P24821 (TENA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tenascin
Short name=TN

Alternative name(s):
Cytotactin
GMEM
GP 150-225
Glioma-associated-extracellular matrix antigen
Hexabrachion
JI
Myotendinous antigen
Neuronectin
Tenascin-C
Short name=TN-C

Gene names

Name:	TNC
Synonyms:	HXB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Subunit structure	Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Ref.8
Subcellular location	Secreted › extracellular space › extracellular matrix.
Induction	By TGFB1.
Sequence similarities	Belongs to the tenascin family. Contains 15 EGF-like domains. Contains 1 fibrinogen C-terminal domain. Contains 15 fibronectin type-III domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc mesenchymal-epithelial cell signaling involved in prostate gland development Inferred from electronic annotation. Source: Compara neuromuscular junction development Inferred from electronic annotation. Source: Compara peripheral nervous system axon regeneration Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara prostate gland epithelium morphogenesis Inferred from electronic annotation. Source: Compara response to wounding Inferred from expression pattern PubMed 16891397. Source: BHF-UCL
Cellular_component	basement membrane Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay PubMed 20551380. Source: BHF-UCL interstitial matrix Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Isoforms are produced in a tissue- and time-specific manner during development.

Isoform 1 (identifier: P24821-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P24821-2)

Also known as: HT-5;

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1435: Missing.
     1527-1617: Missing.

Isoform 3 (identifier: P24821-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1435: Missing.

Isoform 4 (identifier: P24821-4)

Also known as: HT-33;

The sequence of this isoform differs from the canonical sequence as follows:
     1527-1617: Missing.

Isoform 5 (identifier: P24821-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1617: Missing.

Isoform 6 (identifier: P24821-6)

Also known as: P31;

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1708: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

22

Ref.2

Chain

23 – 2201

2179

Tenascin

PRO_0000007741

Regions

Domain

174 – 186

13

EGF-like 1; incomplete

Domain

186 – 217

32

EGF-like 2

Domain

217 – 248

32

EGF-like 3

Domain

248 – 280

33

EGF-like 4

Domain

280 – 311

32

EGF-like 5

Domain

311 – 342

32

EGF-like 6

Domain

342 – 373

32

EGF-like 7

Domain

373 – 404

32

EGF-like 8

Domain

404 – 435

32

EGF-like 9

Domain

435 – 466

32

EGF-like 10

Domain

466 – 497

32

EGF-like 11

Domain

497 – 528

32

EGF-like 12

Domain

528 – 559

32

EGF-like 13

Domain

559 – 590

32

EGF-like 14

Domain

590 – 621

32

EGF-like 15

Domain

622 – 710

89

Fibronectin type-III 1

Domain

713 – 801

89

Fibronectin type-III 2

Domain

802 – 891

90

Fibronectin type-III 3

Domain

892 – 983

92

Fibronectin type-III 4

Domain

984 – 1071

88

Fibronectin type-III 5

Domain

1075 – 1162

88

Fibronectin type-III 6

Domain

1164 – 1253

90

Fibronectin type-III 7

Domain

1255 – 1344

90

Fibronectin type-III 8

Domain

1348 – 1435

88

Fibronectin type-III 9

Domain

1439 – 1526

88

Fibronectin type-III 10

Domain

1528 – 1617

90

Fibronectin type-III 11

Domain

1619 – 1708

90

Fibronectin type-III 12

Domain

1709 – 1797

89

Fibronectin type-III 13

Domain

1798 – 1885

88

Fibronectin type-III 14

Domain

1886 – 1973

88

Fibronectin type-III 15

Domain

1975 – 2190

216

Fibrinogen C-terminal

Coiled coil

118 – 145

28

Potential

Amino acid modifications

Modified residue

70

1

Phosphoserine By similarity

Modified residue

72

1

Phosphoserine By similarity

Glycosylation

38

1

N-linked (GlcNAc...) Potential

Glycosylation

166

1

N-linked (GlcNAc...) Potential

Glycosylation

184

1

N-linked (GlcNAc...) Ref.10

Glycosylation

327

1

N-linked (GlcNAc...) Potential

Glycosylation

788

1

N-linked (GlcNAc...) Potential

Glycosylation

1018

1

N-linked (GlcNAc...) Ref.11

Glycosylation

1034

1

N-linked (GlcNAc...) Ref.11

Glycosylation

1079

1

N-linked (GlcNAc...) Ref.10

Glycosylation

1093

1

N-linked (GlcNAc...) Ref.10

Glycosylation

1119

1

N-linked (GlcNAc...) Potential

Glycosylation

1184

1

N-linked (GlcNAc...) Ref.11

Glycosylation

1210

1

N-linked (GlcNAc...) Potential

Glycosylation

1261

1

N-linked (GlcNAc...) Ref.10

Glycosylation

1275

1

N-linked (GlcNAc...) Ref.11

Glycosylation

1301

1

N-linked (GlcNAc...) Ref.10 Ref.11

Glycosylation

1366

1

N-linked (GlcNAc...) Ref.11

Glycosylation

1392

1

N-linked (GlcNAc...) Potential

Glycosylation

1445

1

N-linked (GlcNAc...) Potential

Glycosylation

1455

1

N-linked (GlcNAc...) Potential

Glycosylation

1485

1

N-linked (GlcNAc...) Ref.10 Ref.11

Glycosylation

1534

1

N-linked (GlcNAc...) Potential

Glycosylation

1809

1

N-linked (GlcNAc...) Ref.9

Glycosylation

2162

1

N-linked (GlcNAc...) Ref.10

Disulfide bond

190 ↔ 200

By similarity

Disulfide bond

194 ↔ 205

By similarity

Disulfide bond

207 ↔ 216

By similarity

Disulfide bond

221 ↔ 231

By similarity

Disulfide bond

225 ↔ 236

By similarity

Disulfide bond

238 ↔ 247

By similarity

Disulfide bond

252 ↔ 263

By similarity

Disulfide bond

256 ↔ 268

By similarity

Disulfide bond

270 ↔ 279

By similarity

Disulfide bond

284 ↔ 294

By similarity

Disulfide bond

288 ↔ 299

By similarity

Disulfide bond

301 ↔ 310

By similarity

Disulfide bond

315 ↔ 325

By similarity

Disulfide bond

319 ↔ 330

By similarity

Disulfide bond

332 ↔ 341

By similarity

Disulfide bond

346 ↔ 356

By similarity

Disulfide bond

350 ↔ 361

By similarity

Disulfide bond

363 ↔ 372

By similarity

Disulfide bond

377 ↔ 387

By similarity

Disulfide bond

381 ↔ 392

By similarity

Disulfide bond

394 ↔ 403

By similarity

Disulfide bond

408 ↔ 418

By similarity

Disulfide bond

412 ↔ 423

By similarity

Disulfide bond

425 ↔ 434

By similarity

Disulfide bond

439 ↔ 449

By similarity

Disulfide bond

443 ↔ 454

By similarity

Disulfide bond

456 ↔ 465

By similarity

Disulfide bond

470 ↔ 480

By similarity

Disulfide bond

474 ↔ 485

By similarity

Disulfide bond

487 ↔ 496

By similarity

Disulfide bond

501 ↔ 511

By similarity

Disulfide bond

505 ↔ 516

By similarity

Disulfide bond

518 ↔ 527

By similarity

Disulfide bond

532 ↔ 542

By similarity

Disulfide bond

536 ↔ 547

By similarity

Disulfide bond

549 ↔ 558

By similarity

Disulfide bond

563 ↔ 573

By similarity

Disulfide bond

567 ↔ 578

By similarity

Disulfide bond

580 ↔ 589

By similarity

Disulfide bond

594 ↔ 604

By similarity

Disulfide bond

598 ↔ 609

By similarity

Disulfide bond

611 ↔ 620

By similarity

Natural variations

Alternative sequence

1072 – 1708

637

Missing in isoform 6.

VSP_001415

Alternative sequence

1072 – 1617

546

Missing in isoform 5.

VSP_001414

Alternative sequence

1072 – 1435

364

Missing in isoform 2 and isoform 3.

VSP_001412

Alternative sequence

1527 – 1617

91

Missing in isoform 2 and isoform 4.

VSP_001413

Natural variant

213

1

G → S.
Corresponds to variant rs7020958 [ dbSNP | Ensembl ].

VAR_055778

Natural variant

539

1

Q → R. Ref.1 Ref.3 Ref.7
Corresponds to variant rs1757095 [ dbSNP | Ensembl ].

VAR_024266

Natural variant

605

1

V → I.
Corresponds to variant rs3827816 [ dbSNP | Ensembl ].

VAR_024267

Natural variant

680

1

Q → R. Ref.2
Corresponds to variant rs1061494 [ dbSNP | Ensembl ].

VAR_024268

Natural variant

850

1

D → H.
Corresponds to variant rs3748169 [ dbSNP | Ensembl ].

VAR_055779

Natural variant

1677

1

I → L. Ref.1 Ref.3 Ref.4 Ref.7
Corresponds to variant rs2104772 [ dbSNP | Ensembl ].

VAR_060738

Natural variant

1781

1

A → T.
Corresponds to variant rs2274750 [ dbSNP | Ensembl ].

VAR_020169

Natural variant

2008

1

E → Q. Ref.1 Ref.2 Ref.3 Ref.4 Ref.7
Corresponds to variant rs13321 [ dbSNP | Ensembl ].

VAR_014665

Experimental info

Sequence conflict

244

1

Missing in CAA39628. Ref.2

Sequence conflict

370

1

V → L no nucleotide entry Ref.1

Sequence conflict

370

1

V → L in AAA88083. Ref.3

Sequence conflict

370

1

V → L in CAA55309. Ref.4

Sequence conflict

1066

1

R → H no nucleotide entry Ref.1

Sequence conflict

1066

1

R → H in AAA88083. Ref.3

Sequence conflict

1066

1

R → H in AAA52703. Ref.7

Sequence conflict

1600 – 1608

9

SGFTQGHQT → LWLHPRASN no nucleotide entry Ref.1

Sequence conflict

1600 – 1608

9

SGFTQGHQT → LWLHPRASN in AAA88083. Ref.3

Sequence conflict

1600 – 1608

9

SGFTQGHQT → LWLHPRASN in AAA52703. Ref.7

Sequence conflict

2054

1

F → FLH no nucleotide entry Ref.1

Sequence conflict

2054

1

F → FLH in AAA88083. Ref.3

Sequence conflict

2055

1

W → L in AAA52703. Ref.7

Sequence conflict

2140 – 2143

4

YKGA → TRG in CAA39628. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2201

Helix Strand Turn

Details...

Beta strand

807 – 813

7

Beta strand

819 – 824

6

Helix

827 – 829

3

Beta strand

831 – 839

9

Beta strand

842 – 844

3

Beta strand

847 – 852

6

Beta strand

857 – 860

4

Beta strand

868 – 877

10

Beta strand

885 – 890

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 15, 2009. Version 3. Checksum: B2BEF378AA6F1D85	FASTA	2,201	240,853
	10 20 30 40 50 60 MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 70 80 90 100 110 120 GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 250 260 270 280 290 300 GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 370 380 390 400 410 420 CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 550 560 570 580 590 600 RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 610 620 630 640 650 660 LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 670 680 690 700 710 720 EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 850 860 870 880 890 900 DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TEQAPELENL 1090 1100 1110 1120 1130 1140 TVTEVGWDGL RLNWTAADQA YEHFIIQVQE ANKVEAARNL TVPGSLRAVD IPGLKAATPY 1150 1160 1170 1180 1190 1200 TVSIYGVIQG YRTPVLSAEA STGETPNLGE VVVAEVGWDA LKLNWTAPEG AYEYFFIQVQ 1210 1220 1230 1240 1250 1260 EADTVEAAQN LTVPGGLRST DLPGLKAATH YTITIRGVTQ DFSTTPLSVE VLTEEVPDMG 1270 1280 1290 1300 1310 1320 NLTVTEVSWD ALRLNWTTPD GTYDQFTIQV QEADQVEEAH NLTVPGSLRS MEIPGLRAGT 1330 1340 1350 1360 1370 1380 PYTVTLHGEV RGHSTRPLAV EVVTEDLPQL GDLAVSEVGW DGLRLNWTAA DNAYEHFVIQ 1390 1400 1410 1420 1430 1440 VQEVNKVEAA QNLTLPGSLR AVDIPGLEAA TPYRVSIYGV IRGYRTPVLS AEASTAKEPE 1450 1460 1470 1480 1490 1500 IGNLNVSDIT PESFNLSWMA TDGIFETFTI EIIDSNRLLE TVEYNISGAE RTAHISGLPP 1510 1520 1530 1540 1550 1560 STDFIVYLSG LAPSIRTKTI SATATTEALP LLENLTISDI NPYGFTVSWM ASENAFDSFL 1570 1580 1590 1600 1610 1620 VTVVDSGKLL DPQEFTLSGT QRKLELRGLI TGIGYEVMVS GFTQGHQTKP LRAEIVTEAE 1630 1640 1650 1660 1670 1680 PEVDNLLVSD ATPDGFRLSW TADEGVFDNF VLKIRDTKKQ SEPLEITLLA PERTRDITGL 1690 1700 1710 1720 1730 1740 REATEYEIEL YGISKGRRSQ TVSAIATTAM GSPKEVIFSD ITENSATVSW RAPTAQVESF 1750 1760 1770 1780 1790 1800 RITYVPITGG TPSMVTVDGT KTQTRLVKLI PGVEYLVSII AMKGFEESEP VSGSFTTALD 1810 1820 1830 1840 1850 1860 GPSGLVTANI TDSEALARWQ PAIATVDSYV ISYTGEKVPE ITRTVSGNTV EYALTDLEPA 1870 1880 1890 1900 1910 1920 TEYTLRIFAE KGPQKSSTIT AKFTTDLDSP RDLTATEVQS ETALLTWRPP RASVTGYLLV 1930 1940 1950 1960 1970 1980 YESVDGTVKE VIVGPDTTSY SLADLSPSTH YTAKIQALNG PLRSNMIQTI FTTIGLLYPF 1990 2000 2010 2020 2030 2040 PKDCSQAMLN GDTTSGLYTI YLNGDKAEAL EVFCDMTSDG GGWIVFLRRK NGRENFYQNW 2050 2060 2070 2080 2090 2100 KAYAAGFGDR REEFWLGLDN LNKITAQGQY ELRVDLRDHG ETAFAVYDKF SVGDAKTRYK 2110 2120 2130 2140 2150 2160 LKVEGYSGTA GDSMAYHNGR SFSTFDKDTD SAITNCALSY KGAFWYRNCH RVNLMGRYGD 2170 2180 2190 2200 NNHSQGVNWF HWKGHEHSIQ FAEMKLRPSN FRNLEGRRKR A
	Isoform 2 (HT-5) [UniParc]. Checksum: 588B877CF66A227D	FASTA	1,746	191,373
	10 20 30 40 50 60 MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 70 80 90 100 110 120 GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 250 260 270 280 290 300 GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 370 380 390 400 410 420 CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 550 560 570 580 590 600 RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 610 620 630 640 650 660 LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 670 680 690 700 710 720 EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 850 860 870 880 890 900 DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TAKEPEIGNL 1090 1100 1110 1120 1130 1140 NVSDITPESF NLSWMATDGI FETFTIEIID SNRLLETVEY NISGAERTAH ISGLPPSTDF 1150 1160 1170 1180 1190 1200 IVYLSGLAPS IRTKTISATA TTEAEPEVDN LLVSDATPDG FRLSWTADEG VFDNFVLKIR 1210 1220 1230 1240 1250 1260 DTKKQSEPLE ITLLAPERTR DITGLREATE YEIELYGISK GRRSQTVSAI ATTAMGSPKE 1270 1280 1290 1300 1310 1320 VIFSDITENS ATVSWRAPTA QVESFRITYV PITGGTPSMV TVDGTKTQTR LVKLIPGVEY 1330 1340 1350 1360 1370 1380 LVSIIAMKGF EESEPVSGSF TTALDGPSGL VTANITDSEA LARWQPAIAT VDSYVISYTG 1390 1400 1410 1420 1430 1440 EKVPEITRTV SGNTVEYALT DLEPATEYTL RIFAEKGPQK SSTITAKFTT DLDSPRDLTA 1450 1460 1470 1480 1490 1500 TEVQSETALL TWRPPRASVT GYLLVYESVD GTVKEVIVGP DTTSYSLADL SPSTHYTAKI 1510 1520 1530 1540 1550 1560 QALNGPLRSN MIQTIFTTIG LLYPFPKDCS QAMLNGDTTS GLYTIYLNGD KAEALEVFCD 1570 1580 1590 1600 1610 1620 MTSDGGGWIV FLRRKNGREN FYQNWKAYAA GFGDRREEFW LGLDNLNKIT AQGQYELRVD 1630 1640 1650 1660 1670 1680 LRDHGETAFA VYDKFSVGDA KTRYKLKVEG YSGTAGDSMA YHNGRSFSTF DKDTDSAITN 1690 1700 1710 1720 1730 1740 CALSYKGAFW YRNCHRVNLM GRYGDNNHSQ GVNWFHWKGH EHSIQFAEMK LRPSNFRNLE GRRKRA
	Isoform 3 [UniParc]. Checksum: 54B916A3A6664FDE	FASTA	1,837	201,359
	10 20 30 40 50 60 MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 70 80 90 100 110 120 GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 250 260 270 280 290 300 GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 370 380 390 400 410 420 CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 550 560 570 580 590 600 RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 610 620 630 640 650 660 LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 670 680 690 700 710 720 EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 850 860 870 880 890 900 DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TAKEPEIGNL 1090 1100 1110 1120 1130 1140 NVSDITPESF NLSWMATDGI FETFTIEIID SNRLLETVEY NISGAERTAH ISGLPPSTDF 1150 1160 1170 1180 1190 1200 IVYLSGLAPS IRTKTISATA TTEALPLLEN LTISDINPYG FTVSWMASEN AFDSFLVTVV 1210 1220 1230 1240 1250 1260 DSGKLLDPQE FTLSGTQRKL ELRGLITGIG YEVMVSGFTQ GHQTKPLRAE IVTEAEPEVD 1270 1280 1290 1300 1310 1320 NLLVSDATPD GFRLSWTADE GVFDNFVLKI RDTKKQSEPL EITLLAPERT RDITGLREAT 1330 1340 1350 1360 1370 1380 EYEIELYGIS KGRRSQTVSA IATTAMGSPK EVIFSDITEN SATVSWRAPT AQVESFRITY 1390 1400 1410 1420 1430 1440 VPITGGTPSM VTVDGTKTQT RLVKLIPGVE YLVSIIAMKG FEESEPVSGS FTTALDGPSG 1450 1460 1470 1480 1490 1500 LVTANITDSE ALARWQPAIA TVDSYVISYT GEKVPEITRT VSGNTVEYAL TDLEPATEYT 1510 1520 1530 1540 1550 1560 LRIFAEKGPQ KSSTITAKFT TDLDSPRDLT ATEVQSETAL LTWRPPRASV TGYLLVYESV 1570 1580 1590 1600 1610 1620 DGTVKEVIVG PDTTSYSLAD LSPSTHYTAK IQALNGPLRS NMIQTIFTTI GLLYPFPKDC 1630 1640 1650 1660 1670 1680 SQAMLNGDTT SGLYTIYLNG DKAEALEVFC DMTSDGGGWI VFLRRKNGRE NFYQNWKAYA 1690 1700 1710 1720 1730 1740 AGFGDRREEF WLGLDNLNKI TAQGQYELRV DLRDHGETAF AVYDKFSVGD AKTRYKLKVE 1750 1760 1770 1780 1790 1800 GYSGTAGDSM AYHNGRSFST FDKDTDSAIT NCALSYKGAF WYRNCHRVNL MGRYGDNNHS 1810 1820 1830 QGVNWFHWKG HEHSIQFAEM KLRPSNFRNL EGRRKRA
	Isoform 4 (HT-33) [UniParc]. Checksum: 379795176A2B7252	FASTA	2,110	230,867
	10 20 30 40 50 60 MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 70 80 90 100 110 120 GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 250 260 270 280 290 300 GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 370 380 390 400 410 420 CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 550 560 570 580 590 600 RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 610 620 630 640 650 660 LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 670 680 690 700 710 720 EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 850 860 870 880 890 900 DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TEQAPELENL 1090 1100 1110 1120 1130 1140 TVTEVGWDGL RLNWTAADQA YEHFIIQVQE ANKVEAARNL TVPGSLRAVD IPGLKAATPY 1150 1160 1170 1180 1190 1200 TVSIYGVIQG YRTPVLSAEA STGETPNLGE VVVAEVGWDA LKLNWTAPEG AYEYFFIQVQ 1210 1220 1230 1240 1250 1260 EADTVEAAQN LTVPGGLRST DLPGLKAATH YTITIRGVTQ DFSTTPLSVE VLTEEVPDMG 1270 1280 1290 1300 1310 1320 NLTVTEVSWD ALRLNWTTPD GTYDQFTIQV QEADQVEEAH NLTVPGSLRS MEIPGLRAGT 1330 1340 1350 1360 1370 1380 PYTVTLHGEV RGHSTRPLAV EVVTEDLPQL GDLAVSEVGW DGLRLNWTAA DNAYEHFVIQ 1390 1400 1410 1420 1430 1440 VQEVNKVEAA QNLTLPGSLR AVDIPGLEAA TPYRVSIYGV IRGYRTPVLS AEASTAKEPE 1450 1460 1470 1480 1490 1500 IGNLNVSDIT PESFNLSWMA TDGIFETFTI EIIDSNRLLE TVEYNISGAE RTAHISGLPP 1510 1520 1530 1540 1550 1560 STDFIVYLSG LAPSIRTKTI SATATTEAEP EVDNLLVSDA TPDGFRLSWT ADEGVFDNFV 1570 1580 1590 1600 1610 1620 LKIRDTKKQS EPLEITLLAP ERTRDITGLR EATEYEIELY GISKGRRSQT VSAIATTAMG 1630 1640 1650 1660 1670 1680 SPKEVIFSDI TENSATVSWR APTAQVESFR ITYVPITGGT PSMVTVDGTK TQTRLVKLIP 1690 1700 1710 1720 1730 1740 GVEYLVSIIA MKGFEESEPV SGSFTTALDG PSGLVTANIT DSEALARWQP AIATVDSYVI 1750 1760 1770 1780 1790 1800 SYTGEKVPEI TRTVSGNTVE YALTDLEPAT EYTLRIFAEK GPQKSSTITA KFTTDLDSPR 1810 1820 1830 1840 1850 1860 DLTATEVQSE TALLTWRPPR ASVTGYLLVY ESVDGTVKEV IVGPDTTSYS LADLSPSTHY 1870 1880 1890 1900 1910 1920 TAKIQALNGP LRSNMIQTIF TTIGLLYPFP KDCSQAMLNG DTTSGLYTIY LNGDKAEALE 1930 1940 1950 1960 1970 1980 VFCDMTSDGG GWIVFLRRKN GRENFYQNWK AYAAGFGDRR EEFWLGLDNL NKITAQGQYE 1990 2000 2010 2020 2030 2040 LRVDLRDHGE TAFAVYDKFS VGDAKTRYKL KVEGYSGTAG DSMAYHNGRS FSTFDKDTDS 2050 2060 2070 2080 2090 2100 AITNCALSYK GAFWYRNCHR VNLMGRYGDN NHSQGVNWFH WKGHEHSIQF AEMKLRPSNF 2110 RNLEGRRKRA
	Isoform 5 [UniParc]. Checksum: FA3D6624965AE06A	FASTA	1,655	181,528
	10 20 30 40 50 60 MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 70 80 90 100 110 120 GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 250 260 270 280 290 300 GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 370 380 390 400 410 420 CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 550 560 570 580 590 600 RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 610 620 630 640 650 660 LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 670 680 690 700 710 720 EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 850 860 870 880 890 900 DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TEAEPEVDNL 1090 1100 1110 1120 1130 1140 LVSDATPDGF RLSWTADEGV FDNFVLKIRD TKKQSEPLEI TLLAPERTRD ITGLREATEY 1150 1160 1170 1180 1190 1200 EIELYGISKG RRSQTVSAIA TTAMGSPKEV IFSDITENSA TVSWRAPTAQ VESFRITYVP 1210 1220 1230 1240 1250 1260 ITGGTPSMVT VDGTKTQTRL VKLIPGVEYL VSIIAMKGFE ESEPVSGSFT TALDGPSGLV 1270 1280 1290 1300 1310 1320 TANITDSEAL ARWQPAIATV DSYVISYTGE KVPEITRTVS GNTVEYALTD LEPATEYTLR 1330 1340 1350 1360 1370 1380 IFAEKGPQKS STITAKFTTD LDSPRDLTAT EVQSETALLT WRPPRASVTG YLLVYESVDG 1390 1400 1410 1420 1430 1440 TVKEVIVGPD TTSYSLADLS PSTHYTAKIQ ALNGPLRSNM IQTIFTTIGL LYPFPKDCSQ 1450 1460 1470 1480 1490 1500 AMLNGDTTSG LYTIYLNGDK AEALEVFCDM TSDGGGWIVF LRRKNGRENF YQNWKAYAAG 1510 1520 1530 1540 1550 1560 FGDRREEFWL GLDNLNKITA QGQYELRVDL RDHGETAFAV YDKFSVGDAK TRYKLKVEGY 1570 1580 1590 1600 1610 1620 SGTAGDSMAY HNGRSFSTFD KDTDSAITNC ALSYKGAFWY RNCHRVNLMG RYGDNNHSQG 1630 1640 1650 VNWFHWKGHE HSIQFAEMKL RPSNFRNLEG RRKRA
	Isoform 6 (P31) [UniParc]. Checksum: B240934A9414ABC4	FASTA	1,564	171,360
	10 20 30 40 50 60 MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 70 80 90 100 110 120 GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 130 140 150 160 170 180 ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 190 200 210 220 230 240 KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 250 260 270 280 290 300 GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 310 320 330 340 350 360 CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 370 380 390 400 410 420 CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 430 440 450 460 470 480 GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 490 500 510 520 530 540 VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 550 560 570 580 590 600 RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 610 620 630 640 650 660 LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 670 680 690 700 710 720 EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 730 740 750 760 770 780 KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 790 800 810 820 830 840 ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 850 860 870 880 890 900 DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 910 920 930 940 950 960 RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 970 980 990 1000 1010 1020 YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1030 1040 1050 1060 1070 1080 LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TAMGSPKEVI 1090 1100 1110 1120 1130 1140 FSDITENSAT VSWRAPTAQV ESFRITYVPI TGGTPSMVTV DGTKTQTRLV KLIPGVEYLV 1150 1160 1170 1180 1190 1200 SIIAMKGFEE SEPVSGSFTT ALDGPSGLVT ANITDSEALA RWQPAIATVD SYVISYTGEK 1210 1220 1230 1240 1250 1260 VPEITRTVSG NTVEYALTDL EPATEYTLRI FAEKGPQKSS TITAKFTTDL DSPRDLTATE 1270 1280 1290 1300 1310 1320 VQSETALLTW RPPRASVTGY LLVYESVDGT VKEVIVGPDT TSYSLADLSP STHYTAKIQA 1330 1340 1350 1360 1370 1380 LNGPLRSNMI QTIFTTIGLL YPFPKDCSQA MLNGDTTSGL YTIYLNGDKA EALEVFCDMT 1390 1400 1410 1420 1430 1440 SDGGGWIVFL RRKNGRENFY QNWKAYAAGF GDRREEFWLG LDNLNKITAQ GQYELRVDLR 1450 1460 1470 1480 1490 1500 DHGETAFAVY DKFSVGDAKT RYKLKVEGYS GTAGDSMAYH NGRSFSTFDK DTDSAITNCA 1510 1520 1530 1540 1550 1560 LSYKGAFWYR NCHRVNLMGR YGDNNHSQGV NWFHWKGHEH SIQFAEMKLR PSNFRNLEGR RKRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats." Nies D.E., Hemesath T.J., Kim J.H., Gulcher J.R., Stefansson K. J. Biol. Chem. 266:2818-2823(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-539; LEU-1677 AND GLN-2008.
[2]	"Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies." Siri A., Carnemolla B., Saginati M., Leprini A., Casari G., Baralle F., Zardi L. Nucleic Acids Res. 19:525-531(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 5), PROTEIN SEQUENCE OF 23-32, VARIANTS ARG-680 AND GLN-2008. Tissue: Fetal brain and Melanoma.
[3]	"Structure of the human hexabrachion (tenascin) gene." Gulcher J.R., Nies D.E., Alexakos M.J., Ravikant N.A., Sturgill M.E., Marton L.S., Stefansson K. Proc. Natl. Acad. Sci. U.S.A. 88:9438-9442(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ARG-539; LEU-1677 AND GLN-2008.
[4]	"Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences." Gherzi R., Carnemolla B., Siri A., Ponassi M., Balza E., Zardi L. J. Biol. Chem. 270:3429-3434(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS LEU-1677 AND GLN-2008.
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes." Glumoff V., Savontaus M., Vehanen J., Vuorio E. Biochim. Biophys. Acta 1219:613-622(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-125 (ISOFORMS 1/2/3/4/5/6). Tissue: Fetal cartilage.
[7]	"An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites." Gulcher J.R., Nies D.E., Marton L.S., Stefansson K. Proc. Natl. Acad. Sci. U.S.A. 86:1588-1592(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 431-2055 (ISOFORMS 1 AND 6), VARIANTS ARG-539; LEU-1677 AND GLN-2008. Tissue: Glioblastoma.
[8]	"Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules." Burg M.A., Tillet E., Timpl R., Stallcup W.B. J. Biol. Chem. 271:26110-26116(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CSPG4.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809, MASS SPECTROMETRY. Tissue: Plasma.
[10]	"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry." Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F. Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-1079; ASN-1093; ASN-1261; ASN-1301; ASN-1485 AND ASN-2162, MASS SPECTROMETRY. Tissue: Milk.
[11]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1018; ASN-1034; ASN-1184; ASN-1275; ASN-1301; ASN-1366 AND ASN-1485, MASS SPECTROMETRY. Tissue: Liver.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein." Leahy D.J., Hendrickson W.A., Aukhil I., Erickson H.P. Science 258:987-991(1992) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF FIBRONECTIN TYPE-III 3.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M55618 mRNA. Translation: AAA88083.1.
X56160 mRNA. Translation: CAA39628.1.
X78565 mRNA. Translation: CAA55309.1.
AL162425 Genomic DNA. Translation: CAI15110.1.
X80280 mRNA. No translation available.
M24630 mRNA. Translation: AAA52703.1.

IPI

IPI00031008.
IPI00220211.
IPI00220213.
IPI00220214.
IPI00220216.
IPI01015608.

PIR

A32160. I38337.

RefSeq

NP_002151.2. NM_002160.3.

UniGene

Hs.143250.
Hs.734766.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TEN	X-ray	1.80	A	802-891	[»]
2RB8	X-ray	1.45	A	802-893	[»]
2RBL	X-ray	2.10	A/B/M	802-893	[»]

ProteinModelPortal

P24821.

SMR

P24821. Positions 94-1976, 1980-2189.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000265131.

PTM databases

PhosphoSite

P24821.

Polymorphism databases

DMDM

281185495.

Proteomic databases

PaxDb

P24821.

PRIDE

P24821.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000340094; ENSP00000344400; ENSG00000041982.
ENST00000345230; ENSP00000345861; ENSG00000041982.
ENST00000346706; ENSP00000344555; ENSG00000041982.
ENST00000350763; ENSP00000265131; ENSG00000041982.
ENST00000535648; ENSP00000438152; ENSG00000041982.
ENST00000537320; ENSP00000443478; ENSG00000041982.

GeneID

3371.

KEGG

hsa:3371.

UCSC

uc004bjj.4. human.

Organism-specific databases

CTD

3371.

GeneCards

GC09M117782.

HGNC

HGNC:5318. TNC.

HPA

CAB004592.
HPA004823.

MIM

187380. gene.

neXtProt

NX_P24821.

PharmGKB

PA35103.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG12793.

HOVERGEN

HBG008949.

InParanoid

P24821.

KO

K06252.

OMA

GQRSCPN.

OrthoDB

EOG4MSCX9.

PhylomeDB

P24821.

Enzyme and pathway databases

Pathway_Interaction_DB

syndecan_4_pathway. Syndecan-4-mediated signaling events.

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P24821.

Bgee

P24821.

CleanEx

HS_TNC.

Genevestigator

P24821.

GermOnline

ENSG00000041982. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 15 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.

InterPro

IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]

Pfam

PF07974. EGF_2. 7 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 15 hits.
PF12661. hEGF. 3 hits.
[Graphical view]

SMART

SM00181. EGF. 12 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 15 hits.
[Graphical view]

SUPFAM

SSF56496. Fibrinogen_a/b/g_C. 1 hit.
SSF49265. FN_III-like. 15 hits.

PROSITE

PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 15 hits.
PS50026. EGF_3. 5 hits.
PS00514. FIBRINOGEN_C_1. False negative.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 15 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P24821.

GenomeRNAi

3371.

NextBio

13334.

SOURCE

Search...

Entry information

Entry name

TENA_HUMAN

Accession

Primary (citable) accession number: P24821
Secondary accession number(s): C9IYT7 , C9J575, C9J6D9, C9J848, Q14583, Q15567, Q5T7S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	December 15, 2009
Last modified:	May 1, 2013
This is version 158 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.