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P24891

- COX3_CAEEL

UniProt

P24891 - COX3_CAEEL

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Protein

Cytochrome c oxidase subunit 3

Gene

cox-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox-3
Synonyms:coIII
ORF Names:MTCE.23
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Cytochrome c oxidase subunit 3PRO_0000183750Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP24891. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.MTCE.23.

Structurei

3D structure databases

ProteinModelPortaliP24891.
SMRiP24891. Positions 3-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
InParanoidiP24891.
KOiK02262.
PhylomeDBiP24891.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24891-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHNFHILSL SSYAYNLFFA SAGMLSSLVM FFKFGLYELF IFTLFSVLFI
60 70 80 90 100
SFAWGKDIAM EGLSGYHNFF VMDGFKFGVI LFVFSEFMFF FCIFCTFFDA
110 120 130 140 150
ALVPVHELGE TWSPFGMHLV NPFGVPLLNT IILLSSGVTV TWAHHSLLSN
160 170 180 190 200
KSCTNSMILT CLLAAYFTGI QLMEYMEASF SIADGVFGSI FYLSTGFHGI
210 220 230 240 250
HVLCGGLFLA FNFLRLLKNH FNYNHHLGLE FAILYWHFVD VVWLFLFVFV

YWWSY
Length:255
Mass (Da):29,387
Last modified:April 11, 2003 - v3
Checksum:i064200C7300696CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951C → W in CAA38157. (PubMed:1551572)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851G → W in strain: PB306. 1 Publication
Natural varianti187 – 1871F → L in strain: PB306. 1 Publication
Natural varianti222 – 2221N → S in strain: CB4854. 1 Publication
Natural varianti235 – 2351Y → N in strain: CB4856. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54252 Genomic DNA. Translation: CAA38157.1.
AY171178 Genomic DNA. Translation: AAO16431.1.
AY171179 Genomic DNA. Translation: AAO16433.1.
AY171180 Genomic DNA. Translation: AAO16435.1.
AY171181 Genomic DNA. Translation: AAO16437.1.
AY171182 Genomic DNA. Translation: AAO16439.1.
AY171183 Genomic DNA. Translation: AAO16441.1.
AY171184 Genomic DNA. Translation: AAO16443.1.
AY171185 Genomic DNA. Translation: AAO16445.1.
AY171186 Genomic DNA. Translation: AAO16447.1.
AY171187 Genomic DNA. Translation: AAO16449.1.
AY171188 Genomic DNA. Translation: AAO16451.1.
AY171189 Genomic DNA. Translation: AAO16453.1.
AY171190 Genomic DNA. Translation: AAO16455.1.
AY171191 Genomic DNA. Translation: AAO16457.1.
AY171192 Genomic DNA. Translation: AAO16459.1.
AY171193 Genomic DNA. Translation: AAO16250.1.
AY171194 Genomic DNA. Translation: AAO16254.1.
AY171195 Genomic DNA. Translation: AAO16258.1.
AY171196 Genomic DNA. Translation: AAO16262.1.
AY171197 Genomic DNA. Translation: AAO16266.1.
AY171198 Genomic DNA. Translation: AAO16270.1.
AY171199 Genomic DNA. Translation: AAO16274.1.
AY171200 Genomic DNA. Translation: AAO16278.1.
AY171201 Genomic DNA. Translation: AAO16282.1.
AY171202 Genomic DNA. Translation: AAO16286.1.
AY171203 Genomic DNA. Translation: AAO16290.1.
AY171204 Genomic DNA. Translation: AAO16294.1.
AY171205 Genomic DNA. Translation: AAO16298.1.
AY171206 Genomic DNA. Translation: AAO16302.1.
AY171207 Genomic DNA. Translation: AAO16306.1.
PIRiS26032.
RefSeqiNP_006959.1. NC_001328.1.

Genome annotation databases

GeneIDi2565701.
KEGGicel:COX3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54252 Genomic DNA. Translation: CAA38157.1 .
AY171178 Genomic DNA. Translation: AAO16431.1 .
AY171179 Genomic DNA. Translation: AAO16433.1 .
AY171180 Genomic DNA. Translation: AAO16435.1 .
AY171181 Genomic DNA. Translation: AAO16437.1 .
AY171182 Genomic DNA. Translation: AAO16439.1 .
AY171183 Genomic DNA. Translation: AAO16441.1 .
AY171184 Genomic DNA. Translation: AAO16443.1 .
AY171185 Genomic DNA. Translation: AAO16445.1 .
AY171186 Genomic DNA. Translation: AAO16447.1 .
AY171187 Genomic DNA. Translation: AAO16449.1 .
AY171188 Genomic DNA. Translation: AAO16451.1 .
AY171189 Genomic DNA. Translation: AAO16453.1 .
AY171190 Genomic DNA. Translation: AAO16455.1 .
AY171191 Genomic DNA. Translation: AAO16457.1 .
AY171192 Genomic DNA. Translation: AAO16459.1 .
AY171193 Genomic DNA. Translation: AAO16250.1 .
AY171194 Genomic DNA. Translation: AAO16254.1 .
AY171195 Genomic DNA. Translation: AAO16258.1 .
AY171196 Genomic DNA. Translation: AAO16262.1 .
AY171197 Genomic DNA. Translation: AAO16266.1 .
AY171198 Genomic DNA. Translation: AAO16270.1 .
AY171199 Genomic DNA. Translation: AAO16274.1 .
AY171200 Genomic DNA. Translation: AAO16278.1 .
AY171201 Genomic DNA. Translation: AAO16282.1 .
AY171202 Genomic DNA. Translation: AAO16286.1 .
AY171203 Genomic DNA. Translation: AAO16290.1 .
AY171204 Genomic DNA. Translation: AAO16294.1 .
AY171205 Genomic DNA. Translation: AAO16298.1 .
AY171206 Genomic DNA. Translation: AAO16302.1 .
AY171207 Genomic DNA. Translation: AAO16306.1 .
PIRi S26032.
RefSeqi NP_006959.1. NC_001328.1.

3D structure databases

ProteinModelPortali P24891.
SMRi P24891. Positions 3-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.MTCE.23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2565701.
KEGGi cel:COX3.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000264954.
InParanoidi P24891.
KOi K02262.
PhylomeDBi P24891.

Miscellaneous databases

NextBioi 953877.

Gene expression databases

ExpressionAtlasi P24891. baseline.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
    Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
    Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
    Denver D.R., Morris K., Thomas W.K.
    Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96 AND 119-255, VARIANTS TRP-185; LEU-187; SER-222 AND ASN-235.
    Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
  3. "Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
    Okimoto R., Macfarlane J.L., Wolstenholme D.R.
    Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

Entry informationi

Entry nameiCOX3_CAEEL
AccessioniPrimary (citable) accession number: P24891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: April 11, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3