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P24856

- ANP_NOTNE

UniProt

P24856 - ANP_NOTNE

Protein

Ice-structuring glycoprotein

Gene

afgp8

Organism
Notothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (11 Jun 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Antifreeze proteins lower the blood freezing point.

    GO - Biological processi

    1. response to freezing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antifreeze protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ice-structuring glycoprotein
    Short name:
    ISGP
    Alternative name(s):
    Antifreeze glycopeptide polyprotein
    Short name:
    AFGP polyprotein
    Cleaved into the following 8 chains:
    Alternative name(s):
    AFGP 7
    Alternative name(s):
    AFGP 7
    Alternative name(s):
    AFGP 8
    Alternative name(s):
    AFGP 8
    Alternative name(s):
    AFGP 8
    Alternative name(s):
    AFGP 8
    Alternative name(s):
    AFGP 8
    Gene namesi
    Name:afgp8
    OrganismiNotothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
    Taxonomic identifieri202063 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesNotothenioideiNototheniidaeNotothenia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei‹1 – 5›5PRO_0000001634
    Chaini6 – 790785Ice-structuring glycoproteinPRO_0000001635Add
    BLAST
    Peptidei6 – 1914AFGP8-1PRO_0000001636Add
    BLAST
    Peptidei23 – 3614AFGP8-5PRO_0000001637Add
    BLAST
    Peptidei40 – 5314AFGP8-1PRO_0000001638Add
    BLAST
    Peptidei57 – 7014AFGP8-4PRO_0000001639Add
    BLAST
    Peptidei74 – 8714AFGP8-2PRO_0000001640Add
    BLAST
    Peptidei91 – 10414AFGP8-4PRO_0000001641Add
    BLAST
    Peptidei108 – 12114AFGP8-3PRO_0000001642Add
    BLAST
    Peptidei125 – 13814AFGP8-4PRO_0000001643Add
    BLAST
    Peptidei142 – 15514AFGP8-3PRO_0000001644Add
    BLAST
    Peptidei159 – 17214AFGP8-4PRO_0000001645Add
    BLAST
    Peptidei176 – 18914AFGP8-1PRO_0000001646Add
    BLAST
    Peptidei193 – 20614AFGP8-4PRO_0000001647Add
    BLAST
    Peptidei210 – 22314AFGP8-1PRO_0000001648Add
    BLAST
    Peptidei227 – 24014AFGP8-1PRO_0000001649Add
    BLAST
    Peptidei244 – 25714AFGP8-4PRO_0000001650Add
    BLAST
    Peptidei261 – 27414AFGP8-1PRO_0000001651Add
    BLAST
    Peptidei278 – 29114AFGP8-4PRO_0000001652Add
    BLAST
    Peptidei295 – 30814AFGP8-1PRO_0000001653Add
    BLAST
    Peptidei312 – 32514AFGP8-4PRO_0000001654Add
    BLAST
    Peptidei329 – 34214AFGP8-1PRO_0000001655Add
    BLAST
    Peptidei346 – 35914AFGP8-4PRO_0000001656Add
    BLAST
    Peptidei363 – 37614AFGP8-1PRO_0000001657Add
    BLAST
    Peptidei380 – 39314AFGP8-3PRO_0000001658Add
    BLAST
    Peptidei397 – 41014AFGP8-4PRO_0000001659Add
    BLAST
    Peptidei414 – 42714AFGP8-1PRO_0000001660Add
    BLAST
    Peptidei431 – 44414AFGP8-4PRO_0000001661Add
    BLAST
    Peptidei448 – 46114AFGP8-1PRO_0000001662Add
    BLAST
    Peptidei465 – 47814AFGP8-1PRO_0000001663Add
    BLAST
    Peptidei482 – 49514AFGP8-4PRO_0000001664Add
    BLAST
    Peptidei499 – 51214AFGP8-1PRO_0000001665Add
    BLAST
    Peptidei516 – 52914AFGP8-1PRO_0000001666Add
    BLAST
    Peptidei533 – 54614AFGP8-4PRO_0000001667Add
    BLAST
    Peptidei550 – 56314AFGP8-1PRO_0000001668Add
    BLAST
    Peptidei567 – 58014AFGP8-4PRO_0000001669Add
    BLAST
    Peptidei584 – 59714AFGP8-3PRO_0000001670Add
    BLAST
    Peptidei601 – 61414AFGP8-4PRO_0000001671Add
    BLAST
    Peptidei618 – 63114AFGP8-1PRO_0000001672Add
    BLAST
    Peptidei635 – 64814AFGP8-1PRO_0000001673Add
    BLAST
    Peptidei652 – 66514AFGP8-4PRO_0000001674Add
    BLAST
    Peptidei669 – 68214AFGP8-1PRO_0000001675Add
    BLAST
    Peptidei686 – 69914AFGP8-4PRO_0000001676Add
    BLAST
    Peptidei703 – 71614AFGP8-1PRO_0000001677Add
    BLAST
    Peptidei720 – 73617AFGP7-1PRO_0000001678Add
    BLAST
    Peptidei740 – 75617AFGP7-2PRO_0000001679Add
    BLAST
    Peptidei760 – 77314AFGP8-3PRO_0000001680Add
    BLAST
    Peptidei777 – 79014AFGP8-likePRO_0000001681Add
    BLAST

    Post-translational modificationi

    O-glycosylated; contains disaccharide galactose-N-acetylgalactosamine attached to threonines in AFGP8 and AFGP7.

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Synthesized by the liver and secreted into the blood from which they become distributed to almost the entire extracellular space.

    Structurei

    3D structure databases

    ProteinModelPortaliP24856.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Keywords - Domaini

    Repeat

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24856-1 [UniParc]FASTAAdd to Basket

    « Hide

    VTAAPAATAA TAATPATAAL NFAATAATPA TPATPALIFA ATAATAATPA    50
    TAALNFAATA ATPATAATPA LIFAAAAATA ATPATAALNF AATAATPATA 100
    ATPALIFAAT AATAATPATP AFHFAATAAT PATAATPALI FAATAATAAT 150
    PATPAFHFAA TAATPATAAT PALIFAATAA TAATPATAAL NFAATAATPA 200
    TAATPALIFA ATAATAATPA TAALNFAATA ATAATPATAA CNFAATAATP 250
    ATAATPALIF AATAATAATP ATAACNFAAT AATPATAATP ALIFAATAAT 300
    AATPATAALN FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA 350
    TPATAATPAL IFAATAATAA TPATAALNFA ATAATAATPA TPAFNFAATA 400
    ATPATAATPA LIFAATAATA ATPATAALNF AATAATPATA ATPALIFAAT 450
    AATAATPATA ALHFAATAAT AATPATAALN FAATAATPAT AATPALIFAA 500
    TAATAATPAT AAFNFAATAA TAATPATAAL NFAATAATPA TAATPALIFA 550
    ATAATAATPA TAALNFAATA ATPATAATPA LIFAATAATA ATPATPAFHF 600
    AATAATPATA ATPALIFAAT AATAATPATA ALNFAATAAT AATPATAALN 650
    FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL 700
    IFAATAATAA TPATAAFNFA ATAATAATPA TAATPALIFA ATAATAATPA 750
    TPATPALIFA ATAATAATPA TPALNFAATA ATAATTAARG 790
    Length:790
    Mass (Da):71,267
    Last modified:May 30, 2000 - v2
    Checksum:i4C7CCCADC48FE902
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55000 Genomic DNA. Translation: AAA49392.2.
    PIRiA38420.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Cool news - Issue 5 of December 2000

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55000 Genomic DNA. Translation: AAA49392.2 .
    PIRi A38420.

    3D structure databases

    ProteinModelPortali P24856.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number."
      Hsiao K.-C., Cheng C.-H.C., Fernandes I.E., Detrich H.W. III, Devries A.L.
      Proc. Natl. Acad. Sci. U.S.A. 87:9265-9269(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Testis.
    2. Cheng C.-H.C.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO N-TERMINUS AND 457.

    Entry informationi

    Entry nameiANP_NOTNE
    AccessioniPrimary (citable) accession number: P24856
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: May 30, 2000
    Last modified: June 11, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

    External Data

    Dasty 3