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Protein

Myosin heavy chain, striated muscle

Gene
N/A
Organism
Argopecten irradians (Bay scallop) (Aequipecten irradians)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.
Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 1838ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin heavy chain, striated muscle
OrganismiArgopecten irradians (Bay scallop) (Aequipecten irradians)
Taxonomic identifieri31199 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaeArgopecten

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19381938Myosin heavy chain, striated musclePRO_0000123384Add
BLAST

Proteomic databases

PRIDEiP24733.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Structurei

Secondary structure

1
1938
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 103Combined sources
Turni11 – 133Combined sources
Beta strandi17 – 204Combined sources
Beta strandi21 – 266Combined sources
Turni30 – 323Combined sources
Beta strandi33 – 386Combined sources
Turni39 – 413Combined sources
Beta strandi42 – 5211Combined sources
Beta strandi55 – 606Combined sources
Turni61 – 633Combined sources
Beta strandi66 – 705Combined sources
Helixi71 – 733Combined sources
Helixi80 – 823Combined sources
Helixi88 – 903Combined sources
Beta strandi91 – 933Combined sources
Helixi96 – 10813Combined sources
Beta strandi113 – 1164Combined sources
Beta strandi119 – 1235Combined sources
Helixi130 – 1323Combined sources
Helixi134 – 1407Combined sources
Helixi145 – 1473Combined sources
Helixi152 – 16615Combined sources
Beta strandi168 – 1758Combined sources
Beta strandi177 – 1815Combined sources
Helixi182 – 19615Combined sources
Turni206 – 2083Combined sources
Helixi215 – 23016Combined sources
Beta strandi231 – 2344Combined sources
Beta strandi240 – 25112Combined sources
Beta strandi255 – 26511Combined sources
Helixi269 – 2724Combined sources
Helixi283 – 2886Combined sources
Turni289 – 2913Combined sources
Helixi294 – 2963Combined sources
Helixi297 – 3004Combined sources
Helixi306 – 3083Combined sources
Turni310 – 3123Combined sources
Beta strandi313 – 3153Combined sources
Helixi324 – 33714Combined sources
Helixi342 – 35817Combined sources
Beta strandi367 – 3693Combined sources
Beta strandi373 – 3753Combined sources
Helixi378 – 38710Combined sources
Helixi391 – 3999Combined sources
Beta strandi405 – 4073Combined sources
Helixi416 – 44631Combined sources
Beta strandi454 – 4607Combined sources
Beta strandi468 – 4703Combined sources
Helixi472 – 50231Combined sources
Helixi514 – 52411Combined sources
Helixi529 – 5368Combined sources
Helixi544 – 55512Combined sources
Turni556 – 5583Combined sources
Beta strandi560 – 5634Combined sources
Beta strandi570 – 5723Combined sources
Beta strandi577 – 5826Combined sources
Beta strandi585 – 5895Combined sources
Helixi594 – 5985Combined sources
Helixi604 – 6118Combined sources
Helixi616 – 6216Combined sources
Helixi645 – 66016Combined sources
Beta strandi663 – 6719Combined sources
Helixi684 – 6918Combined sources
Beta strandi694 – 6963Combined sources
Helixi700 – 7045Combined sources
Beta strandi709 – 7124Combined sources
Helixi713 – 7208Combined sources
Helixi721 – 7233Combined sources
Helixi725 – 7273Combined sources
Helixi735 – 74612Combined sources
Helixi750 – 7523Combined sources
Beta strandi753 – 7553Combined sources
Beta strandi757 – 7626Combined sources
Helixi776 – 82247Combined sources
Helixi825 – 8339Combined sources
Turni834 – 8363Combined sources
Helixi841 – 88545Combined sources
Helixi891 – 8933Combined sources
Helixi901 – 92121Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B7TX-ray2.50A1-835[»]
1DFKX-ray4.20A6-835[»]
1DFLX-ray4.20A/B5-835[»]
1KK7X-ray3.20A1-837[»]
1KK8X-ray2.30A1-837[»]
1KQMX-ray3.00A1-835[»]
1KWOX-ray3.80A1-835[»]
1L2OX-ray2.80A1-835[»]
1QVIX-ray2.54A1-840[»]
1S5GX-ray3.10A1-840[»]
1SCMX-ray2.80A777-836[»]
1SR6X-ray2.75A1-840[»]
1WDCX-ray2.00A774-837[»]
2W4Telectron microscopy35.00C5-835[»]
2W4Velectron microscopy35.00C5-835[»]
2W4Welectron microscopy35.00C5-835[»]
3BASX-ray2.30A/B835-885[»]
3BATX-ray2.30A/B/C/D835-885[»]
3JTDX-ray2.57A773-836[»]
3JVTX-ray2.10A773-837[»]
ProteinModelPortaliP24733.
SMRiP24733. Positions 6-921.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 775693Myosin motorAdd
BLAST
Domaini778 – 80528IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni836 – 19381103Rodlike tail (S2 and LMM domains)Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili836 – 19381103Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDFSDPDF QYLAVDRKKL MKEQTAAFDG KKNCWVPDEK EGFASAEIQS
60 70 80 90 100
SKGDEITVKI VADSSTRTVK KDDIQSMNPP KFEKLEDMAN MTYLNEASVL
110 120 130 140 150
YNLRSRYTSG LIYTYSGLFC IAVNPYRRLP IYTDSVIAKY RGKRKTEIPP
160 170 180 190 200
HLFSVADNAY QNMVTDRENQ SCLITGESGA GKTENTKKVI MYLAKVACAV
210 220 230 240 250
KKKDEEASDK KEGSLEDQII QANPVLEAYG NAKTTRNNNS SRFGKFIRIH
260 270 280 290 300
FGPTGKIAGA DIETYLLEKS RVTYQQSAER NYHIFYQICS NAIPELNDVM
310 320 330 340 350
LVTPDSGLYS FINQGCLTVD NIDDVEEFKL CDEAFDILGF TKEEKQSMFK
360 370 380 390 400
CTASILHMGE MKFKQRPREE QAESDGTAEA EKVAFLCGIN AGDLLKALLK
410 420 430 440 450
PKVKVGTEMV TKGQNMNQVV NSVGALAKSL YDRMFNWLVR RVNKTLDTKA
460 470 480 490 500
KRNYYIGVLD IAGFEIFDFN SFEQLCINYT NERLQQFFNH HMFILEQEEY
510 520 530 540 550
KKEGIAWEFI DFGMDLQMCI DLIEKPMGIL SILEEECMFP KADDKSFQDK
560 570 580 590 600
LYQNHMGKNR MFTKPGKPTR PNQGPAHFEL HHYAGNVPYS ITGWLEKNKD
610 620 630 640 650
PINENVVALL GASKEPLVAE LFKAPEEPAG GGKKKKGKSS AFQTISAVHR
660 670 680 690 700
ESLNKLMKNL YSTHPHFVRC IIPNELKQPG LVDAELVLHQ LQCNGVLEGI
710 720 730 740 750
RICRKGFPSR LIYSEFKQRY SILAPNAIPQ GFVDGKTVSE KILAGLQMDP
760 770 780 790 800
AEYRLGTTKV FFKAGVLGNL EEMRDERLSK IISMFQAHIR GYLIRKAYKK
810 820 830 840 850
LQDQRIGLSV IQRNIRKWLV LRNWQWWKLY SKVKPLLSIA RQEEEMKEQL
860 870 880 890 900
KQMDKMKEDL AKTERIKKEL EEQNVTLLEQ KNDLFLQLQT LEDSMGDQEE
910 920 930 940 950
RVEKLIMQKA DFESQIKELE ERLLDEEDAA ADLEGIKKKM EADNANLKKD
960 970 980 990 1000
IGDLENTLQK AEQDKAHKDN QISTLQGEIS QQDEHIGKLN KEKKALEEAN
1010 1020 1030 1040 1050
KKTSDSLQAE EDKCNHLNKL KAKLEQALDE LEDNLEREKK VRGDVEKAKR
1060 1070 1080 1090 1100
KVEQDLKSTQ ENVEDLERVK RELEENVRRK EAEISSLNSK LEDEQNLVSQ
1110 1120 1130 1140 1150
LQRKIKELQA RIEELEEELE AERNARAKVE KQRAELNREL EELGERLDEA
1160 1170 1180 1190 1200
GGATSAQIEL NKKREAELLK IRRDLEEASL QHEAQISALR KKHQDAANEM
1210 1220 1230 1240 1250
ADQVDQLQKV KSKLEKDKKD LKREMDDLES QMTHNMKNKG CSEKVMKQFE
1260 1270 1280 1290 1300
SQMSDLNARL EDSQRSINEL QSQKSRLQAE NSDLTRQLED AEHRVSVLSK
1310 1320 1330 1340 1350
EKSQLSSQLE DARRSLEEET RARSKLQNEV RNMHADMDAI REQLEEEQES
1360 1370 1380 1390 1400
KSDVQRQLSK ANNEIQQWRS KFESEGANRT EELEDQKRKL LGKLSEAEQT
1410 1420 1430 1440 1450
TEAANAKCSA LEKAKSRLQQ ELEDMSIEVD RANASVNQME KKQRAFDKTT
1460 1470 1480 1490 1500
AEWQAKVNSL QSELENSQKE SRGYSAELYR IKASIEEYQD SIGALRRENK
1510 1520 1530 1540 1550
NLADEIHDLT DQLSEGGRST HELDKARRRL EMEKEELQAA LEEAEGALEQ
1560 1570 1580 1590 1600
EEAKVMRAQL EIATVRNEID KRIQEKEEEF DNTRRNHQRA LESMQASLEA
1610 1620 1630 1640 1650
EAKGKADAMR IKKKLEQDIN ELEVALDASN RGKAEMEKTV KRYQQQIREM
1660 1670 1680 1690 1700
QTSIEEEQRQ RDEARESYNM AERRCTLMSG EVEELRAALE QAERARKASD
1710 1720 1730 1740 1750
NELADANDRV NELTSQVSSV QGQKRKLEGD INAMQTDLDE MHGELKGADE
1760 1770 1780 1790 1800
RCKKAMADAA RLADELRAEQ DHSNQVEKVR KNLESQVKEF QIRLDEAEAS
1810 1820 1830 1840 1850
SLKGGKKMIQ KLESRVHELE AELDNEQRRH AETQKNMRKA DRRLKELAFQ
1860 1870 1880 1890 1900
ADEDRKNQER LQELIDKLNA KIKTFKRQVE EAEEIAAINL AKYRKAQHEL
1910 1920 1930
EEAEERADTA DSTLQKFRAK SRSSVSVQRS SVSVSASN
Length:1,938
Mass (Da):222,822
Last modified:March 1, 1992 - v1
Checksum:iA5CCE4127D1A4896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55714 mRNA. Translation: CAA39247.1.
PIRiA40997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55714 mRNA. Translation: CAA39247.1.
PIRiA40997.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B7TX-ray2.50A1-835[»]
1DFKX-ray4.20A6-835[»]
1DFLX-ray4.20A/B5-835[»]
1KK7X-ray3.20A1-837[»]
1KK8X-ray2.30A1-837[»]
1KQMX-ray3.00A1-835[»]
1KWOX-ray3.80A1-835[»]
1L2OX-ray2.80A1-835[»]
1QVIX-ray2.54A1-840[»]
1S5GX-ray3.10A1-840[»]
1SCMX-ray2.80A777-836[»]
1SR6X-ray2.75A1-840[»]
1WDCX-ray2.00A774-837[»]
2W4Telectron microscopy35.00C5-835[»]
2W4Velectron microscopy35.00C5-835[»]
2W4Welectron microscopy35.00C5-835[»]
3BASX-ray2.30A/B835-885[»]
3BATX-ray2.30A/B/C/D835-885[»]
3JTDX-ray2.57A773-836[»]
3JVTX-ray2.10A773-837[»]
ProteinModelPortaliP24733.
SMRiP24733. Positions 6-921.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP24733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP24733.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete primary structure of a scallop striated muscle myosin heavy chain. Sequence comparison with other heavy chains reveals regions that might be critical for regulation."
    Nyitray L., Goodwin E.B., Szent-Gyorgyi A.G.
    J. Biol. Chem. 266:18469-18476(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adductor muscle.
  2. "Nucleotide sequence of full length cDNA for a scallop striated muscle myosin heavy chain."
    Nyitray L., Goodwin E.B., Szent-Gyorgyi A.G.
    Nucleic Acids Res. 18:7158-7158(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adductor muscle.
  3. "Structure of the regulatory domain of scallop myosin at 2.8-A resolution."
    Xie X., Harrison D.H., Schlichting I., Sweet R.M., Kalabokis V.N., Szent-Gyorgyi A.G., Cohen C.
    Nature 368:306-312(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 777-836.
  4. "Structure of the regulatory domain of scallop myosin at 2-A resolution: implications for regulation."
    Houdusse A., Cohen C.
    Structure 4:21-32(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 777-836.

Entry informationi

Entry nameiMYS_ARGIR
AccessioniPrimary (citable) accession number: P24733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.