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Protein

Cytochrome c oxidase subunit 3

Gene

ctc-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:ctc-3Imported
Synonyms:coIIIImported, cox-3Imported
ORF Names:MTCE.23Imported
Encoded oniMitochondrion
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Mitochondrion

Organism-specific databases

WormBaseiMTCE.23; CE34069; WBGene00010962; ctc-3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837501 – 255Cytochrome c oxidase subunit 3Add BLAST255

Proteomic databases

PaxDbiP24891.

Expressioni

Gene expression databases

BgeeiWBGene00010962.
ExpressionAtlasiP24891. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.MTCE.23.

Structurei

3D structure databases

ProteinModelPortaliP24891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
HOGENOMiHOG000264954.
InParanoidiP24891.
KOiK02262.
PhylomeDBiP24891.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

P24891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHNFHILSL SSYAYNLFFA SAGMLSSLVM FFKFGLYELF IFTLFSVLFI
60 70 80 90 100
SFAWGKDIAM EGLSGYHNFF VMDGFKFGVI LFVFSEFMFF FCIFCTFFDA
110 120 130 140 150
ALVPVHELGE TWSPFGMHLV NPFGVPLLNT IILLSSGVTV TWAHHSLLSN
160 170 180 190 200
KSCTNSMILT CLLAAYFTGI QLMEYMEASF SIADGVFGSI FYLSTGFHGI
210 220 230 240 250
HVLCGGLFLA FNFLRLLKNH FNYNHHLGLE FAILYWHFVD VVWLFLFVFV

YWWSY
Length:255
Mass (Da):29,387
Last modified:April 11, 2003 - v3
Checksum:i064200C7300696CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95C → W in CAA38157 (PubMed:1551572).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti185G → W in strain: PB306. 1 Publication1
Natural varianti187F → L in strain: PB306. 1 Publication1
Natural varianti222N → S in strain: CB4854. 1 Publication1
Natural varianti235Y → N in strain: CB4856. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54252 Genomic DNA. Translation: CAA38157.1.
AY171178 Genomic DNA. Translation: AAO16431.1.
AY171179 Genomic DNA. Translation: AAO16433.1.
AY171180 Genomic DNA. Translation: AAO16435.1.
AY171181 Genomic DNA. Translation: AAO16437.1.
AY171182 Genomic DNA. Translation: AAO16439.1.
AY171183 Genomic DNA. Translation: AAO16441.1.
AY171184 Genomic DNA. Translation: AAO16443.1.
AY171185 Genomic DNA. Translation: AAO16445.1.
AY171186 Genomic DNA. Translation: AAO16447.1.
AY171187 Genomic DNA. Translation: AAO16449.1.
AY171188 Genomic DNA. Translation: AAO16451.1.
AY171189 Genomic DNA. Translation: AAO16453.1.
AY171190 Genomic DNA. Translation: AAO16455.1.
AY171191 Genomic DNA. Translation: AAO16457.1.
AY171192 Genomic DNA. Translation: AAO16459.1.
AY171193 Genomic DNA. Translation: AAO16250.1.
AY171194 Genomic DNA. Translation: AAO16254.1.
AY171195 Genomic DNA. Translation: AAO16258.1.
AY171196 Genomic DNA. Translation: AAO16262.1.
AY171197 Genomic DNA. Translation: AAO16266.1.
AY171198 Genomic DNA. Translation: AAO16270.1.
AY171199 Genomic DNA. Translation: AAO16274.1.
AY171200 Genomic DNA. Translation: AAO16278.1.
AY171201 Genomic DNA. Translation: AAO16282.1.
AY171202 Genomic DNA. Translation: AAO16286.1.
AY171203 Genomic DNA. Translation: AAO16290.1.
AY171204 Genomic DNA. Translation: AAO16294.1.
AY171205 Genomic DNA. Translation: AAO16298.1.
AY171206 Genomic DNA. Translation: AAO16302.1.
AY171207 Genomic DNA. Translation: AAO16306.1.
PIRiS26032.
RefSeqiNP_006959.1. NC_001328.1.

Genome annotation databases

GeneIDi2565701.
KEGGicel:COX3.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOX3_CAEEL
AccessioniPrimary (citable) accession number: P24891
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: April 11, 2003
Last modified: April 12, 2017
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families