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P24788

- CD11B_MOUSE

UniProt

P24788 - CD11B_MOUSE

Protein

Cyclin-dependent kinase 11B

Gene

Cdk11b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone h1, casein, and galactosyltransferase. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Phosphorylation at Thr-437 or Tyr-438 inactivates the enzyme, while phosphorylation at Thr-584 activates it.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei456 – 4561ATPPROSITE-ProRule annotation
    Active sitei551 – 5511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi433 – 4419ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. blastocyst development Source: MGI
    2. cell cycle Source: UniProtKB-KW
    3. negative regulation of apoptotic signaling pathway Source: MGI
    4. regulation of mitosis Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 3474.
    ReactomeiREACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 11B
    Alternative name(s):
    Cell division cycle 2-like protein kinase 1
    Cell division protein kinase 11
    Cyclin-dependent kinase 11 (EC:2.7.11.22)
    Galactosyltransferase-associated protein kinase p58/GTA
    PITSLRE serine/threonine-protein kinase CDC2L1
    Gene namesi
    Name:Cdk11b
    Synonyms:Cdc2l1, Cdk11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:88353. Cdk11b.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 784784Cyclin-dependent kinase 11BPRO_0000024313Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei115 – 1151PhosphoserineBy similarity
    Modified residuei471 – 4711Phosphoserine; by CDK7By similarity
    Modified residuei477 – 4771Phosphothreonine; by CDK7By similarity
    Modified residuei578 – 5781PhosphoserineBy similarity
    Modified residuei583 – 5831PhosphotyrosineBy similarity
    Modified residuei584 – 5841PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP24788.
    PaxDbiP24788.
    PRIDEiP24788.

    PTM databases

    PhosphoSiteiP24788.

    Expressioni

    Gene expression databases

    ArrayExpressiP24788.
    BgeeiP24788.
    CleanExiMM_CDC2L1.
    GenevestigatoriP24788.

    Interactioni

    Protein-protein interaction databases

    BioGridi198625. 2 interactions.
    IntActiP24788. 2 interactions.
    MINTiMINT-4090174.

    Structurei

    3D structure databases

    ProteinModelPortaliP24788.
    SMRiP24788. Positions 405-754.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini427 – 712286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi291 – 30414Poly-GluAdd
    BLAST
    Compositional biasi309 – 32517Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114964.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiP24788.
    KOiK08818.
    OMAiDGRKPVK.
    OrthoDBiEOG74BJS4.
    PhylomeDBiP24788.
    TreeFamiTF101035.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: P24788-1) [UniParc]FASTAAdd to Basket

    Also known as: p130PITSLRE

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE    50
    GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR 100
    KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER 150
    QKRREMAREH SRRERDRLEQ LERKRERERK LREQQKEQRE QKERERRAEE 200
    RRKEREARRE VSAHHRTMRE EYSDKGKVGH WSRSPLRPPR ERFEMGDNRK 250
    PVKEEKVEER DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE 300
    EEEEGSTSEE SEEEEEEEEE EEEEETGSNS EEASEQSAEE VSDEEMSEDE 350
    DRENENHILV VPESRFDRDS GDSEEGEEEV GEGTPQSSAP TEGDYVPDSP 400
    ALSPIELKQE LPKYLPALQG CRSVEEFQCL NRIEEGTYGV VYRAKDKKTD 450
    EIVALKRLKM EKEKEGFPIT SLREINTILK AQHPNIVTVR EIVVGSNMDK 500
    IYIVMNYVEH DLKSLMETMK QPFLPGEVKT LMIQLLSGVK HLHDNWILHR 550
    DLKTSNLLLS HAGILKVGDF GLAREYGSPL KAYTPVVVTL WYRAPELLLG 600
    AKEYSTAVDM WSVGCIFGEL LTQKPLFPGK SDIDQINKIF KDLGTPSEKI 650
    WPGYNDLPAV KKMTFSEYPY NNLRKRFGAL LSDQGFDLMN KFLTYYPGRR 700
    INAEDGLKHE YFRETPLPID PSMFPTWPAK SEQQRVKRGT SPRPPEGGLG 750
    YSQLGDDDLK ETGFHLTTTN QGASAAGPGF SLKF 784
    Length:784
    Mass (Da):91,513
    Last modified:January 4, 2005 - v2
    Checksum:iCDF03AC3957FA351
    GO
    Isoform 2 (identifier: P24788-2) [UniParc]FASTAAdd to Basket

    Also known as: p58clk-1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-345: Missing.

    Show »
    Length:439
    Mass (Da):49,509
    Checksum:iA31D79C4919C1A3B
    GO

    Sequence cautioni

    The sequence AAA03518.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 373LKN → MSQ in AAH52920. (PubMed:15489334)Curated
    Sequence conflicti284 – 2841Missing in AAA66169. (PubMed:7528743)Curated
    Sequence conflicti560 – 5601S → T in AAA03518. (PubMed:2069872)Curated
    Sequence conflicti608 – 6081V → C in AAA03518. (PubMed:2069872)Curated
    Sequence conflicti645 – 6451T → S in AAA03518. (PubMed:2069872)Curated
    Sequence conflicti668 – 6681Y → I in AAA03518. (PubMed:2069872)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 345345Missing in isoform 2. 1 PublicationVSP_018835Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58633 mRNA. Translation: AAA03518.1. Frameshift.
    L37092 mRNA. Translation: AAA66169.1.
    AK077668 mRNA. Translation: BAC36942.1.
    AK147133 mRNA. Translation: BAE27703.1.
    BC052920 mRNA. Translation: AAH52920.1.
    CCDSiCCDS19033.1. [P24788-1]
    PIRiA55817.
    RefSeqiNP_031687.2. NM_007661.3. [P24788-1]
    XP_006538570.1. XM_006538507.1. [P24788-1]
    XP_006538571.1. XM_006538508.1.
    XP_006538572.1. XM_006538509.1.
    XP_006538573.1. XM_006538510.1.
    XP_006538574.1. XM_006538511.1.
    UniGeneiMm.267410.

    Genome annotation databases

    EnsembliENSMUST00000067081; ENSMUSP00000070527; ENSMUSG00000029062. [P24788-1]
    ENSMUST00000105600; ENSMUSP00000101225; ENSMUSG00000029062. [P24788-1]
    GeneIDi12537.
    KEGGimmu:12537.
    UCSCiuc008wea.1. mouse. [P24788-1]

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58633 mRNA. Translation: AAA03518.1 . Frameshift.
    L37092 mRNA. Translation: AAA66169.1 .
    AK077668 mRNA. Translation: BAC36942.1 .
    AK147133 mRNA. Translation: BAE27703.1 .
    BC052920 mRNA. Translation: AAH52920.1 .
    CCDSi CCDS19033.1. [P24788-1 ]
    PIRi A55817.
    RefSeqi NP_031687.2. NM_007661.3. [P24788-1 ]
    XP_006538570.1. XM_006538507.1. [P24788-1 ]
    XP_006538571.1. XM_006538508.1.
    XP_006538572.1. XM_006538509.1.
    XP_006538573.1. XM_006538510.1.
    XP_006538574.1. XM_006538511.1.
    UniGenei Mm.267410.

    3D structure databases

    ProteinModelPortali P24788.
    SMRi P24788. Positions 405-754.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198625. 2 interactions.
    IntActi P24788. 2 interactions.
    MINTi MINT-4090174.

    PTM databases

    PhosphoSitei P24788.

    Proteomic databases

    MaxQBi P24788.
    PaxDbi P24788.
    PRIDEi P24788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067081 ; ENSMUSP00000070527 ; ENSMUSG00000029062 . [P24788-1 ]
    ENSMUST00000105600 ; ENSMUSP00000101225 ; ENSMUSG00000029062 . [P24788-1 ]
    GeneIDi 12537.
    KEGGi mmu:12537.
    UCSCi uc008wea.1. mouse. [P24788-1 ]

    Organism-specific databases

    CTDi 984.
    MGIi MGI:88353. Cdk11b.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114964.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi P24788.
    KOi K08818.
    OMAi DGRKPVK.
    OrthoDBi EOG74BJS4.
    PhylomeDBi P24788.
    TreeFami TF101035.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 3474.
    Reactomei REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    ChiTaRSi CDK11B. mouse.
    NextBioi 281574.
    PROi P24788.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24788.
    Bgeei P24788.
    CleanExi MM_CDC2L1.
    Genevestigatori P24788.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulated expression of a cell division control-related protein kinase during development."
      Kidd V.J., Luo W., Xiang J.L., Tu F., Easton J., McCune S., Snead M.L.
      Cell Growth Differ. 2:85-93(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand."
      Malek S.N., Desiderio S.
      J. Biol. Chem. 269:33009-33020(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Stomach.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-784 (ISOFORM 1).
      Tissue: Eye.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCD11B_MOUSE
    AccessioniPrimary (citable) accession number: P24788
    Secondary accession number(s): Q3UI03
    , Q61399, Q7TST4, Q8BP53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3