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Protein

G2/mitotic-specific cyclin-1

Gene

CLB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: SGD
  • mitotic spindle organization in nucleus Source: SGD
  • positive regulation of spindle pole body separation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of meiosis I Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30817-MONOMER.
ReactomeiR-SCE-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-SCE-2299718. Condensation of Prophase Chromosomes.
R-SCE-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-SCE-3214858. RMTs methylate histone arginines.
R-SCE-4419969. Depolymerisation of the Nuclear Lamina.
R-SCE-5687128. MAPK6/MAPK4 signaling.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-SCE-68949. Orc1 removal from chromatin.
R-SCE-69202. Cyclin E associated events during G1/S transition.
R-SCE-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SCE-69231. Cyclin D associated events in G1.
R-SCE-69273. Cyclin A/B1/B2 associated events during G2/M transition.
R-SCE-69478. G2/M DNA replication checkpoint.
R-SCE-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-SCE-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-1
Gene namesi
Name:CLB1
Synonyms:SCB1
Ordered Locus Names:YGR108W
ORF Names:G5967
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR108W.
SGDiS000003340. CLB1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804031 – 471G2/mitotic-specific cyclin-1Add BLAST471

Proteomic databases

PRIDEiP24868.

Expressioni

Developmental stagei

Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33352. 87 interactors.
DIPiDIP-1261N.
IntActiP24868. 12 interactors.
MINTiMINT-410951.
STRINGi4932.YGR108W.

Structurei

3D structure databases

ProteinModelPortaliP24868.
SMRiP24868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
InParanoidiP24868.
KOiK02220.
OrthoDBiEOG092C2S0G.

Family and domain databases

CDDicd00043. CYCLIN. 2 hits.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P24868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSLLVENS RTINSNEEKG VNESQYILQK RNVPRTILGN VTNNANILQE
60 70 80 90 100
ISMNRKIGMK NFSKLNNFFP LKDDVSRADD FTSSFNDSRQ GVKQEVLNNK
110 120 130 140 150
ENIPEYGYSE QEKQQCSNDD SFHTNSTALS CNRLIYSENK SISTQMEWQK
160 170 180 190 200
KIMREDSKKK RPISTLVEQD DQKKFKLHEL TTEEEVLEEY EWDDLDEEDC
210 220 230 240 250
DDPLMVSEEV NDIFDYLHHL EIITLPNKAN LYKHKNIKQN RDILVNWIIK
260 270 280 290 300
IHNKFGLLPE TLYLAINIMD RFLCEEVVQL NRLQLVGTSC LFIASKYEEI
310 320 330 340 350
YSPSIKHFAY ETDGACSVED IKEGERFILE KLDFQISFAN PMNFLRRISK
360 370 380 390 400
ADDYDIQSRT LAKFLMEISI VDFKFIGILP SLCASAAMFL SRKMLGKGTW
410 420 430 440 450
DGNLIHYSGG YTKAKLYPVC QLLMDYLVGS TIHDEFLKKY QSRRFLKASI
460 470
ISIEWALKVR KNGYDIMTLH E
Length:471
Mass (Da):54,871
Last modified:March 1, 1992 - v1
Checksum:i4B347E96DD188735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65069 Genomic DNA. Translation: AAA34501.1.
M62389 Genomic DNA. Translation: AAA35019.1.
Z72893 Genomic DNA. Translation: CAA97112.1.
BK006941 Genomic DNA. Translation: DAA08200.1.
PIRiS14165.
RefSeqiNP_011622.1. NM_001181237.1.

Genome annotation databases

EnsemblFungiiYGR108W; YGR108W; YGR108W.
GeneIDi853002.
KEGGisce:YGR108W.

Similar proteinsi

Entry informationi

Entry nameiCG21_YEAST
AccessioniPrimary (citable) accession number: P24868
Secondary accession number(s): D6VUN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 27, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names