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P24855

- DNAS1_HUMAN

UniProt

P24855 - DNAS1_HUMAN

Protein

Deoxyribonuclease-1

Gene

DNASE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.

    Cofactori

    Divalent cations. Prefers calcium or magnesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001By similarity
    Active sitei156 – 1561By similarity

    GO - Molecular functioni

    1. deoxyribonuclease I activity Source: UniProtKB-EC
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Actin-binding, Calcium

    Enzyme and pathway databases

    BRENDAi3.1.21.1. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyribonuclease-1 (EC:3.1.21.1)
    Alternative name(s):
    Deoxyribonuclease I
    Short name:
    DNase I
    INN: Dornase alfa
    Gene namesi
    Name:DNASE1
    Synonyms:DNL1, DRNI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2956. DNASE1.

    Subcellular locationi

    Secreted. Nucleus envelope
    Note: Secretory protein, stored in zymogen granules and found in the nuclear envelope.

    GO - Cellular componenti

    1. extracellular region Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt
    3. nuclear envelope Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Pharmaceutical usei

    Available under the name Pulmozyme (Genentech). Used to reduce the viscosity of cystic fibrosis sputum by hydrolyzing the extracellular DNA released by degenerating leukocytes that accumulate in response to infection.

    Keywords - Diseasei

    Systemic lupus erythematosus

    Organism-specific databases

    MIMi152700. phenotype.
    Orphaneti536. Systemic lupus erythematosus.
    PharmGKBiPA27427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22222 PublicationsAdd
    BLAST
    Chaini23 – 282260Deoxyribonuclease-1PRO_0000007277Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)
    Disulfide bondi123 ↔ 126By similarity
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi195 ↔ 231Essential for enzymatic activityBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP24855.
    PRIDEiP24855.

    PTM databases

    PhosphoSiteiP24855.

    Expressioni

    Tissue specificityi

    Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

    Gene expression databases

    ArrayExpressiP24855.
    BgeeiP24855.
    CleanExiHS_DNASE1.
    GenevestigatoriP24855.

    Organism-specific databases

    HPAiHPA010703.

    Interactioni

    Protein-protein interaction databases

    BioGridi108112. 1 interaction.
    MINTiMINT-4722539.
    STRINGi9606.ENSP00000246949.

    Structurei

    Secondary structure

    1
    282
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 3411
    Helixi35 – 384
    Helixi41 – 5111
    Beta strandi55 – 628
    Helixi68 – 7710
    Turni78 – 803
    Beta strandi86 – 894
    Beta strandi93 – 986
    Beta strandi100 – 1067
    Turni108 – 1103
    Beta strandi112 – 1187
    Turni124 – 1274
    Beta strandi136 – 1416
    Beta strandi149 – 1546
    Helixi159 – 1613
    Helixi162 – 18019
    Beta strandi185 – 1906
    Turni195 – 1973
    Helixi200 – 2056
    Helixi207 – 2104
    Beta strandi214 – 2163
    Beta strandi225 – 2284
    Beta strandi234 – 2407
    Helixi241 – 2466
    Helixi257 – 2604
    Helixi265 – 2717
    Beta strandi277 – 2815

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AWNX-ray1.95A23-282[»]
    ProteinModelPortaliP24855.
    SMRiP24855. Positions 23-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNase I family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46375.
    HOGENOMiHOG000059570.
    HOVERGENiHBG051368.
    InParanoidiP24855.
    KOiK11994.
    OMAiTSTHCAY.
    PhylomeDBiP24855.
    TreeFamiTF329541.

    Family and domain databases

    Gene3Di3.60.10.10. 1 hit.
    InterProiIPR018057. Deoxyribonuclease-1_AS.
    IPR016202. DNase_I.
    IPR005135. Endo/exonuclease/phosphatase.
    [Graphical view]
    PANTHERiPTHR11371. PTHR11371. 1 hit.
    PfamiPF03372. Exo_endo_phos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000988. DNase_I_euk. 1 hit.
    PRINTSiPR00130. DNASEI.
    SMARTiSM00476. DNaseIc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56219. SSF56219. 1 hit.
    PROSITEiPS00919. DNASE_I_1. 1 hit.
    PS00918. DNASE_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI    50
    LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE 100
    RYLFVYRPDQ VSAVDSYYYD DGCEPCGNDT FNREPAIVRF FSRFTEVREF 150
    AIVPLHAAPG DAVAEIDALY DVYLDVQEKW GLEDVMLMGD FNAGCSYVRP 200
    SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG MLLRGAVVPD 250
    SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK 282
    Length:282
    Mass (Da):31,434
    Last modified:March 1, 1992 - v1
    Checksum:i040042E2D23555B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti143 – 1431R → Q in BAE96964. (PubMed:16771825)Curated

    Polymorphismi

    At least 6 alleles of DNASE1 are known: DNASE1*1 to DNASE1*6. The sequence shown is that of DNASE1*2.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21R → S.
    Corresponds to variant rs8176927 [ dbSNP | Ensembl ].
    VAR_024434
    Natural varianti31 – 311Q → E in allele DNASE1*4.
    Corresponds to variant rs77254040 [ dbSNP | Ensembl ].
    VAR_002264
    Natural varianti107 – 1071R → G.
    Corresponds to variant rs8176928 [ dbSNP | Ensembl ].
    VAR_029172
    Natural varianti114 – 1141V → M in allele DNASE1*5.
    VAR_009300
    Natural varianti127 – 1271G → R.
    Corresponds to variant rs8176919 [ dbSNP | Ensembl ].
    VAR_024435
    Natural varianti154 – 1541P → A in allele DNASE1*3.
    Corresponds to variant rs1799891 [ dbSNP | Ensembl ].
    VAR_002265
    Natural varianti207 – 2071R → C in allele DNASE1*6.
    Corresponds to variant rs148373909 [ dbSNP | Ensembl ].
    VAR_009301
    Natural varianti231 – 2311C → Y.
    Corresponds to variant rs8176940 [ dbSNP | Ensembl ].
    VAR_029173
    Natural varianti244 – 2441R → Q in allele DNASE1*1. 1 Publication
    Corresponds to variant rs1053874 [ dbSNP | Ensembl ].
    VAR_002266
    Natural varianti246 – 2461A → P.
    Corresponds to variant rs8176939 [ dbSNP | Ensembl ].
    VAR_029174
    Natural varianti262 – 2621G → D.
    Corresponds to variant rs8176924 [ dbSNP | Ensembl ].
    VAR_029175

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55983 mRNA. Translation: AAA63170.1.
    D83195 Genomic DNA. Translation: BAA11841.1.
    AJ298844 mRNA. Translation: CAC12813.1.
    AB188151 mRNA. Translation: BAE96964.1.
    AB188152 mRNA. Translation: BAE96965.1.
    AC005203 Genomic DNA. Translation: AAC24721.1.
    CH471112 Genomic DNA. Translation: EAW85344.1.
    BC029437 mRNA. Translation: AAH29437.1.
    CCDSiCCDS10507.1.
    PIRiA38417. NDHU1.
    RefSeqiNP_005214.2. NM_005223.3.
    XP_006720915.1. XM_006720852.1.
    XP_006720916.1. XM_006720853.1.
    UniGeneiHs.629638.
    Hs.733045.

    Genome annotation databases

    EnsembliENST00000246949; ENSP00000246949; ENSG00000213918.
    ENST00000407479; ENSP00000385905; ENSG00000213918.
    GeneIDi1773.
    KEGGihsa:1773.
    UCSCiuc002cvr.3. human.

    Polymorphism databases

    DMDMi118919.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Pulmozyme

    Clinical information on Pulmozyme

    Wikipedia

    Deoxyribonuclease entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55983 mRNA. Translation: AAA63170.1 .
    D83195 Genomic DNA. Translation: BAA11841.1 .
    AJ298844 mRNA. Translation: CAC12813.1 .
    AB188151 mRNA. Translation: BAE96964.1 .
    AB188152 mRNA. Translation: BAE96965.1 .
    AC005203 Genomic DNA. Translation: AAC24721.1 .
    CH471112 Genomic DNA. Translation: EAW85344.1 .
    BC029437 mRNA. Translation: AAH29437.1 .
    CCDSi CCDS10507.1.
    PIRi A38417. NDHU1.
    RefSeqi NP_005214.2. NM_005223.3.
    XP_006720915.1. XM_006720852.1.
    XP_006720916.1. XM_006720853.1.
    UniGenei Hs.629638.
    Hs.733045.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AWN X-ray 1.95 A 23-282 [» ]
    ProteinModelPortali P24855.
    SMRi P24855. Positions 23-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108112. 1 interaction.
    MINTi MINT-4722539.
    STRINGi 9606.ENSP00000246949.

    Chemistry

    DrugBanki DB00003. Dornase Alfa.

    PTM databases

    PhosphoSitei P24855.

    Polymorphism databases

    DMDMi 118919.

    Proteomic databases

    PaxDbi P24855.
    PRIDEi P24855.

    Protocols and materials databases

    DNASUi 1773.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246949 ; ENSP00000246949 ; ENSG00000213918 .
    ENST00000407479 ; ENSP00000385905 ; ENSG00000213918 .
    GeneIDi 1773.
    KEGGi hsa:1773.
    UCSCi uc002cvr.3. human.

    Organism-specific databases

    CTDi 1773.
    GeneCardsi GC16P003663.
    HGNCi HGNC:2956. DNASE1.
    HPAi HPA010703.
    MIMi 125505. gene.
    152700. phenotype.
    neXtProti NX_P24855.
    Orphaneti 536. Systemic lupus erythematosus.
    PharmGKBi PA27427.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46375.
    HOGENOMi HOG000059570.
    HOVERGENi HBG051368.
    InParanoidi P24855.
    KOi K11994.
    OMAi TSTHCAY.
    PhylomeDBi P24855.
    TreeFami TF329541.

    Enzyme and pathway databases

    BRENDAi 3.1.21.1. 2681.

    Miscellaneous databases

    ChiTaRSi DNASE1. human.
    GeneWikii Deoxyribonuclease_I.
    GenomeRNAii 1773.
    NextBioi 7213.
    PROi P24855.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24855.
    Bgeei P24855.
    CleanExi HS_DNASE1.
    Genevestigatori P24855.

    Family and domain databases

    Gene3Di 3.60.10.10. 1 hit.
    InterProi IPR018057. Deoxyribonuclease-1_AS.
    IPR016202. DNase_I.
    IPR005135. Endo/exonuclease/phosphatase.
    [Graphical view ]
    PANTHERi PTHR11371. PTHR11371. 1 hit.
    Pfami PF03372. Exo_endo_phos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000988. DNase_I_euk. 1 hit.
    PRINTSi PR00130. DNASEI.
    SMARTi SM00476. DNaseIc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56219. SSF56219. 1 hit.
    PROSITEi PS00919. DNASE_I_1. 1 hit.
    PS00918. DNASE_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum."
      Shak S., Capon D.J., Hellmiss R., Marsters S.A., Baker C.L.
      Proc. Natl. Acad. Sci. U.S.A. 87:9188-9192(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the human deoxyribonuclease I (DNase I) gene: identification of the nucleotide substitution that generates its classical genetic polymorphism."
      Yasuda T., Kishi K., Yanagawa Y., Yoshida A.
      Ann. Hum. Genet. 59:1-15(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-244.
      Tissue: Placenta.
    3. "DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis."
      Oliveri M., Daga A., Cantoni C., Lunardi C., Millo R., Puccetti A.
      Eur. J. Immunol. 31:743-751(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation."
      Kominato Y., Ueki M., Iida R., Kawai Y., Nakajima T., Makita C., Itoi M., Tajima Y., Kishi K., Yasuda T.
      FEBS J. 273:3094-3105(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    5. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    8. "A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I."
      Rosenstreich D.L., Tu J.H., Kinkade P.R., Maurer-Fogy I., Kahn J., Barton R.W., Farina P.R.
      J. Exp. Med. 168:1767-1779(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-45 AND 73-95.
      Tissue: Urine.
    9. "Human genetically polymorphic deoxyribonuclease: purification, characterization, and multiplicity of urine deoxyribonuclease I."
      Yasuda T., Awazu S., Sato W., Iida R., Tanaka Y., Kishi K.
      J. Biochem. 108:393-398(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-49.
      Tissue: Urine.
    10. "Mutation of DNASE1 in people with systemic lupus erythematosus."
      Yasutomo K., Horiuchi T., Kagami S., Tsukamoto H., Hashimura C., Urushihara M., Kuroda Y.
      Nat. Genet. 28:313-314(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SLE.
    11. "Molecular analysis of the third allele of human deoxyribonuclease I polymorphism."
      Yasuda T., Nadano D., Takeshita H., Tenjo E., Kishi K.
      Ann. Hum. Genet. 59:139-147(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DNASE1*3.
    12. "The molecular basis for genetic polymorphism of human deoxyribonuclease I: identification of the nucleotide substitution that generates the fourth allele."
      Yasuda T., Nadano D., Takeshita H., Tenjo E., Sawazaki K., Ootani M., Kishi K.
      FEBS Lett. 359:211-214(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DNASE1*4.
    13. "The fifth allele of the human deoxyribonuclease I (DNase I) polymorphism."
      Iida R., Yasuda T., Aoyama M., Tsubota E., Kobayashi M., Yuasa I., Matsuki T., Kishi K.
      Electrophoresis 18:1936-1939(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DNASE1*5.
    14. "A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability."
      Yasuda T., Takeshita H., Iida R., Kogure S., Kishi K.
      Biochem. Biophys. Res. Commun. 260:280-283(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DNASE1*6.

    Entry informationi

    Entry nameiDNAS1_HUMAN
    AccessioniPrimary (citable) accession number: P24855
    Secondary accession number(s): Q14UU9, Q14UV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 155 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3