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Protein

Chalcone synthase C2

Gene

C2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase C2 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase C2
Gene namesi
Name:C2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi13853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002160041 – 400Chalcone synthase C2Add BLAST400

Proteomic databases

PaxDbiP24825.

Expressioni

Gene expression databases

ExpressionAtlasiP24825. baseline and differential.
GenevisibleiP24825. ZM.

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G151227_P01.

Structurei

3D structure databases

ProteinModelPortaliP24825.
SMRiP24825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKG2. Eukaryota.
COG3424. LUCA.
HOGENOMiHOG000245460.
KOiK00660.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiView protein in PROSITE
PS00441. CHALCONE_SYNTH. 1 hit.

Sequencei

Sequence statusi: Complete.

P24825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVYQADY PDYYFRITKS
60 70 80 90 100
EHLTDLKEKF KRMCDKSMIR KRYMHLTEEF LAENPSMCAY MAPSLDARQD
110 120 130 140 150
VVVVEVPKLG KAAAQKAIKE WGQPKSRITH LVFCTTSGVD MPGADYQLTK
160 170 180 190 200
ALGLRPSVNR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV
210 220 230 240 250
TFRGPSESHL DSLVGQALFG DGAAAVVVGA DPDDRVERPL FQLVSAAQTI
260 270 280 290 300
LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIGRALDDA FKPLGISDWN
310 320 330 340 350
SIFWVAHPGG PAILDQVEAK VGLDKARMRA TRHVLSEYGN MSSACVLFIL
360 370 380 390 400
DEMRKRSAED GQATTGEGLD WGVLFGFGPG LTVETVVLHS VPITTGAATA
Length:400
Mass (Da):43,196
Last modified:March 1, 1992 - v1
Checksum:i17D1095EE077DEC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60205 Genomic DNA. Translation: CAA42764.1.
PIRiS16598. SYZMCC.
RefSeqiNP_001142246.1. NM_001148774.1.
UniGeneiZm.77787.

Genome annotation databases

EnsemblPlantsiZm00001d052673_T001; Zm00001d052673_P001; Zm00001d052673.
GeneIDi100274415.
GrameneiZm00001d052673_T001; Zm00001d052673_P001; Zm00001d052673.
KEGGizma:100274415.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCHS2_MAIZE
AccessioniPrimary (citable) accession number: P24825
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: July 5, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families