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Protein

Multifunctional tryptophan biosynthesis protein

Gene

trpC

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway:iL-tryptophan biosynthesis

This protein is involved in step 1, 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (trpC)
  2. no protein annotated in this organism
  3. Multifunctional tryptophan biosynthesis protein (trpC)
  4. Multifunctional tryptophan biosynthesis protein (trpC)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021For GATase activityBy similarity
Active sitei197 – 1971For GATase activityBy similarity
Active sitei199 – 1991For GATase activityBy similarity

GO - Molecular functioni

GO - Biological processi

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Protein family/group databases

MEROPSiC26.959.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752Multifunctional tryptophan biosynthesis proteinPRO_0000056862Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002559645.1.

Structurei

3D structure databases

ProteinModelPortaliP24773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 223201Glutamine amidotransferase type-1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni239 – 503265Indole-3-glycerol phosphate synthaseAdd
BLAST
Regioni519 – 752234N-(5'-phosphoribosyl)anthranilate isomeraseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

PhylomeDBiP24773.

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLVDHSPH HATKAAKLAS ASNVILIDNY DSFTWNIYQY LVLEGATVTV
60 70 80 90 100
YRNDEVTVED LVAKKPTQLV ISPGPGHPDT DAGISNAVIK HFSGKVPIFG
110 120 130 140 150
VCMGQQCMIT SFGGKVDVTG EILHGKTSEL KHDSKGVYQG LPTSLEVTRY
160 170 180 190 200
HSLAGTHSTI PDCLEVTSRV ELGDASGKNI IMGVRHKEFA VEGVQFHPES
210 220 230 240 250
ILTQYGRKMF RNFLELTAGT WDNKQGAAVA APADKKLSIL DKIYAHRKNA
260 270 280 290 300
VDEQKKIPAL RPEALQAAYD LNIAPPQLSF PDRLRQSDYP LSLMAEIKRA
310 320 330 340 350
SPSKGIISAN VCAPAQAREY AKAGASVISV LTEPEWFKGT IDDLRAVRQS
360 370 380 390 400
LEGLPNRPAV LRKEFVFEEY QILEARLAGA DTVLLIVKML DIELLTRLYH
410 420 430 440 450
YSRSLGMEPL VEVNTPEEMK IAVDLGSEVI GVNNRDLTSF EVDLGTTSRL
460 470 480 490 500
MDQVPESTIV CALSGISGPQ DVEAYKKEGV KAILVGEALM RAPDTSAFVA
510 520 530 540 550
QLLGGSNQNF AGASPSSPLV KICGTRTEEG ALAAIQAGAD LIGIIMVQGR
560 570 580 590 600
SRLVPDDVAL GISRVVKSTP RPADTLQQPS SATSLEWFDH STNILRHPSR
610 620 630 640 650
ALLVGVFMNQ PLSYVVSQQQ KLGLDVVQLH GSEPLEWSSL IPVPVIRKFA
660 670 680 690 700
PGDIGIARRA YHTLPLLDSG AGGSGELLEE SGVKKVLDSD EGLRVILAGG
710 720 730 740 750
LNPDNVAGTV KKLGQSGQKV VGLDVSSGVE TNGAQDLEKI RAFVKSAKSI

RQ
Length:752
Mass (Da):81,035
Last modified:March 1, 1992 - v1
Checksum:iD6256C3818E22FDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05033 Genomic DNA. Translation: CAA28707.1.
PIRiS30084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05033 Genomic DNA. Translation: CAA28707.1.
PIRiS30084.

3D structure databases

ProteinModelPortaliP24773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002559645.1.

Protein family/group databases

MEROPSiC26.959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

PhylomeDBiP24773.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040.
UPA00035; UER00042.
UPA00035; UER00043.

Family and domain databases

Gene3Di3.20.20.70. 3 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR016302. Anthranilate_synth_II.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
SUPFAMiSSF51366. SSF51366. 3 hits.
SSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete nucleotide sequence of the trpC gene from Penicillium chrysogenum."
    Penalva M.A., Sanchez F.
    Nucleic Acids Res. 15:1874-1874(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTRPG_PENCH
AccessioniPrimary (citable) accession number: P24773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 24, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.