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P24797

- AT1A2_CHICK

UniProt

P24797 - AT1A2_CHICK

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Protein
Sodium/potassium-transporting ATPase subunit alpha-2
Gene
ATP1A2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei371 – 37114-aspartylphosphate intermediate By similarity
Binding sitei502 – 5021ATP By similarity
Metal bindingi711 – 7111Magnesium By similarity
Metal bindingi715 – 7151Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. neurotransmitter uptake Source: AgBase
  3. regulation of striated muscle contraction Source: AgBase
  4. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-2 subunit
Alternative name(s):
Sodium pump subunit alpha-2
Gene namesi
Name:ATP1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8282Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 12623Extracellular Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Topological domaini148 – 283136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei284 – 30320Helical; Reviewed prediction
Add
BLAST
Topological domaini304 – 31512Extracellular Reviewed prediction
Add
BLAST
Transmembranei316 – 33318Helical; Reviewed prediction
Add
BLAST
Topological domaini334 – 766433Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei767 – 78620Helical; Reviewed prediction
Add
BLAST
Topological domaini787 – 79610Extracellular Reviewed prediction
Transmembranei797 – 81721Helical; Reviewed prediction
Add
BLAST
Topological domaini818 – 83720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei838 – 86023Helical; Reviewed prediction
Add
BLAST
Topological domaini861 – 91252Extracellular Reviewed prediction
Add
BLAST
Transmembranei913 – 93220Helical; Reviewed prediction
Add
BLAST
Topological domaini933 – 94513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei946 – 96419Helical; Reviewed prediction
Add
BLAST
Topological domaini965 – 97915Extracellular Reviewed prediction
Add
BLAST
Transmembranei980 – 100021Helical; Reviewed prediction
Add
BLAST
Topological domaini1001 – 101717Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10171017Sodium/potassium-transporting ATPase subunit alpha-2
PRO_0000046297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei937 – 9371Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24797.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP24797.
SMRiP24797. Positions 22-1017.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 793Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
KOiK01539.
PhylomeDBiP24797.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24797-1 [UniParc]FASTAAdd to Basket

« Hide

MDGREYSPAA TTSENGGGRR KQKEKELDEL KKEVNLDDHK LSLDELGRKY     50
QVDLSRGLSN ARAAEVLAQD GPNALTPPPT TPEWVKFCRQ LFGGFSILLW 100
IGAILCFLAY GIQAAMEDEP SNDNLYLGVV LAAVVIVTGC FSYYQEAKSS 150
KIMDSFKNMV PQQALVIREG EKIQINAENV VVGDLVEVKG GDRVPADMRI 200
ISSHGCKVDN SSLTGESEPQ TRSPEFTHEN PLETRNICFF STNCVEGTAR 250
GIVISTGDRT VMGRIASLAS GLEVGRTPIA MEIEHFIRLI TGVAVFLGLS 300
FFILSLILGY TWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN 350
CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTED 400
QSGATFDKRS PTWAALSRIA GLCNRAVFKP GQENISISKR DTAGDASESA 450
LLKCIQLSCG SVKKMRDKNP KVTEIPFNST NKYQLSIHER EEDPQGHILV 500
MKGAPERILE RCSRILLQGQ EVPLDEEMKE AFQNAYLELG GLGERVLGFC 550
HLYLPPDKFP RGFRFDADEV NFPTSDLCFV GLMSMIDPPR AAVPDAVGKC 600
RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA RLNIPVSQVN 650
PREAKACVVH GSDLKDMTAE QLDEILRNHT EIVFARTSPQ QKLIIVEGCQ 700
RQGAIVAVTG DGVNDSPALK KADIGIAMGI AGSDVSKQAA DMILLDDNFA 750
SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLLFIIA NIPLPLGTVT 800
ILCIDLGTDM VPAISLAYEA AESDIMKRQP RNPRTDKLVN ERLISMAYGQ 850
IGMIQALGGF FTYFVILAEN GFLPARLLGV RLAWDDRSTN DLEDSYGQEW 900
TYEQRKVVEF TCHTAFFASI VVVQWADLII CKTRRNSVFQ QGMKNKILIF 950
GLLEETALAA FLSYCPGMGV ALRMYPLKVT WWFCAFPYSL LIFAYDEVRK 1000
LILRRYPGGW VEKETYY 1017
Length:1,017
Mass (Da):112,051
Last modified:March 1, 1992 - v1
Checksum:i38E87C1BDE93B8C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59959 mRNA. Translation: AAA48981.1.
PIRiI50394. A37227.
RefSeqiNP_990807.1. NM_205476.1.
UniGeneiGga.4300.

Genome annotation databases

GeneIDi396468.
KEGGigga:396468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M59959 mRNA. Translation: AAA48981.1 .
PIRi I50394. A37227.
RefSeqi NP_990807.1. NM_205476.1.
UniGenei Gga.4300.

3D structure databases

ProteinModelPortali P24797.
SMRi P24797. Positions 22-1017.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396468.
KEGGi gga:396468.

Organism-specific databases

CTDi 477.

Phylogenomic databases

HOVERGENi HBG004298.
KOi K01539.
PhylomeDBi P24797.

Miscellaneous databases

NextBioi 20816507.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution."
    Takeyasu K., Lemas V., Fambrough D.M.
    Am. J. Physiol. 259:C619-C630(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A2_CHICK
AccessioniPrimary (citable) accession number: P24797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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