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P24856 (ANP_NOTCO) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ice-structuring glycoprotein
Short name=ISGP
Alternative name(s):
Antifreeze glycopeptide polyprotein
Short name=AFGP polyprotein

Cleaved into the following 3 chains:

  1. AFGP7
    Alternative name(s):
    AFGP 7
  2. AFGP8
    Alternative name(s):
    AFGP 8
  3. AFGP8-like
Gene names
Name:afgp8
OrganismNotothenia coriiceps neglecta (Black rockcod) (Yellowbelly rockcod)
Taxonomic identifier202063 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Nototheniidae › Notothenia

Protein attributes

Sequence length790 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antifreeze proteins lower the blood freezing point.

Subcellular location

Secreted.

Tissue specificity

Synthesized by the liver and secreted into the blood from which they become distributed to almost the entire extracellular space.

Domain

Contains 44 copies of AFGP8 and two copies of AFGP7.

Post-translational modification

O-glycosylated; contains disaccharide galactose-N-acetylgalactosamine attached to threonines in AFGP8 and AFGP7.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
   Molecular functionAntifreeze protein
   PTMGlycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processresponse to freezing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide‹1 – 5›5
PRO_0000001634
Chain6 – 790785Ice-structuring glycoprotein
PRO_0000001635
Peptide6 – 1914AFGP8
PRO_0000001636
Peptide23 – 3614AFGP8
PRO_0000001637
Peptide40 – 5314AFGP8
PRO_0000001638
Peptide57 – 7014AFGP8
PRO_0000001639
Peptide74 – 8714AFGP8
PRO_0000001640
Peptide91 – 10414AFGP8
PRO_0000001641
Peptide108 – 12114AFGP8
PRO_0000001642
Peptide125 – 13814AFGP8
PRO_0000001643
Peptide142 – 15514AFGP8
PRO_0000001644
Peptide159 – 17214AFGP8
PRO_0000001645
Peptide176 – 18914AFGP8
PRO_0000001646
Peptide193 – 20614AFGP8
PRO_0000001647
Peptide210 – 22314AFGP8
PRO_0000001648
Peptide227 – 24014AFGP8
PRO_0000001649
Peptide244 – 25714AFGP8
PRO_0000001650
Peptide261 – 27414AFGP8
PRO_0000001651
Peptide278 – 29114AFGP8
PRO_0000001652
Peptide295 – 30814AFGP8
PRO_0000001653
Peptide312 – 32514AFGP8
PRO_0000001654
Peptide329 – 34214AFGP8
PRO_0000001655
Peptide346 – 35914AFGP8
PRO_0000001656
Peptide363 – 37614AFGP8
PRO_0000001657
Peptide380 – 39314AFGP8
PRO_0000001658
Peptide397 – 41014AFGP8
PRO_0000001659
Peptide414 – 42714AFGP8
PRO_0000001660
Peptide431 – 44414AFGP8
PRO_0000001661
Peptide448 – 46114AFGP8
PRO_0000001662
Peptide465 – 47814AFGP8
PRO_0000001663
Peptide482 – 49514AFGP8
PRO_0000001664
Peptide499 – 51214AFGP8
PRO_0000001665
Peptide516 – 52914AFGP8
PRO_0000001666
Peptide533 – 54614AFGP8
PRO_0000001667
Peptide550 – 56314AFGP8
PRO_0000001668
Peptide567 – 58014AFGP8
PRO_0000001669
Peptide584 – 59714AFGP8
PRO_0000001670
Peptide601 – 61414AFGP8
PRO_0000001671
Peptide618 – 63114AFGP8
PRO_0000001672
Peptide635 – 64814AFGP8
PRO_0000001673
Peptide652 – 66514AFGP8
PRO_0000001674
Peptide669 – 68214AFGP8
PRO_0000001675
Peptide686 – 69914AFGP8
PRO_0000001676
Peptide703 – 71614AFGP8
PRO_0000001677
Peptide720 – 73617AFGP7
PRO_0000001678
Peptide740 – 75617AFGP7
PRO_0000001679
Peptide760 – 77314AFGP8
PRO_0000001680
Peptide777 – 79014AFGP8-like
PRO_0000001681

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P24856 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 4C7CCCADC48FE902

FASTA79071,267
        10         20         30         40         50         60 
VTAAPAATAA TAATPATAAL NFAATAATPA TPATPALIFA ATAATAATPA TAALNFAATA 

        70         80         90        100        110        120 
ATPATAATPA LIFAAAAATA ATPATAALNF AATAATPATA ATPALIFAAT AATAATPATP 

       130        140        150        160        170        180 
AFHFAATAAT PATAATPALI FAATAATAAT PATPAFHFAA TAATPATAAT PALIFAATAA 

       190        200        210        220        230        240 
TAATPATAAL NFAATAATPA TAATPALIFA ATAATAATPA TAALNFAATA ATAATPATAA 

       250        260        270        280        290        300 
CNFAATAATP ATAATPALIF AATAATAATP ATAACNFAAT AATPATAATP ALIFAATAAT 

       310        320        330        340        350        360 
AATPATAALN FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL 

       370        380        390        400        410        420 
IFAATAATAA TPATAALNFA ATAATAATPA TPAFNFAATA ATPATAATPA LIFAATAATA 

       430        440        450        460        470        480 
ATPATAALNF AATAATPATA ATPALIFAAT AATAATPATA ALHFAATAAT AATPATAALN 

       490        500        510        520        530        540 
FAATAATPAT AATPALIFAA TAATAATPAT AAFNFAATAA TAATPATAAL NFAATAATPA 

       550        560        570        580        590        600 
TAATPALIFA ATAATAATPA TAALNFAATA ATPATAATPA LIFAATAATA ATPATPAFHF 

       610        620        630        640        650        660 
AATAATPATA ATPALIFAAT AATAATPATA ALNFAATAAT AATPATAALN FAATAATPAT 

       670        680        690        700        710        720 
AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL IFAATAATAA TPATAAFNFA 

       730        740        750        760        770        780 
ATAATAATPA TAATPALIFA ATAATAATPA TPATPALIFA ATAATAATPA TPALNFAATA 

       790 
ATAATTAARG

« Hide

References

[1]"An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number."
Hsiao K.-C., Cheng C.-H.C., Fernandes I.E., Detrich H.W. III, Devries A.L.
Proc. Natl. Acad. Sci. U.S.A. 87:9265-9269(1990) [PubMed: 2251271] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Testis.
[2]Cheng C.-H.C.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO N-TERMINUS AND 457.

Web resources

Protein Spotlight

Cool news - Issue 5 of December 2000

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M55000 Genomic DNA. Translation: AAA49392.2.
PIRA38420.

3D structure databases

ProteinModelPortalP24856.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameANP_NOTCO
AccessionPrimary (citable) accession number: P24856
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: September 21, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Recent format changes

Overview of recent format changes

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents