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P24868 (CG21_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G2/mitotic-specific cyclin-1
Gene names
Name:CLB1
Synonyms:SCB1
Ordered Locus Names:YGR108W
ORF Names:G5967
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Developmental stage

Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CKS1P204863EBI-4508,EBI-4746

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471G2/mitotic-specific cyclin-1
PRO_0000080403

Sequences

Sequence LengthMass (Da)Tools
P24868 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 4B347E96DD188735

FASTA47154,871
        10         20         30         40         50         60 
MSRSLLVENS RTINSNEEKG VNESQYILQK RNVPRTILGN VTNNANILQE ISMNRKIGMK 

        70         80         90        100        110        120 
NFSKLNNFFP LKDDVSRADD FTSSFNDSRQ GVKQEVLNNK ENIPEYGYSE QEKQQCSNDD 

       130        140        150        160        170        180 
SFHTNSTALS CNRLIYSENK SISTQMEWQK KIMREDSKKK RPISTLVEQD DQKKFKLHEL 

       190        200        210        220        230        240 
TTEEEVLEEY EWDDLDEEDC DDPLMVSEEV NDIFDYLHHL EIITLPNKAN LYKHKNIKQN 

       250        260        270        280        290        300 
RDILVNWIIK IHNKFGLLPE TLYLAINIMD RFLCEEVVQL NRLQLVGTSC LFIASKYEEI 

       310        320        330        340        350        360 
YSPSIKHFAY ETDGACSVED IKEGERFILE KLDFQISFAN PMNFLRRISK ADDYDIQSRT 

       370        380        390        400        410        420 
LAKFLMEISI VDFKFIGILP SLCASAAMFL SRKMLGKGTW DGNLIHYSGG YTKAKLYPVC 

       430        440        450        460        470 
QLLMDYLVGS TIHDEFLKKY QSRRFLKASI ISIEWALKVR KNGYDIMTLH E 

« Hide

References

« Hide 'large scale' references
[1]"The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae."
Surana U., Robitsch H., Price C., Schuster T., Fitch I., Futcher A.B., Nasmyth K.
Cell 65:145-161(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis."
Ghiara J.B., Richardson H.E., Sugimoto K., Henze M., Lew D.J., Wittenberg C., Reed S.I.
Cell 65:163-174(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M65069 Genomic DNA. Translation: AAA34501.1.
M62389 Genomic DNA. Translation: AAA35019.1.
Z72893 Genomic DNA. Translation: CAA97112.1.
BK006941 Genomic DNA. Translation: DAA08200.1.
PIRS14165.
RefSeqNP_011622.1. NM_001181237.1.

3D structure databases

ProteinModelPortalP24868.
SMRP24868. Positions 207-451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33352. 65 interactions.
DIPDIP-1261N.
IntActP24868. 5 interactions.
MINTMINT-410951.
STRING4932.YGR108W.

Proteomic databases

PaxDbP24868.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR108W; YGR108W; YGR108W.
GeneID853002.
KEGGsce:YGR108W.

Organism-specific databases

CYGDYGR108w.
SGDS000003340. CLB1.

Phylogenomic databases

eggNOGCOG5024.
GeneTreeENSGT00750000117276.
HOGENOMHOG000167672.
KOK02220.
OrthoDBEOG7FNCJX.

Enzyme and pathway databases

BioCycYEAST:G3O-30817-MONOMER.

Gene expression databases

GenevestigatorP24868.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio972846.

Entry information

Entry nameCG21_YEAST
AccessionPrimary (citable) accession number: P24868
Secondary accession number(s): D6VUN9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families