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P24797

- AT1A2_CHICK

UniProt

P24797 - AT1A2_CHICK

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Protein

Sodium/potassium-transporting ATPase subunit alpha-2

Gene

ATP1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei371 – 37114-aspartylphosphate intermediateBy similarity
Binding sitei502 – 5021ATPBy similarity
Metal bindingi711 – 7111MagnesiumBy similarity
Metal bindingi715 – 7151MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. neurotransmitter uptake Source: AgBase
  3. regulation of striated muscle contraction Source: AgBase
  4. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-2 subunit
Alternative name(s):
Sodium pump subunit alpha-2
Gene namesi
Name:ATP1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10171017Sodium/potassium-transporting ATPase subunit alpha-2PRO_0000046297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei937 – 9371Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24797.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP24797.
SMRiP24797. Positions 22-1017.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini104 – 12623ExtracellularSequence AnalysisAdd
BLAST
Topological domaini148 – 283136CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini304 – 31512ExtracellularSequence AnalysisAdd
BLAST
Topological domaini334 – 766433CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini787 – 79610ExtracellularSequence Analysis
Topological domaini818 – 83720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini861 – 91252ExtracellularSequence AnalysisAdd
BLAST
Topological domaini933 – 94513CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini965 – 97915ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1001 – 101717CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30320HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33318HelicalSequence AnalysisAdd
BLAST
Transmembranei767 – 78620HelicalSequence AnalysisAdd
BLAST
Transmembranei797 – 81721HelicalSequence AnalysisAdd
BLAST
Transmembranei838 – 86023HelicalSequence AnalysisAdd
BLAST
Transmembranei913 – 93220HelicalSequence AnalysisAdd
BLAST
Transmembranei946 – 96419HelicalSequence AnalysisAdd
BLAST
Transmembranei980 – 100021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 793Interaction with phosphoinositide-3 kinaseBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
InParanoidiP24797.
KOiK01539.
PhylomeDBiP24797.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24797-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGREYSPAA TTSENGGGRR KQKEKELDEL KKEVNLDDHK LSLDELGRKY
60 70 80 90 100
QVDLSRGLSN ARAAEVLAQD GPNALTPPPT TPEWVKFCRQ LFGGFSILLW
110 120 130 140 150
IGAILCFLAY GIQAAMEDEP SNDNLYLGVV LAAVVIVTGC FSYYQEAKSS
160 170 180 190 200
KIMDSFKNMV PQQALVIREG EKIQINAENV VVGDLVEVKG GDRVPADMRI
210 220 230 240 250
ISSHGCKVDN SSLTGESEPQ TRSPEFTHEN PLETRNICFF STNCVEGTAR
260 270 280 290 300
GIVISTGDRT VMGRIASLAS GLEVGRTPIA MEIEHFIRLI TGVAVFLGLS
310 320 330 340 350
FFILSLILGY TWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN
360 370 380 390 400
CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTED
410 420 430 440 450
QSGATFDKRS PTWAALSRIA GLCNRAVFKP GQENISISKR DTAGDASESA
460 470 480 490 500
LLKCIQLSCG SVKKMRDKNP KVTEIPFNST NKYQLSIHER EEDPQGHILV
510 520 530 540 550
MKGAPERILE RCSRILLQGQ EVPLDEEMKE AFQNAYLELG GLGERVLGFC
560 570 580 590 600
HLYLPPDKFP RGFRFDADEV NFPTSDLCFV GLMSMIDPPR AAVPDAVGKC
610 620 630 640 650
RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA RLNIPVSQVN
660 670 680 690 700
PREAKACVVH GSDLKDMTAE QLDEILRNHT EIVFARTSPQ QKLIIVEGCQ
710 720 730 740 750
RQGAIVAVTG DGVNDSPALK KADIGIAMGI AGSDVSKQAA DMILLDDNFA
760 770 780 790 800
SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLLFIIA NIPLPLGTVT
810 820 830 840 850
ILCIDLGTDM VPAISLAYEA AESDIMKRQP RNPRTDKLVN ERLISMAYGQ
860 870 880 890 900
IGMIQALGGF FTYFVILAEN GFLPARLLGV RLAWDDRSTN DLEDSYGQEW
910 920 930 940 950
TYEQRKVVEF TCHTAFFASI VVVQWADLII CKTRRNSVFQ QGMKNKILIF
960 970 980 990 1000
GLLEETALAA FLSYCPGMGV ALRMYPLKVT WWFCAFPYSL LIFAYDEVRK
1010
LILRRYPGGW VEKETYY
Length:1,017
Mass (Da):112,051
Last modified:March 1, 1992 - v1
Checksum:i38E87C1BDE93B8C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59959 mRNA. Translation: AAA48981.1.
PIRiI50394. A37227.
RefSeqiNP_990807.1. NM_205476.1.
UniGeneiGga.4300.

Genome annotation databases

GeneIDi396468.
KEGGigga:396468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59959 mRNA. Translation: AAA48981.1 .
PIRi I50394. A37227.
RefSeqi NP_990807.1. NM_205476.1.
UniGenei Gga.4300.

3D structure databases

ProteinModelPortali P24797.
SMRi P24797. Positions 22-1017.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396468.
KEGGi gga:396468.

Organism-specific databases

CTDi 477.

Phylogenomic databases

HOVERGENi HBG004298.
InParanoidi P24797.
KOi K01539.
PhylomeDBi P24797.

Miscellaneous databases

NextBioi 20816507.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution."
    Takeyasu K., Lemas V., Fambrough D.M.
    Am. J. Physiol. 259:C619-C630(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A2_CHICK
AccessioniPrimary (citable) accession number: P24797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3