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Protein

GemA protein

Gene

gemA

Organism
Escherichia phage D108 (Bacteriophage D108)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Early protein responsible for decreasing host DNA gyrase activity. Promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host cell cycle by virus, Viral latency

Names & Taxonomyi

Protein namesi
Recommended name:
GemA protein
Alternative name(s):
Gene product 16
Short name:
gp16
Gene namesi
Name:gemA
OrganismiEscherichia phage D108 (Bacteriophage D108)
Taxonomic identifieri665033 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeMuvirusunclassified Mu-like viruses
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000320 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000777881 – 183GemA proteinAdd BLAST183

Expressioni

Inductioni

This protein is constitively expressed from the Pgem promoter unlike most other early proteins which are expressed under the control of the Pe promoter. Its expression seems to escape repression by repressor protein c and thus occurs throughout latency (Probable).Curated

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the mulikevirus gemA protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000U3.

Family and domain databases

InterProiView protein in InterPro
IPR009363. Phage_Mu_Gp16.
PfamiView protein in Pfam
PF06252. DUF1018. 1 hit.

Sequencei

Sequence statusi: Complete.

P24796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTSLIKLI HVARRELQLD DDTYRAFLMQ KTGKISCREL TVTQLEQVLD
60 70 80 90 100
AMKERGFKKL NKYPRRRFKE HVTPREKVYK IWQQMAEDGF ITDGGDVALD
110 120 130 140 150
KYVQRLTAKR NGGQGVSTLA WCHGESLQVV LETLKQWHIR CIREAFSRHG
160 170 180
LPLPVSPSGR ELRGYDAMTA AYAHARKTRR MAQ
Length:183
Mass (Da):21,218
Last modified:June 11, 2014 - v2
Checksum:i6F971FE19BA7FAC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54298 Genomic DNA. Translation: CAA38198.1.
GQ357916 Genomic DNA. Translation: ACV50274.1.
PIRiS12146.
RefSeqiYP_003335763.1. NC_013594.1.

Genome annotation databases

GeneIDi8658826.
KEGGivg:8658826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54298 Genomic DNA. Translation: CAA38198.1.
GQ357916 Genomic DNA. Translation: ACV50274.1.
PIRiS12146.
RefSeqiYP_003335763.1. NC_013594.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8658826.
KEGGivg:8658826.

Phylogenomic databases

OrthoDBiVOG090000U3.

Family and domain databases

InterProiView protein in InterPro
IPR009363. Phage_Mu_Gp16.
PfamiView protein in Pfam
PF06252. DUF1018. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGEMA_BPD10
AccessioniPrimary (citable) accession number: P24796
Secondary accession number(s): C9DGM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 11, 2014
Last modified: May 10, 2017
This is version 37 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.