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P24754

- OMPA_ESCHE

UniProt

P24754 - OMPA_ESCHE

Protein

Outer membrane protein A

Gene

ompA

Organism
Escherichia hermannii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.By similarity

    GO - Molecular functioni

    1. porin activity Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. conjugation Source: UniProtKB-KW
    2. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Porin

    Keywords - Biological processi

    Conjugation, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane protein A
    Alternative name(s):
    Outer membrane protein II
    Gene namesi
    Name:ompA
    OrganismiEscherichia hermannii
    Taxonomic identifieri565 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. pore complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›243›243Outer membrane protein APRO_0000196255Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi217 ↔ 229By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP24754.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliP24754.
    SMRiP24754. Positions 1-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei‹1 – 8›8Beta strandedSequence Analysis
    Transmembranei12 – 2716Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei47 – 5812Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8017Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei86 – 9712Beta strandedSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati107 – 10821
    Repeati109 – 11022
    Repeati111 – 11223
    Repeati113 – 11424
    Domaini116 – ›243›128OmpA-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 11484 X 2 AA tandem repeats of A-P

    Sequence similaritiesi

    Belongs to the OmpA family.Curated
    Contains 1 OmpA-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane beta strand

    Family and domain databases

    Gene3Di2.40.160.20. 1 hit.
    3.30.1330.60. 1 hit.
    InterProiIPR011250. OMP/PagP_b-brl.
    IPR006664. OMP_bac.
    IPR002368. OmpA.
    IPR006690. OMPA-like_CS.
    IPR000498. OmpA-like_TM_dom.
    IPR006665. OmpA/MotB_C.
    [Graphical view]
    PfamiPF00691. OmpA. 1 hit.
    PF01389. OmpA_membrane. 1 hit.
    [Graphical view]
    PRINTSiPR01021. OMPADOMAIN.
    PR01022. OUTRMMBRANEA.
    SUPFAMiSSF103088. SSF103088. 1 hit.
    SSF56925. SSF56925. 1 hit.
    PROSITEiPS01068. OMPA_1. 1 hit.
    PS51123. OMPA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P24754-1 [UniParc]FASTAAdd to Basket

    « Hide

    LTAKLGYPIT DELDIYTRLG GMVWRADSKY NIPGGASFKD HDTGVSPVFA    50
    GGLEWAVTRD IATRLEYQWT NNIGDANTVG TRPDNGLLSV GVSYRFGQQE 100
    AAAPVVAPAP APAPEVQTKH FTLKSDVLFN FNKATLKPEG QQALDQMYTQ 150
    LSNLDPKDGS VVVLGFTDRI GSDAYNQGLS EKRAQSVVDY LISKGIPSDK 200
    ISARGMGESN PVTGNTCDNV KPRAALIDCL APDRRVEIEV KGI 243
    Length:243
    Mass (Da):26,202
    Last modified:March 1, 1992 - v1
    Checksum:iAA6CB6BA390D1E9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei243 – 2431

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63346 Genomic DNA. Translation: AAA24234.1.
    M63347 Genomic DNA. Translation: AAA24238.1.
    PIRiI62386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63346 Genomic DNA. Translation: AAA24234.1 .
    M63347 Genomic DNA. Translation: AAA24238.1 .
    PIRi I62386.

    3D structure databases

    ProteinModelPortali P24754.
    SMRi P24754. Positions 1-102.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P24754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.40.160.20. 1 hit.
    3.30.1330.60. 1 hit.
    InterProi IPR011250. OMP/PagP_b-brl.
    IPR006664. OMP_bac.
    IPR002368. OmpA.
    IPR006690. OMPA-like_CS.
    IPR000498. OmpA-like_TM_dom.
    IPR006665. OmpA/MotB_C.
    [Graphical view ]
    Pfami PF00691. OmpA. 1 hit.
    PF01389. OmpA_membrane. 1 hit.
    [Graphical view ]
    PRINTSi PR01021. OMPADOMAIN.
    PR01022. OUTRMMBRANEA.
    SUPFAMi SSF103088. SSF103088. 1 hit.
    SSF56925. SSF56925. 1 hit.
    PROSITEi PS01068. OMPA_1. 1 hit.
    PS51123. OMPA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and evolutionary relationships among enteric bacteria."
      Lawrence J.G., Ochman H., Hartl D.L.
      J. Gen. Microbiol. 137:1911-1921(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 33650 / CDC 980-72 / DSM 4560 / JCM 1473 / NCTC 12129 and ATCC 33652 / CDC 1479-80.

    Entry informationi

    Entry nameiOMPA_ESCHE
    AccessioniPrimary (citable) accession number: P24754
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3