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Protein

Signal transducer CD24

Gene

Cd24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (By similarity). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983). Plays a role in the control of autoimmunity (PubMed:20200274).By similarity2 Publications

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • apoptotic nuclear changes Source: MGI
  • apoptotic signaling pathway Source: MGI
  • axon guidance Source: Reactome
  • B cell receptor transport into membrane raft Source: UniProtKB
  • cell activation Source: UniProtKB
  • cell migration Source: UniProtKB
  • cell surface receptor signaling pathway Source: MGI
  • chemokine receptor transport out of membrane raft Source: UniProtKB
  • cholesterol homeostasis Source: UniProtKB
  • glomerular parietal epithelial cell differentiation Source: UniProtKB
  • glomerular visceral epithelial cell differentiation Source: UniProtKB
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • homotypic cell-cell adhesion Source: MGI
  • innate immune response Source: UniProtKB-KW
  • leukocyte cell-cell adhesion Source: MGI
  • leukocyte migration involved in inflammatory response Source: MGI
  • negative regulation of B cell proliferation Source: MGI
  • negative regulation of erythrocyte aggregation Source: MGI
  • negative regulation of erythrocyte clearance Source: MGI
  • negative regulation of neuroblast proliferation Source: MGI
  • negative regulation of neurogenesis Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of T cell homeostatic proliferation Source: MGI
  • negative regulation of transforming growth factor beta3 production Source: UniProtKB
  • neuromuscular synaptic transmission Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of alpha-beta T cell proliferation Source: MGI
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of calcium-mediated signaling Source: MGI
  • positive regulation of cell adhesion mediated by integrin Source: MGI
  • positive regulation of cell-cell adhesion Source: MGI
  • positive regulation of cell-cell adhesion mediated by integrin Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of inflammatory response to antigenic stimulus Source: MGI
  • positive regulation of integrin activation Source: MGI
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  • positive regulation of neuron projection development Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of T cell homeostatic proliferation Source: MGI
  • positive regulation of T cell mediated immune response to tumor cell Source: MGI
  • pre-B cell differentiation Source: MGI
  • regulation of B cell differentiation Source: MGI
  • regulation of cell-cell adhesion Source: MGI
  • regulation of cell-cell adhesion mediated by integrin Source: MGI
  • regulation of cytokine-mediated signaling pathway Source: UniProtKB
  • regulation of MAPK cascade Source: UniProtKB
  • regulation of phosphorylation Source: UniProtKB
  • respiratory burst Source: UniProtKB
  • response to estrogen Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • synaptic vesicle endocytosis Source: MGI
  • T cell costimulation Source: UniProtKB

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Lymphocyte antigen 52
Short name:
Ly-52
M1/69-J11D heat stable antigen
Short name:
HSA
Nectadrin
R13-Ag
X62 heat stable antigen
CD_antigen: CD24
Gene namesi
Name:Cd24
Synonyms:Cd24a, Ly-52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88323. Cd24a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cd22/Siglec10 double-deficient mice develop autoimmune disease, which is not observed in single-deficient mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
PeptideiPRO_000002089527 – 53Signal transducer CD24Add BLAST27
PropeptideiPRO_000002089654 – 76Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi30O-linked (GalNAc...) serine1 Publication1
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi41O-linked (GalNAc...) serine; partial1 Publication1
Glycosylationi43O-linked (GalNAc...) serine; partial1 Publication1
Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi51O-linked (GalNAc...) threonine; partial1 Publication1
Lipidationi53GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

The identity of the N- and O-linked polysaccharides are not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei45Not glycosylated1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP24807.
PRIDEiP24807.

Expressioni

Tissue specificityi

In lymphoid, myeloid, and erythroid cells.

Gene expression databases

BgeeiENSMUSG00000047139.
CleanExiMM_CD24A.
ExpressionAtlasiP24807. baseline and differential.
GenevisibleiP24807. MM.

Interactioni

Subunit structurei

Interacts with SIGLEC10; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057983.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JF9E. Eukaryota.
ENOG4111B8V. LUCA.
GeneTreeiENSGT00390000018829.
HOVERGENiHBG005274.
InParanoidiP24807.
KOiK06469.
OMAiQTSVAPF.
OrthoDBiEOG091G1CCU.
PhylomeDBiP24807.
TreeFamiTF338512.

Family and domain databases

InterProiView protein in InterPro
IPR028029. CD24.
PfamiView protein in Pfam
PF14984. CD24. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAMVARLG LGLLLLALLL PTQIYCNQTS VAPFPGNQNI SASPNPSNAT
60 70
TRGGGSSLQS TAGLLALSLS LLHLYC
Length:76
Mass (Da):7,797
Last modified:March 1, 1992 - v1
Checksum:i6853F121B33625EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58661 mRNA. Translation: AAA39481.1.
X56469 Genomic DNA. Translation: CAA39841.1.
X72910 Genomic DNA. Translation: CAA51415.1.
X53825 mRNA. Translation: CAA37822.1.
BC075622 mRNA. Translation: AAH75622.1.
CCDSiCCDS23821.1.
PIRiA43537.
RefSeqiNP_033976.1. NM_009846.2.
UniGeneiMm.29742.

Genome annotation databases

EnsembliENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139.
GeneIDi12484.
KEGGimmu:12484.
UCSCiuc007ezl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCD24_MOUSE
AccessioniPrimary (citable) accession number: P24807
Secondary accession number(s): P26691
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 27, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families