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Protein

Chalcone synthase C2

Gene

C2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase C2 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase C2
Gene namesi
Name:C2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea
ProteomesiUP000007305: Chromosome 4

Organism-specific databases

GrameneiP24825.
MaizeGDBi13853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Chalcone synthase C2PRO_0000216004Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP24825. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliP24825.
SMRiP24825. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

HOGENOMiHOG000245460.
KOiK00660.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVYQADY PDYYFRITKS
60 70 80 90 100
EHLTDLKEKF KRMCDKSMIR KRYMHLTEEF LAENPSMCAY MAPSLDARQD
110 120 130 140 150
VVVVEVPKLG KAAAQKAIKE WGQPKSRITH LVFCTTSGVD MPGADYQLTK
160 170 180 190 200
ALGLRPSVNR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEITAV
210 220 230 240 250
TFRGPSESHL DSLVGQALFG DGAAAVVVGA DPDDRVERPL FQLVSAAQTI
260 270 280 290 300
LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIGRALDDA FKPLGISDWN
310 320 330 340 350
SIFWVAHPGG PAILDQVEAK VGLDKARMRA TRHVLSEYGN MSSACVLFIL
360 370 380 390 400
DEMRKRSAED GQATTGEGLD WGVLFGFGPG LTVETVVLHS VPITTGAATA
Length:400
Mass (Da):43,196
Last modified:March 1, 1992 - v1
Checksum:i17D1095EE077DEC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60205 Genomic DNA. Translation: CAA42764.1.
PIRiS16598. SYZMCC.
RefSeqiNP_001142246.1. NM_001148774.1.
UniGeneiZm.77787.

Genome annotation databases

EnsemblPlantsiGRMZM2G422750_T03; GRMZM2G422750_P03; GRMZM2G422750.
GeneIDi100274415.
KEGGizma:100274415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60205 Genomic DNA. Translation: CAA42764.1.
PIRiS16598. SYZMCC.
RefSeqiNP_001142246.1. NM_001148774.1.
UniGeneiZm.77787.

3D structure databases

ProteinModelPortaliP24825.
SMRiP24825. Positions 7-393.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGRMZM2G422750_T03; GRMZM2G422750_P03; GRMZM2G422750.
GeneIDi100274415.
KEGGizma:100274415.

Organism-specific databases

GrameneiP24825.
MaizeGDBi13853.

Phylogenomic databases

HOGENOMiHOG000245460.
KOiK00660.

Enzyme and pathway databases

UniPathwayiUPA00154.

Gene expression databases

ExpressionAtlasiP24825. baseline and differential.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The duplicated chalcone synthase genes C2 and Whp (white pollen) of Zea mays are independently regulated; evidence for translational control of Whp expression by the anthocyanin intensifying gene in."
    Franken P., Niesbach-Kloesgen U., Weydemann U., Marechal-Drouard L., Saedler H., Wienand U.
    EMBO J. 10:2605-2612(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Line C1-P.
    Tissue: Leaf.

Entry informationi

Entry nameiCHS2_MAIZE
AccessioniPrimary (citable) accession number: P24825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.