Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24797

- AT1A2_CHICK

UniProt

P24797 - AT1A2_CHICK

Protein

Sodium/potassium-transporting ATPase subunit alpha-2

Gene

ATP1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei371 – 37114-aspartylphosphate intermediateBy similarity
    Binding sitei502 – 5021ATPBy similarity
    Metal bindingi711 – 7111MagnesiumBy similarity
    Metal bindingi715 – 7151MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. neurotransmitter uptake Source: AgBase
    3. regulation of striated muscle contraction Source: AgBase
    4. sodium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-2 subunit
    Alternative name(s):
    Sodium pump subunit alpha-2
    Gene namesi
    Name:ATP1A2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10171017Sodium/potassium-transporting ATPase subunit alpha-2PRO_0000046297Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei937 – 9371Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP24797.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP24797.
    SMRiP24797. Positions 22-1017.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8282CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 12623ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 283136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 31512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 766433CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini787 – 79610ExtracellularSequence Analysis
    Topological domaini818 – 83720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini861 – 91252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini933 – 94513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini965 – 97915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1001 – 101717CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei767 – 78620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei797 – 81721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei838 – 86023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei913 – 93220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei946 – 96419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei980 – 100021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni77 – 793Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004298.
    KOiK01539.
    PhylomeDBiP24797.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24797-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGREYSPAA TTSENGGGRR KQKEKELDEL KKEVNLDDHK LSLDELGRKY     50
    QVDLSRGLSN ARAAEVLAQD GPNALTPPPT TPEWVKFCRQ LFGGFSILLW 100
    IGAILCFLAY GIQAAMEDEP SNDNLYLGVV LAAVVIVTGC FSYYQEAKSS 150
    KIMDSFKNMV PQQALVIREG EKIQINAENV VVGDLVEVKG GDRVPADMRI 200
    ISSHGCKVDN SSLTGESEPQ TRSPEFTHEN PLETRNICFF STNCVEGTAR 250
    GIVISTGDRT VMGRIASLAS GLEVGRTPIA MEIEHFIRLI TGVAVFLGLS 300
    FFILSLILGY TWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN 350
    CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTED 400
    QSGATFDKRS PTWAALSRIA GLCNRAVFKP GQENISISKR DTAGDASESA 450
    LLKCIQLSCG SVKKMRDKNP KVTEIPFNST NKYQLSIHER EEDPQGHILV 500
    MKGAPERILE RCSRILLQGQ EVPLDEEMKE AFQNAYLELG GLGERVLGFC 550
    HLYLPPDKFP RGFRFDADEV NFPTSDLCFV GLMSMIDPPR AAVPDAVGKC 600
    RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA RLNIPVSQVN 650
    PREAKACVVH GSDLKDMTAE QLDEILRNHT EIVFARTSPQ QKLIIVEGCQ 700
    RQGAIVAVTG DGVNDSPALK KADIGIAMGI AGSDVSKQAA DMILLDDNFA 750
    SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLLFIIA NIPLPLGTVT 800
    ILCIDLGTDM VPAISLAYEA AESDIMKRQP RNPRTDKLVN ERLISMAYGQ 850
    IGMIQALGGF FTYFVILAEN GFLPARLLGV RLAWDDRSTN DLEDSYGQEW 900
    TYEQRKVVEF TCHTAFFASI VVVQWADLII CKTRRNSVFQ QGMKNKILIF 950
    GLLEETALAA FLSYCPGMGV ALRMYPLKVT WWFCAFPYSL LIFAYDEVRK 1000
    LILRRYPGGW VEKETYY 1017
    Length:1,017
    Mass (Da):112,051
    Last modified:March 1, 1992 - v1
    Checksum:i38E87C1BDE93B8C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59959 mRNA. Translation: AAA48981.1.
    PIRiI50394. A37227.
    RefSeqiNP_990807.1. NM_205476.1.
    UniGeneiGga.4300.

    Genome annotation databases

    GeneIDi396468.
    KEGGigga:396468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M59959 mRNA. Translation: AAA48981.1 .
    PIRi I50394. A37227.
    RefSeqi NP_990807.1. NM_205476.1.
    UniGenei Gga.4300.

    3D structure databases

    ProteinModelPortali P24797.
    SMRi P24797. Positions 22-1017.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P24797.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396468.
    KEGGi gga:396468.

    Organism-specific databases

    CTDi 477.

    Phylogenomic databases

    HOVERGENi HBG004298.
    KOi K01539.
    PhylomeDBi P24797.

    Miscellaneous databases

    NextBioi 20816507.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution."
      Takeyasu K., Lemas V., Fambrough D.M.
      Am. J. Physiol. 259:C619-C630(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAT1A2_CHICK
    AccessioniPrimary (citable) accession number: P24797
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3