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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164Copper ACurated1
Metal bindingi199Copper ACurated1
Metal bindingi203Copper ACurated1
Metal bindingi207Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30Mitochondrial intermembraneSequence analysisAdd BLAST30
Transmembranei31 – 52HelicalSequence analysisAdd BLAST22
Topological domaini53 – 69Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei70 – 89HelicalSequence analysisAdd BLAST20
Topological domaini90 – 232Mitochondrial intermembraneSequence analysisAdd BLAST143

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835041 – 232Cytochrome c oxidase subunit 2Add BLAST232

Structurei

3D structure databases

ProteinModelPortaliP24882
SMRiP24882
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P24882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFFQDFNL LFSSSLFSSY MDWFYNFNCS LLFGVLSFVS TMFVYLLLSS
60 70 80 90 100
FYFKSKKIEY QFGELLCSVF PTLILVMQMV PSLSLLYYYG LMNLDSSLTV
110 120 130 140 150
KVTGHQWYWS YEFSDIPGLE FDSYMKSLDQ LELGEPRLLE VDNRCVVPCD
160 170 180 190 200
VNIRFCITSG DVIHSWALPS MSIKLDAMSG ILSTLSYSFP VVGVFYGQCS
210 220 230
EICGANHSFM PVALEVTLLD NFKSWCVGLL SD
Length:232
Mass (Da):26,518
Last modified:November 1, 1995 - v2
Checksum:i58F9B683FF9DA4C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54253 Genomic DNA Translation: CAA38172.1
PIRiS26023
RefSeqiNP_006950.1, NC_001327.1

Genome annotation databases

GeneIDi807670

Similar proteinsi

Entry informationi

Entry nameiCOX2_ASCSU
AccessioniPrimary (citable) accession number: P24882
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health