P24754 (OMPA_ESCHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer membrane protein A

Alternative name(s):
Outer membrane protein II

Gene names

Name:

ompA

Organism

Escherichia hermannii

Taxonomic identifier

565 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	243 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.
Subunit structure	Monomer Probable.
Subcellular location	Cell outer membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the OmpA family. Contains 1 OmpA-like domain.

Ontologies

Keywords
Biological process	Conjugation Ion transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Repeat Transmembrane Transmembrane beta strand
Molecular function	Porin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	conjugation Inferred from electronic annotation. Source: UniProtKB-KW ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	porin activity Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›243	›243	Outer membrane protein A		PRO_0000196255
Regions
	Transmembrane	‹1 – 8	›8	Beta stranded; Potential
	Transmembrane	12 – 27	16	Beta stranded; Potential
	Transmembrane	47 – 58	12	Beta stranded; Potential
	Transmembrane	64 – 80	17	Beta stranded; Potential
	Transmembrane	86 – 97	12	Beta stranded; Potential
	Repeat	107 – 108	2	1
	Repeat	109 – 110	2	2
	Repeat	111 – 112	2	3
	Repeat	113 – 114	2	4
	Domain	116 – ›243	›128	OmpA-like
	Region	107 – 114	8	4 X 2 AA tandem repeats of A-P
Amino acid modifications
	Disulfide bond	217 ↔ 229		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	243	1

Sequences

	Sequence		Length	Mass (Da)
	P24754 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: AA6CB6BA390D1E9D	FASTA	243	26,202
	10 20 30 40 50 60 LTAKLGYPIT DELDIYTRLG GMVWRADSKY NIPGGASFKD HDTGVSPVFA GGLEWAVTRD 70 80 90 100 110 120 IATRLEYQWT NNIGDANTVG TRPDNGLLSV GVSYRFGQQE AAAPVVAPAP APAPEVQTKH 130 140 150 160 170 180 FTLKSDVLFN FNKATLKPEG QQALDQMYTQ LSNLDPKDGS VVVLGFTDRI GSDAYNQGLS 190 200 210 220 230 240 EKRAQSVVDY LISKGIPSDK ISARGMGESN PVTGNTCDNV KPRAALIDCL APDRRVEIEV KGI

References

[1]

"Molecular and evolutionary relationships among enteric bacteria." Lawrence J.G., Ochman H., Hartl D.L. J. Gen. Microbiol. 137:1911-1921(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 33650 / CDC 980-72 / DSM 4560 / JCM 1473 / NCTC 12129 and ATCC 33652 / CDC 1479-80.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63346 Genomic DNA. Translation: AAA24234.1. M63347 Genomic DNA. Translation: AAA24238.1.
PIR	I62386.
3D structure databases
ProteinModelPortal	P24754.
SMR	P24754. Positions 1-102.
ModBase	Search...
Proteomic databases
PRIDE	P24754.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.40.160.20. 1 hit. 3.30.1330.60. 1 hit.
InterPro	IPR011250. OMP/PagP_b-brl. IPR006664. OMP_bac. IPR002368. OmpA. IPR006690. OMPA-like_CS. IPR000498. OmpA-like_TM_dom. IPR006665. OmpA/MotB_C. [Graphical view]
Pfam	PF00691. OmpA. 1 hit. PF01389. OmpA_membrane. 1 hit. [Graphical view]
PRINTS	PR01021. OMPADOMAIN. PR01022. OUTRMMBRANEA.
SUPFAM	SSF103088. OmpA/MotB_C. 1 hit. SSF56925. SSF56925. 1 hit.
PROSITE	PS01068. OMPA_1. 1 hit. PS51123. OMPA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OMPA_ESCHE

Accession

Primary (citable) accession number: P24754

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program