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P24868

- CG21_YEAST

UniProt

P24868 - CG21_YEAST

Protein

G2/mitotic-specific cyclin-1

Gene

CLB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: SGD
    2. meiotic G2/MI transition Source: SGD
    3. mitotic nuclear division Source: UniProtKB-KW
    4. mitotic spindle organization in nucleus Source: SGD
    5. positive regulation of spindle pole body separation Source: SGD
    6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30817-MONOMER.
    ReactomeiREACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_188487. Cyclin A/B1 associated events during G2/M transition.
    REACT_188488. G2/M DNA replication checkpoint.
    REACT_188908. Condensation of Prometaphase Chromosomes.
    REACT_188916. MASTL Facilitates Mitotic Progression.
    REACT_205363. Cyclin B2 mediated events.
    REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
    REACT_224510. Depolymerisation of the Nuclear Lamina.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G2/mitotic-specific cyclin-1
    Gene namesi
    Name:CLB1
    Synonyms:SCB1
    Ordered Locus Names:YGR108W
    ORF Names:G5967
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR108w.
    SGDiS000003340. CLB1.

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: SGD
    2. cytoplasm Source: SGD
    3. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471G2/mitotic-specific cyclin-1PRO_0000080403Add
    BLAST

    Proteomic databases

    PaxDbiP24868.

    Expressioni

    Developmental stagei

    Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.

    Gene expression databases

    GenevestigatoriP24868.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CKS1P204863EBI-4508,EBI-4746

    Protein-protein interaction databases

    BioGridi33352. 65 interactions.
    DIPiDIP-1261N.
    IntActiP24868. 5 interactions.
    MINTiMINT-410951.
    STRINGi4932.YGR108W.

    Structurei

    3D structure databases

    ProteinModelPortaliP24868.
    SMRiP24868. Positions 207-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00750000117276.
    HOGENOMiHOG000167672.
    KOiK02220.
    OrthoDBiEOG7FNCJX.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24868-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSLLVENS RTINSNEEKG VNESQYILQK RNVPRTILGN VTNNANILQE    50
    ISMNRKIGMK NFSKLNNFFP LKDDVSRADD FTSSFNDSRQ GVKQEVLNNK 100
    ENIPEYGYSE QEKQQCSNDD SFHTNSTALS CNRLIYSENK SISTQMEWQK 150
    KIMREDSKKK RPISTLVEQD DQKKFKLHEL TTEEEVLEEY EWDDLDEEDC 200
    DDPLMVSEEV NDIFDYLHHL EIITLPNKAN LYKHKNIKQN RDILVNWIIK 250
    IHNKFGLLPE TLYLAINIMD RFLCEEVVQL NRLQLVGTSC LFIASKYEEI 300
    YSPSIKHFAY ETDGACSVED IKEGERFILE KLDFQISFAN PMNFLRRISK 350
    ADDYDIQSRT LAKFLMEISI VDFKFIGILP SLCASAAMFL SRKMLGKGTW 400
    DGNLIHYSGG YTKAKLYPVC QLLMDYLVGS TIHDEFLKKY QSRRFLKASI 450
    ISIEWALKVR KNGYDIMTLH E 471
    Length:471
    Mass (Da):54,871
    Last modified:March 1, 1992 - v1
    Checksum:i4B347E96DD188735
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65069 Genomic DNA. Translation: AAA34501.1.
    M62389 Genomic DNA. Translation: AAA35019.1.
    Z72893 Genomic DNA. Translation: CAA97112.1.
    BK006941 Genomic DNA. Translation: DAA08200.1.
    PIRiS14165.
    RefSeqiNP_011622.1. NM_001181237.1.

    Genome annotation databases

    EnsemblFungiiYGR108W; YGR108W; YGR108W.
    GeneIDi853002.
    KEGGisce:YGR108W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65069 Genomic DNA. Translation: AAA34501.1 .
    M62389 Genomic DNA. Translation: AAA35019.1 .
    Z72893 Genomic DNA. Translation: CAA97112.1 .
    BK006941 Genomic DNA. Translation: DAA08200.1 .
    PIRi S14165.
    RefSeqi NP_011622.1. NM_001181237.1.

    3D structure databases

    ProteinModelPortali P24868.
    SMRi P24868. Positions 207-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33352. 65 interactions.
    DIPi DIP-1261N.
    IntActi P24868. 5 interactions.
    MINTi MINT-410951.
    STRINGi 4932.YGR108W.

    Proteomic databases

    PaxDbi P24868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR108W ; YGR108W ; YGR108W .
    GeneIDi 853002.
    KEGGi sce:YGR108W.

    Organism-specific databases

    CYGDi YGR108w.
    SGDi S000003340. CLB1.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00750000117276.
    HOGENOMi HOG000167672.
    KOi K02220.
    OrthoDBi EOG7FNCJX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30817-MONOMER.
    Reactomei REACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_188487. Cyclin A/B1 associated events during G2/M transition.
    REACT_188488. G2/M DNA replication checkpoint.
    REACT_188908. Condensation of Prometaphase Chromosomes.
    REACT_188916. MASTL Facilitates Mitotic Progression.
    REACT_205363. Cyclin B2 mediated events.
    REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
    REACT_224510. Depolymerisation of the Nuclear Lamina.

    Miscellaneous databases

    NextBioi 972846.

    Gene expression databases

    Genevestigatori P24868.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae."
      Surana U., Robitsch H., Price C., Schuster T., Fitch I., Futcher A.B., Nasmyth K.
      Cell 65:145-161(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis."
      Ghiara J.B., Richardson H.E., Sugimoto K., Henze M., Lew D.J., Wittenberg C., Reed S.I.
      Cell 65:163-174(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCG21_YEAST
    AccessioniPrimary (citable) accession number: P24868
    Secondary accession number(s): D6VUN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3