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P24882 (COX2_ASCSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifier6253 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Cytochrome c oxidase subunit 2
PRO_0000183504

Regions

Topological domain1 – 3030Mitochondrial intermembrane Potential
Transmembrane31 – 5222Helical; Potential
Topological domain53 – 6917Mitochondrial matrix Potential
Transmembrane70 – 8920Helical; Potential
Topological domain90 – 232143Mitochondrial intermembrane Potential

Sites

Metal binding1641Copper A Probable
Metal binding1991Copper A Probable
Metal binding2031Copper A Probable
Metal binding2071Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P24882 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 58F9B683FF9DA4C5

FASTA23226,518
        10         20         30         40         50         60 
MNNFFQDFNL LFSSSLFSSY MDWFYNFNCS LLFGVLSFVS TMFVYLLLSS FYFKSKKIEY 

        70         80         90        100        110        120 
QFGELLCSVF PTLILVMQMV PSLSLLYYYG LMNLDSSLTV KVTGHQWYWS YEFSDIPGLE 

       130        140        150        160        170        180 
FDSYMKSLDQ LELGEPRLLE VDNRCVVPCD VNIRFCITSG DVIHSWALPS MSIKLDAMSG 

       190        200        210        220        230 
ILSTLSYSFP VVGVFYGQCS EICGANHSFM PVALEVTLLD NFKSWCVGLL SD 

« Hide

References

[1]"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Body wall muscle and Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54253 Genomic DNA. Translation: CAA38172.1.
PIRS26023.
RefSeqNP_006950.1. NC_001327.1.

3D structure databases

ProteinModelPortalP24882.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807670.

Organism-specific databases

CTD4513.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_ASCSU
AccessionPrimary (citable) accession number: P24882
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families