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P24798

- AT1A3_CHICK

UniProt

P24798 - AT1A3_CHICK

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Protein
Sodium/potassium-transporting ATPase subunit alpha-3
Gene
ATP1A3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 36314-aspartylphosphate intermediate By similarity
Metal bindingi704 – 7041Magnesium By similarity
Metal bindingi708 – 7081Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:ATP1A3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Reviewed prediction
Add
BLAST
Topological domaini96 – 11823Extracellular Reviewed prediction
Add
BLAST
Transmembranei119 – 13921Helical; Reviewed prediction
Add
BLAST
Topological domaini140 – 275136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei276 – 29520Helical; Reviewed prediction
Add
BLAST
Topological domaini296 – 30712Extracellular Reviewed prediction
Add
BLAST
Transmembranei308 – 32518Helical; Reviewed prediction
Add
BLAST
Topological domaini326 – 759434Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei760 – 77920Helical; Reviewed prediction
Add
BLAST
Topological domaini780 – 78910Extracellular Reviewed prediction
Transmembranei790 – 81021Helical; Reviewed prediction
Add
BLAST
Topological domaini811 – 83020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei831 – 85323Helical; Reviewed prediction
Add
BLAST
Topological domaini854 – 90552Extracellular Reviewed prediction
Add
BLAST
Transmembranei906 – 92520Helical; Reviewed prediction
Add
BLAST
Topological domaini926 – 93813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei939 – 95719Helical; Reviewed prediction
Add
BLAST
Topological domaini958 – 97215Extracellular Reviewed prediction
Add
BLAST
Transmembranei973 – 99321Helical; Reviewed prediction
Add
BLAST
Topological domaini994 – 101017Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
  5. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10101010Sodium/potassium-transporting ATPase subunit alpha-3
PRO_0000046301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei930 – 9301Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24798.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP24798.
SMRiP24798. Positions 13-1010.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 713Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
KOiK01539.
PhylomeDBiP24798.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24798-1 [UniParc]FASTAAdd to Basket

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MGDKGEKESP KKGKGKRDLD DLKKEVAMTE HKMSIEEVCR KYNTDCVQGL     50
THSKAQEILA RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWIGAILCFL 100
AYGIQAGTED EPSNDNLYLG IVLAAVVIIT GCFSYYQEAK SSKIMESFKN 150
MVPQQALVIR EGEKMQLNAE EVVVGDLVEV KGGDRVPADL RIISAHGCKV 200
DNSSLTGESE PQTRSPDCTH DNPLETRNIT FFSTNCVEGT ARGVVIATGD 250
RTVMGRIATL ASGLEVGKTP IAVEIEHFIQ LITGVAVFLG ISFFVLSLIL 300
GYTWLEAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAR KNCLVKNLEA 350
VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGTSFDK 400
SSATWVALSH IAGLCNRAVF KGGQENVPIL KRDVAGDASE SALLKCIELS 450
SGSVKVMRER NKKVAEIPFN STNKYQLSIH ETEDPNDNRY LLVMKGAPER 500
ILDRCSTILL QGKEQPLDEE MKEAFQNAYL ELGGLGERVL GFCHFYLPEE 550
QYPKGFAFDC DDVNFATDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV 600
IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC 650
VIHGTDLKDM SSEQIDEILQ NHTEIVFART SPQQKLIIVE GCQRQGAIVA 700
VTGDGVNDSP ALKKADIGVA MGIRGSDVSK QAADMILLDD NFASIVTGVE 750
EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IMANIPLPLG TITILCIDLG 800
TDMVPAISLA YEAAESDIMK RQPRNPRSDK LVNERLISMA YGQIGMIQAL 850
GGFFSYFVIL AENGFLPSCL VGIRLSWDDR TINDLEDSYG QQWTYEQRKV 900
VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA 950
LAAFLSYCPG MDVALRMYPL KPSWWFCAFP YSFLIFVYDE IRKLILRRNP 1000
GGWVEKETYY 1010
Length:1,010
Mass (Da):111,284
Last modified:March 1, 1992 - v1
Checksum:i71526BC25633BFA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59960 mRNA. Translation: AAA48982.1.
PIRiB37227.
RefSeqiNP_990806.1. NM_205475.1.
UniGeneiGga.838.

Genome annotation databases

GeneIDi396467.
KEGGigga:396467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59960 mRNA. Translation: AAA48982.1 .
PIRi B37227.
RefSeqi NP_990806.1. NM_205475.1.
UniGenei Gga.838.

3D structure databases

ProteinModelPortali P24798.
SMRi P24798. Positions 13-1010.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396467.
KEGGi gga:396467.

Organism-specific databases

CTDi 478.

Phylogenomic databases

HOVERGENi HBG004298.
KOi K01539.
PhylomeDBi P24798.

Miscellaneous databases

NextBioi 20816506.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution."
    Takeyasu K., Lemas V., Fambrough D.M.
    Am. J. Physiol. 259:C619-C630(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A3_CHICK
AccessioniPrimary (citable) accession number: P24798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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