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Protein

Protein A41

Gene

VACWR166

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May interact with several cellular chemokines to interfere with chemokine-glycosaminoglycan (GAG) interactions at the cell surface to alter chemotaxis of nearby responsive cells.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host chemokines by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A41
Gene namesi
Ordered Locus Names:VACWR166
ORF Names:A41L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000004060317 – 219Protein A41Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP24766

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

IntActiP24766, 10 interactors
MINTiP24766

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 46Combined sources18
Beta strandi54 – 58Combined sources5
Beta strandi61 – 66Combined sources6
Beta strandi69 – 77Combined sources9
Beta strandi84 – 90Combined sources7
Beta strandi93 – 99Combined sources7
Turni103 – 105Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi111 – 113Combined sources3
Helixi114 – 123Combined sources10
Beta strandi125 – 132Combined sources8
Helixi150 – 152Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi165 – 168Combined sources4
Beta strandi173 – 192Combined sources20
Beta strandi197 – 203Combined sources7
Beta strandi210 – 212Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VGAX-ray1.90A21-219[»]
ProteinModelPortaliP24766
SMRiP24766
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24766

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae A41 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG090000PT

Family and domain databases

Gene3Di2.60.240.10, 1 hit
InterProiView protein in InterPro
IPR003184 Orthopox_35kDa
IPR036540 Pox_vCCI-like_sf
PfamiView protein in Pfam
PF02250 Orthopox_35kD, 1 hit
SUPFAMiSSF49889 SSF49889, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSLVFVILM CIPFSFQTVY DDKSVCDSDN KEYMGIEVYV EATLDEPLRQ
60 70 80 90 100
TTCESKIHKY GASVSNGGLN ISVDLLNCFL NFHTVGVYTN RDTVYAKFAS
110 120 130 140 150
LDPWTTEPIN SMTHDDLVKL TEECIVDIYL KCEVDKTKDF MKTNGNRLKP
160 170 180 190 200
RDFKTVPPSN VGSMIELQSD YCVNDVTTYV KIYDECGNIK QHSIPTLRDY
210
FTTKNGQPRK ILKKKFDNC
Length:219
Mass (Da):25,093
Last modified:March 1, 1992 - v1
Checksum:i905CE997BBC605D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58052 Genomic DNA Translation: AAA48341.1
D11079 Genomic DNA Translation: BAA01814.1
M72474 Genomic DNA Translation: AAA48307.1
AY243312 Genomic DNA Translation: AAO89445.1
PIRiJQ1778
RefSeqiYP_233048.1, NC_006998.1

Genome annotation databases

GeneIDi3707696
KEGGivg:3707696

Similar proteinsi

Entry informationi

Entry nameiA41_VACCW
AccessioniPrimary (citable) accession number: P24766
Secondary accession number(s): Q76ZN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health