ID   CHS1_MAIZE              Reviewed;         400 AA.
AC   P24824;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=Chalcone synthase WHP1;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase WHP1;
DE   AltName: Full=White pollen;
GN   Name=WHP1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Line C1-P; TISSUE=Leaf;
RX   PubMed=1714383; DOI=10.1002/j.1460-2075.1991.tb07802.x;
RA   Franken P., Niesbach-Kloesgen U., Weydemann U., Marechal-Drouard L.,
RA   Saedler H., Wienand U.;
RT   "The duplicated chalcone synthase genes C2 and Whp (white pollen) of Zea
RT   mays are independently regulated; evidence for translational control of Whp
RT   expression by the anthocyanin intensifying gene in.";
RL   EMBO J. 10:2605-2612(1991).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X60204; CAA42763.1; -; Genomic_DNA.
DR   PIR; S16599; SYZMW1.
DR   AlphaFoldDB; P24824; -.
DR   SMR; P24824; -.
DR   STRING; 4577.P24824; -.
DR   MaizeGDB; 13853; -.
DR   InParanoid; P24824; -.
DR   UniPathway; UPA00154; -.
DR   Proteomes; UP000007305; Unplaced.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..400
FT                   /note="Chalcone synthase WHP1"
FT                   /id="PRO_0000216003"
FT   ACT_SITE        167
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   400 AA;  43172 MW;  8AB661A86253616C CRC64;
     MAGATVTVDE VRKGQRATGP ATVLAIGTAT PANCVYQADY PDYYFRITKS DHLTDLKEKF
     KRMCDKSMIR KRYMHLTEEF LSENPSMCAY MAPSLDARQD VVVTEVPKLG KAAAQEAIKE
     WGQPKSRITH LVFCTTSGVD MPGADYQLTK ALGLRVVNRL MMYQQGCFAG GTVLRVAKDV
     AENNRGARVM VVCSEITAVT FRGPSESHVD SLVGQALFGD GAAAGRGGAD PDGRVERPLF
     QLVSAAQTIL PDSEGAIDGH LREVGLAFHL LKDVPGLISK NIERALEDAF EPLGISDWNS
     IFWVAHPGGP AILDQVEAKV GLDKARMRAT RHVLSEYGNM SSACVLFILD EMRKRPAEDG
     QSTTGEGLDW GVLFGFGPGL TVETVVLHSV PITTGAPTAA
//