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P24863

- CCNC_HUMAN

UniProt

P24863 - CCNC_HUMAN

Protein

Cyclin-C

Gene

CCNC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. gene expression Source: Reactome
    2. Notch signaling pathway Source: Reactome
    3. positive regulation of transcription from RNA polymerase II promoter Source: Reactome
    4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    5. transcription, DNA-templated Source: Reactome
    6. transcription initiation from RNA polymerase II promoter Source: Reactome
    7. transforming growth factor beta receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Activator, Cyclin, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_12627. Generic Transcription Pathway.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiP24863.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-C
    Alternative name(s):
    SRB11 homolog
    Short name:
    hSRB11
    Gene namesi
    Name:CCNC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:1581. CCNC.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, holoenzyme Source: InterPro
    2. mediator complex Source: Ensembl
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26149.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Cyclin-CPRO_0000080420Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP24863.
    PaxDbiP24863.
    PRIDEiP24863.

    PTM databases

    PhosphoSiteiP24863.

    Expressioni

    Tissue specificityi

    Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

    Gene expression databases

    ArrayExpressiP24863.
    BgeeiP24863.
    CleanExiHS_CCNC.
    GenevestigatoriP24863.

    Organism-specific databases

    HPAiCAB010499.

    Interactioni

    Subunit structurei

    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK8P493367EBI-395261,EBI-394377

    Protein-protein interaction databases

    BioGridi107333. 30 interactions.
    DIPiDIP-32920N.
    IntActiP24863. 14 interactions.
    STRINGi9606.ENSP00000358222.

    Structurei

    Secondary structure

    283
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni1 – 33
    Helixi5 – 73
    Helixi9 – 135
    Helixi18 – 2912
    Helixi34 – 5421
    Helixi59 – 7517
    Turni78 – 803
    Helixi83 – 9715
    Beta strandi98 – 1003
    Helixi105 – 11915
    Turni121 – 1233
    Helixi132 – 14514
    Turni146 – 1483
    Helixi156 – 16611
    Helixi169 – 18315
    Turni184 – 1874
    Helixi188 – 1914
    Helixi194 – 20815
    Helixi214 – 2185
    Helixi224 – 24320
    Helixi246 – 25611

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RGFX-ray2.20B1-283[»]
    4F6SX-ray2.60B1-283[»]
    4F6UX-ray2.10B1-283[»]
    4F6WX-ray2.39B1-283[»]
    4F70X-ray3.00B1-283[»]
    4F7JX-ray2.60B1-283[»]
    4F7LX-ray2.90B1-283[»]
    4F7NX-ray2.65B1-283[»]
    4F7SX-ray2.20B1-283[»]
    4G6LX-ray2.70B1-283[»]
    ProteinModelPortaliP24863.
    SMRiP24863. Positions 1-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 14499Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin C subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG5333.
    HOGENOMiHOG000008007.
    HOVERGENiHBG050836.
    InParanoidiP24863.
    KOiK15161.
    OMAiCLQIACV.
    OrthoDBiEOG7WX08X.
    PhylomeDBiP24863.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR006671. Cyclin_N.
    IPR023598. CyclinC.
    [Graphical view]
    PANTHERiPTHR10026. PTHR10026. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028758. PIRSF028758. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P24863-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA    50
    LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF 100
    GVVSNTRLIA AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL 150
    IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA 200
    CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM 250
    ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS 283
    Length:283
    Mass (Da):33,243
    Last modified:January 15, 2008 - v2
    Checksum:iCF8AC5E94E621F4C
    GO
    Isoform 2 (identifier: P24863-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:198
    Mass (Da):22,945
    Checksum:i1A22C22167A775E7
    GO

    Sequence cautioni

    The sequence AAC50825.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_043075Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74091 mRNA. No translation available.
    U40739
    , U40728, U40729, U40730, U40731, U40732, U40733, U40734, U40735, U40736, U40737, U40738 Genomic DNA. Translation: AAC50825.1. Different initiation.
    AK298558 mRNA. Translation: BAG60753.1.
    AL137784 Genomic DNA. Translation: CAC14563.1.
    CCDSiCCDS34502.1. [P24863-1]
    CCDS47461.1. [P24863-2]
    PIRiA40268.
    RefSeqiNP_001013417.1. NM_001013399.1. [P24863-2]
    NP_005181.2. NM_005190.3. [P24863-1]
    UniGeneiHs.430646.
    Hs.633351.

    Genome annotation databases

    EnsembliENST00000520429; ENSP00000428982; ENSG00000112237. [P24863-1]
    ENST00000523799; ENSP00000430014; ENSG00000112237. [P24863-2]
    ENST00000523985; ENSP00000430119; ENSG00000112237. [P24863-2]
    GeneIDi892.
    KEGGihsa:892.
    UCSCiuc003pqd.3. human. [P24863-1]

    Polymorphism databases

    DMDMi166214910.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74091 mRNA. No translation available.
    U40739
    , U40728 , U40729 , U40730 , U40731 , U40732 , U40733 , U40734 , U40735 , U40736 , U40737 , U40738 Genomic DNA. Translation: AAC50825.1 . Different initiation.
    AK298558 mRNA. Translation: BAG60753.1 .
    AL137784 Genomic DNA. Translation: CAC14563.1 .
    CCDSi CCDS34502.1. [P24863-1 ]
    CCDS47461.1. [P24863-2 ]
    PIRi A40268.
    RefSeqi NP_001013417.1. NM_001013399.1. [P24863-2 ]
    NP_005181.2. NM_005190.3. [P24863-1 ]
    UniGenei Hs.430646.
    Hs.633351.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3RGF X-ray 2.20 B 1-283 [» ]
    4F6S X-ray 2.60 B 1-283 [» ]
    4F6U X-ray 2.10 B 1-283 [» ]
    4F6W X-ray 2.39 B 1-283 [» ]
    4F70 X-ray 3.00 B 1-283 [» ]
    4F7J X-ray 2.60 B 1-283 [» ]
    4F7L X-ray 2.90 B 1-283 [» ]
    4F7N X-ray 2.65 B 1-283 [» ]
    4F7S X-ray 2.20 B 1-283 [» ]
    4G6L X-ray 2.70 B 1-283 [» ]
    ProteinModelPortali P24863.
    SMRi P24863. Positions 1-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107333. 30 interactions.
    DIPi DIP-32920N.
    IntActi P24863. 14 interactions.
    STRINGi 9606.ENSP00000358222.

    Chemistry

    ChEMBLi CHEMBL3038474.

    PTM databases

    PhosphoSitei P24863.

    Polymorphism databases

    DMDMi 166214910.

    Proteomic databases

    MaxQBi P24863.
    PaxDbi P24863.
    PRIDEi P24863.

    Protocols and materials databases

    DNASUi 892.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000520429 ; ENSP00000428982 ; ENSG00000112237 . [P24863-1 ]
    ENST00000523799 ; ENSP00000430014 ; ENSG00000112237 . [P24863-2 ]
    ENST00000523985 ; ENSP00000430119 ; ENSG00000112237 . [P24863-2 ]
    GeneIDi 892.
    KEGGi hsa:892.
    UCSCi uc003pqd.3. human. [P24863-1 ]

    Organism-specific databases

    CTDi 892.
    GeneCardsi GC06M100037.
    HGNCi HGNC:1581. CCNC.
    HPAi CAB010499.
    MIMi 123838. gene.
    neXtProti NX_P24863.
    PharmGKBi PA26149.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5333.
    HOGENOMi HOG000008007.
    HOVERGENi HBG050836.
    InParanoidi P24863.
    KOi K15161.
    OMAi CLQIACV.
    OrthoDBi EOG7WX08X.
    PhylomeDBi P24863.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_12627. Generic Transcription Pathway.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki P24863.

    Miscellaneous databases

    GeneWikii CCNC_(gene).
    GenomeRNAii 892.
    NextBioi 3690.
    PROi P24863.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24863.
    Bgeei P24863.
    CleanExi HS_CCNC.
    Genevestigatori P24863.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR006671. Cyclin_N.
    IPR023598. CyclinC.
    [Graphical view ]
    PANTHERi PTHR10026. PTHR10026. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028758. PIRSF028758. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast."
      Lew D.J., Dulic V., Reed S.I.
      Cell 66:1197-1206(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors."
      Li H., Lahti J.M., Valentine M., Saito M., Reed S.I., Look A.T., Kidd V.J.
      Genomics 32:253-259(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II."
      Rickert P., Seghezzi W., Shanahan F., Cho H., Lees E.
      Oncogene 12:2631-2640(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
      Sun X., Zhang Y., Cho H., Rickert P., Lees E., Lane W.S., Reinberg D.
      Mol. Cell 2:213-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A FORM OF THE MEDIATOR COMPLEX.
    7. "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
      Gu W., Malik S., Ito M., Yuan C.-X., Fondell J.D., Zhang X., Martinez E., Qin J., Roeder R.G.
      Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SMCC COMPLEX.
    8. "TFIIH is negatively regulated by cdk8-containing mediator complexes."
      Akoulitchev S., Chuikov S., Reinberg D.
      Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MED6.
    9. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
      Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
    10. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
      Baek H.J., Kang Y.K., Roeder R.G.
      J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MED1 AND MED10.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder."
      Schneider E.V., Bottcher J., Blaesse M., Neumann L., Huber R., Maskos K.
      J. Mol. Biol. 412:251-266(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH CDK8 AND INHIBITOR.

    Entry informationi

    Entry nameiCCNC_HUMAN
    AccessioniPrimary (citable) accession number: P24863
    Secondary accession number(s): B4DPZ1, Q9H543
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3