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Protein

Signal transducer CD24

Gene

Cd24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a specific role to play in early thymocyte development.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • apoptotic nuclear changes Source: MGI
  • apoptotic signaling pathway Source: MGI
  • axon guidance Source: Reactome
  • B cell receptor transport into membrane raft Source: UniProtKB
  • cell activation Source: UniProtKB
  • cell migration Source: UniProtKB
  • cell surface receptor signaling pathway Source: MGI
  • chemokine receptor transport out of membrane raft Source: UniProtKB
  • cholesterol homeostasis Source: UniProtKB
  • glomerular parietal epithelial cell differentiation Source: UniProtKB
  • glomerular visceral epithelial cell differentiation Source: UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • homotypic cell-cell adhesion Source: MGI
  • immune response Source: Ensembl
  • leukocyte cell-cell adhesion Source: MGI
  • leukocyte migration involved in inflammatory response Source: MGI
  • negative regulation of B cell proliferation Source: MGI
  • negative regulation of erythrocyte aggregation Source: MGI
  • negative regulation of erythrocyte clearance Source: MGI
  • negative regulation of neuroblast proliferation Source: MGI
  • negative regulation of neurogenesis Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of T cell homeostatic proliferation Source: MGI
  • negative regulation of transforming growth factor beta3 production Source: UniProtKB
  • neuromuscular synaptic transmission Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of alpha-beta T cell proliferation Source: MGI
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of cell adhesion mediated by integrin Source: MGI
  • positive regulation of cell-cell adhesion Source: MGI
  • positive regulation of cell-cell adhesion mediated by integrin Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of inflammatory response to antigenic stimulus Source: MGI
  • positive regulation of integrin activation Source: MGI
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  • positive regulation of neuron projection development Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of protein tyrosine kinase activity Source: GOC
  • positive regulation of T cell homeostatic proliferation Source: MGI
  • positive regulation of T cell mediated immune response to tumor cell Source: MGI
  • pre-B cell differentiation Source: MGI
  • regulation of B cell differentiation Source: MGI
  • regulation of cell-cell adhesion Source: MGI
  • regulation of cell-cell adhesion mediated by integrin Source: MGI
  • regulation of cytokine-mediated signaling pathway Source: UniProtKB
  • regulation of MAPK cascade Source: UniProtKB
  • regulation of phosphorylation Source: UniProtKB
  • respiratory burst Source: UniProtKB
  • response to estrogen Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • synaptic vesicle endocytosis Source: MGI
  • T cell costimulation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Lymphocyte antigen 52
Short name:
Ly-52
M1/69-J11D heat stable antigen
Short name:
HSA
Nectadrin
R13-Ag
X62 heat stable antigen
CD_antigen: CD24
Gene namesi
Name:Cd24
Synonyms:Cd24a, Ly-52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88323. Cd24a.

Subcellular locationi

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: MGI
  • cell surface Source: MGI
  • ciliary membrane Source: MGI
  • cytosol Source: GOC
  • external side of plasma membrane Source: MGI
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • microvillus membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Peptidei27 – 5327Signal transducer CD24PRO_0000020895Add
BLAST
Propeptidei54 – 7623Removed in mature formSequence analysisPRO_0000020896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)1 Publication
Glycosylationi30 – 301O-linked (GalNAc...)1 Publication
Glycosylationi39 – 391N-linked (GlcNAc...)1 Publication
Glycosylationi41 – 411O-linked (GalNAc...); partial1 Publication
Glycosylationi43 – 431O-linked (GalNAc...); partial1 Publication
Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication
Glycosylationi51 – 511O-linked (GalNAc...); partial1 Publication
Lipidationi53 – 531GPI-anchor amidated glycineSequence analysis

Post-translational modificationi

The identity of the N- and O-linked polysaccharides are not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei45 – 451Not glycosylated

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP24807.

Expressioni

Tissue specificityi

In lymphoid, myeloid, and erythroid cells.

Gene expression databases

BgeeiP24807.
CleanExiMM_CD24A.
ExpressionAtlasiP24807. baseline and differential.
GenevisibleiP24807. MM.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057983.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
HOVERGENiHBG005274.
InParanoidiP24807.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG7F515H.
PhylomeDBiP24807.
TreeFamiTF338512.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAMVARLG LGLLLLALLL PTQIYCNQTS VAPFPGNQNI SASPNPSNAT
60 70
TRGGGSSLQS TAGLLALSLS LLHLYC
Length:76
Mass (Da):7,797
Last modified:March 1, 1992 - v1
Checksum:i6853F121B33625EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58661 mRNA. Translation: AAA39481.1.
X56469 Genomic DNA. Translation: CAA39841.1.
X72910 Genomic DNA. Translation: CAA51415.1.
X53825 mRNA. Translation: CAA37822.1.
BC075622 mRNA. Translation: AAH75622.1.
CCDSiCCDS23821.1.
PIRiA43537.
RefSeqiNP_033976.1. NM_009846.2.
UniGeneiMm.29742.

Genome annotation databases

EnsembliENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139.
GeneIDi12484.
KEGGimmu:12484.
UCSCiuc007ezl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58661 mRNA. Translation: AAA39481.1.
X56469 Genomic DNA. Translation: CAA39841.1.
X72910 Genomic DNA. Translation: CAA51415.1.
X53825 mRNA. Translation: CAA37822.1.
BC075622 mRNA. Translation: AAH75622.1.
CCDSiCCDS23821.1.
PIRiA43537.
RefSeqiNP_033976.1. NM_009846.2.
UniGeneiMm.29742.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057983.

Proteomic databases

PaxDbiP24807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139.
GeneIDi12484.
KEGGimmu:12484.
UCSCiuc007ezl.1. mouse.

Organism-specific databases

CTDi12484.
MGIiMGI:88323. Cd24a.

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
HOVERGENiHBG005274.
InParanoidiP24807.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG7F515H.
PhylomeDBiP24807.
TreeFamiTF338512.

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Miscellaneous databases

PROiP24807.
SOURCEiSearch...

Gene expression databases

BgeeiP24807.
CleanExiMM_CD24A.
ExpressionAtlasiP24807. baseline and differential.
GenevisibleiP24807. MM.

Family and domain databases

InterProiIPR028029. CD24.
[Graphical view]
PfamiPF14984. CD24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens."
    Kay R., Takei F., Humphries R.K.
    J. Immunol. 145:1952-1959(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genes for a mouse hematopoietic differentiation marker called the heat-stable antigen."
    Wenger R.H., Ayane M., Bose R., Koehler G., Nielsen P.J.
    Eur. J. Immunol. 21:1039-1046(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6 X CBA and Swiss albino X BALB/c.
    Tissue: Spleen.
  3. Nielsen P.J.
    Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter."
    Wenger R.H., Rochelle J.M., Seldin M.F., Koehler G., Nielsen P.J.
    J. Biol. Chem. 268:23345-23352(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6 X CBA.
    Tissue: Spleen.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  6. Cited for: PROTEIN SEQUENCE OF 27-53, GLYCOSYLATION AT ASN-27; SER-30; ASN-39; SER-41; SER-43; ASN-48 AND THR-51.
    Strain: C57BL/6J.

Entry informationi

Entry nameiCD24_MOUSE
AccessioniPrimary (citable) accession number: P24807
Secondary accession number(s): P26691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.