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P24798

- AT1A3_CHICK

UniProt

P24798 - AT1A3_CHICK

Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

ATP1A3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei363 – 36314-aspartylphosphate intermediateBy similarity
    Metal bindingi704 – 7041MagnesiumBy similarity
    Metal bindingi708 – 7081MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. sodium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-3 subunit
    Alternative name(s):
    Na(+)/K(+) ATPase alpha(III) subunit
    Sodium pump subunit alpha-3
    Gene namesi
    Name:ATP1A3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB
    5. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10101010Sodium/potassium-transporting ATPase subunit alpha-3PRO_0000046301Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei930 – 9301Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP24798.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP24798.
    SMRiP24798. Positions 13-1010.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 11823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 275136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 30712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 759434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini780 – 78910ExtracellularSequence Analysis
    Topological domaini811 – 83020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini854 – 90552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini926 – 93813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini958 – 97215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini994 – 101017CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei760 – 77920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei790 – 81021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei831 – 85323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei906 – 92520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei939 – 95719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei973 – 99321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 713Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004298.
    KOiK01539.
    PhylomeDBiP24798.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24798-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDKGEKESP KKGKGKRDLD DLKKEVAMTE HKMSIEEVCR KYNTDCVQGL     50
    THSKAQEILA RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWIGAILCFL 100
    AYGIQAGTED EPSNDNLYLG IVLAAVVIIT GCFSYYQEAK SSKIMESFKN 150
    MVPQQALVIR EGEKMQLNAE EVVVGDLVEV KGGDRVPADL RIISAHGCKV 200
    DNSSLTGESE PQTRSPDCTH DNPLETRNIT FFSTNCVEGT ARGVVIATGD 250
    RTVMGRIATL ASGLEVGKTP IAVEIEHFIQ LITGVAVFLG ISFFVLSLIL 300
    GYTWLEAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAR KNCLVKNLEA 350
    VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGTSFDK 400
    SSATWVALSH IAGLCNRAVF KGGQENVPIL KRDVAGDASE SALLKCIELS 450
    SGSVKVMRER NKKVAEIPFN STNKYQLSIH ETEDPNDNRY LLVMKGAPER 500
    ILDRCSTILL QGKEQPLDEE MKEAFQNAYL ELGGLGERVL GFCHFYLPEE 550
    QYPKGFAFDC DDVNFATDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV 600
    IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC 650
    VIHGTDLKDM SSEQIDEILQ NHTEIVFART SPQQKLIIVE GCQRQGAIVA 700
    VTGDGVNDSP ALKKADIGVA MGIRGSDVSK QAADMILLDD NFASIVTGVE 750
    EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IMANIPLPLG TITILCIDLG 800
    TDMVPAISLA YEAAESDIMK RQPRNPRSDK LVNERLISMA YGQIGMIQAL 850
    GGFFSYFVIL AENGFLPSCL VGIRLSWDDR TINDLEDSYG QQWTYEQRKV 900
    VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA 950
    LAAFLSYCPG MDVALRMYPL KPSWWFCAFP YSFLIFVYDE IRKLILRRNP 1000
    GGWVEKETYY 1010
    Length:1,010
    Mass (Da):111,284
    Last modified:March 1, 1992 - v1
    Checksum:i71526BC25633BFA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59960 mRNA. Translation: AAA48982.1.
    PIRiB37227.
    RefSeqiNP_990806.1. NM_205475.1.
    UniGeneiGga.838.

    Genome annotation databases

    GeneIDi396467.
    KEGGigga:396467.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59960 mRNA. Translation: AAA48982.1 .
    PIRi B37227.
    RefSeqi NP_990806.1. NM_205475.1.
    UniGenei Gga.838.

    3D structure databases

    ProteinModelPortali P24798.
    SMRi P24798. Positions 13-1010.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P24798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396467.
    KEGGi gga:396467.

    Organism-specific databases

    CTDi 478.

    Phylogenomic databases

    HOVERGENi HBG004298.
    KOi K01539.
    PhylomeDBi P24798.

    Miscellaneous databases

    NextBioi 20816506.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution."
      Takeyasu K., Lemas V., Fambrough D.M.
      Am. J. Physiol. 259:C619-C630(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAT1A3_CHICK
    AccessioniPrimary (citable) accession number: P24798
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3