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Protein

G2/mitotic-specific cyclin-4

Gene

CLB4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Miscellaneous

Present with 98 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: SGD
  • positive regulation of mitotic spindle pole body separation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of mitotic spindle assembly Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32327-MONOMER
ReactomeiR-SCE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-SCE-187577 SCF(Skp2)-mediated degradation of p27/p21
R-SCE-2299718 Condensation of Prophase Chromosomes
R-SCE-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-5689880 Ub-specific processing proteases
R-SCE-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-SCE-68949 Orc1 removal from chromatin
R-SCE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SCE-69202 Cyclin E associated events during G1/S transition
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SCE-69478 G2/M DNA replication checkpoint
R-SCE-69656 Cyclin A:Cdk2-associated events at S phase entry
R-SCE-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-4
Gene namesi
Name:CLB4
Ordered Locus Names:YLR210W
ORF Names:L8167.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR210W
SGDiS000004200 CLB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804061 – 460G2/mitotic-specific cyclin-4Add BLAST460

Proteomic databases

PaxDbiP24871
PRIDEiP24871

PTM databases

iPTMnetiP24871

Interactioni

Protein-protein interaction databases

BioGridi31478, 99 interactors
DIPiDIP-2268N
IntActiP24871, 3 interactors
MINTiP24871
STRINGi4932.YLR210W

Structurei

3D structure databases

ProteinModelPortaliP24871
SMRiP24871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
InParanoidiP24871
KOiK06659
OMAiYDVTMVA
OrthoDBiEOG092C2S0G

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P24871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLEGYTVQP PQSTLIGDIE IQDENANQEV KNVLYQGVQK GIKRLEKRQR
60 70 80 90 100
RVALGDVTSQ KANKIHNAIH NKFHQTKNNF EIENIRSSAL VKEQQRDVRH
110 120 130 140 150
EDSDYFLIDS SEGSSTDDEQ VNEDAIDDLL SRRVNDQQIQ ADEVYEDFDG
160 170 180 190 200
EMQDVIEEDV DSQIEPLSPI NNDEIQTELD RAFEKYFRSV PNPLDDDTHD
210 220 230 240 250
VVMVVEYASD IFYYLRELEV KYRPNPYYMQ NQVELTWPFR RTMIDWLVQL
260 270 280 290 300
HFRFQLLPET LYLTINIVDR FLSKKTVTLN RFQLVGVSAL FIAAKFEEIN
310 320 330 340 350
CPTLDDLVYM LENTYTRDDI IRAEQYMIDT LEFEIGWPGP MPFLRRISKA
360 370 380 390 400
DDYDFEPRTL AKYLLETTIV EPKLVAAAPS WLAAGAYFLS RTILGSNDWS
410 420 430 440 450
LKHVFYSGYT SSQIIPLASL ILENCKNASR RHHSIWKKYF DQKHYRCSQI
460
VEEWIVSTEA
Length:460
Mass (Da):53,853
Last modified:October 1, 1993 - v2
Checksum:i2BAFCEC706F2FBA2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255Q → R no nucleotide entry (PubMed:1849457).Curated1
Sequence conflicti318D → S no nucleotide entry (PubMed:1849457).Curated1
Sequence conflicti328I → T no nucleotide entry (PubMed:1849457).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69426 Genomic DNA Translation: CAA49202.1
M80303 Genomic DNA Translation: AAA73136.1
U14913 Genomic DNA Translation: AAB67425.1
BK006945 Genomic DNA Translation: DAA09527.1
PIRiB60048
RefSeqiNP_013311.1, NM_001182097.1

Genome annotation databases

EnsemblFungiiYLR210W; YLR210W; YLR210W
GeneIDi850907
KEGGisce:YLR210W

Similar proteinsi

Entry informationi

Entry nameiCG24_YEAST
AccessioniPrimary (citable) accession number: P24871
Secondary accession number(s): D6VYL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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