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Protein

G2/mitotic-specific cyclin-2

Gene

CLB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: SGD
  • negative regulation of protein dephosphorylation Source: SGD
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • positive regulation of spindle pole body separation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of mitotic spindle elongation Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-34258-MONOMER
ReactomeiR-SCE-176408 Regulation of APC/C activators between G1/S and early anaphase
R-SCE-2299718 Condensation of Prophase Chromosomes
R-SCE-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-SCE-3214858 RMTs methylate histone arginines
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-5689880 Ub-specific processing proteases
R-SCE-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-SCE-68949 Orc1 removal from chromatin
R-SCE-69202 Cyclin E associated events during G1/S transition
R-SCE-69229 Ubiquitin-dependent degradation of Cyclin D1
R-SCE-69231 Cyclin D associated events in G1
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SCE-69478 G2/M DNA replication checkpoint
R-SCE-69656 Cyclin A:Cdk2-associated events at S phase entry
R-SCE-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-2
Gene namesi
Name:CLB2
Ordered Locus Names:YPR119W
ORF Names:P9642.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR119W
SGDiS000006323 CLB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000804042 – 491G2/mitotic-specific cyclin-2Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP24869
PaxDbiP24869
PRIDEiP24869

PTM databases

iPTMnetiP24869

Expressioni

Developmental stagei

Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.

Interactioni

Subunit structurei

Interacts with NAP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36287280 interactors.
DIPiDIP-658N
ELMiP24869
IntActiP24869 28 interactors.
MINTiP24869
STRINGi4932.YPR119W

Structurei

3D structure databases

ProteinModelPortaliP24869
SMRiP24869
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
InParanoidiP24869
KOiK02220
OMAiSETDGAC
OrthoDBiEOG092C2S0G

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24869-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPIENTEN SQNTSSSRFL RNVQRLALNN VTNTTFQKSN ANNPALTNFK
60 70 80 90 100
STLNSVKKEG SRIPQFTRES VSRSTAAQEE KRTLKENGIQ LPKNNLLDDK
110 120 130 140 150
ENQDPSSQQF GALTSIKEGR AELPANISLQ ESSSAKEIIQ HDPLKGVGSS
160 170 180 190 200
TEVVHNSVEN EKLHPARSQL QVRNTESETD SGKKRPISTI VEQELPKKFK
210 220 230 240 250
VCDENGKEEY EWEDLDAEDV NDPFMVSEYV NDIFEYLHQL EVITLPKKED
260 270 280 290 300
LYQHRNIHQN RDILVNWLVK IHNKFGLLPE TLYLAINIMD RFLGKELVQL
310 320 330 340 350
DKLQLVGTSC LFIASKYEEV YSPSIKHFAS ETDGACTEDE IKEGEKFILK
360 370 380 390 400
TLKFNLNYPN PMNFLRRISK ADDYDIQSRT LAKFLLEISL VDFRFIGILP
410 420 430 440 450
SLCAAAAMFM SRKMLGKGKW DGNLIHYSGG YTKEELAPVC HMIMDYLVSP
460 470 480 490
IVHDEFHRKY QSRRFMKASI ISVQWALKVR KNGYDIMTLH E
Length:491
Mass (Da):56,247
Last modified:March 1, 1992 - v1
Checksum:iB68FF888871022A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65070 Genomic DNA Translation: AAA34502.1
X62319 Genomic DNA Translation: CAA44195.1
U40828 Genomic DNA Translation: AAB68060.1
BK006949 Genomic DNA Translation: DAA11534.1
PIRiS14166
RefSeqiNP_015444.1, NM_001184216.1

Genome annotation databases

EnsemblFungiiYPR119W; YPR119W; YPR119W
GeneIDi856236
KEGGisce:YPR119W

Similar proteinsi

Entry informationi

Entry nameiCG22_YEAST
AccessioniPrimary (citable) accession number: P24869
Secondary accession number(s): D6W4B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: March 28, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome