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P24865

- CG21_SCHPO

UniProt

P24865 - CG21_SCHPO

Protein

G2/mitotic-specific cyclin cig1

Gene

cig1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Required for efficient passage of the G1/S transition.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: PomBase

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    3. regulation of mitotic cell cycle Source: PomBase

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_188254. Condensation of Prometaphase Chromosomes.
    REACT_188278. MASTL Facilitates Mitotic Progression.
    REACT_199398. Cyclin A/B1 associated events during G2/M transition.
    REACT_219807. Resolution of Sister Chromatid Cohesion.
    REACT_219991. Cyclin B2 mediated events.
    REACT_221258. Depolymerisation of the Nuclear Lamina.
    REACT_222028. Regulation of APC/C activators between G1/S and early anaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G2/mitotic-specific cyclin cig1
    Gene namesi
    Name:cig1
    ORF Names:SPCC4E9.02, SPCC645.01
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC4E9.02.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415G2/mitotic-specific cyclin cig1PRO_0000080400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei96 – 961Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP24865.

    Interactioni

    Protein-protein interaction databases

    BioGridi275996. 8 interactions.
    STRINGi4896.SPCC4E9.02-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP24865.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin G subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    HOGENOMiHOG000167672.
    OMAiHATFASW.
    OrthoDBiEOG7FNCJX.
    PhylomeDBiP24865.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24865-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVSTQTRHA TYFQDENQLQ KDHIYVKKKS HIKLNTGVRA PFKAVDNINQ    50
    QDEPTLIEGN NESSISSSTG DTFEEDFAYQ DKVEIEERSI RSTPKSIGDD 100
    DLENREGSFD APEGILTHGK HRLPTIPEWT KEDLAALSEA AARLQANPSP 150
    EDIETDPSMV PDYDPEIFHY MQSLERKLAP PPNYMSVQQE IDWVTRHMLV 200
    DWIVQVQIHF RLLPETLFLA VNLIDRFLSI KVVSLQKVQL VGLSALLIAC 250
    KYEEIHPPSI YNFAHVVQGI FTVDEIIRAE RYMLMLLDFD ISWPGPMSFL 300
    RRISRADSYD HDIRMLAKYL QEVTLMDEIF IGAHISFIAA TAYYLSMQML 350
    GHLDWTPCHV YYSGYTARQL KPCAIIIMEC LVDAPNHHNA IYRKYSENRM 400
    KRVSAFAHNW VLSVI 415
    Length:415
    Mass (Da):47,808
    Last modified:January 11, 2001 - v2
    Checksum:i352A6E48D309D06B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391R → P in AAA35288. (PubMed:1829983)Curated
    Sequence conflicti307 – 3071D → H in AAA35288. (PubMed:1829983)Curated
    Sequence conflicti375 – 3751I → N in AAA35288. (PubMed:1829983)Curated
    Sequence conflicti378 – 3781M → W in AAA35288. (PubMed:1829983)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68881 Genomic DNA. Translation: AAA35288.1.
    CU329672 Genomic DNA. Translation: CAB57300.1.
    PIRiT41518.
    RefSeqiNP_588110.2. NM_001023100.2.

    Genome annotation databases

    EnsemblFungiiSPCC4E9.02.1; SPCC4E9.02.1:pep; SPCC4E9.02.
    GeneIDi2539433.
    KEGGispo:SPCC4E9.02.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68881 Genomic DNA. Translation: AAA35288.1 .
    CU329672 Genomic DNA. Translation: CAB57300.1 .
    PIRi T41518.
    RefSeqi NP_588110.2. NM_001023100.2.

    3D structure databases

    ProteinModelPortali P24865.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275996. 8 interactions.
    STRINGi 4896.SPCC4E9.02-1.

    Proteomic databases

    MaxQBi P24865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC4E9.02.1 ; SPCC4E9.02.1:pep ; SPCC4E9.02 .
    GeneIDi 2539433.
    KEGGi spo:SPCC4E9.02.

    Organism-specific databases

    PomBasei SPCC4E9.02.

    Phylogenomic databases

    eggNOGi COG5024.
    HOGENOMi HOG000167672.
    OMAi HATFASW.
    OrthoDBi EOG7FNCJX.
    PhylomeDBi P24865.

    Enzyme and pathway databases

    Reactomei REACT_188254. Condensation of Prometaphase Chromosomes.
    REACT_188278. MASTL Facilitates Mitotic Progression.
    REACT_199398. Cyclin A/B1 associated events during G2/M transition.
    REACT_219807. Resolution of Sister Chromatid Cohesion.
    REACT_219991. Cyclin B2 mediated events.
    REACT_221258. Depolymerisation of the Nuclear Lamina.
    REACT_222028. Regulation of APC/C activators between G1/S and early anaphase.

    Miscellaneous databases

    NextBioi 20800595.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A fission yeast B-type cyclin functioning early in the cell cycle."
      Bueno A., Richardson H.E., Reed S.I., Russell P.
      Cell 66:149-159(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCG21_SCHPO
    AccessioniPrimary (citable) accession number: P24865
    Secondary accession number(s): Q9USI7, Q9USI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3