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Protein

Cyclin-dependent kinase 11B

Gene

Cdk11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. May act as a negative regulator of normal cell cycle progression.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Phosphorylation at Thr-437 or Tyr-438 inactivates the enzyme, while phosphorylation at Thr-584 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei456ATPPROSITE-ProRule annotation1
Active sitei551Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi433 – 441ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • blastocyst development Source: MGI
  • cell cycle Source: UniProtKB-KW
  • negative regulation of apoptotic signaling pathway Source: MGI
  • protein phosphorylation Source: MGI
  • regulation of mitotic nuclear division Source: MGI
  • regulation of mRNA processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 3474.
ReactomeiR-MMU-381340. Transcriptional regulation of white adipocyte differentiation.
R-MMU-442533. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 11B
Alternative name(s):
Cell division cycle 2-like protein kinase 1
Cell division protein kinase 11
Cyclin-dependent kinase 11 (EC:2.7.11.22)
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L1
Gene namesi
Name:Cdk11b
Synonyms:Cdc2l1, Cdk11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88353. Cdk11b.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000243131 – 784Cyclin-dependent kinase 11BAdd BLAST784

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei115PhosphoserineBy similarity1
Modified residuei270PhosphoserineCombined sources1
Modified residuei471Phosphoserine; by CDK7By similarity1
Modified residuei477Phosphothreonine; by CDK7By similarity1
Modified residuei578PhosphoserineCombined sources1
Modified residuei583PhosphotyrosineBy similarity1
Modified residuei584PhosphothreonineCombined sources1
Modified residuei740PhosphothreonineCombined sources1
Modified residuei741PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP24788.
MaxQBiP24788.
PaxDbiP24788.
PeptideAtlasiP24788.
PRIDEiP24788.

PTM databases

iPTMnetiP24788.
PhosphoSitePlusiP24788.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029062.
CleanExiMM_CDC2L1.
ExpressionAtlasiP24788. baseline and differential.
GenevisibleiP24788. MM.

Interactioni

Subunit structurei

May interact PAK1 and RANBP9. p110C interacts with RNPS1. Interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.By similarity

Protein-protein interaction databases

BioGridi198625. 2 interactors.
IntActiP24788. 2 interactors.
MINTiMINT-4090174.
STRINGi10090.ENSMUSP00000070527.

Structurei

3D structure databases

ProteinModelPortaliP24788.
SMRiP24788.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 712Protein kinasePROSITE-ProRule annotationAdd BLAST286

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi291 – 304Poly-GluAdd BLAST14
Compositional biasi309 – 325Poly-GluAdd BLAST17

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0663. Eukaryota.
ENOG410XQ50. LUCA.
GeneTreeiENSGT00830000128256.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP24788.
KOiK08818.
OMAiQRDKPEQ.
OrthoDBiEOG091G048P.
PhylomeDBiP24788.
TreeFamiTF101035.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P24788-1) [UniParc]FASTAAdd to basket
Also known as: p130PITSLRE

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKAHHR
110 120 130 140 150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER
160 170 180 190 200
QKRREMAREH SRRERDRLEQ LERKRERERK LREQQKEQRE QKERERRAEE
210 220 230 240 250
RRKEREARRE VSAHHRTMRE EYSDKGKVGH WSRSPLRPPR ERFEMGDNRK
260 270 280 290 300
PVKEEKVEER DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE
310 320 330 340 350
EEEEGSTSEE SEEEEEEEEE EEEEETGSNS EEASEQSAEE VSDEEMSEDE
360 370 380 390 400
DRENENHILV VPESRFDRDS GDSEEGEEEV GEGTPQSSAP TEGDYVPDSP
410 420 430 440 450
ALSPIELKQE LPKYLPALQG CRSVEEFQCL NRIEEGTYGV VYRAKDKKTD
460 470 480 490 500
EIVALKRLKM EKEKEGFPIT SLREINTILK AQHPNIVTVR EIVVGSNMDK
510 520 530 540 550
IYIVMNYVEH DLKSLMETMK QPFLPGEVKT LMIQLLSGVK HLHDNWILHR
560 570 580 590 600
DLKTSNLLLS HAGILKVGDF GLAREYGSPL KAYTPVVVTL WYRAPELLLG
610 620 630 640 650
AKEYSTAVDM WSVGCIFGEL LTQKPLFPGK SDIDQINKIF KDLGTPSEKI
660 670 680 690 700
WPGYNDLPAV KKMTFSEYPY NNLRKRFGAL LSDQGFDLMN KFLTYYPGRR
710 720 730 740 750
INAEDGLKHE YFRETPLPID PSMFPTWPAK SEQQRVKRGT SPRPPEGGLG
760 770 780
YSQLGDDDLK ETGFHLTTTN QGASAAGPGF SLKF
Length:784
Mass (Da):91,513
Last modified:January 4, 2005 - v2
Checksum:iCDF03AC3957FA351
GO
Isoform 2 (identifier: P24788-2) [UniParc]FASTAAdd to basket
Also known as: p58clk-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-345: Missing.

Show »
Length:439
Mass (Da):49,509
Checksum:iA31D79C4919C1A3B
GO

Sequence cautioni

The sequence AAA03518 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35 – 37LKN → MSQ in AAH52920 (PubMed:15489334).Curated3
Sequence conflicti284Missing in AAA66169 (PubMed:7528743).Curated1
Sequence conflicti560S → T in AAA03518 (PubMed:2069872).Curated1
Sequence conflicti608V → C in AAA03518 (PubMed:2069872).Curated1
Sequence conflicti645T → S in AAA03518 (PubMed:2069872).Curated1
Sequence conflicti668Y → I in AAA03518 (PubMed:2069872).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188351 – 345Missing in isoform 2. 1 PublicationAdd BLAST345

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58633 mRNA. Translation: AAA03518.1. Frameshift.
L37092 mRNA. Translation: AAA66169.1.
AK077668 mRNA. Translation: BAC36942.1.
AK147133 mRNA. Translation: BAE27703.1.
BC052920 mRNA. Translation: AAH52920.1.
CCDSiCCDS19033.1. [P24788-1]
PIRiA55817.
RefSeqiNP_031687.2. NM_007661.3. [P24788-1]
XP_006538571.1. XM_006538508.2.
XP_006538573.1. XM_006538510.2.
XP_006538574.1. XM_006538511.2.
XP_011248481.1. XM_011250179.2. [P24788-1]
XP_017175418.1. XM_017319929.1.
XP_017175419.1. XM_017319930.1.
XP_017175422.1. XM_017319933.1. [P24788-2]
XP_017175423.1. XM_017319934.1. [P24788-2]
UniGeneiMm.267410.

Genome annotation databases

EnsembliENSMUST00000067081; ENSMUSP00000070527; ENSMUSG00000029062. [P24788-1]
ENSMUST00000105600; ENSMUSP00000101225; ENSMUSG00000029062. [P24788-1]
GeneIDi12537.
KEGGimmu:12537.
UCSCiuc008wea.1. mouse. [P24788-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58633 mRNA. Translation: AAA03518.1. Frameshift.
L37092 mRNA. Translation: AAA66169.1.
AK077668 mRNA. Translation: BAC36942.1.
AK147133 mRNA. Translation: BAE27703.1.
BC052920 mRNA. Translation: AAH52920.1.
CCDSiCCDS19033.1. [P24788-1]
PIRiA55817.
RefSeqiNP_031687.2. NM_007661.3. [P24788-1]
XP_006538571.1. XM_006538508.2.
XP_006538573.1. XM_006538510.2.
XP_006538574.1. XM_006538511.2.
XP_011248481.1. XM_011250179.2. [P24788-1]
XP_017175418.1. XM_017319929.1.
XP_017175419.1. XM_017319930.1.
XP_017175422.1. XM_017319933.1. [P24788-2]
XP_017175423.1. XM_017319934.1. [P24788-2]
UniGeneiMm.267410.

3D structure databases

ProteinModelPortaliP24788.
SMRiP24788.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198625. 2 interactors.
IntActiP24788. 2 interactors.
MINTiMINT-4090174.
STRINGi10090.ENSMUSP00000070527.

PTM databases

iPTMnetiP24788.
PhosphoSitePlusiP24788.

Proteomic databases

EPDiP24788.
MaxQBiP24788.
PaxDbiP24788.
PeptideAtlasiP24788.
PRIDEiP24788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067081; ENSMUSP00000070527; ENSMUSG00000029062. [P24788-1]
ENSMUST00000105600; ENSMUSP00000101225; ENSMUSG00000029062. [P24788-1]
GeneIDi12537.
KEGGimmu:12537.
UCSCiuc008wea.1. mouse. [P24788-1]

Organism-specific databases

CTDi984.
MGIiMGI:88353. Cdk11b.

Phylogenomic databases

eggNOGiKOG0663. Eukaryota.
ENOG410XQ50. LUCA.
GeneTreeiENSGT00830000128256.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP24788.
KOiK08818.
OMAiQRDKPEQ.
OrthoDBiEOG091G048P.
PhylomeDBiP24788.
TreeFamiTF101035.

Enzyme and pathway databases

BRENDAi2.7.11.22. 3474.
ReactomeiR-MMU-381340. Transcriptional regulation of white adipocyte differentiation.
R-MMU-442533. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

ChiTaRSiCdk11b. mouse.
PROiP24788.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029062.
CleanExiMM_CDC2L1.
ExpressionAtlasiP24788. baseline and differential.
GenevisibleiP24788. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD11B_MOUSE
AccessioniPrimary (citable) accession number: P24788
Secondary accession number(s): Q3UI03
, Q61399, Q7TST4, Q8BP53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.