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P24754 (OMPA_ESCHE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene names
Name:ompA
OrganismEscherichia hermannii
Taxonomic identifier565 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length243 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.

Subunit structure

Monomer Probable.

Subcellular location

Cell outer membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the OmpA family.

Contains 1 OmpA-like domain.

Ontologies

Keywords
   Biological processConjugation
Ion transport
Transport
   Cellular componentCell outer membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane beta strand
   Molecular functionPorin
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processconjugation

Inferred from electronic annotation. Source: UniProtKB-KW

ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

pore complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionporin activity

Inferred from electronic annotation. Source: UniProtKB-KW

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›243›243Outer membrane protein A
PRO_0000196255

Regions

Transmembrane‹1 – 8›8Beta stranded; Potential
Transmembrane12 – 2716Beta stranded; Potential
Transmembrane47 – 5812Beta stranded; Potential
Transmembrane64 – 8017Beta stranded; Potential
Transmembrane86 – 9712Beta stranded; Potential
Repeat107 – 10821
Repeat109 – 11022
Repeat111 – 11223
Repeat113 – 11424
Domain116 – ›243›128OmpA-like
Region107 – 11484 X 2 AA tandem repeats of A-P

Amino acid modifications

Disulfide bond217 ↔ 229 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2431

Sequences

Sequence LengthMass (Da)Tools
P24754 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: AA6CB6BA390D1E9D

FASTA24326,202
        10         20         30         40         50         60 
LTAKLGYPIT DELDIYTRLG GMVWRADSKY NIPGGASFKD HDTGVSPVFA GGLEWAVTRD 

        70         80         90        100        110        120 
IATRLEYQWT NNIGDANTVG TRPDNGLLSV GVSYRFGQQE AAAPVVAPAP APAPEVQTKH 

       130        140        150        160        170        180 
FTLKSDVLFN FNKATLKPEG QQALDQMYTQ LSNLDPKDGS VVVLGFTDRI GSDAYNQGLS 

       190        200        210        220        230        240 
EKRAQSVVDY LISKGIPSDK ISARGMGESN PVTGNTCDNV KPRAALIDCL APDRRVEIEV 


KGI 

« Hide

References

[1]"Molecular and evolutionary relationships among enteric bacteria."
Lawrence J.G., Ochman H., Hartl D.L.
J. Gen. Microbiol. 137:1911-1921(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33650 / CDC 980-72 / DSM 4560 / JCM 1473 / NCTC 12129 and ATCC 33652 / CDC 1479-80.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63346 Genomic DNA. Translation: AAA24234.1.
M63347 Genomic DNA. Translation: AAA24238.1.
PIRI62386.

3D structure databases

ProteinModelPortalP24754.
SMRP24754. Positions 1-102.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP24754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view]
PfamPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOMPA_ESCHE
AccessionPrimary (citable) accession number: P24754
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families