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P24798

- AT1A3_CHICK

UniProt

P24798 - AT1A3_CHICK

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Protein

Sodium/potassium-transporting ATPase subunit alpha-3

Gene

ATP1A3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 36314-aspartylphosphate intermediateBy similarity
Metal bindingi704 – 7041MagnesiumBy similarity
Metal bindingi708 – 7081MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-3 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-3 subunit
Alternative name(s):
Na(+)/K(+) ATPase alpha(III) subunit
Sodium pump subunit alpha-3
Gene namesi
Name:ATP1A3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
  5. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10101010Sodium/potassium-transporting ATPase subunit alpha-3PRO_0000046301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei930 – 9301Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24798.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP24798.
SMRiP24798. Positions 13-1010.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini96 – 11823ExtracellularSequence AnalysisAdd
BLAST
Topological domaini140 – 275136CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini296 – 30712ExtracellularSequence AnalysisAdd
BLAST
Topological domaini326 – 759434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini780 – 78910ExtracellularSequence Analysis
Topological domaini811 – 83020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini854 – 90552ExtracellularSequence AnalysisAdd
BLAST
Topological domaini926 – 93813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini958 – 97215ExtracellularSequence AnalysisAdd
BLAST
Topological domaini994 – 101017CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei276 – 29520HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32518HelicalSequence AnalysisAdd
BLAST
Transmembranei760 – 77920HelicalSequence AnalysisAdd
BLAST
Transmembranei790 – 81021HelicalSequence AnalysisAdd
BLAST
Transmembranei831 – 85323HelicalSequence AnalysisAdd
BLAST
Transmembranei906 – 92520HelicalSequence AnalysisAdd
BLAST
Transmembranei939 – 95719HelicalSequence AnalysisAdd
BLAST
Transmembranei973 – 99321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 713Interaction with phosphoinositide-3 kinaseBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
InParanoidiP24798.
KOiK01539.
PhylomeDBiP24798.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24798-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDKGEKESP KKGKGKRDLD DLKKEVAMTE HKMSIEEVCR KYNTDCVQGL
60 70 80 90 100
THSKAQEILA RDGPNALTPP PTTPEWVKFC RQLFGGFSIL LWIGAILCFL
110 120 130 140 150
AYGIQAGTED EPSNDNLYLG IVLAAVVIIT GCFSYYQEAK SSKIMESFKN
160 170 180 190 200
MVPQQALVIR EGEKMQLNAE EVVVGDLVEV KGGDRVPADL RIISAHGCKV
210 220 230 240 250
DNSSLTGESE PQTRSPDCTH DNPLETRNIT FFSTNCVEGT ARGVVIATGD
260 270 280 290 300
RTVMGRIATL ASGLEVGKTP IAVEIEHFIQ LITGVAVFLG ISFFVLSLIL
310 320 330 340 350
GYTWLEAVIF LIGIIVANVP EGLLATVTVC LTLTAKRMAR KNCLVKNLEA
360 370 380 390 400
VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIHEADTT EDQSGTSFDK
410 420 430 440 450
SSATWVALSH IAGLCNRAVF KGGQENVPIL KRDVAGDASE SALLKCIELS
460 470 480 490 500
SGSVKVMRER NKKVAEIPFN STNKYQLSIH ETEDPNDNRY LLVMKGAPER
510 520 530 540 550
ILDRCSTILL QGKEQPLDEE MKEAFQNAYL ELGGLGERVL GFCHFYLPEE
560 570 580 590 600
QYPKGFAFDC DDVNFATDNL CFVGLMSMID PPRAAVPDAV GKCRSAGIKV
610 620 630 640 650
IMVTGDHPIT AKAIAKGVGI ISEGNETVED IAARLNIPVS QVNPRDAKAC
660 670 680 690 700
VIHGTDLKDM SSEQIDEILQ NHTEIVFART SPQQKLIIVE GCQRQGAIVA
710 720 730 740 750
VTGDGVNDSP ALKKADIGVA MGIRGSDVSK QAADMILLDD NFASIVTGVE
760 770 780 790 800
EGRLIFDNLK KSIAYTLTSN IPEITPFLLF IMANIPLPLG TITILCIDLG
810 820 830 840 850
TDMVPAISLA YEAAESDIMK RQPRNPRSDK LVNERLISMA YGQIGMIQAL
860 870 880 890 900
GGFFSYFVIL AENGFLPSCL VGIRLSWDDR TINDLEDSYG QQWTYEQRKV
910 920 930 940 950
VEFTCHTAFF VSIVVVQWAD LIICKTRRNS VFQQGMKNKI LIFGLFEETA
960 970 980 990 1000
LAAFLSYCPG MDVALRMYPL KPSWWFCAFP YSFLIFVYDE IRKLILRRNP
1010
GGWVEKETYY
Length:1,010
Mass (Da):111,284
Last modified:March 1, 1992 - v1
Checksum:i71526BC25633BFA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59960 mRNA. Translation: AAA48982.1.
PIRiB37227.
RefSeqiNP_990806.1. NM_205475.1.
UniGeneiGga.838.

Genome annotation databases

GeneIDi396467.
KEGGigga:396467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59960 mRNA. Translation: AAA48982.1 .
PIRi B37227.
RefSeqi NP_990806.1. NM_205475.1.
UniGenei Gga.838.

3D structure databases

ProteinModelPortali P24798.
SMRi P24798. Positions 13-1010.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396467.
KEGGi gga:396467.

Organism-specific databases

CTDi 478.

Phylogenomic databases

HOVERGENi HBG004298.
InParanoidi P24798.
KOi K01539.
PhylomeDBi P24798.

Miscellaneous databases

NextBioi 20816506.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution."
    Takeyasu K., Lemas V., Fambrough D.M.
    Am. J. Physiol. 259:C619-C630(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A3_CHICK
AccessioniPrimary (citable) accession number: P24798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3