 3

PRO_0000183750

Regions

Transmembrane

12 – 32

Helical; Potential

Transmembrane

34 – 54

Helical; Potential

Transmembrane

77 – 97

Helical; Potential

Transmembrane

123 – 143

Helical; Potential

Transmembrane

156 – 176

Helical; Potential

Transmembrane

190 – 210

Helical; Potential

Transmembrane

231 – 251

Helical; Potential

Natural variations

Natural variant

185

G → W in strain: PB306. Ref.2

Natural variant

187

F → L in strain: PB306. Ref.2

Natural variant

222

N → S in strain: CB4854. Ref.2

Natural variant

235

Y → N in strain: CB4856. Ref.2

Experimental info

Sequence conflict

C → W in CAA38157. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P24891 [UniParc].

Last modified April 11, 2003. Version 3.
Checksum: 064200C7300696CD
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FASTA

255

29,387

        10         20         30         40         50         60 
MFHNFHILSL SSYAYNLFFA SAGMLSSLVM FFKFGLYELF IFTLFSVLFI SFAWGKDIAM 

        70         80         90        100        110        120 
EGLSGYHNFF VMDGFKFGVI LFVFSEFMFF FCIFCTFFDA ALVPVHELGE TWSPFGMHLV 

       130        140        150        160        170        180 
NPFGVPLLNT IILLSSGVTV TWAHHSLLSN KSCTNSMILT CLLAAYFTGI QLMEYMEASF 

       190        200        210        220        230        240 
SIADGVFGSI FYLSTGFHGI HVLCGGLFLA FNFLRLLKNH FNYNHHLGLE FAILYWHFVD 

       250 
VVWLFLFVFV YWWSY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum." Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R. Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing." Denver D.R., Morris K., Thomas W.K. Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96 AND 119-255, VARIANTS TRP-185; LEU-187; SER-222 AND ASN-235. Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
[3]	"Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans." Okimoto R., Macfarlane J.L., Wolstenholme D.R. Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X54252 Genomic DNA. Translation: CAA38157.1. AY171178 Genomic DNA. Translation: AAO16431.1. AY171179 Genomic DNA. Translation: AAO16433.1. AY171180 Genomic DNA. Translation: AAO16435.1. AY171181 Genomic DNA. Translation: AAO16437.1. AY171182 Genomic DNA. Translation: AAO16439.1. AY171183 Genomic DNA. Translation: AAO16441.1. AY171184 Genomic DNA. Translation: AAO16443.1. AY171185 Genomic DNA. Translation: AAO16445.1. AY171186 Genomic DNA. Translation: AAO16447.1. AY171187 Genomic DNA. Translation: AAO16449.1. AY171188 Genomic DNA. Translation: AAO16451.1. AY171189 Genomic DNA. Translation: AAO16453.1. AY171190 Genomic DNA. Translation: AAO16455.1. AY171191 Genomic DNA. Translation: AAO16457.1. AY171192 Genomic DNA. Translation: AAO16459.1. AY171193 Genomic DNA. Translation: AAO16250.1. AY171194 Genomic DNA. Translation: AAO16254.1. AY171195 Genomic DNA. Translation: AAO16258.1. AY171196 Genomic DNA. Translation: AAO16262.1. AY171197 Genomic DNA. Translation: AAO16266.1. AY171198 Genomic DNA. Translation: AAO16270.1. AY171199 Genomic DNA. Translation: AAO16274.1. AY171200 Genomic DNA. Translation: AAO16278.1. AY171201 Genomic DNA. Translation: AAO16282.1. AY171202 Genomic DNA. Translation: AAO16286.1. AY171203 Genomic DNA. Translation: AAO16290.1. AY171204 Genomic DNA. Translation: AAO16294.1. AY171205 Genomic DNA. Translation: AAO16298.1. AY171206 Genomic DNA. Translation: AAO16302.1. AY171207 Genomic DNA. Translation: AAO16306.1.
PIR	S26032.
RefSeq	NP_006959.1. NC_001328.1.
3D structure databases
ProteinModelPortal	P24891.
SMR	P24891. Positions 3-253.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.MTCE.23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2565701.
KEGG	cel:COX3.
Organism-specific databases
CTD	4514.
Phylogenomic databases
eggNOG	COG1845.
HOGENOM	HOG000264954.
KO	K02262.
ProtClustDB	MTH00083.
Gene expression databases
ArrayExpress	P24891.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	953877.

Entry information

Entry name

COX3_CAEEL

Accession

Primary (citable) accession number: P24891

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	April 11, 2003
Last modified:	May 1, 2013
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents