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Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

ATP1A3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3634-aspartylphosphate intermediateBy similarity1
Metal bindingi704MagnesiumBy similarity1
Metal bindingi708MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:ATP1A3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 118ExtracellularSequence analysisAdd BLAST23
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 275CytoplasmicSequence analysisAdd BLAST136
Transmembranei276 – 295HelicalSequence analysisAdd BLAST20
Topological domaini296 – 307ExtracellularSequence analysisAdd BLAST12
Transmembranei308 – 325HelicalSequence analysisAdd BLAST18
Topological domaini326 – 759CytoplasmicSequence analysisAdd BLAST434
Transmembranei760 – 779HelicalSequence analysisAdd BLAST20
Topological domaini780 – 789ExtracellularSequence analysis10
Transmembranei790 – 810HelicalSequence analysisAdd BLAST21
Topological domaini811 – 830CytoplasmicSequence analysisAdd BLAST20
Transmembranei831 – 853HelicalSequence analysisAdd BLAST23
Topological domaini854 – 905ExtracellularSequence analysisAdd BLAST52
Transmembranei906 – 925HelicalSequence analysisAdd BLAST20
Topological domaini926 – 938CytoplasmicSequence analysisAdd BLAST13
Transmembranei939 – 957HelicalSequence analysisAdd BLAST19
Topological domaini958 – 972ExtracellularSequence analysisAdd BLAST15
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Topological domaini994 – 1010CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463011 – 1010Sodium/potassium-transporting ATPase subunit alpha-3Add BLAST1010

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei930Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24798.

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated

Structurei

3D structure databases

ProteinModelPortaliP24798.
SMRiP24798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 71Interaction with phosphoinositide-3 kinaseBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
InParanoidiP24798.
KOiK01539.
PhylomeDBiP24798.

Family and domain databases

CDDicd02608. P-type_ATPase_Na-K_like. 1 hit.
Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

P24798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKGEKESP KKGKGKRDLD DLKKEVAMTE HKMSIEEVCR KYNTDCVQGL
60 70 80 90 100
THSKAQEILA RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWIGAILCFL
110 120 130 140 150
AYGIQAGTED EPSNDNLYLG IVLAAVVIIT GCFSYYQEAK SSKIMESFKN
160 170 180 190 200
MVPQQALVIR EGEKMQLNAE EVVVGDLVEV KGGDRVPADL RIISAHGCKV
210 220 230 240 250
DNSSLTGESE PQTRSPDCTH DNPLETRNIT FFSTNCVEGT ARGVVIATGD
260 270 280 290 300
RTVMGRIATL ASGLEVGKTP IAVEIEHFIQ LITGVAVFLG ISFFVLSLIL
310 320 330 340 350
GYTWLEAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAR KNCLVKNLEA
360 370 380 390 400
VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGTSFDK
410 420 430 440 450
SSATWVALSH IAGLCNRAVF KGGQENVPIL KRDVAGDASE SALLKCIELS
460 470 480 490 500
SGSVKVMRER NKKVAEIPFN STNKYQLSIH ETEDPNDNRY LLVMKGAPER
510 520 530 540 550
ILDRCSTILL QGKEQPLDEE MKEAFQNAYL ELGGLGERVL GFCHFYLPEE
560 570 580 590 600
QYPKGFAFDC DDVNFATDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV
610 620 630 640 650
IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC
660 670 680 690 700
VIHGTDLKDM SSEQIDEILQ NHTEIVFART SPQQKLIIVE GCQRQGAIVA
710 720 730 740 750
VTGDGVNDSP ALKKADIGVA MGIRGSDVSK QAADMILLDD NFASIVTGVE
760 770 780 790 800
EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IMANIPLPLG TITILCIDLG
810 820 830 840 850
TDMVPAISLA YEAAESDIMK RQPRNPRSDK LVNERLISMA YGQIGMIQAL
860 870 880 890 900
GGFFSYFVIL AENGFLPSCL VGIRLSWDDR TINDLEDSYG QQWTYEQRKV
910 920 930 940 950
VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA
960 970 980 990 1000
LAAFLSYCPG MDVALRMYPL KPSWWFCAFP YSFLIFVYDE IRKLILRRNP
1010
GGWVEKETYY
Length:1,010
Mass (Da):111,284
Last modified:March 1, 1992 - v1
Checksum:i71526BC25633BFA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59960 mRNA. Translation: AAA48982.1.
PIRiB37227.
RefSeqiNP_990806.1. NM_205475.1.
UniGeneiGga.838.

Genome annotation databases

GeneIDi396467.
KEGGigga:396467.

Similar proteinsi

Entry informationi

Entry nameiAT1A3_CHICK
AccessioniPrimary (citable) accession number: P24798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 22, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families