Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium/potassium-transporting ATPase subunit alpha-2

Gene

ATP1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3714-aspartylphosphate intermediateBy similarity1
Binding sitei502ATPBy similarity1
Metal bindingi711MagnesiumBy similarity1
Metal bindingi715MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-2 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-2 subunit
Alternative name(s):
Sodium pump subunit alpha-2
Gene namesi
Name:ATP1A2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 126ExtracellularSequence analysisAdd BLAST23
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 283CytoplasmicSequence analysisAdd BLAST136
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Topological domaini304 – 315ExtracellularSequence analysisAdd BLAST12
Transmembranei316 – 333HelicalSequence analysisAdd BLAST18
Topological domaini334 – 766CytoplasmicSequence analysisAdd BLAST433
Transmembranei767 – 786HelicalSequence analysisAdd BLAST20
Topological domaini787 – 796ExtracellularSequence analysis10
Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 837CytoplasmicSequence analysisAdd BLAST20
Transmembranei838 – 860HelicalSequence analysisAdd BLAST23
Topological domaini861 – 912ExtracellularSequence analysisAdd BLAST52
Transmembranei913 – 932HelicalSequence analysisAdd BLAST20
Topological domaini933 – 945CytoplasmicSequence analysisAdd BLAST13
Transmembranei946 – 964HelicalSequence analysisAdd BLAST19
Topological domaini965 – 979ExtracellularSequence analysisAdd BLAST15
Transmembranei980 – 1000HelicalSequence analysisAdd BLAST21
Topological domaini1001 – 1017CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462971 – 1017Sodium/potassium-transporting ATPase subunit alpha-2Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei937Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP24797.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP24797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 79Interaction with phosphoinositide-3 kinaseBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
InParanoidiP24797.
KOiK01539.
PhylomeDBiP24797.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGREYSPAA TTSENGGGRR KQKEKELDEL KKEVNLDDHK LSLDELGRKY
60 70 80 90 100
QVDLSRGLSN ARAAEVLAQD GPNALTPPPT TPEWVKFCRQ LFGGFSILLW
110 120 130 140 150
IGAILCFLAY GIQAAMEDEP SNDNLYLGVV LAAVVIVTGC FSYYQEAKSS
160 170 180 190 200
KIMDSFKNMV PQQALVIREG EKIQINAENV VVGDLVEVKG GDRVPADMRI
210 220 230 240 250
ISSHGCKVDN SSLTGESEPQ TRSPEFTHEN PLETRNICFF STNCVEGTAR
260 270 280 290 300
GIVISTGDRT VMGRIASLAS GLEVGRTPIA MEIEHFIRLI TGVAVFLGLS
310 320 330 340 350
FFILSLILGY TWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN
360 370 380 390 400
CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTED
410 420 430 440 450
QSGATFDKRS PTWAALSRIA GLCNRAVFKP GQENISISKR DTAGDASESA
460 470 480 490 500
LLKCIQLSCG SVKKMRDKNP KVTEIPFNST NKYQLSIHER EEDPQGHILV
510 520 530 540 550
MKGAPERILE RCSRILLQGQ EVPLDEEMKE AFQNAYLELG GLGERVLGFC
560 570 580 590 600
HLYLPPDKFP RGFRFDADEV NFPTSDLCFV GLMSMIDPPR AAVPDAVGKC
610 620 630 640 650
RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA RLNIPVSQVN
660 670 680 690 700
PREAKACVVH GSDLKDMTAE QLDEILRNHT EIVFARTSPQ QKLIIVEGCQ
710 720 730 740 750
RQGAIVAVTG DGVNDSPALK KADIGIAMGI AGSDVSKQAA DMILLDDNFA
760 770 780 790 800
SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLLFIIA NIPLPLGTVT
810 820 830 840 850
ILCIDLGTDM VPAISLAYEA AESDIMKRQP RNPRTDKLVN ERLISMAYGQ
860 870 880 890 900
IGMIQALGGF FTYFVILAEN GFLPARLLGV RLAWDDRSTN DLEDSYGQEW
910 920 930 940 950
TYEQRKVVEF TCHTAFFASI VVVQWADLII CKTRRNSVFQ QGMKNKILIF
960 970 980 990 1000
GLLEETALAA FLSYCPGMGV ALRMYPLKVT WWFCAFPYSL LIFAYDEVRK
1010
LILRRYPGGW VEKETYY
Length:1,017
Mass (Da):112,051
Last modified:March 1, 1992 - v1
Checksum:i38E87C1BDE93B8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59959 mRNA. Translation: AAA48981.1.
PIRiI50394. A37227.
RefSeqiNP_990807.1. NM_205476.1.
UniGeneiGga.4300.

Genome annotation databases

GeneIDi396468.
KEGGigga:396468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59959 mRNA. Translation: AAA48981.1.
PIRiI50394. A37227.
RefSeqiNP_990807.1. NM_205476.1.
UniGeneiGga.4300.

3D structure databases

ProteinModelPortaliP24797.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP24797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396468.
KEGGigga:396468.

Organism-specific databases

CTDi477.

Phylogenomic databases

HOVERGENiHBG004298.
InParanoidiP24797.
KOiK01539.
PhylomeDBiP24797.

Miscellaneous databases

PROiP24797.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A2_CHICK
AccessioniPrimary (citable) accession number: P24797
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 5, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.