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Protein

G2/mitotic-specific cyclin-3

Gene

CLB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: SGD
  • meiosis II Source: SGD
  • positive regulation of mitotic spindle pole body separation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of mitotic spindle assembly Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29550-MONOMER
ReactomeiR-SCE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-SCE-187577 SCF(Skp2)-mediated degradation of p27/p21
R-SCE-2299718 Condensation of Prophase Chromosomes
R-SCE-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-5689880 Ub-specific processing proteases
R-SCE-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-SCE-68949 Orc1 removal from chromatin
R-SCE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SCE-69202 Cyclin E associated events during G1/S transition
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SCE-69478 G2/M DNA replication checkpoint
R-SCE-69656 Cyclin A:Cdk2-associated events at S phase entry
R-SCE-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-3
Gene namesi
Name:CLB3
Ordered Locus Names:YDL155W
ORF Names:D1539
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL155W
SGDiS000002314 CLB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804051 – 427G2/mitotic-specific cyclin-3Add BLAST427

Proteomic databases

PaxDbiP24870
PRIDEiP24870

PTM databases

iPTMnetiP24870

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31908, 160 interactors
DIPiDIP-1266N
IntActiP24870, 32 interactors
MINTiP24870
STRINGi4932.YDL155W

Structurei

3D structure databases

ProteinModelPortaliP24870
SMRiP24870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
InParanoidiP24870
KOiK06659
OMAiIDACDEM
OrthoDBiEOG092C2S0G

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P24870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHNSQSLSS GHIRSPEDEN VAPIGNLKHR TGSLSHISSA HPRVALSDVT
60 70 80 90 100
NIVATNSSNN SISKPKVAPI KERLDSAAII EEERLDANSV AQRKEADHND
110 120 130 140 150
LLTDREQEEP VEDDGESEED EEEDQEPLLL QHYASDTLVW EHAFRTYYRT
160 170 180 190 200
TLDPNDDDVY DVVMVAELSN EIFEYMRKLE DLYKPNPYYM DKQPELRWSF
210 220 230 240 250
RSTLIDWIVQ VHEKFQLLPE TLYLCINIID RYLCKEVVPV NKFQLVGAAS
260 270 280 290 300
LFIAAKYEEI NCPTIKDFVY MSENCYSRND LLDAERTILN GLEFELGWPG
310 320 330 340 350
PMSFLRRISK ADDYEHDTRT LAKYLLESTI MDHRLVSAQP SWLAAGAYFL
360 370 380 390 400
SKIILGQNQW SLAHVYYSNY TQEQILPLAT IILENCRYAS KRHNAIWRKY
410 420
SSRRYLHSSQ IVAKWIALAE HRVERSN
Length:427
Mass (Da):49,476
Last modified:October 25, 2004 - v3
Checksum:i91EE26655A5EC72D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48D → R in CAA49201 (PubMed:1427070).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69425 Genomic DNA Translation: CAA49201.1
M80302 Genomic DNA Translation: AAA34765.1
X97751 Genomic DNA Translation: CAA66336.1
Z74203 Genomic DNA Translation: CAA98729.1
AY692856 Genomic DNA Translation: AAT92875.1
BK006938 Genomic DNA Translation: DAA11705.1
PIRiA60048
RefSeqiNP_010126.1, NM_001180215.1

Genome annotation databases

EnsemblFungiiYDL155W; YDL155W; YDL155W
GeneIDi851400
KEGGisce:YDL155W

Similar proteinsi

Entry informationi

Entry nameiCG23_YEAST
AccessioniPrimary (citable) accession number: P24870
Secondary accession number(s): D6VRJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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