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P24855

- DNAS1_HUMAN

UniProt

P24855 - DNAS1_HUMAN

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Protein

Deoxyribonuclease-1

Gene

DNASE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.

Cofactori

Divalent cations. Prefers calcium or magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001By similarity
Active sitei156 – 1561By similarity

GO - Molecular functioni

  1. deoxyribonuclease I activity Source: UniProtKB-EC

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Actin-binding, Calcium

Enzyme and pathway databases

BRENDAi3.1.21.1. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-1 (EC:3.1.21.1)
Alternative name(s):
Deoxyribonuclease I
Short name:
DNase I
INN: Dornase alfa
Gene namesi
Name:DNASE1
Synonyms:DNL1, DRNI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:2956. DNASE1.

Subcellular locationi

Secreted. Nucleus envelope
Note: Secretory protein, stored in zymogen granules and found in the nuclear envelope.

GO - Cellular componenti

  1. extracellular region Source: ProtInc
  2. extracellular vesicular exosome Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Pharmaceutical usei

Available under the name Pulmozyme (Genentech). Used to reduce the viscosity of cystic fibrosis sputum by hydrolyzing the extracellular DNA released by degenerating leukocytes that accumulate in response to infection.

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

MIMi152700. phenotype.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA27427.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22222 PublicationsAdd
BLAST
Chaini23 – 282260Deoxyribonuclease-1PRO_0000007277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)
Disulfide bondi123 ↔ 126By similarity
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi195 ↔ 231Essential for enzymatic activityBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24855.
PRIDEiP24855.

PTM databases

PhosphoSiteiP24855.

Expressioni

Tissue specificityi

Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

Gene expression databases

BgeeiP24855.
CleanExiHS_DNASE1.
ExpressionAtlasiP24855. baseline and differential.
GenevestigatoriP24855.

Organism-specific databases

HPAiHPA010703.

Interactioni

Protein-protein interaction databases

BioGridi108112. 1 interaction.
MINTiMINT-4722539.
STRINGi9606.ENSP00000246949.

Structurei

Secondary structure

1
282
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 3411
Helixi35 – 384
Helixi41 – 5111
Beta strandi55 – 628
Helixi68 – 7710
Turni78 – 803
Beta strandi86 – 894
Beta strandi93 – 986
Beta strandi100 – 1067
Turni108 – 1103
Beta strandi112 – 1187
Turni124 – 1274
Beta strandi136 – 1416
Beta strandi149 – 1546
Helixi159 – 1613
Helixi162 – 18019
Beta strandi185 – 1906
Turni195 – 1973
Helixi200 – 2056
Helixi207 – 2104
Beta strandi214 – 2163
Beta strandi225 – 2284
Beta strandi234 – 2407
Helixi241 – 2466
Helixi257 – 2604
Helixi265 – 2717
Beta strandi277 – 2815

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AWNX-ray1.95A23-282[»]
ProteinModelPortaliP24855.
SMRiP24855. Positions 23-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46375.
GeneTreeiENSGT00390000013146.
HOGENOMiHOG000059570.
HOVERGENiHBG051368.
InParanoidiP24855.
KOiK11994.
OMAiTSTHCAY.
PhylomeDBiP24855.
TreeFamiTF329541.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR11371. PTHR11371. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
PRINTSiPR00130. DNASEI.
SMARTiSM00476. DNaseIc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
PROSITEiPS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P24855-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI
60 70 80 90 100
LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE
110 120 130 140 150
RYLFVYRPDQ VSAVDSYYYD DGCEPCGNDT FNREPAIVRF FSRFTEVREF
160 170 180 190 200
AIVPLHAAPG DAVAEIDALY DVYLDVQEKW GLEDVMLMGD FNAGCSYVRP
210 220 230 240 250
SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG MLLRGAVVPD
260 270 280
SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK
Length:282
Mass (Da):31,434
Last modified:March 1, 1992 - v1
Checksum:i040042E2D23555B6
GO
Isoform 2 (identifier: P24855-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MRGMKLLGAL...ALVQEVRDSH → MHQTPITTWS...PLSGSSPGSQ
     67-183: Missing.
     268-282: AQAISDHYPVEVMLK → FSVHTCSGAGLGERHGLPASAALPSNTCRAGTHRVST

Note: No experimental confirmation available

Show »
Length:187
Mass (Da):19,771
Checksum:iC66A988635746FB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431R → Q in BAE96964. (PubMed:16771825)Curated

Polymorphismi

At least 6 alleles of DNASE1 are known: DNASE1*1 to DNASE1*6. The sequence shown is that of DNASE1*2.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21R → S.
Corresponds to variant rs8176927 [ dbSNP | Ensembl ].
VAR_024434
Natural varianti31 – 311Q → E in allele DNASE1*4.
Corresponds to variant rs77254040 [ dbSNP | Ensembl ].
VAR_002264
Natural varianti107 – 1071R → G.
Corresponds to variant rs8176928 [ dbSNP | Ensembl ].
VAR_029172
Natural varianti114 – 1141V → M in allele DNASE1*5.
VAR_009300
Natural varianti127 – 1271G → R.
Corresponds to variant rs8176919 [ dbSNP | Ensembl ].
VAR_024435
Natural varianti154 – 1541P → A in allele DNASE1*3.
Corresponds to variant rs1799891 [ dbSNP | Ensembl ].
VAR_002265
Natural varianti207 – 2071R → C in allele DNASE1*6.
Corresponds to variant rs148373909 [ dbSNP | Ensembl ].
VAR_009301
Natural varianti231 – 2311C → Y.
Corresponds to variant rs8176940 [ dbSNP | Ensembl ].
VAR_029173
Natural varianti244 – 2441R → Q in allele DNASE1*1. 1 Publication
Corresponds to variant rs1053874 [ dbSNP | Ensembl ].
VAR_002266
Natural varianti246 – 2461A → P.
Corresponds to variant rs8176939 [ dbSNP | Ensembl ].
VAR_029174
Natural varianti262 – 2621G → D.
Corresponds to variant rs8176924 [ dbSNP | Ensembl ].
VAR_029175

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666MRGMK…VRDSH → MHQTPITTWSVSHWDGTAIR SATCSCTGLTRCLRWTATTT MMAASPAGTTPSTESQPLSG SSPGSQ in isoform 2. 1 PublicationVSP_056974Add
BLAST
Alternative sequencei67 – 183117Missing in isoform 2. 1 PublicationVSP_056975Add
BLAST
Alternative sequencei268 – 28215AQAIS…EVMLK → FSVHTCSGAGLGERHGLPAS AALPSNTCRAGTHRVST in isoform 2. 1 PublicationVSP_056976Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55983 mRNA. Translation: AAA63170.1.
D83195 Genomic DNA. Translation: BAA11841.1.
AJ298844 mRNA. Translation: CAC12813.1.
AB188151 mRNA. Translation: BAE96964.1.
AB188152 mRNA. Translation: BAE96965.1.
AK300914 mRNA. Translation: BAG62547.1.
AC005203 Genomic DNA. Translation: AAC24721.1.
AC006111 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85344.1.
BC029437 mRNA. Translation: AAH29437.1.
CCDSiCCDS10507.1.
PIRiA38417. NDHU1.
RefSeqiNP_005214.2. NM_005223.3.
XP_006720915.1. XM_006720852.1.
XP_006720916.1. XM_006720853.1.
UniGeneiHs.629638.
Hs.733045.

Genome annotation databases

EnsembliENST00000246949; ENSP00000246949; ENSG00000213918.
ENST00000407479; ENSP00000385905; ENSG00000213918.
GeneIDi1773.
KEGGihsa:1773.
UCSCiuc002cvr.3. human.

Polymorphism databases

DMDMi118919.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Pulmozyme

Clinical information on Pulmozyme

Wikipedia

Deoxyribonuclease entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55983 mRNA. Translation: AAA63170.1 .
D83195 Genomic DNA. Translation: BAA11841.1 .
AJ298844 mRNA. Translation: CAC12813.1 .
AB188151 mRNA. Translation: BAE96964.1 .
AB188152 mRNA. Translation: BAE96965.1 .
AK300914 mRNA. Translation: BAG62547.1 .
AC005203 Genomic DNA. Translation: AAC24721.1 .
AC006111 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85344.1 .
BC029437 mRNA. Translation: AAH29437.1 .
CCDSi CCDS10507.1.
PIRi A38417. NDHU1.
RefSeqi NP_005214.2. NM_005223.3.
XP_006720915.1. XM_006720852.1.
XP_006720916.1. XM_006720853.1.
UniGenei Hs.629638.
Hs.733045.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AWN X-ray 1.95 A 23-282 [» ]
ProteinModelPortali P24855.
SMRi P24855. Positions 23-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108112. 1 interaction.
MINTi MINT-4722539.
STRINGi 9606.ENSP00000246949.

PTM databases

PhosphoSitei P24855.

Polymorphism databases

DMDMi 118919.

Proteomic databases

PaxDbi P24855.
PRIDEi P24855.

Protocols and materials databases

DNASUi 1773.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246949 ; ENSP00000246949 ; ENSG00000213918 .
ENST00000407479 ; ENSP00000385905 ; ENSG00000213918 .
GeneIDi 1773.
KEGGi hsa:1773.
UCSCi uc002cvr.3. human.

Organism-specific databases

CTDi 1773.
GeneCardsi GC16P003663.
HGNCi HGNC:2956. DNASE1.
HPAi HPA010703.
MIMi 125505. gene.
152700. phenotype.
neXtProti NX_P24855.
Orphaneti 536. Systemic lupus erythematosus.
PharmGKBi PA27427.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46375.
GeneTreei ENSGT00390000013146.
HOGENOMi HOG000059570.
HOVERGENi HBG051368.
InParanoidi P24855.
KOi K11994.
OMAi TSTHCAY.
PhylomeDBi P24855.
TreeFami TF329541.

Enzyme and pathway databases

BRENDAi 3.1.21.1. 2681.

Miscellaneous databases

ChiTaRSi DNASE1. human.
GeneWikii Deoxyribonuclease_I.
GenomeRNAii 1773.
NextBioi 7213.
PROi P24855.
SOURCEi Search...

Gene expression databases

Bgeei P24855.
CleanExi HS_DNASE1.
ExpressionAtlasi P24855. baseline and differential.
Genevestigatori P24855.

Family and domain databases

Gene3Di 3.60.10.10. 1 hit.
InterProi IPR018057. Deoxyribonuclease-1_AS.
IPR016202. DNase_I.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view ]
PANTHERi PTHR11371. PTHR11371. 1 hit.
Pfami PF03372. Exo_endo_phos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000988. DNase_I_euk. 1 hit.
PRINTSi PR00130. DNASEI.
SMARTi SM00476. DNaseIc. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 1 hit.
PROSITEi PS00919. DNASE_I_1. 1 hit.
PS00918. DNASE_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum."
    Shak S., Capon D.J., Hellmiss R., Marsters S.A., Baker C.L.
    Proc. Natl. Acad. Sci. U.S.A. 87:9188-9192(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism."
    Yasuda T., Kishi K., Yanagawa Y., Yoshida A.
    Ann. Hum. Genet. 59:1-15(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-244.
    Tissue: Placenta.
  3. "DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis."
    Oliveri M., Daga A., Cantoni C., Lunardi C., Millo R., Puccetti A.
    Eur. J. Immunol. 31:743-751(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation."
    Kominato Y., Ueki M., Iida R., Kawai Y., Nakajima T., Makita C., Itoi M., Tajima Y., Kishi K., Yasuda T.
    FEBS J. 273:3094-3105(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  6. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  9. "A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I."
    Rosenstreich D.L., Tu J.H., Kinkade P.R., Maurer-Fogy I., Kahn J., Barton R.W., Farina P.R.
    J. Exp. Med. 168:1767-1779(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-45 AND 73-95.
    Tissue: Urine.
  10. "Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I."
    Yasuda T., Awazu S., Sato W., Iida R., Tanaka Y., Kishi K.
    J. Biochem. 108:393-398(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-49.
    Tissue: Urine.
  11. "Mutation of DNASE1 in people with systemic lupus erythematosus."
    Yasutomo K., Horiuchi T., Kagami S., Tsukamoto H., Hashimura C., Urushihara M., Kuroda Y.
    Nat. Genet. 28:313-314(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SLE.
  12. "Molecular analysis of the third allele of human deoxyribonuclease I polymorphism."
    Yasuda T., Nadano D., Takeshita H., Tenjo E., Kishi K.
    Ann. Hum. Genet. 59:139-147(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DNASE1*3.
  13. "The molecular basis for genetic polymorphism of human deoxyribonuclease I: identification of the nucleotide substitution that generates the fourth allele."
    Yasuda T., Nadano D., Takeshita H., Tenjo E., Sawazaki K., Ootani M., Kishi K.
    FEBS Lett. 359:211-214(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DNASE1*4.
  14. "The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism."
    Iida R., Yasuda T., Aoyama M., Tsubota E., Kobayashi M., Yuasa I., Matsuki T., Kishi K.
    Electrophoresis 18:1936-1939(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DNASE1*5.
  15. "A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability."
    Yasuda T., Takeshita H., Iida R., Kogure S., Kishi K.
    Biochem. Biophys. Res. Commun. 260:280-283(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DNASE1*6.

Entry informationi

Entry nameiDNAS1_HUMAN
AccessioniPrimary (citable) accession number: P24855
Secondary accession number(s): B4DV35, Q14UU9, Q14UV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3