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P24881

- COX1_ASCSU

UniProt

P24881 - COX1_ASCSU

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Iron (heme A axial ligand) Inferred
Metal bindingi247 – 2471Copper B Inferred
Metal bindingi251 – 2511Copper B Inferred
Metal bindingi297 – 2971Copper B Inferred
Metal bindingi298 – 2981Copper B Inferred
Metal bindingi383 – 3831Iron (heme A3 axial ligand) Inferred
Metal bindingi385 – 3851Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Reviewed prediction
Add
BLAST
Transmembranei387 – 40721Helical; Reviewed prediction
Add
BLAST
Transmembranei420 – 44021Helical; Reviewed prediction
Add
BLAST
Transmembranei459 – 47921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Cytochrome c oxidase subunit 1
PRO_0000183288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki247 ↔ 2511'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP24881.
SMRiP24881. Positions 12-512.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24881-1 [UniParc]FASTAAdd to Basket

« Hide

MSGFYKYQGG LSVWLESSNH KDIGTLYFLF GLWSGMVGTS LSLVIRLELA    50
KPGLLLGSGQ LYNSVITAHA ILMIFFMVMP TMIGGFGNWM LPLMLGAPDM 100
SFPRLNNLSF WLLPTAMFLI LDACFVDMGC GTSWTVYPPL STMGHPGGSV 150
DLAIFSLHCA GVSSILGAIN FMTTTKNLRS SSISLEHMSL FVWTVFVTVF 200
LLVLSLPVLA GAITMLLTDR NLNTSFFDPS TGGNPLIYQH LFWFFGHPEV 250
YILILPAFGI ISQSSLYLTG KKEVFGSLGM VYAILSIGLI GCVVWAHHMY 300
TVGMDLDSRA YFTAATMVIA VPTGVKVFSW LATLFGMKMV FQPLLLWVMG 350
FIFLFTIGGL TGVMLSNSSL DIILHDTYYV VSHFHYVLSL GAVFGIFTGV 400
TLWWSFITGF VYDKMMMSSV FVLMFVGVNL TFFPLHFAGI HGYPRKYLDY 450
PDVYSVWNIM ASYGSMISVF ALFLFIYVLL ESFVGHRIFL FDYYVNSGPE 500
YSLSGYVFGH SYQSEIFYSS IVFKF 525
Length:525
Mass (Da):58,529
Last modified:November 1, 1995 - v2
Checksum:i2EFB6A50522F7FBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54253 Genomic DNA. Translation: CAA38171.1.
PIRiS26022.
RefSeqiNP_006949.1. NC_001327.1.

Genome annotation databases

GeneIDi807671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54253 Genomic DNA. Translation: CAA38171.1 .
PIRi S26022.
RefSeqi NP_006949.1. NC_001327.1.

3D structure databases

ProteinModelPortali P24881.
SMRi P24881. Positions 12-512.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807671.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum."
    Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.
    Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Body wall muscle and Egg.

Entry informationi

Entry nameiCOX1_ASCSU
AccessioniPrimary (citable) accession number: P24881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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