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P24865

- CG21_SCHPO

UniProt

P24865 - CG21_SCHPO

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Protein

G2/mitotic-specific cyclin cig1

Gene

cig1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for efficient passage of the G1/S transition.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: PomBase

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: PomBase
  3. regulation of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_188254. Condensation of Prometaphase Chromosomes.
REACT_188278. MASTL Facilitates Mitotic Progression.
REACT_199398. Cyclin A/B1 associated events during G2/M transition.
REACT_219807. Resolution of Sister Chromatid Cohesion.
REACT_219991. Cyclin B2 mediated events.
REACT_221258. Depolymerisation of the Nuclear Lamina.
REACT_222028. Regulation of APC/C activators between G1/S and early anaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin cig1
Gene namesi
Name:cig1
ORF Names:SPCC4E9.02, SPCC645.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC4E9.02.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415G2/mitotic-specific cyclin cig1PRO_0000080400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24865.

Interactioni

Protein-protein interaction databases

BioGridi275996. 8 interactions.
STRINGi4896.SPCC4E9.02-1.

Structurei

3D structure databases

ProteinModelPortaliP24865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000167672.
InParanoidiP24865.
OMAiHATFASW.
OrthoDBiEOG7FNCJX.
PhylomeDBiP24865.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24865-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVSTQTRHA TYFQDENQLQ KDHIYVKKKS HIKLNTGVRA PFKAVDNINQ
60 70 80 90 100
QDEPTLIEGN NESSISSSTG DTFEEDFAYQ DKVEIEERSI RSTPKSIGDD
110 120 130 140 150
DLENREGSFD APEGILTHGK HRLPTIPEWT KEDLAALSEA AARLQANPSP
160 170 180 190 200
EDIETDPSMV PDYDPEIFHY MQSLERKLAP PPNYMSVQQE IDWVTRHMLV
210 220 230 240 250
DWIVQVQIHF RLLPETLFLA VNLIDRFLSI KVVSLQKVQL VGLSALLIAC
260 270 280 290 300
KYEEIHPPSI YNFAHVVQGI FTVDEIIRAE RYMLMLLDFD ISWPGPMSFL
310 320 330 340 350
RRISRADSYD HDIRMLAKYL QEVTLMDEIF IGAHISFIAA TAYYLSMQML
360 370 380 390 400
GHLDWTPCHV YYSGYTARQL KPCAIIIMEC LVDAPNHHNA IYRKYSENRM
410
KRVSAFAHNW VLSVI
Length:415
Mass (Da):47,808
Last modified:January 11, 2001 - v2
Checksum:i352A6E48D309D06B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391R → P in AAA35288. (PubMed:1829983)Curated
Sequence conflicti307 – 3071D → H in AAA35288. (PubMed:1829983)Curated
Sequence conflicti375 – 3751I → N in AAA35288. (PubMed:1829983)Curated
Sequence conflicti378 – 3781M → W in AAA35288. (PubMed:1829983)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68881 Genomic DNA. Translation: AAA35288.1.
CU329672 Genomic DNA. Translation: CAB57300.1.
PIRiT41518.
RefSeqiNP_588110.2. NM_001023100.2.

Genome annotation databases

EnsemblFungiiSPCC4E9.02.1; SPCC4E9.02.1:pep; SPCC4E9.02.
GeneIDi2539433.
KEGGispo:SPCC4E9.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68881 Genomic DNA. Translation: AAA35288.1 .
CU329672 Genomic DNA. Translation: CAB57300.1 .
PIRi T41518.
RefSeqi NP_588110.2. NM_001023100.2.

3D structure databases

ProteinModelPortali P24865.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275996. 8 interactions.
STRINGi 4896.SPCC4E9.02-1.

Proteomic databases

MaxQBi P24865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC4E9.02.1 ; SPCC4E9.02.1:pep ; SPCC4E9.02 .
GeneIDi 2539433.
KEGGi spo:SPCC4E9.02.

Organism-specific databases

PomBasei SPCC4E9.02.

Phylogenomic databases

eggNOGi COG5024.
HOGENOMi HOG000167672.
InParanoidi P24865.
OMAi HATFASW.
OrthoDBi EOG7FNCJX.
PhylomeDBi P24865.

Enzyme and pathway databases

Reactomei REACT_188254. Condensation of Prometaphase Chromosomes.
REACT_188278. MASTL Facilitates Mitotic Progression.
REACT_199398. Cyclin A/B1 associated events during G2/M transition.
REACT_219807. Resolution of Sister Chromatid Cohesion.
REACT_219991. Cyclin B2 mediated events.
REACT_221258. Depolymerisation of the Nuclear Lamina.
REACT_222028. Regulation of APC/C activators between G1/S and early anaphase.

Miscellaneous databases

NextBioi 20800595.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A fission yeast B-type cyclin functioning early in the cell cycle."
    Bueno A., Richardson H.E., Reed S.I., Russell P.
    Cell 66:149-159(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCG21_SCHPO
AccessioniPrimary (citable) accession number: P24865
Secondary accession number(s): Q9USI7, Q9USI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 11, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3