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Protein

N-acetylmuramoyl-L-alanine amidase CwlA

Gene

cwlA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCell wall biogenesis/degradation, Competence, Sporulation

Enzyme and pathway databases

BioCyciBSUB:BSU25900-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase CwlA (EC:3.5.1.28)
Alternative name(s):
Autolysin
Cell wall hydrolase
Gene namesi
Name:cwlA
Ordered Locus Names:BSU25900
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000064532 – 272N-acetylmuramoyl-L-alanine amidase CwlAAdd BLAST271

Proteomic databases

PaxDbiP24808
PRIDEiP24808

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014171

Structurei

3D structure databases

ProteinModelPortaliP24808
SMRiP24808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105T4X Bacteria
COG3409 LUCA
COG5632 LUCA
HOGENOMiHOG000273688
InParanoidiP24808
KOiK01447
OMAiANLQSWN
PhylomeDBiP24808

Family and domain databases

CDDicd06583 PGRP, 1 hit
Gene3Di1.10.101.10, 1 hit
3.40.80.10, 1 hit
InterProiView protein in InterPro
IPR036505 Amidase/PGRP_sf
IPR002502 Amidase_domain
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PfamiView protein in Pfam
PF01510 Amidase_2, 1 hit
PF01471 PG_binding_1, 1 hit
SMARTiView protein in SMART
SM00644 Ami_2, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF55846 SSF55846, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKVVKNLV SKSKYGLKCP NPMKAEYITI HNTANDASAA NEISYMKNNS
60 70 80 90 100
SSTSFHFAVD DKQVIQGIPT NRNAWHTGDG TNGTGNRKSI GVEICYSKSG
110 120 130 140 150
GVRYKAAEKL AIKFVAQLLK ERGWGIDRVR KHQDWNGKYC PHRILSEGRW
160 170 180 190 200
IQVKTAIEAE LKKLGGKTNS SKASVAKKKT TNTSSKKTSY ALPSGIFKVK
210 220 230 240 250
SPMMRGEKVT QIQKALAALY FYPDKGAKNN GIDGVYGPKT ADAIRRFQSM
260 270
YGLTQDGIYG PKTKAKLEAL LK
Length:272
Mass (Da):29,958
Last modified:March 1, 1992 - v1
Checksum:i43B2AB1ADC1F5DFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51424 Genomic DNA Translation: CAA35788.1
M59232 Genomic DNA Translation: AAA62676.1
D32216 Genomic DNA Translation: BAA06960.1
D84432 Genomic DNA Translation: BAA12424.1
AL009126 Genomic DNA Translation: CAB14531.1
PIRiS26671 C44816
RefSeqiNP_390467.1, NC_000964.3
WP_003229946.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14531; CAB14531; BSU25900
GeneIDi937772
KEGGibsu:BSU25900
PATRICifig|224308.179.peg.2815

Similar proteinsi

Entry informationi

Entry nameiCWLA_BACSU
AccessioniPrimary (citable) accession number: P24808
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

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