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Protein

Chalcone synthase 1

Gene

CHS1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002160621 – 388Chalcone synthase 1Add BLAST388

Proteomic databases

PRIDEiP24826

Expressioni

Gene expression databases

GenevisibleiP24826 GM

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA08G11620.1

Structurei

3D structure databases

ProteinModelPortaliP24826
SMRiP24826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKG2 Eukaryota
COG3424 LUCA
InParanoidiP24826
KOiK00660
OMAiAMRYDWD

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR012328 Chalcone/stilbene_synth_C
IPR018088 Chalcone/stilbene_synthase_AS
IPR001099 Chalcone/stilbene_synthase_N
IPR011141 Polyketide_synthase_type-III
IPR016039 Thiolase-like
PANTHERiPTHR11877 PTHR11877, 1 hit
PfamiView protein in Pfam
PF02797 Chal_sti_synt_C, 1 hit
PF00195 Chal_sti_synt_N, 1 hit
PIRSFiPIRSF000451 PKS_III, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00441 CHALCONE_SYNTH, 1 hit

Sequencei

Sequence statusi: Complete.

P24826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVEEIRKA QRAEGPATVM AIGTATPPNC VDQSTYPDYY FRITNSEHMT
60 70 80 90 100
ELKEKFKRMC DKSMIKKRYM YLNEEILKEN PSVCAYMAPS LDARQDMVVV
110 120 130 140 150
EVPKLGKEAA TKAIKEWGQP KSKITHLIFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPSVKRYMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEITAVTFRG
210 220 230 240 250
PTDTHLDSLV GQALFGDGAA AVIVGSDPLP VEKPLFQLVW TAQTILPDSE
260 270 280 290 300
GAIDGHLREV GLTFHLLKDV PGLISKNIEK ALVEAFQPLG ISDYNSIFWI
310 320 330 340 350
AHPGGPAILD QVEAKLGLKP EKMEATRHVL SEYGNMSSAC VLFILDQMRK
360 370 380
KSIENGLGTT GEGLDWGVLF GFGPGLTVET VVLRSVTL
Length:388
Mass (Da):42,516
Last modified:March 1, 1992 - v1
Checksum:i73AC3B59A4E91BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54644 Genomic DNA Translation: CAA38456.1
PIRiS15006 SYSYC1
RefSeqiXP_003531225.1, XM_003531177.3
UniGeneiGma.17605

Genome annotation databases

EnsemblPlantsiKRH42759; KRH42759; GLYMA_08G109400
GeneIDi732575
GrameneiKRH42759; KRH42759; GLYMA_08G109400
KEGGigmx:732575

Similar proteinsi

Entry informationi

Entry nameiCHS1_SOYBN
AccessioniPrimary (citable) accession number: P24826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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