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Protein

G2/mitotic-specific cyclin-3

Gene

CLB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: SGD
  • meiosis II Source: SGD
  • positive regulation of spindle pole body separation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of mitotic spindle assembly Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29550-MONOMER.
ReactomeiR-SCE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-SCE-2299718. Condensation of Prophase Chromosomes.
R-SCE-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-SCE-3214858. RMTs methylate histone arginines.
R-SCE-4419969. Depolymerisation of the Nuclear Lamina.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-SCE-68949. Orc1 removal from chromatin.
R-SCE-69202. Cyclin E associated events during G1/S transition.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69231. Cyclin D associated events in G1.
R-SCE-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-SCE-69478. G2/M DNA replication checkpoint.
R-SCE-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-SCE-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-3
Gene namesi
Name:CLB3
Ordered Locus Names:YDL155W
ORF Names:D1539
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL155W.
SGDiS000002314. CLB3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804051 – 427G2/mitotic-specific cyclin-3Add BLAST427

Proteomic databases

PaxDbiP24870.
PRIDEiP24870.

PTM databases

iPTMnetiP24870.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31908. 160 interactors.
DIPiDIP-1266N.
IntActiP24870. 36 interactors.
MINTiP24870.
STRINGi4932.YDL155W.

Structurei

3D structure databases

ProteinModelPortaliP24870.
SMRiP24870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
InParanoidiP24870.
KOiK06659.
OMAiIDACDEM.
OrthoDBiEOG092C2S0G.

Family and domain databases

CDDicd00043. CYCLIN. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR036915. Cyclin-like_sf.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P24870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHNSQSLSS GHIRSPEDEN VAPIGNLKHR TGSLSHISSA HPRVALSDVT
60 70 80 90 100
NIVATNSSNN SISKPKVAPI KERLDSAAII EEERLDANSV AQRKEADHND
110 120 130 140 150
LLTDREQEEP VEDDGESEED EEEDQEPLLL QHYASDTLVW EHAFRTYYRT
160 170 180 190 200
TLDPNDDDVY DVVMVAELSN EIFEYMRKLE DLYKPNPYYM DKQPELRWSF
210 220 230 240 250
RSTLIDWIVQ VHEKFQLLPE TLYLCINIID RYLCKEVVPV NKFQLVGAAS
260 270 280 290 300
LFIAAKYEEI NCPTIKDFVY MSENCYSRND LLDAERTILN GLEFELGWPG
310 320 330 340 350
PMSFLRRISK ADDYEHDTRT LAKYLLESTI MDHRLVSAQP SWLAAGAYFL
360 370 380 390 400
SKIILGQNQW SLAHVYYSNY TQEQILPLAT IILENCRYAS KRHNAIWRKY
410 420
SSRRYLHSSQ IVAKWIALAE HRVERSN
Length:427
Mass (Da):49,476
Last modified:October 25, 2004 - v3
Checksum:i91EE26655A5EC72D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48D → R in CAA49201 (PubMed:1427070).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69425 Genomic DNA. Translation: CAA49201.1.
M80302 Genomic DNA. Translation: AAA34765.1.
X97751 Genomic DNA. Translation: CAA66336.1.
Z74203 Genomic DNA. Translation: CAA98729.1.
AY692856 Genomic DNA. Translation: AAT92875.1.
BK006938 Genomic DNA. Translation: DAA11705.1.
PIRiA60048.
RefSeqiNP_010126.1. NM_001180215.1.

Genome annotation databases

EnsemblFungiiYDL155W; YDL155W; YDL155W.
GeneIDi851400.
KEGGisce:YDL155W.

Similar proteinsi

Entry informationi

Entry nameiCG23_YEAST
AccessioniPrimary (citable) accession number: P24870
Secondary accession number(s): D6VRJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 25, 2004
Last modified: March 28, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome