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Protein

Outer membrane protein A

Gene

ompA

Organism
Atlantibacter hermannii (Escherichia hermannii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Conjugation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene namesi
Name:ompA
OrganismiAtlantibacter hermannii (Escherichia hermannii)
Taxonomic identifieri565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeAtlantibacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 8Beta strandedSequence analysis›8
Transmembranei12 – 27Beta strandedSequence analysisAdd BLAST16
Transmembranei47 – 58Beta strandedSequence analysisAdd BLAST12
Transmembranei64 – 80Beta strandedSequence analysisAdd BLAST17
Transmembranei86 – 97Beta strandedSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000196255‹1 – ›243Outer membrane protein AAdd BLAST›243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi217 ↔ 229By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP24754.

Interactioni

Subunit structurei

Monomer.Curated

Structurei

3D structure databases

ProteinModelPortaliP24754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati107 – 10812
Repeati109 – 11022
Repeati111 – 11232
Repeati113 – 11442
Domaini116 – ›243OmpA-likePROSITE-ProRule annotationAdd BLAST›128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 1144 X 2 AA tandem repeats of A-P8

Sequence similaritiesi

Belongs to the OmpA family.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane beta strand

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P24754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LTAKLGYPIT DELDIYTRLG GMVWRADSKY NIPGGASFKD HDTGVSPVFA
60 70 80 90 100
GGLEWAVTRD IATRLEYQWT NNIGDANTVG TRPDNGLLSV GVSYRFGQQE
110 120 130 140 150
AAAPVVAPAP APAPEVQTKH FTLKSDVLFN FNKATLKPEG QQALDQMYTQ
160 170 180 190 200
LSNLDPKDGS VVVLGFTDRI GSDAYNQGLS EKRAQSVVDY LISKGIPSDK
210 220 230 240
ISARGMGESN PVTGNTCDNV KPRAALIDCL APDRRVEIEV KGI
Length:243
Mass (Da):26,202
Last modified:March 1, 1992 - v1
Checksum:iAA6CB6BA390D1E9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63346 Genomic DNA. Translation: AAA24234.1.
M63347 Genomic DNA. Translation: AAA24238.1.
PIRiI62386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63346 Genomic DNA. Translation: AAA24234.1.
M63347 Genomic DNA. Translation: AAA24238.1.
PIRiI62386.

3D structure databases

ProteinModelPortaliP24754.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP24754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPA_ATLHE
AccessioniPrimary (citable) accession number: P24754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.