DNASE1

Functionⁱ

Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).By similarity

Catalytic activityⁱ

Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.

Cofactorⁱ

Ca²⁺, Mg²⁺Note: Divalent metal cations. Prefers Ca²⁺ or Mg²⁺.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	100	By similarity		1
Active siteⁱ	156	By similarity		1

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
deoxyribonuclease I activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
DNA catabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Actin-binding, Endonuclease, Hydrolase, Nuclease
Biological process	Apoptosis
Ligand	Calcium

Enzyme and pathway databases

BRENDAⁱ	3.1.21.1. 2681.

BRENDAⁱ

3.1.21.1. 2681.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Deoxyribonuclease-1 (EC:3.1.21.1) Alternative name(s): Deoxyribonuclease I Short name: DNase I INN: Dornase alfa
Gene namesⁱ	Name:DNASE1 Synonyms:DNL1, DRNI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2956. DNASE1.

HGNCⁱ

HGNC:2956. DNASE1.

Subcellular locationⁱ

Secreted
Nucleus envelope

Note:

Secretory protein, stored in zymogen granules and found in the nuclear envelope.

GO - Cellular componentⁱ

extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 23376485
- 23533145
extracellular region
Source: ProtInc
Traceable author statementⁱ
- 2349940
nuclear envelope Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Systemic lupus erythematosus (SLE)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Pharmaceutical useⁱ

Available under the name Pulmozyme (Genentech). Used to reduce the viscosity of cystic fibrosis sputum by hydrolyzing the extracellular DNA released by degenerating leukocytes that accumulate in response to infection.

Keywords - Diseaseⁱ

Systemic lupus erythematosus

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1773.
MalaCards human disease database More...MalaCardsⁱ	DNASE1.
MIMⁱ	152700. phenotype.
Open Targets More...OpenTargetsⁱ	ENSG00000213918.
Orphanetⁱ	536. Systemic lupus erythematosus.
PharmGKBⁱ	PA27427.

Chemistry databases

ChEMBLⁱ	CHEMBL3351219.

ChEMBLⁱ

CHEMBL3351219.

Polymorphism and mutation databases

BioMutaⁱ	DNASE1.
DMDMⁱ	118919.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	2 PublicationsAdd BLAST		22
ChainⁱPRO_0000007277	23 – 282	Deoxyribonuclease-1Add BLAST		260

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	40	N-linked (GlcNAc...) asparagine	1
Disulfide bondⁱ	123 ↔ 126	By similarity
Glycosylationⁱ	128	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	195 ↔ 231	Essential for enzymatic activityBy similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P24855.
PeptideAtlas More...PeptideAtlasⁱ	P24855.
PRIDEⁱ	P24855.

PTM databases

iPTMnetⁱ	P24855.
PhosphoSitePlusⁱ	P24855.

Expressionⁱ

Tissue specificityⁱ

Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

Gene expression databases

Bgeeⁱ	ENSG00000213918.
CleanExⁱ	HS_DNASE1.
ExpressionAtlasⁱ	P24855. baseline and differential.
Genevisibleⁱ	P24855. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010703.

HPAⁱ

HPA010703.

Interactionⁱ

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	108112. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4722539.
STRINGⁱ	9606.ENSP00000246949.

Chemistry databases

BindingDBⁱ

P24855.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 34	Combined sources	11
Helixⁱ	35 – 38	Combined sources	4
Helixⁱ	41 – 51	Combined sources	11
Beta strandⁱ	55 – 62	Combined sources	8
Helixⁱ	68 – 77	Combined sources	10
Turnⁱ	78 – 80	Combined sources	3
Beta strandⁱ	86 – 89	Combined sources	4
Beta strandⁱ	93 – 98	Combined sources	6
Beta strandⁱ	100 – 106	Combined sources	7
Turnⁱ	108 – 110	Combined sources	3
Beta strandⁱ	112 – 118	Combined sources	7
Turnⁱ	124 – 127	Combined sources	4
Beta strandⁱ	136 – 141	Combined sources	6
Beta strandⁱ	149 – 154	Combined sources	6
Helixⁱ	159 – 161	Combined sources	3
Helixⁱ	162 – 180	Combined sources	19
Beta strandⁱ	185 – 190	Combined sources	6
Turnⁱ	195 – 197	Combined sources	3
Helixⁱ	200 – 205	Combined sources	6
Helixⁱ	207 – 210	Combined sources	4
Beta strandⁱ	214 – 216	Combined sources	3
Beta strandⁱ	225 – 228	Combined sources	4
Beta strandⁱ	234 – 240	Combined sources	7
Helixⁱ	241 – 246	Combined sources	6
Helixⁱ	257 – 260	Combined sources	4
Helixⁱ	265 – 271	Combined sources	7
Beta strandⁱ	277 – 281	Combined sources	5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4AWN	X-ray	1.95	A	23-282	[»]
ProteinModelPortalⁱ	P24855.
SMRⁱ	P24855.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DNase I family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IFZB. Eukaryota. ENOG410Z4MV. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013146.
HOGENOMⁱ	HOG000059570.
HOVERGENⁱ	HBG051368.
InParanoidⁱ	P24855.
KEGG Orthology (KO) More...KOⁱ	K11994.
OMAⁱ	RYLFVFR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B.
PhylomeDBⁱ	P24855.
TreeFamⁱ	TF329541.

Family and domain databases

Gene3Dⁱ	3.60.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I. IPR033125. DNASE_I_2. IPR005135. Endo/exonuclease/phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372. Exo_endo_phos. 1 hit.
PIRSFⁱ	PIRSF000988. DNase_I_euk. 1 hit.
PRINTSⁱ	PR00130. DNASEI.
SMARTⁱ	View protein in SMART SM00476. DNaseIc. 1 hit.
SUPFAMⁱ	SSF56219. SSF56219. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P24855-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI 
        60         70         80         90        100
LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE 
       110        120        130        140        150
RYLFVYRPDQ VSAVDSYYYD DGCEPCGNDT FNREPAIVRF FSRFTEVREF 
       160        170        180        190        200
AIVPLHAAPG DAVAEIDALY DVYLDVQEKW GLEDVMLMGD FNAGCSYVRP 
       210        220        230        240        250
SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG MLLRGAVVPD 
       260        270        280 
SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK

Length:282

Mass (Da):31,434

Last modified:March 1, 1992 - v1

Checksum:ⁱ040042E2D23555B6

GO

Isoform 2 (identifier: P24855-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MRGMKLLGAL...ALVQEVRDSH → MHQTPITTWS...PLSGSSPGSQ
     67-183: Missing.
     268-282: AQAISDHYPVEVMLK → FSVHTCSGAGLGERHGLPASAALPSNTCRAGTHRVST

« Hide

        10         20         30         40         50
MHQTPITTWS VSHWDGTAIR SATCSCTGLT RCLRWTATTT MMAASPAGTT 
        60         70         80         90        100
PSTESQPLSG SSPGSQDVML MGDFNAGCSY VRPSQWSSIR LWTSPTFQWL 
       110        120        130        140        150
IPDSADTTAT PTHCAYDRIV VAGMLLRGAV VPDSALPFNF QAAYGLSDQL 
       160        170        180 
FSVHTCSGAG LGERHGLPAS AALPSNTCRA GTHRVST

Note: No experimental confirmation available.

Show »

Length:187

Mass (Da):19,771

Checksum:ⁱC66A988635746FB9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	143	R → Q in BAE96964 (PubMed:16771825).Curated		1

Polymorphismⁱ

At least 6 alleles of DNASE1 are known: DNASE1*1 to DNASE1*6. The sequence shown is that of DNASE1*2.4 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024434	2	R → S. Corresponds to variant dbSNP:rs8176927Ensembl.	1
Natural variantⁱVAR_002264	31	Q → E in allele DNASE1*4. Corresponds to variant dbSNP:rs77254040Ensembl.	1
Natural variantⁱVAR_029172	107	R → G. Corresponds to variant dbSNP:rs8176928Ensembl.	1
Natural variantⁱVAR_009300	114	V → M in allele DNASE1*5. Corresponds to variant dbSNP:rs530214101Ensembl.	1
Natural variantⁱVAR_024435	127	G → R. Corresponds to variant dbSNP:rs8176919Ensembl.	1
Natural variantⁱVAR_002265	154	P → A in allele DNASE1*3. Corresponds to variant dbSNP:rs1799891Ensembl.	1
Natural variantⁱVAR_009301	207	R → C in allele DNASE1*6. Corresponds to variant dbSNP:rs148373909Ensembl.	1
Natural variantⁱVAR_029173	231	C → Y. Corresponds to variant dbSNP:rs8176940Ensembl.	1
Natural variantⁱVAR_002266	244	R → Q in allele DNASE1*1. 1 PublicationCorresponds to variant dbSNP:rs1053874Ensembl.	1
Natural variantⁱVAR_029174	246	A → P. Corresponds to variant dbSNP:rs8176939Ensembl.	1
Natural variantⁱVAR_029175	262	G → D. Corresponds to variant dbSNP:rs8176924Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056974	1 – 66	MRGMK…VRDSH → MHQTPITTWSVSHWDGTAIR SATCSCTGLTRCLRWTATTT MMAASPAGTTPSTESQPLSG SSPGSQ in isoform 2. 1 PublicationAdd BLAST	66
Alternative sequenceⁱVSP_056975	67 – 183	Missing in isoform 2. 1 PublicationAdd BLAST	117
Alternative sequenceⁱVSP_056976	268 – 282	AQAIS…EVMLK → FSVHTCSGAGLGERHGLPAS AALPSNTCRAGTHRVST in isoform 2. 1 PublicationAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55983 mRNA. Translation: AAA63170.1. D83195 Genomic DNA. Translation: BAA11841.1. AJ298844 mRNA. Translation: CAC12813.1. AB188151 mRNA. Translation: BAE96964.1. AB188152 mRNA. Translation: BAE96965.1. AK300914 mRNA. Translation: BAG62547.1. AC005203 Genomic DNA. Translation: AAC24721.1. AC006111 Genomic DNA. No translation available. CH471112 Genomic DNA. Translation: EAW85344.1. BC029437 mRNA. Translation: AAH29437.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10507.1. [P24855-1]
PIRⁱ	A38417. NDHU1.
NCBI Reference Sequences More...RefSeqⁱ	NP_005214.2. NM_005223.3. [P24855-1] XP_011520695.1. XM_011522393.2. [P24855-1] XP_016878488.1. XM_017022999.1. [P24855-1] XP_016878492.1. XM_017023003.1. [P24855-2] XP_016878493.1. XM_017023004.1. [P24855-2] XP_016878494.1. XM_017023005.1. [P24855-2] XP_016878495.1. XM_017023006.1. [P24855-2]
UniGeneⁱ	Hs.629638. Hs.733045.

Genome annotation databases

Ensemblⁱ	ENST00000246949; ENSP00000246949; ENSG00000213918. [P24855-1] ENST00000407479; ENSP00000385905; ENSG00000213918. [P24855-1]
GeneIDⁱ	1773.
KEGGⁱ	hsa:1773.
UCSC genome browser More...UCSCⁱ	uc002cvr.4. human. [P24855-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Web resourcesⁱ

Pulmozyme

Clinical information on Pulmozyme

Wikipedia

Deoxyribonuclease entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55983 mRNA. Translation: AAA63170.1. D83195 Genomic DNA. Translation: BAA11841.1. AJ298844 mRNA. Translation: CAC12813.1. AB188151 mRNA. Translation: BAE96964.1. AB188152 mRNA. Translation: BAE96965.1. AK300914 mRNA. Translation: BAG62547.1. AC005203 Genomic DNA. Translation: AAC24721.1. AC006111 Genomic DNA. No translation available. CH471112 Genomic DNA. Translation: EAW85344.1. BC029437 mRNA. Translation: AAH29437.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10507.1. [P24855-1]
PIRⁱ	A38417. NDHU1.
NCBI Reference Sequences More...RefSeqⁱ	NP_005214.2. NM_005223.3. [P24855-1] XP_011520695.1. XM_011522393.2. [P24855-1] XP_016878488.1. XM_017022999.1. [P24855-1] XP_016878492.1. XM_017023003.1. [P24855-2] XP_016878493.1. XM_017023004.1. [P24855-2] XP_016878494.1. XM_017023005.1. [P24855-2] XP_016878495.1. XM_017023006.1. [P24855-2]
UniGeneⁱ	Hs.629638. Hs.733045.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4AWN	X-ray	1.95	A	23-282	[»]
ProteinModelPortalⁱ	P24855.
SMRⁱ	P24855.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108112. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4722539.
STRINGⁱ	9606.ENSP00000246949.

Chemistry databases

BindingDBⁱ	P24855.
ChEMBLⁱ	CHEMBL3351219.

PTM databases

iPTMnetⁱ	P24855.
PhosphoSitePlusⁱ	P24855.

Polymorphism and mutation databases

BioMutaⁱ	DNASE1.
DMDMⁱ	118919.

Proteomic databases

PaxDbⁱ	P24855.
PeptideAtlas More...PeptideAtlasⁱ	P24855.
PRIDEⁱ	P24855.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1773.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000246949; ENSP00000246949; ENSG00000213918. [P24855-1] ENST00000407479; ENSP00000385905; ENSG00000213918. [P24855-1]
GeneIDⁱ	1773.
KEGGⁱ	hsa:1773.
UCSC genome browser More...UCSCⁱ	uc002cvr.4. human. [P24855-1]

Organism-specific databases

CTDⁱ	1773.
DisGeNET More...DisGeNETⁱ	1773.
GeneCardsⁱ	DNASE1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2956. DNASE1.
Human Protein Atlas More...HPAⁱ	HPA010703.
MalaCards human disease database More...MalaCardsⁱ	DNASE1.
MIMⁱ	125505. gene. 152700. phenotype.
neXtProtⁱ	NX_P24855.
Open Targets More...OpenTargetsⁱ	ENSG00000213918.
Orphanetⁱ	536. Systemic lupus erythematosus.
PharmGKBⁱ	PA27427.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFZB. Eukaryota. ENOG410Z4MV. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013146.
HOGENOMⁱ	HOG000059570.
HOVERGENⁱ	HBG051368.
InParanoidⁱ	P24855.
KEGG Orthology (KO) More...KOⁱ	K11994.
OMAⁱ	RYLFVFR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B.
PhylomeDBⁱ	P24855.
TreeFamⁱ	TF329541.

Enzyme and pathway databases

BRENDAⁱ	3.1.21.1. 2681.

BRENDAⁱ

3.1.21.1. 2681.

Miscellaneous databases

ChiTaRSⁱ	DNASE1. human.
GeneWikiⁱ	Deoxyribonuclease_I.
GenomeRNAiⁱ	1773.
Protein Ontology More...PROⁱ	PR:P24855.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000213918.
CleanExⁱ	HS_DNASE1.
ExpressionAtlasⁱ	P24855. baseline and differential.
Genevisibleⁱ	P24855. HS.

Family and domain databases

Gene3Dⁱ	3.60.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018057. Deoxyribonuclease-1_AS. IPR016202. DNase_I. IPR033125. DNASE_I_2. IPR005135. Endo/exonuclease/phosphatase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372. Exo_endo_phos. 1 hit.
PIRSFⁱ	PIRSF000988. DNase_I_euk. 1 hit.
PRINTSⁱ	PR00130. DNASEI.
SMARTⁱ	View protein in SMART SM00476. DNaseIc. 1 hit.
SUPFAMⁱ	SSF56219. SSF56219. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00919. DNASE_I_1. 1 hit. PS00918. DNASE_I_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNAS1_HUMAN
Accessionⁱ	P24855Primary (citable) accession number: P24855 Secondary accession number(s): B4DV35, Q14UU9, Q14UV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	June 7, 2017
	This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24855 (DNAS1_HUMAN)

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Deoxyribonuclease-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ