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P24868

- CG21_YEAST

UniProt

P24868 - CG21_YEAST

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Protein

G2/mitotic-specific cyclin-1

Gene
CLB1, SCB1, YGR108W, G5967
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
  2. protein binding Source: IntAct

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: SGD
  2. meiotic G2/MI transition Source: SGD
  3. mitotic nuclear division Source: UniProtKB-KW
  4. mitotic spindle organization in nucleus Source: SGD
  5. positive regulation of spindle pole body separation Source: SGD
  6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30817-MONOMER.
ReactomeiREACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
REACT_188487. Cyclin A/B1 associated events during G2/M transition.
REACT_188488. G2/M DNA replication checkpoint.
REACT_188908. Condensation of Prometaphase Chromosomes.
REACT_188916. MASTL Facilitates Mitotic Progression.
REACT_205363. Cyclin B2 mediated events.
REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
REACT_224510. Depolymerisation of the Nuclear Lamina.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-1
Gene namesi
Name:CLB1
Synonyms:SCB1
Ordered Locus Names:YGR108W
ORF Names:G5967
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR108w.
SGDiS000003340. CLB1.

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: SGD
  2. cytoplasm Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471G2/mitotic-specific cyclin-1PRO_0000080403Add
BLAST

Proteomic databases

PaxDbiP24868.

Expressioni

Developmental stagei

Maximally expressed before mitosis. The levels peak late in the G2 phase of the cell cycle and are at a minimum in G1 phase.

Gene expression databases

GenevestigatoriP24868.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CKS1P204863EBI-4508,EBI-4746

Protein-protein interaction databases

BioGridi33352. 65 interactions.
DIPiDIP-1261N.
IntActiP24868. 5 interactions.
MINTiMINT-410951.
STRINGi4932.YGR108W.

Structurei

3D structure databases

ProteinModelPortaliP24868.
SMRiP24868. Positions 207-451.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00750000117276.
HOGENOMiHOG000167672.
KOiK02220.
OrthoDBiEOG7FNCJX.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24868-1 [UniParc]FASTAAdd to Basket

« Hide

MSRSLLVENS RTINSNEEKG VNESQYILQK RNVPRTILGN VTNNANILQE    50
ISMNRKIGMK NFSKLNNFFP LKDDVSRADD FTSSFNDSRQ GVKQEVLNNK 100
ENIPEYGYSE QEKQQCSNDD SFHTNSTALS CNRLIYSENK SISTQMEWQK 150
KIMREDSKKK RPISTLVEQD DQKKFKLHEL TTEEEVLEEY EWDDLDEEDC 200
DDPLMVSEEV NDIFDYLHHL EIITLPNKAN LYKHKNIKQN RDILVNWIIK 250
IHNKFGLLPE TLYLAINIMD RFLCEEVVQL NRLQLVGTSC LFIASKYEEI 300
YSPSIKHFAY ETDGACSVED IKEGERFILE KLDFQISFAN PMNFLRRISK 350
ADDYDIQSRT LAKFLMEISI VDFKFIGILP SLCASAAMFL SRKMLGKGTW 400
DGNLIHYSGG YTKAKLYPVC QLLMDYLVGS TIHDEFLKKY QSRRFLKASI 450
ISIEWALKVR KNGYDIMTLH E 471
Length:471
Mass (Da):54,871
Last modified:March 1, 1992 - v1
Checksum:i4B347E96DD188735
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65069 Genomic DNA. Translation: AAA34501.1.
M62389 Genomic DNA. Translation: AAA35019.1.
Z72893 Genomic DNA. Translation: CAA97112.1.
BK006941 Genomic DNA. Translation: DAA08200.1.
PIRiS14165.
RefSeqiNP_011622.1. NM_001181237.1.

Genome annotation databases

EnsemblFungiiYGR108W; YGR108W; YGR108W.
GeneIDi853002.
KEGGisce:YGR108W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65069 Genomic DNA. Translation: AAA34501.1 .
M62389 Genomic DNA. Translation: AAA35019.1 .
Z72893 Genomic DNA. Translation: CAA97112.1 .
BK006941 Genomic DNA. Translation: DAA08200.1 .
PIRi S14165.
RefSeqi NP_011622.1. NM_001181237.1.

3D structure databases

ProteinModelPortali P24868.
SMRi P24868. Positions 207-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33352. 65 interactions.
DIPi DIP-1261N.
IntActi P24868. 5 interactions.
MINTi MINT-410951.
STRINGi 4932.YGR108W.

Proteomic databases

PaxDbi P24868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR108W ; YGR108W ; YGR108W .
GeneIDi 853002.
KEGGi sce:YGR108W.

Organism-specific databases

CYGDi YGR108w.
SGDi S000003340. CLB1.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00750000117276.
HOGENOMi HOG000167672.
KOi K02220.
OrthoDBi EOG7FNCJX.

Enzyme and pathway databases

BioCyci YEAST:G3O-30817-MONOMER.
Reactomei REACT_188466. Regulation of APC/C activators between G1/S and early anaphase.
REACT_188487. Cyclin A/B1 associated events during G2/M transition.
REACT_188488. G2/M DNA replication checkpoint.
REACT_188908. Condensation of Prometaphase Chromosomes.
REACT_188916. MASTL Facilitates Mitotic Progression.
REACT_205363. Cyclin B2 mediated events.
REACT_211772. E2F-enabled inhibition of pre-replication complex formation.
REACT_224510. Depolymerisation of the Nuclear Lamina.

Miscellaneous databases

NextBioi 972846.

Gene expression databases

Genevestigatori P24868.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae."
    Surana U., Robitsch H., Price C., Schuster T., Fitch I., Futcher A.B., Nasmyth K.
    Cell 65:145-161(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis."
    Ghiara J.B., Richardson H.E., Sugimoto K., Henze M., Lew D.J., Wittenberg C., Reed S.I.
    Cell 65:163-174(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCG21_YEAST
AccessioniPrimary (citable) accession number: P24868
Secondary accession number(s): D6VUN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 300 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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