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P24882

- COX2_ASCSU

UniProt

P24882 - COX2_ASCSU

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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641Copper ACurated
Metal bindingi199 – 1991Copper ACurated
Metal bindingi203 – 2031Copper ACurated
Metal bindingi207 – 2071Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei31 – 5222HelicalSequence AnalysisAdd
BLAST
Topological domaini53 – 6917Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei70 – 8920HelicalSequence AnalysisAdd
BLAST
Topological domaini90 – 232143Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Cytochrome c oxidase subunit 2PRO_0000183504Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP24882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24882-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNFFQDFNL LFSSSLFSSY MDWFYNFNCS LLFGVLSFVS TMFVYLLLSS
60 70 80 90 100
FYFKSKKIEY QFGELLCSVF PTLILVMQMV PSLSLLYYYG LMNLDSSLTV
110 120 130 140 150
KVTGHQWYWS YEFSDIPGLE FDSYMKSLDQ LELGEPRLLE VDNRCVVPCD
160 170 180 190 200
VNIRFCITSG DVIHSWALPS MSIKLDAMSG ILSTLSYSFP VVGVFYGQCS
210 220 230
EICGANHSFM PVALEVTLLD NFKSWCVGLL SD
Length:232
Mass (Da):26,518
Last modified:November 1, 1995 - v2
Checksum:i58F9B683FF9DA4C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54253 Genomic DNA. Translation: CAA38172.1.
PIRiS26023.
RefSeqiNP_006950.1. NC_001327.1.

Genome annotation databases

GeneIDi807670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54253 Genomic DNA. Translation: CAA38172.1 .
PIRi S26023.
RefSeqi NP_006950.1. NC_001327.1.

3D structure databases

ProteinModelPortali P24882.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807670.

Organism-specific databases

CTDi 4513.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
    Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
    Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Body wall muscle and Egg.

Entry informationi

Entry nameiCOX2_ASCSU
AccessioniPrimary (citable) accession number: P24882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3