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Protein

ATP-dependent RNA helicase dbp2

Gene

dbp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 173ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processNonsense-mediated mRNA decay, Ribosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-3899300 SUMOylation of transcription cofactors
R-SPO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase dbp2 (EC:3.6.4.13)
Alternative name(s):
p68-like protein
Gene namesi
Name:dbp2
ORF Names:SPBP8B7.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.16c
PomBaseiSPBP8B7.16c dbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549981 – 550ATP-dependent RNA helicase dbp2Add BLAST550

Proteomic databases

MaxQBiP24782
PaxDbiP24782
PRIDEiP24782

PTM databases

iPTMnetiP24782

Interactioni

Subunit structurei

Associates with polysomes.By similarity

Protein-protein interaction databases

BioGridi277894, 5 interactors
IntActiP24782, 1 interactor
STRINGi4896.SPBP8B7.16c.1

Structurei

3D structure databases

ProteinModelPortaliP24782
SMRiP24782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 328Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini340 – 503Helicase C-terminalPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni510 – 533RNA-binding RGG-boxAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 150Q motifAdd BLAST29
Motifi276 – 279DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000268804
InParanoidiP24782
KOiK12823
OMAiANMHNGM
OrthoDBiEOG092C1B4A
PhylomeDBiP24782

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

P24782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYRDNEYSG NYNGKEDGYN SRGRYGGGYR NNYSRGGGRG GFNDGASYGY
60 70 80 90 100
DQRGQGRNFY ESDGPGANLV KKDWKNETLI PFQKDFYKEH ENVRNRSDAE
110 120 130 140 150
VTEYRKEKEI VVHGLNVPKP VTTFEEAGFP NYVLKEVKQL GFEAPTPIQQ
160 170 180 190 200
QAWPMAMSGR DMVGISATGS GKTLSYCLPA IVHINAQPLL SPGDGPIVLV
210 220 230 240 250
LAPTRELAVQ IQQECTKFGK SSRIRNTCVY GGVPRGPQIR DLIRGVEICI
260 270 280 290 300
ATPGRLLDML DSNKTNLRRV TYLVLDEADR MLDMGFEPQI RKIVDQIRPD
310 320 330 340 350
RQTVMFSATW PKEVQRLARD YLNDYIQVTV GSLDLAASHN IKQIVEVVDN
360 370 380 390 400
ADKRARLGKD IEEVLKDRDN KVLIFTGTKR VADDITRFLR QDGWPALAIH
410 420 430 440 450
GDKAQDERDW VLNEFRTGKS PIMVATDVAS RGIDVKGITH VFNYDFPGNT
460 470 480 490 500
EDYVHRIGRT GRAGAKGTAY TYFTSDNAKQ ARELVSILSE AKQDIDPKLE
510 520 530 540 550
EMARYSSGGR GGNYRRGGYG RGGFRRGGGY GNRNRGFTGS NSAPLARSRW
Length:550
Mass (Da):61,548
Last modified:December 1, 2000 - v2
Checksum:i3BD1636D14275451
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235R → L in CAA36873 (PubMed:1996094).Curated1
Sequence conflicti240R → L in CAA36873 (PubMed:1996094).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52648 Genomic DNA Translation: CAA36873.1
L11574 mRNA Translation: AAA35319.1
CU329671 Genomic DNA Translation: CAA21801.1
PIRiT40810 S14048
RefSeqiNP_596523.1, NM_001022444.2

Genome annotation databases

EnsemblFungiiSPBP8B7.16c.1; SPBP8B7.16c.1:pep; SPBP8B7.16c
GeneIDi2541383
KEGGispo:SPBP8B7.16c

Similar proteinsi

Entry informationi

Entry nameiDBP2_SCHPO
AccessioniPrimary (citable) accession number: P24782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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