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Protein

Cytochrome c oxidase subunit 3

Gene

ctc-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:ctc-3Imported
Synonyms:coIIIImported, cox-3Imported
ORF Names:MTCE.23Imported
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Mitochondrion

Organism-specific databases

WormBaseiMTCE.23 ; CE34069 ; WBGene00010962 ; ctc-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837501 – 255Cytochrome c oxidase subunit 3Add BLAST255

Proteomic databases

PaxDbiP24891

Expressioni

Gene expression databases

BgeeiWBGene00010962
ExpressionAtlasiP24891 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.MTCE.23

Structurei

3D structure databases

ProteinModelPortaliP24891
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
HOGENOMiHOG000264954
InParanoidiP24891
KOiK02262
PhylomeDBiP24891

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P24891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHNFHILSL SSYAYNLFFA SAGMLSSLVM FFKFGLYELF IFTLFSVLFI
60 70 80 90 100
SFAWGKDIAM EGLSGYHNFF VMDGFKFGVI LFVFSEFMFF FCIFCTFFDA
110 120 130 140 150
ALVPVHELGE TWSPFGMHLV NPFGVPLLNT IILLSSGVTV TWAHHSLLSN
160 170 180 190 200
KSCTNSMILT CLLAAYFTGI QLMEYMEASF SIADGVFGSI FYLSTGFHGI
210 220 230 240 250
HVLCGGLFLA FNFLRLLKNH FNYNHHLGLE FAILYWHFVD VVWLFLFVFV

YWWSY
Length:255
Mass (Da):29,387
Last modified:April 11, 2003 - v3
Checksum:i064200C7300696CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95C → W in CAA38157 (PubMed:1551572).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti185G → W in strain: PB306. 1 Publication1
Natural varianti187F → L in strain: PB306. 1 Publication1
Natural varianti222N → S in strain: CB4854. 1 Publication1
Natural varianti235Y → N in strain: CB4856. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54252 Genomic DNA Translation: CAA38157.1
AY171178 Genomic DNA Translation: AAO16431.1
AY171179 Genomic DNA Translation: AAO16433.1
AY171180 Genomic DNA Translation: AAO16435.1
AY171181 Genomic DNA Translation: AAO16437.1
AY171182 Genomic DNA Translation: AAO16439.1
AY171183 Genomic DNA Translation: AAO16441.1
AY171184 Genomic DNA Translation: AAO16443.1
AY171185 Genomic DNA Translation: AAO16445.1
AY171186 Genomic DNA Translation: AAO16447.1
AY171187 Genomic DNA Translation: AAO16449.1
AY171188 Genomic DNA Translation: AAO16451.1
AY171189 Genomic DNA Translation: AAO16453.1
AY171190 Genomic DNA Translation: AAO16455.1
AY171191 Genomic DNA Translation: AAO16457.1
AY171192 Genomic DNA Translation: AAO16459.1
AY171193 Genomic DNA Translation: AAO16250.1
AY171194 Genomic DNA Translation: AAO16254.1
AY171195 Genomic DNA Translation: AAO16258.1
AY171196 Genomic DNA Translation: AAO16262.1
AY171197 Genomic DNA Translation: AAO16266.1
AY171198 Genomic DNA Translation: AAO16270.1
AY171199 Genomic DNA Translation: AAO16274.1
AY171200 Genomic DNA Translation: AAO16278.1
AY171201 Genomic DNA Translation: AAO16282.1
AY171202 Genomic DNA Translation: AAO16286.1
AY171203 Genomic DNA Translation: AAO16290.1
AY171204 Genomic DNA Translation: AAO16294.1
AY171205 Genomic DNA Translation: AAO16298.1
AY171206 Genomic DNA Translation: AAO16302.1
AY171207 Genomic DNA Translation: AAO16306.1
PIRiS26032
RefSeqiNP_006959.1, NC_001328.1

Genome annotation databases

GeneIDi2565701
KEGGicel:COX3

Similar proteinsi

Entry informationi

Entry nameiCOX3_CAEEL
AccessioniPrimary (citable) accession number: P24891
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: April 11, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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