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P24825 (CHS2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase C2

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase C2
Gene names
Name:C2
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Chalcone synthase C2
PRO_0000216004

Sites

Active site1681 By similarity

Sequences

Sequence LengthMass (Da)Tools
P24825 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 17D1095EE077DEC3

FASTA40043,196
        10         20         30         40         50         60 
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVYQADY PDYYFRITKS EHLTDLKEKF 

        70         80         90        100        110        120 
KRMCDKSMIR KRYMHLTEEF LAENPSMCAY MAPSLDARQD VVVVEVPKLG KAAAQKAIKE 

       130        140        150        160        170        180 
WGQPKSRITH LVFCTTSGVD MPGADYQLTK ALGLRPSVNR LMMYQQGCFA GGTVLRVAKD 

       190        200        210        220        230        240 
LAENNRGARV LVVCSEITAV TFRGPSESHL DSLVGQALFG DGAAAVVVGA DPDDRVERPL 

       250        260        270        280        290        300 
FQLVSAAQTI LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIGRALDDA FKPLGISDWN 

       310        320        330        340        350        360 
SIFWVAHPGG PAILDQVEAK VGLDKARMRA TRHVLSEYGN MSSACVLFIL DEMRKRSAED 

       370        380        390        400 
GQATTGEGLD WGVLFGFGPG LTVETVVLHS VPITTGAATA 

« Hide

References

[1]"The duplicated chalcone synthase genes C2 and Whp (white pollen) of Zea mays are independently regulated; evidence for translational control of Whp expression by the anthocyanin intensifying gene in."
Franken P., Niesbach-Kloesgen U., Weydemann U., Marechal-Drouard L., Saedler H., Wienand U.
EMBO J. 10:2605-2612(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Line C1-P.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60205 Genomic DNA. Translation: CAA42764.1.
PIRSYZMCC. S16598.
RefSeqNP_001142246.1. NM_001148774.1.
UniGeneZm.77787.

3D structure databases

ProteinModelPortalP24825.
SMRP24825. Positions 7-393.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100274415.
KEGGzma:100274415.

Organism-specific databases

GrameneP24825.
MaizeGDB13853.

Phylogenomic databases

HOGENOMHOG000245460.
KOK00660.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS2_MAIZE
AccessionPrimary (citable) accession number: P24825
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 16, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways