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P24856

- ANP_NOTNE

UniProt

P24856 - ANP_NOTNE

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Protein

Ice-structuring glycoprotein

Gene

afgp8

Organism
Notothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Antifreeze proteins lower the blood freezing point.

GO - Biological processi

  1. response to freezing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antifreeze protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring glycoprotein
Short name:
ISGP
Alternative name(s):
Antifreeze glycopeptide polyprotein
Short name:
AFGP polyprotein
Cleaved into the following 8 chains:
Alternative name(s):
AFGP 7
Alternative name(s):
AFGP 7
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Gene namesi
Name:afgp8
OrganismiNotothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
Taxonomic identifieri202063 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeNotothenia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei‹1 – 5›5PRO_0000001634
Chaini6 – 790785Ice-structuring glycoproteinPRO_0000001635Add
BLAST
Peptidei6 – 1914AFGP8-1PRO_0000001636Add
BLAST
Peptidei23 – 3614AFGP8-5PRO_0000001637Add
BLAST
Peptidei40 – 5314AFGP8-1PRO_0000001638Add
BLAST
Peptidei57 – 7014AFGP8-4PRO_0000001639Add
BLAST
Peptidei74 – 8714AFGP8-2PRO_0000001640Add
BLAST
Peptidei91 – 10414AFGP8-4PRO_0000001641Add
BLAST
Peptidei108 – 12114AFGP8-3PRO_0000001642Add
BLAST
Peptidei125 – 13814AFGP8-4PRO_0000001643Add
BLAST
Peptidei142 – 15514AFGP8-3PRO_0000001644Add
BLAST
Peptidei159 – 17214AFGP8-4PRO_0000001645Add
BLAST
Peptidei176 – 18914AFGP8-1PRO_0000001646Add
BLAST
Peptidei193 – 20614AFGP8-4PRO_0000001647Add
BLAST
Peptidei210 – 22314AFGP8-1PRO_0000001648Add
BLAST
Peptidei227 – 24014AFGP8-1PRO_0000001649Add
BLAST
Peptidei244 – 25714AFGP8-4PRO_0000001650Add
BLAST
Peptidei261 – 27414AFGP8-1PRO_0000001651Add
BLAST
Peptidei278 – 29114AFGP8-4PRO_0000001652Add
BLAST
Peptidei295 – 30814AFGP8-1PRO_0000001653Add
BLAST
Peptidei312 – 32514AFGP8-4PRO_0000001654Add
BLAST
Peptidei329 – 34214AFGP8-1PRO_0000001655Add
BLAST
Peptidei346 – 35914AFGP8-4PRO_0000001656Add
BLAST
Peptidei363 – 37614AFGP8-1PRO_0000001657Add
BLAST
Peptidei380 – 39314AFGP8-3PRO_0000001658Add
BLAST
Peptidei397 – 41014AFGP8-4PRO_0000001659Add
BLAST
Peptidei414 – 42714AFGP8-1PRO_0000001660Add
BLAST
Peptidei431 – 44414AFGP8-4PRO_0000001661Add
BLAST
Peptidei448 – 46114AFGP8-1PRO_0000001662Add
BLAST
Peptidei465 – 47814AFGP8-1PRO_0000001663Add
BLAST
Peptidei482 – 49514AFGP8-4PRO_0000001664Add
BLAST
Peptidei499 – 51214AFGP8-1PRO_0000001665Add
BLAST
Peptidei516 – 52914AFGP8-1PRO_0000001666Add
BLAST
Peptidei533 – 54614AFGP8-4PRO_0000001667Add
BLAST
Peptidei550 – 56314AFGP8-1PRO_0000001668Add
BLAST
Peptidei567 – 58014AFGP8-4PRO_0000001669Add
BLAST
Peptidei584 – 59714AFGP8-3PRO_0000001670Add
BLAST
Peptidei601 – 61414AFGP8-4PRO_0000001671Add
BLAST
Peptidei618 – 63114AFGP8-1PRO_0000001672Add
BLAST
Peptidei635 – 64814AFGP8-1PRO_0000001673Add
BLAST
Peptidei652 – 66514AFGP8-4PRO_0000001674Add
BLAST
Peptidei669 – 68214AFGP8-1PRO_0000001675Add
BLAST
Peptidei686 – 69914AFGP8-4PRO_0000001676Add
BLAST
Peptidei703 – 71614AFGP8-1PRO_0000001677Add
BLAST
Peptidei720 – 73617AFGP7-1PRO_0000001678Add
BLAST
Peptidei740 – 75617AFGP7-2PRO_0000001679Add
BLAST
Peptidei760 – 77314AFGP8-3PRO_0000001680Add
BLAST
Peptidei777 – 79014AFGP8-likePRO_0000001681Add
BLAST

Post-translational modificationi

O-glycosylated; contains disaccharide galactose-N-acetylgalactosamine attached to threonines in AFGP8 and AFGP7.

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Synthesized by the liver and secreted into the blood from which they become distributed to almost the entire extracellular space.

Structurei

3D structure databases

ProteinModelPortaliP24856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Keywords - Domaini

Repeat

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24856 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
VTAAPAATAA TAATPATAAL NFAATAATPA TPATPALIFA ATAATAATPA
60 70 80 90 100
TAALNFAATA ATPATAATPA LIFAAAAATA ATPATAALNF AATAATPATA
110 120 130 140 150
ATPALIFAAT AATAATPATP AFHFAATAAT PATAATPALI FAATAATAAT
160 170 180 190 200
PATPAFHFAA TAATPATAAT PALIFAATAA TAATPATAAL NFAATAATPA
210 220 230 240 250
TAATPALIFA ATAATAATPA TAALNFAATA ATAATPATAA CNFAATAATP
260 270 280 290 300
ATAATPALIF AATAATAATP ATAACNFAAT AATPATAATP ALIFAATAAT
310 320 330 340 350
AATPATAALN FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA
360 370 380 390 400
TPATAATPAL IFAATAATAA TPATAALNFA ATAATAATPA TPAFNFAATA
410 420 430 440 450
ATPATAATPA LIFAATAATA ATPATAALNF AATAATPATA ATPALIFAAT
460 470 480 490 500
AATAATPATA ALHFAATAAT AATPATAALN FAATAATPAT AATPALIFAA
510 520 530 540 550
TAATAATPAT AAFNFAATAA TAATPATAAL NFAATAATPA TAATPALIFA
560 570 580 590 600
ATAATAATPA TAALNFAATA ATPATAATPA LIFAATAATA ATPATPAFHF
610 620 630 640 650
AATAATPATA ATPALIFAAT AATAATPATA ALNFAATAAT AATPATAALN
660 670 680 690 700
FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL
710 720 730 740 750
IFAATAATAA TPATAAFNFA ATAATAATPA TAATPALIFA ATAATAATPA
760 770 780 790
TPATPALIFA ATAATAATPA TPALNFAATA ATAATTAARG
Length:790
Mass (Da):71,267
Last modified:May 30, 2000 - v2
Checksum:i4C7CCCADC48FE902
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55000 Genomic DNA. Translation: AAA49392.2.
PIRiA38420.

Cross-referencesi

Web resourcesi

Protein Spotlight

Cool news - Issue 5 of December 2000

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55000 Genomic DNA. Translation: AAA49392.2 .
PIRi A38420.

3D structure databases

ProteinModelPortali P24856.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number."
    Hsiao K.-C., Cheng C.-H.C., Fernandes I.E., Detrich H.W. III, Devries A.L.
    Proc. Natl. Acad. Sci. U.S.A. 87:9265-9269(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Testis.
  2. Cheng C.-H.C.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO N-TERMINUS AND 457.

Entry informationi

Entry nameiANP_NOTNE
AccessioniPrimary (citable) accession number: P24856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3