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Protein

Protein A41

Gene

VACWR166

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May interact with several cellular chemokines to interfere with chemokine-glycosaminoglycan (GAG) interactions at the cell surface to alter chemotaxis of nearby responsive cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host chemokines by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A41
Gene namesi
Ordered Locus Names:VACWR166
ORF Names:A41L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000004060317 – 219Protein A41Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

IntActiP24766. 10 interactors.
MINTiMINT-6629008.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 46Combined sources18
Beta strandi54 – 58Combined sources5
Beta strandi61 – 66Combined sources6
Beta strandi69 – 77Combined sources9
Beta strandi84 – 90Combined sources7
Beta strandi93 – 99Combined sources7
Turni103 – 105Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi111 – 113Combined sources3
Helixi114 – 123Combined sources10
Beta strandi125 – 132Combined sources8
Helixi150 – 152Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi165 – 168Combined sources4
Beta strandi173 – 192Combined sources20
Beta strandi197 – 203Combined sources7
Beta strandi210 – 212Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VGAX-ray1.90A21-219[»]
ProteinModelPortaliP24766.
SMRiP24766.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24766.

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae A41 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.240.10. 1 hit.
InterProiIPR003184. Orthopox_35kDa.
[Graphical view]
PfamiPF02250. Orthopox_35kD. 1 hit.
[Graphical view]
SUPFAMiSSF49889. SSF49889. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSLVFVILM CIPFSFQTVY DDKSVCDSDN KEYMGIEVYV EATLDEPLRQ
60 70 80 90 100
TTCESKIHKY GASVSNGGLN ISVDLLNCFL NFHTVGVYTN RDTVYAKFAS
110 120 130 140 150
LDPWTTEPIN SMTHDDLVKL TEECIVDIYL KCEVDKTKDF MKTNGNRLKP
160 170 180 190 200
RDFKTVPPSN VGSMIELQSD YCVNDVTTYV KIYDECGNIK QHSIPTLRDY
210
FTTKNGQPRK ILKKKFDNC
Length:219
Mass (Da):25,093
Last modified:March 1, 1992 - v1
Checksum:i905CE997BBC605D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58052 Genomic DNA. Translation: AAA48341.1.
D11079 Genomic DNA. Translation: BAA01814.1.
M72474 Genomic DNA. Translation: AAA48307.1.
AY243312 Genomic DNA. Translation: AAO89445.1.
PIRiJQ1778.
RefSeqiYP_233048.1. NC_006998.1.

Genome annotation databases

GeneIDi3707696.
KEGGivg:3707696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58052 Genomic DNA. Translation: AAA48341.1.
D11079 Genomic DNA. Translation: BAA01814.1.
M72474 Genomic DNA. Translation: AAA48307.1.
AY243312 Genomic DNA. Translation: AAO89445.1.
PIRiJQ1778.
RefSeqiYP_233048.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VGAX-ray1.90A21-219[»]
ProteinModelPortaliP24766.
SMRiP24766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP24766. 10 interactors.
MINTiMINT-6629008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707696.
KEGGivg:3707696.

Miscellaneous databases

EvolutionaryTraceiP24766.

Family and domain databases

Gene3Di2.60.240.10. 1 hit.
InterProiIPR003184. Orthopox_35kDa.
[Graphical view]
PfamiPF02250. Orthopox_35kD. 1 hit.
[Graphical view]
SUPFAMiSSF49889. SSF49889. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA41_VACCW
AccessioniPrimary (citable) accession number: P24766
Secondary accession number(s): Q76ZN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.