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Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-SSC-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Short name:
pIGFBP-2
Gene namesi
Name:IGFBP2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001437230 – 316Insulin-like growth factor-binding protein 2Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi218 ↔ 252PROSITE-ProRule annotation
Disulfide bondi263 ↔ 274PROSITE-ProRule annotation
Disulfide bondi276 ↔ 297PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24853
PeptideAtlasiP24853
PRIDEiP24853

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000026205

Structurei

3D structure databases

ProteinModelPortaliP24853
SMRiP24853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 126IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST96
Domaini215 – 297Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi292 – 294Cell attachment siteSequence analysis3

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOVERGENiHBG002631
InParanoidiP24853

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLGGTAL SLLPLLLLLL GTGGRGARAE VLFRCPPCTP ESLAACRPPP
60 70 80 90 100
AAPPSAGAGP AGDSRAPCEL VREPGCGCCS VCARLEGERC GVYTPRCAQG
110 120 130 140 150
LRCYPHPGSE LPLQALVLGE GTCEKRRDAE YGASPEQVAD NGDDAEGGLV
160 170 180 190 200
ENHVDGNVNL LGGTGGAGRK PLKSGMKELA VFREKVTEQH RQMGKGGKHH
210 220 230 240 250
LGLEEPKKLR PPPARTPCQQ ELDQVLERIS TMRLPDERGP LEHLYSLHIP
260 270 280 290 300
NCDKHGLYNL KQCKMSLNGQ RGECWCVNPN TGKLIQGAPT IRGDPECHLF
310
YNEQQGARGA HTQRMQ
Length:316
Mass (Da):33,937
Last modified:February 1, 2005 - v2
Checksum:iE7812F2DA2A870C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120326 mRNA Translation: AAD33246.1
PIRiJH0515
RefSeqiNP_999168.1, NM_214003.1
UniGeneiSsc.47

Genome annotation databases

EnsembliENSSSCT00000046489; ENSSSCP00000058079; ENSSSCG00000035392
GeneIDi397064
KEGGissc:397064

Similar proteinsi

Entry informationi

Entry nameiIBP2_PIG
AccessioniPrimary (citable) accession number: P24853
Secondary accession number(s): Q9XSC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: February 1, 2005
Last modified: February 28, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health