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P24856 (ANP_NOTCO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ice-structuring glycoprotein

Short name=ISGP
Alternative name(s):
Antifreeze glycopeptide polyprotein
Short name=AFGP polyprotein

Cleaved into the following 8 chains:

  1. AFGP7-1
    Alternative name(s):
    AFGP 7
  2. AFGP7-2
    Alternative name(s):
    AFGP 7
  3. AFGP8-1
    Alternative name(s):
    AFGP 8
  4. AFGP8-2
    Alternative name(s):
    AFGP 8
  5. AFGP8-3
    Alternative name(s):
    AFGP 8
  6. AFGP8-4
    Alternative name(s):
    AFGP 8
  7. AFGP8-5
    Alternative name(s):
    AFGP 8
  8. AFGP8-like
Gene names
Name:afgp8
OrganismNotothenia coriiceps neglecta (Black rockcod) (Yellowbelly rockcod)
Taxonomic identifier202063 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesNotothenioideiNototheniidaeNotothenia

Protein attributes

Sequence length790 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antifreeze proteins lower the blood freezing point.

Subcellular location

Secreted.

Tissue specificity

Synthesized by the liver and secreted into the blood from which they become distributed to almost the entire extracellular space.

Domain

Contains 44 copies of AFGP8 and two copies of AFGP7.

Post-translational modification

O-glycosylated; contains disaccharide galactose-N-acetylgalactosamine attached to threonines in AFGP8 and AFGP7.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
   Molecular functionAntifreeze protein
   PTMGlycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processresponse to freezing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide‹1 – 5›5
PRO_0000001634
Chain6 – 790785Ice-structuring glycoprotein
PRO_0000001635
Peptide6 – 1914AFGP8-1
PRO_0000001636
Peptide23 – 3614AFGP8-5
PRO_0000001637
Peptide40 – 5314AFGP8-1
PRO_0000001638
Peptide57 – 7014AFGP8-4
PRO_0000001639
Peptide74 – 8714AFGP8-2
PRO_0000001640
Peptide91 – 10414AFGP8-4
PRO_0000001641
Peptide108 – 12114AFGP8-3
PRO_0000001642
Peptide125 – 13814AFGP8-4
PRO_0000001643
Peptide142 – 15514AFGP8-3
PRO_0000001644
Peptide159 – 17214AFGP8-4
PRO_0000001645
Peptide176 – 18914AFGP8-1
PRO_0000001646
Peptide193 – 20614AFGP8-4
PRO_0000001647
Peptide210 – 22314AFGP8-1
PRO_0000001648
Peptide227 – 24014AFGP8-1
PRO_0000001649
Peptide244 – 25714AFGP8-4
PRO_0000001650
Peptide261 – 27414AFGP8-1
PRO_0000001651
Peptide278 – 29114AFGP8-4
PRO_0000001652
Peptide295 – 30814AFGP8-1
PRO_0000001653
Peptide312 – 32514AFGP8-4
PRO_0000001654
Peptide329 – 34214AFGP8-1
PRO_0000001655
Peptide346 – 35914AFGP8-4
PRO_0000001656
Peptide363 – 37614AFGP8-1
PRO_0000001657
Peptide380 – 39314AFGP8-3
PRO_0000001658
Peptide397 – 41014AFGP8-4
PRO_0000001659
Peptide414 – 42714AFGP8-1
PRO_0000001660
Peptide431 – 44414AFGP8-4
PRO_0000001661
Peptide448 – 46114AFGP8-1
PRO_0000001662
Peptide465 – 47814AFGP8-1
PRO_0000001663
Peptide482 – 49514AFGP8-4
PRO_0000001664
Peptide499 – 51214AFGP8-1
PRO_0000001665
Peptide516 – 52914AFGP8-1
PRO_0000001666
Peptide533 – 54614AFGP8-4
PRO_0000001667
Peptide550 – 56314AFGP8-1
PRO_0000001668
Peptide567 – 58014AFGP8-4
PRO_0000001669
Peptide584 – 59714AFGP8-3
PRO_0000001670
Peptide601 – 61414AFGP8-4
PRO_0000001671
Peptide618 – 63114AFGP8-1
PRO_0000001672
Peptide635 – 64814AFGP8-1
PRO_0000001673
Peptide652 – 66514AFGP8-4
PRO_0000001674
Peptide669 – 68214AFGP8-1
PRO_0000001675
Peptide686 – 69914AFGP8-4
PRO_0000001676
Peptide703 – 71614AFGP8-1
PRO_0000001677
Peptide720 – 73617AFGP7-1
PRO_0000001678
Peptide740 – 75617AFGP7-2
PRO_0000001679
Peptide760 – 77314AFGP8-3
PRO_0000001680
Peptide777 – 79014AFGP8-like
PRO_0000001681

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P24856 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 4C7CCCADC48FE902

FASTA79071,267
        10         20         30         40         50         60 
VTAAPAATAA TAATPATAAL NFAATAATPA TPATPALIFA ATAATAATPA TAALNFAATA 

        70         80         90        100        110        120 
ATPATAATPA LIFAAAAATA ATPATAALNF AATAATPATA ATPALIFAAT AATAATPATP 

       130        140        150        160        170        180 
AFHFAATAAT PATAATPALI FAATAATAAT PATPAFHFAA TAATPATAAT PALIFAATAA 

       190        200        210        220        230        240 
TAATPATAAL NFAATAATPA TAATPALIFA ATAATAATPA TAALNFAATA ATAATPATAA 

       250        260        270        280        290        300 
CNFAATAATP ATAATPALIF AATAATAATP ATAACNFAAT AATPATAATP ALIFAATAAT 

       310        320        330        340        350        360 
AATPATAALN FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL 

       370        380        390        400        410        420 
IFAATAATAA TPATAALNFA ATAATAATPA TPAFNFAATA ATPATAATPA LIFAATAATA 

       430        440        450        460        470        480 
ATPATAALNF AATAATPATA ATPALIFAAT AATAATPATA ALHFAATAAT AATPATAALN 

       490        500        510        520        530        540 
FAATAATPAT AATPALIFAA TAATAATPAT AAFNFAATAA TAATPATAAL NFAATAATPA 

       550        560        570        580        590        600 
TAATPALIFA ATAATAATPA TAALNFAATA ATPATAATPA LIFAATAATA ATPATPAFHF 

       610        620        630        640        650        660 
AATAATPATA ATPALIFAAT AATAATPATA ALNFAATAAT AATPATAALN FAATAATPAT 

       670        680        690        700        710        720 
AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL IFAATAATAA TPATAAFNFA 

       730        740        750        760        770        780 
ATAATAATPA TAATPALIFA ATAATAATPA TPATPALIFA ATAATAATPA TPALNFAATA 

       790 
ATAATTAARG 

« Hide

References

[1]"An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number."
Hsiao K.-C., Cheng C.-H.C., Fernandes I.E., Detrich H.W. III, Devries A.L.
Proc. Natl. Acad. Sci. U.S.A. 87:9265-9269(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Testis.
[2]Cheng C.-H.C.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO N-TERMINUS AND 457.

Web resources

Protein Spotlight

Cool news - Issue 5 of December 2000

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55000 Genomic DNA. Translation: AAA49392.2.
PIRA38420.

3D structure databases

ProteinModelPortalP24856.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameANP_NOTCO
AccessionPrimary (citable) accession number: P24856
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: February 19, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries