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P24891 (COX3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:cox-3
Synonyms:coIII
ORF Names:MTCE.23
Encoded onMitochondrion
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Cytochrome c oxidase subunit 3
PRO_0000183750

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane231 – 25121Helical; Potential

Natural variations

Natural variant1851G → W in strain: PB306. Ref.2
Natural variant1871F → L in strain: PB306. Ref.2
Natural variant2221N → S in strain: CB4854. Ref.2
Natural variant2351Y → N in strain: CB4856. Ref.2

Experimental info

Sequence conflict951C → W in CAA38157. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24891 [UniParc].

Last modified April 11, 2003. Version 3.
Checksum: 064200C7300696CD

FASTA25529,387
        10         20         30         40         50         60 
MFHNFHILSL SSYAYNLFFA SAGMLSSLVM FFKFGLYELF IFTLFSVLFI SFAWGKDIAM 

        70         80         90        100        110        120 
EGLSGYHNFF VMDGFKFGVI LFVFSEFMFF FCIFCTFFDA ALVPVHELGE TWSPFGMHLV 

       130        140        150        160        170        180 
NPFGVPLLNT IILLSSGVTV TWAHHSLLSN KSCTNSMILT CLLAAYFTGI QLMEYMEASF 

       190        200        210        220        230        240 
SIADGVFGSI FYLSTGFHGI HVLCGGLFLA FNFLRLLKNH FNYNHHLGLE FAILYWHFVD 

       250 
VVWLFLFVFV YWWSY 

« Hide

References

« Hide 'large scale' references
[1]"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
Denver D.R., Morris K., Thomas W.K.
Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96 AND 119-255, VARIANTS TRP-185; LEU-187; SER-222 AND ASN-235.
Strain: AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856, CB4857, CB4858, KR314, PB303, PB306, RW7000 and TR403.
[3]"Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans."
Okimoto R., Macfarlane J.L., Wolstenholme D.R.
Nucleic Acids Res. 18:6113-6118(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54252 Genomic DNA. Translation: CAA38157.1.
AY171178 Genomic DNA. Translation: AAO16431.1.
AY171179 Genomic DNA. Translation: AAO16433.1.
AY171180 Genomic DNA. Translation: AAO16435.1.
AY171181 Genomic DNA. Translation: AAO16437.1.
AY171182 Genomic DNA. Translation: AAO16439.1.
AY171183 Genomic DNA. Translation: AAO16441.1.
AY171184 Genomic DNA. Translation: AAO16443.1.
AY171185 Genomic DNA. Translation: AAO16445.1.
AY171186 Genomic DNA. Translation: AAO16447.1.
AY171187 Genomic DNA. Translation: AAO16449.1.
AY171188 Genomic DNA. Translation: AAO16451.1.
AY171189 Genomic DNA. Translation: AAO16453.1.
AY171190 Genomic DNA. Translation: AAO16455.1.
AY171191 Genomic DNA. Translation: AAO16457.1.
AY171192 Genomic DNA. Translation: AAO16459.1.
AY171193 Genomic DNA. Translation: AAO16250.1.
AY171194 Genomic DNA. Translation: AAO16254.1.
AY171195 Genomic DNA. Translation: AAO16258.1.
AY171196 Genomic DNA. Translation: AAO16262.1.
AY171197 Genomic DNA. Translation: AAO16266.1.
AY171198 Genomic DNA. Translation: AAO16270.1.
AY171199 Genomic DNA. Translation: AAO16274.1.
AY171200 Genomic DNA. Translation: AAO16278.1.
AY171201 Genomic DNA. Translation: AAO16282.1.
AY171202 Genomic DNA. Translation: AAO16286.1.
AY171203 Genomic DNA. Translation: AAO16290.1.
AY171204 Genomic DNA. Translation: AAO16294.1.
AY171205 Genomic DNA. Translation: AAO16298.1.
AY171206 Genomic DNA. Translation: AAO16302.1.
AY171207 Genomic DNA. Translation: AAO16306.1.
PIRS26032.
RefSeqNP_006959.1. NC_001328.1.

3D structure databases

ProteinModelPortalP24891.
SMRP24891. Positions 3-253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.MTCE.23.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2565701.
KEGGcel:COX3.

Organism-specific databases

CTD4514.

Phylogenomic databases

eggNOGCOG1845.
HOGENOMHOG000264954.
KOK02262.
PhylomeDBP24891.
ProtClustDBMTH00083.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio953877.

Entry information

Entry nameCOX3_CAEEL
AccessionPrimary (citable) accession number: P24891
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: April 11, 2003
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase