P24882 (COX2_ASCSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COII

Encoded on

Mitochondrion

Organism

Ascaris suum (Pig roundworm) (Ascaris lumbricoides)

Taxonomic identifier

6253 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Ascarididae › Ascaris

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Cytochrome c oxidase subunit 2		PRO_0000183504
Regions
	Topological domain	1 – 30	30	Mitochondrial intermembrane Potential
	Transmembrane	31 – 52	22	Helical; Potential
	Topological domain	53 – 69	17	Mitochondrial matrix Potential
	Transmembrane	70 – 89	20	Helical; Potential
	Topological domain	90 – 232	143	Mitochondrial intermembrane Potential
Sites
	Metal binding	164	1	Copper A Probable
	Metal binding	199	1	Copper A Probable
	Metal binding	203	1	Copper A Probable
	Metal binding	207	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P24882 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 58F9B683FF9DA4C5	FASTA	232	26,518
	10 20 30 40 50 60 MNNFFQDFNL LFSSSLFSSY MDWFYNFNCS LLFGVLSFVS TMFVYLLLSS FYFKSKKIEY 70 80 90 100 110 120 QFGELLCSVF PTLILVMQMV PSLSLLYYYG LMNLDSSLTV KVTGHQWYWS YEFSDIPGLE 130 140 150 160 170 180 FDSYMKSLDQ LELGEPRLLE VDNRCVVPCD VNIRFCITSG DVIHSWALPS MSIKLDAMSG 190 200 210 220 230 ILSTLSYSFP VVGVFYGQCS EICGANHSFM PVALEVTLLD NFKSWCVGLL SD

References

[1]	"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum." Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R. Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Body wall muscle and Egg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X54253 Genomic DNA. Translation: CAA38172.1.
PIR	S26023.
RefSeq	NP_006950.1. NC_001327.1.
3D structure databases
ProteinModelPortal	P24882.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	807670.
Organism-specific databases
CTD	4513.
Phylogenomic databases
ProtClustDB	MTH00080.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_ASCSU

Accession

Primary (citable) accession number: P24882

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)