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Protein

Multifunctional tryptophan biosynthesis protein

Gene

trpC

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1, 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (EN45_111880), Multifunctional tryptophan biosynthesis protein (trpC)
  2. no protein annotated in this organism
  3. Multifunctional tryptophan biosynthesis protein (EN45_111880), Multifunctional tryptophan biosynthesis protein (trpC)
  4. Multifunctional tryptophan biosynthesis protein (EN45_111880), Multifunctional tryptophan biosynthesis protein (trpC)
  5. Tryptophan synthase (EN45_067440), Tryptophan synthase (EN45_013410)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102Nucleophile; for GATase activityBy similarity1
Binding sitei106GlutamineBy similarity1
Active sitei197For GATase activityBy similarity1
Active sitei199For GATase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00040
UPA00035; UER00042
UPA00035; UER00043

Protein family/group databases

MEROPSiC26.959

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional tryptophan biosynthesis protein
Including the following 3 domains:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Alternative name(s):
Anthranilate synthase, glutamine amidotransferase component
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum species complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568621 – 752Multifunctional tryptophan biosynthesis proteinAdd BLAST752

Proteomic databases

PRIDEiP24773

Structurei

3D structure databases

ProteinModelPortaliP24773
SMRiP24773
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 223Glutamine amidotransferase type-1Add BLAST201

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 76Glutamine bindingBy similarity3
Regioni152 – 153Glutamine bindingBy similarity2
Regioni239 – 503Indole-3-glycerol phosphate synthaseAdd BLAST265
Regioni519 – 752N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST234

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG0026 Eukaryota
KOG4201 Eukaryota
KOG4202 Eukaryota
COG0134 LUCA
COG0135 LUCA
COG0512 LUCA
PhylomeDBiP24773

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
3.40.50.880, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR016302 Anthranilate_synth_II
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
IPR006221 TrpG/PapA_dom
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
PIRSFiPIRSF001382 TrpG-trpC-trpF, 1 hit
SUPFAMiSSF51366 SSF51366, 3 hits
SSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR00566 trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

P24773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLVDHSPH HATKAAKLAS ASNVILIDNY DSFTWNIYQY LVLEGATVTV
60 70 80 90 100
YRNDEVTVED LVAKKPTQLV ISPGPGHPDT DAGISNAVIK HFSGKVPIFG
110 120 130 140 150
VCMGQQCMIT SFGGKVDVTG EILHGKTSEL KHDSKGVYQG LPTSLEVTRY
160 170 180 190 200
HSLAGTHSTI PDCLEVTSRV ELGDASGKNI IMGVRHKEFA VEGVQFHPES
210 220 230 240 250
ILTQYGRKMF RNFLELTAGT WDNKQGAAVA APADKKLSIL DKIYAHRKNA
260 270 280 290 300
VDEQKKIPAL RPEALQAAYD LNIAPPQLSF PDRLRQSDYP LSLMAEIKRA
310 320 330 340 350
SPSKGIISAN VCAPAQAREY AKAGASVISV LTEPEWFKGT IDDLRAVRQS
360 370 380 390 400
LEGLPNRPAV LRKEFVFEEY QILEARLAGA DTVLLIVKML DIELLTRLYH
410 420 430 440 450
YSRSLGMEPL VEVNTPEEMK IAVDLGSEVI GVNNRDLTSF EVDLGTTSRL
460 470 480 490 500
MDQVPESTIV CALSGISGPQ DVEAYKKEGV KAILVGEALM RAPDTSAFVA
510 520 530 540 550
QLLGGSNQNF AGASPSSPLV KICGTRTEEG ALAAIQAGAD LIGIIMVQGR
560 570 580 590 600
SRLVPDDVAL GISRVVKSTP RPADTLQQPS SATSLEWFDH STNILRHPSR
610 620 630 640 650
ALLVGVFMNQ PLSYVVSQQQ KLGLDVVQLH GSEPLEWSSL IPVPVIRKFA
660 670 680 690 700
PGDIGIARRA YHTLPLLDSG AGGSGELLEE SGVKKVLDSD EGLRVILAGG
710 720 730 740 750
LNPDNVAGTV KKLGQSGQKV VGLDVSSGVE TNGAQDLEKI RAFVKSAKSI

RQ
Length:752
Mass (Da):81,035
Last modified:March 1, 1992 - v1
Checksum:iD6256C3818E22FDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05033 Genomic DNA Translation: CAA28707.1
PIRiS30084

Entry informationi

Entry nameiTRPG_PENCH
AccessioniPrimary (citable) accession number: P24773
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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