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Protein

Ice-structuring glycoprotein

Gene

afgp8

Organism
Notothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antifreeze proteins lower the blood freezing point.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antifreeze protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring glycoprotein
Short name:
ISGP
Alternative name(s):
Antifreeze glycopeptide polyprotein
Short name:
AFGP polyprotein
Cleaved into the following 8 chains:
Alternative name(s):
AFGP 7
Alternative name(s):
AFGP 7
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Gene namesi
Name:afgp8
OrganismiNotothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
Taxonomic identifieri202063 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeNotothenia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000001634‹1 – 5›5
ChainiPRO_00000016356 – 790Ice-structuring glycoproteinAdd BLAST785
PeptideiPRO_00000016366 – 19AFGP8-1Add BLAST14
PeptideiPRO_000000163723 – 36AFGP8-5Add BLAST14
PeptideiPRO_000000163840 – 53AFGP8-1Add BLAST14
PeptideiPRO_000000163957 – 70AFGP8-4Add BLAST14
PeptideiPRO_000000164074 – 87AFGP8-2Add BLAST14
PeptideiPRO_000000164191 – 104AFGP8-4Add BLAST14
PeptideiPRO_0000001642108 – 121AFGP8-3Add BLAST14
PeptideiPRO_0000001643125 – 138AFGP8-4Add BLAST14
PeptideiPRO_0000001644142 – 155AFGP8-3Add BLAST14
PeptideiPRO_0000001645159 – 172AFGP8-4Add BLAST14
PeptideiPRO_0000001646176 – 189AFGP8-1Add BLAST14
PeptideiPRO_0000001647193 – 206AFGP8-4Add BLAST14
PeptideiPRO_0000001648210 – 223AFGP8-1Add BLAST14
PeptideiPRO_0000001649227 – 240AFGP8-1Add BLAST14
PeptideiPRO_0000001650244 – 257AFGP8-4Add BLAST14
PeptideiPRO_0000001651261 – 274AFGP8-1Add BLAST14
PeptideiPRO_0000001652278 – 291AFGP8-4Add BLAST14
PeptideiPRO_0000001653295 – 308AFGP8-1Add BLAST14
PeptideiPRO_0000001654312 – 325AFGP8-4Add BLAST14
PeptideiPRO_0000001655329 – 342AFGP8-1Add BLAST14
PeptideiPRO_0000001656346 – 359AFGP8-4Add BLAST14
PeptideiPRO_0000001657363 – 376AFGP8-1Add BLAST14
PeptideiPRO_0000001658380 – 393AFGP8-3Add BLAST14
PeptideiPRO_0000001659397 – 410AFGP8-4Add BLAST14
PeptideiPRO_0000001660414 – 427AFGP8-1Add BLAST14
PeptideiPRO_0000001661431 – 444AFGP8-4Add BLAST14
PeptideiPRO_0000001662448 – 461AFGP8-1Add BLAST14
PeptideiPRO_0000001663465 – 478AFGP8-1Add BLAST14
PeptideiPRO_0000001664482 – 495AFGP8-4Add BLAST14
PeptideiPRO_0000001665499 – 512AFGP8-1Add BLAST14
PeptideiPRO_0000001666516 – 529AFGP8-1Add BLAST14
PeptideiPRO_0000001667533 – 546AFGP8-4Add BLAST14
PeptideiPRO_0000001668550 – 563AFGP8-1Add BLAST14
PeptideiPRO_0000001669567 – 580AFGP8-4Add BLAST14
PeptideiPRO_0000001670584 – 597AFGP8-3Add BLAST14
PeptideiPRO_0000001671601 – 614AFGP8-4Add BLAST14
PeptideiPRO_0000001672618 – 631AFGP8-1Add BLAST14
PeptideiPRO_0000001673635 – 648AFGP8-1Add BLAST14
PeptideiPRO_0000001674652 – 665AFGP8-4Add BLAST14
PeptideiPRO_0000001675669 – 682AFGP8-1Add BLAST14
PeptideiPRO_0000001676686 – 699AFGP8-4Add BLAST14
PeptideiPRO_0000001677703 – 716AFGP8-1Add BLAST14
PeptideiPRO_0000001678720 – 736AFGP7-1Add BLAST17
PeptideiPRO_0000001679740 – 756AFGP7-2Add BLAST17
PeptideiPRO_0000001680760 – 773AFGP8-3Add BLAST14
PeptideiPRO_0000001681777 – 790AFGP8-likeAdd BLAST14

Post-translational modificationi

O-glycosylated; contains disaccharide galactose-N-acetylgalactosamine attached to threonines in AFGP8 and AFGP7.

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Synthesized by the liver and secreted into the blood from which they become distributed to almost the entire extracellular space.

Structurei

3D structure databases

ProteinModelPortaliP24856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Keywords - Domaini

Repeat

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VTAAPAATAA TAATPATAAL NFAATAATPA TPATPALIFA ATAATAATPA
60 70 80 90 100
TAALNFAATA ATPATAATPA LIFAAAAATA ATPATAALNF AATAATPATA
110 120 130 140 150
ATPALIFAAT AATAATPATP AFHFAATAAT PATAATPALI FAATAATAAT
160 170 180 190 200
PATPAFHFAA TAATPATAAT PALIFAATAA TAATPATAAL NFAATAATPA
210 220 230 240 250
TAATPALIFA ATAATAATPA TAALNFAATA ATAATPATAA CNFAATAATP
260 270 280 290 300
ATAATPALIF AATAATAATP ATAACNFAAT AATPATAATP ALIFAATAAT
310 320 330 340 350
AATPATAALN FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA
360 370 380 390 400
TPATAATPAL IFAATAATAA TPATAALNFA ATAATAATPA TPAFNFAATA
410 420 430 440 450
ATPATAATPA LIFAATAATA ATPATAALNF AATAATPATA ATPALIFAAT
460 470 480 490 500
AATAATPATA ALHFAATAAT AATPATAALN FAATAATPAT AATPALIFAA
510 520 530 540 550
TAATAATPAT AAFNFAATAA TAATPATAAL NFAATAATPA TAATPALIFA
560 570 580 590 600
ATAATAATPA TAALNFAATA ATPATAATPA LIFAATAATA ATPATPAFHF
610 620 630 640 650
AATAATPATA ATPALIFAAT AATAATPATA ALNFAATAAT AATPATAALN
660 670 680 690 700
FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL
710 720 730 740 750
IFAATAATAA TPATAAFNFA ATAATAATPA TAATPALIFA ATAATAATPA
760 770 780 790
TPATPALIFA ATAATAATPA TPALNFAATA ATAATTAARG
Length:790
Mass (Da):71,267
Last modified:May 30, 2000 - v2
Checksum:i4C7CCCADC48FE902
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55000 Genomic DNA. Translation: AAA49392.2.
PIRiA38420.

Cross-referencesi

Web resourcesi

Protein Spotlight

Cool news - Issue 5 of December 2000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55000 Genomic DNA. Translation: AAA49392.2.
PIRiA38420.

3D structure databases

ProteinModelPortaliP24856.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiANP_NOTNE
AccessioniPrimary (citable) accession number: P24856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: January 7, 2015
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.