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P24754

- OMPA_ESCHE

UniProt

P24754 - OMPA_ESCHE

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Protein

Outer membrane protein A

Gene

ompA

Organism
Escherichia hermannii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity).By similarity

GO - Molecular functioni

  1. porin activity Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. conjugation Source: UniProtKB-KW
  2. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Conjugation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene namesi
Name:ompA
OrganismiEscherichia hermannii
Taxonomic identifieri565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei‹1 – 8›8Beta strandedSequence Analysis
Transmembranei12 – 2716Beta strandedSequence AnalysisAdd
BLAST
Transmembranei47 – 5812Beta strandedSequence AnalysisAdd
BLAST
Transmembranei64 – 8017Beta strandedSequence AnalysisAdd
BLAST
Transmembranei86 – 9712Beta strandedSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
  2. pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›243›243Outer membrane protein APRO_0000196255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi217 ↔ 229By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP24754.

Interactioni

Subunit structurei

Monomer.Curated

Structurei

3D structure databases

ProteinModelPortaliP24754.
SMRiP24754. Positions 1-102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati107 – 10821
Repeati109 – 11022
Repeati111 – 11223
Repeati113 – 11424
Domaini116 – ›243›128OmpA-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 11484 X 2 AA tandem repeats of A-P

Sequence similaritiesi

Belongs to the OmpA family.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P24754-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LTAKLGYPIT DELDIYTRLG GMVWRADSKY NIPGGASFKD HDTGVSPVFA
60 70 80 90 100
GGLEWAVTRD IATRLEYQWT NNIGDANTVG TRPDNGLLSV GVSYRFGQQE
110 120 130 140 150
AAAPVVAPAP APAPEVQTKH FTLKSDVLFN FNKATLKPEG QQALDQMYTQ
160 170 180 190 200
LSNLDPKDGS VVVLGFTDRI GSDAYNQGLS EKRAQSVVDY LISKGIPSDK
210 220 230 240
ISARGMGESN PVTGNTCDNV KPRAALIDCL APDRRVEIEV KGI
Length:243
Mass (Da):26,202
Last modified:March 1, 1992 - v1
Checksum:iAA6CB6BA390D1E9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei243 – 2431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63346 Genomic DNA. Translation: AAA24234.1.
M63347 Genomic DNA. Translation: AAA24238.1.
PIRiI62386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63346 Genomic DNA. Translation: AAA24234.1 .
M63347 Genomic DNA. Translation: AAA24238.1 .
PIRi I62386.

3D structure databases

ProteinModelPortali P24754.
SMRi P24754. Positions 1-102.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProi IPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view ]
Pfami PF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view ]
PRINTSi PR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMi SSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEi PS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and evolutionary relationships among enteric bacteria."
    Lawrence J.G., Ochman H., Hartl D.L.
    J. Gen. Microbiol. 137:1911-1921(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33650 / CDC 980-72 / DSM 4560 / JCM 1473 / NCTC 12129 and ATCC 33652 / CDC 1479-80.

Entry informationi

Entry nameiOMPA_ESCHE
AccessioniPrimary (citable) accession number: P24754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3