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Protein

G2/mitotic-specific cyclin cig1

Gene

cig1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient passage of the G1/S transition.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_281737. Depolymerisation of the Nuclear Lamina.
REACT_284579. Cyclin B2 mediated events.
REACT_291429. Cyclin A/B1 associated events during G2/M transition.
REACT_297137. G2/M DNA replication checkpoint.
REACT_317100. Regulation of APC/C activators between G1/S and early anaphase.
REACT_321583. E2F-enabled inhibition of pre-replication complex formation.
REACT_322081. Condensation of Prometaphase Chromosomes.
REACT_346337. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin cig1
Gene namesi
Name:cig1
ORF Names:SPCC4E9.02, SPCC645.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC4E9.02.
PomBaseiSPCC4E9.02. cig1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415G2/mitotic-specific cyclin cig1PRO_0000080400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24865.

Interactioni

Protein-protein interaction databases

BioGridi275996. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliP24865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000167672.
InParanoidiP24865.
OMAiDFKISQY.
OrthoDBiEOG7FNCJX.
PhylomeDBiP24865.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSTQTRHA TYFQDENQLQ KDHIYVKKKS HIKLNTGVRA PFKAVDNINQ
60 70 80 90 100
QDEPTLIEGN NESSISSSTG DTFEEDFAYQ DKVEIEERSI RSTPKSIGDD
110 120 130 140 150
DLENREGSFD APEGILTHGK HRLPTIPEWT KEDLAALSEA AARLQANPSP
160 170 180 190 200
EDIETDPSMV PDYDPEIFHY MQSLERKLAP PPNYMSVQQE IDWVTRHMLV
210 220 230 240 250
DWIVQVQIHF RLLPETLFLA VNLIDRFLSI KVVSLQKVQL VGLSALLIAC
260 270 280 290 300
KYEEIHPPSI YNFAHVVQGI FTVDEIIRAE RYMLMLLDFD ISWPGPMSFL
310 320 330 340 350
RRISRADSYD HDIRMLAKYL QEVTLMDEIF IGAHISFIAA TAYYLSMQML
360 370 380 390 400
GHLDWTPCHV YYSGYTARQL KPCAIIIMEC LVDAPNHHNA IYRKYSENRM
410
KRVSAFAHNW VLSVI
Length:415
Mass (Da):47,808
Last modified:January 11, 2001 - v2
Checksum:i352A6E48D309D06B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391R → P in AAA35288 (PubMed:1829983).Curated
Sequence conflicti307 – 3071D → H in AAA35288 (PubMed:1829983).Curated
Sequence conflicti375 – 3751I → N in AAA35288 (PubMed:1829983).Curated
Sequence conflicti378 – 3781M → W in AAA35288 (PubMed:1829983).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68881 Genomic DNA. Translation: AAA35288.1.
CU329672 Genomic DNA. Translation: CAB57300.1.
PIRiT41518.
RefSeqiNP_588110.2. NM_001023100.2.

Genome annotation databases

EnsemblFungiiSPCC4E9.02.1; SPCC4E9.02.1:pep; SPCC4E9.02.
GeneIDi2539433.
KEGGispo:SPCC4E9.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68881 Genomic DNA. Translation: AAA35288.1.
CU329672 Genomic DNA. Translation: CAB57300.1.
PIRiT41518.
RefSeqiNP_588110.2. NM_001023100.2.

3D structure databases

ProteinModelPortaliP24865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275996. 8 interactions.

Proteomic databases

MaxQBiP24865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC4E9.02.1; SPCC4E9.02.1:pep; SPCC4E9.02.
GeneIDi2539433.
KEGGispo:SPCC4E9.02.

Organism-specific databases

EuPathDBiFungiDB:SPCC4E9.02.
PomBaseiSPCC4E9.02. cig1.

Phylogenomic databases

eggNOGiCOG5024.
HOGENOMiHOG000167672.
InParanoidiP24865.
OMAiDFKISQY.
OrthoDBiEOG7FNCJX.
PhylomeDBiP24865.

Enzyme and pathway databases

ReactomeiREACT_281737. Depolymerisation of the Nuclear Lamina.
REACT_284579. Cyclin B2 mediated events.
REACT_291429. Cyclin A/B1 associated events during G2/M transition.
REACT_297137. G2/M DNA replication checkpoint.
REACT_317100. Regulation of APC/C activators between G1/S and early anaphase.
REACT_321583. E2F-enabled inhibition of pre-replication complex formation.
REACT_322081. Condensation of Prometaphase Chromosomes.
REACT_346337. Resolution of Sister Chromatid Cohesion.

Miscellaneous databases

NextBioi20800595.
PROiP24865.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A fission yeast B-type cyclin functioning early in the cell cycle."
    Bueno A., Richardson H.E., Reed S.I., Russell P.
    Cell 66:149-159(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCG21_SCHPO
AccessioniPrimary (citable) accession number: P24865
Secondary accession number(s): Q9USI7, Q9USI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 11, 2001
Last modified: July 22, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.