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Protein

Signal transducer CD24

Gene

Cd24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a specific role to play in early thymocyte development.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • apoptotic nuclear changes Source: MGI
  • apoptotic signaling pathway Source: MGI
  • axon guidance Source: Reactome
  • B cell receptor transport into membrane raft Source: UniProtKB
  • cell activation Source: UniProtKB
  • cell migration Source: UniProtKB
  • cell surface receptor signaling pathway Source: MGI
  • chemokine receptor transport out of membrane raft Source: UniProtKB
  • cholesterol homeostasis Source: UniProtKB
  • glomerular parietal epithelial cell differentiation Source: UniProtKB
  • glomerular visceral epithelial cell differentiation Source: UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • homotypic cell-cell adhesion Source: MGI
  • immune response Source: Ensembl
  • leukocyte cell-cell adhesion Source: MGI
  • leukocyte migration involved in inflammatory response Source: MGI
  • negative regulation of B cell proliferation Source: MGI
  • negative regulation of erythrocyte aggregation Source: MGI
  • negative regulation of erythrocyte clearance Source: MGI
  • negative regulation of neuroblast proliferation Source: MGI
  • negative regulation of neurogenesis Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of T cell homeostatic proliferation Source: MGI
  • negative regulation of transforming growth factor beta3 production Source: UniProtKB
  • neuromuscular synaptic transmission Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of alpha-beta T cell proliferation Source: MGI
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of cell adhesion mediated by integrin Source: MGI
  • positive regulation of cell-cell adhesion Source: MGI
  • positive regulation of cell-cell adhesion mediated by integrin Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of inflammatory response to antigenic stimulus Source: MGI
  • positive regulation of integrin activation Source: MGI
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  • positive regulation of neuron projection development Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of T cell homeostatic proliferation Source: MGI
  • positive regulation of T cell mediated immune response to tumor cell Source: MGI
  • pre-B cell differentiation Source: MGI
  • regulation of B cell differentiation Source: MGI
  • regulation of cell-cell adhesion Source: MGI
  • regulation of cell-cell adhesion mediated by integrin Source: MGI
  • regulation of cytokine-mediated signaling pathway Source: UniProtKB
  • regulation of MAPK cascade Source: UniProtKB
  • regulation of phosphorylation Source: UniProtKB
  • respiratory burst Source: UniProtKB
  • response to estrogen Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • synaptic vesicle endocytosis Source: MGI
  • T cell costimulation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Lymphocyte antigen 52
Short name:
Ly-52
M1/69-J11D heat stable antigen
Short name:
HSA
Nectadrin
R13-Ag
X62 heat stable antigen
CD_antigen: CD24
Gene namesi
Name:Cd24
Synonyms:Cd24a, Ly-52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88323. Cd24a.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: MGI
  • cell surface Source: MGI
  • ciliary membrane Source: MGI
  • external side of plasma membrane Source: MGI
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • microvillus membrane Source: MGI
  • plasma membrane Source: MGI
  • synapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
PeptideiPRO_000002089527 – 53Signal transducer CD24Add BLAST27
PropeptideiPRO_000002089654 – 76Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)1 Publication1
Glycosylationi30O-linked (GalNAc...)1 Publication1
Glycosylationi39N-linked (GlcNAc...)1 Publication1
Glycosylationi41O-linked (GalNAc...); partial1 Publication1
Glycosylationi43O-linked (GalNAc...); partial1 Publication1
Glycosylationi48N-linked (GlcNAc...)1 Publication1
Glycosylationi51O-linked (GalNAc...); partial1 Publication1
Lipidationi53GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

The identity of the N- and O-linked polysaccharides are not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei45Not glycosylated1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP24807.
PRIDEiP24807.

Expressioni

Tissue specificityi

In lymphoid, myeloid, and erythroid cells.

Gene expression databases

BgeeiENSMUSG00000047139.
CleanExiMM_CD24A.
ExpressionAtlasiP24807. baseline and differential.
GenevisibleiP24807. MM.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057983.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
GeneTreeiENSGT00390000018829.
HOVERGENiHBG005274.
InParanoidiP24807.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG091G1CCU.
PhylomeDBiP24807.
TreeFamiTF338512.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAMVARLG LGLLLLALLL PTQIYCNQTS VAPFPGNQNI SASPNPSNAT
60 70
TRGGGSSLQS TAGLLALSLS LLHLYC
Length:76
Mass (Da):7,797
Last modified:March 1, 1992 - v1
Checksum:i6853F121B33625EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58661 mRNA. Translation: AAA39481.1.
X56469 Genomic DNA. Translation: CAA39841.1.
X72910 Genomic DNA. Translation: CAA51415.1.
X53825 mRNA. Translation: CAA37822.1.
BC075622 mRNA. Translation: AAH75622.1.
CCDSiCCDS23821.1.
PIRiA43537.
RefSeqiNP_033976.1. NM_009846.2.
UniGeneiMm.29742.

Genome annotation databases

EnsembliENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139.
GeneIDi12484.
KEGGimmu:12484.
UCSCiuc007ezl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58661 mRNA. Translation: AAA39481.1.
X56469 Genomic DNA. Translation: CAA39841.1.
X72910 Genomic DNA. Translation: CAA51415.1.
X53825 mRNA. Translation: CAA37822.1.
BC075622 mRNA. Translation: AAH75622.1.
CCDSiCCDS23821.1.
PIRiA43537.
RefSeqiNP_033976.1. NM_009846.2.
UniGeneiMm.29742.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057983.

Proteomic databases

PaxDbiP24807.
PRIDEiP24807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139.
GeneIDi12484.
KEGGimmu:12484.
UCSCiuc007ezl.1. mouse.

Organism-specific databases

CTDi12484.
MGIiMGI:88323. Cd24a.

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
GeneTreeiENSGT00390000018829.
HOVERGENiHBG005274.
InParanoidiP24807.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG091G1CCU.
PhylomeDBiP24807.
TreeFamiTF338512.

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Miscellaneous databases

PROiP24807.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047139.
CleanExiMM_CD24A.
ExpressionAtlasiP24807. baseline and differential.
GenevisibleiP24807. MM.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD24_MOUSE
AccessioniPrimary (citable) accession number: P24807
Secondary accession number(s): P26691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 5, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.