P24879 (COX3_ASCSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Ascaris suum (Pig roundworm) (Ascaris lumbricoides)

Taxonomic identifier

6253 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Ascarididae › Ascaris

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Cytochrome c oxidase subunit 3		PRO_0000183741
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P24879 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 05A992684AC92755	FASTA	255	29,094
	10 20 30 40 50 60 MFHNFHILSL SSYPILIFCS SLGFTSSLVV FFKNGIFGGL LFCLFSIFLV SFAWGKDIVM 70 80 90 100 110 120 EGLSGYHNFF VMDGFKFGVL VFIFSEFMFF FGIFWTFFDA ALVPAHDVGG VWSPIGMHLV 130 140 150 160 170 180 NPFGVPLLNT IILLSSGVSV TWAHYSLLSN KGCANSLMLT CILAVYFTGI QLMEYKEASF 190 200 210 220 230 240 SISDGIFGSI FYLSTGFHGV HVLFGGLFLF FNLLRLLMSH FNYNHHLGLE FAIIYWHFVD 250 VVWLFLFVFV YWWSY

References

[1]	"The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum." Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R. Genetics 130:471-498(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Body wall muscle and Egg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X54253 Genomic DNA. Translation: CAA38169.1.
PIR	S26020.
RefSeq	NP_006947.1. NC_001327.1.
3D structure databases
ProteinModelPortal	P24879.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	807665.
Organism-specific databases
CTD	4514.
Phylogenomic databases
ProtClustDB	MTH00083.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_ASCSU

Accession

Primary (citable) accession number: P24879

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)