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Protein

Myosin heavy chain, striated muscle

Gene
N/A
Organism
Argopecten irradians (Bay scallop) (Aequipecten irradians)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.
Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi176 – 183ATPBy similarity8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin heavy chain, striated muscle
OrganismiArgopecten irradians (Bay scallop) (Aequipecten irradians)
Taxonomic identifieri31199 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaeArgopecten

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001233841 – 1938Myosin heavy chain, striated muscleAdd BLAST1938

Proteomic databases

PRIDEiP24733.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Structurei

Secondary structure

11938
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Turni11 – 13Combined sources3
Beta strandi17 – 20Combined sources4
Beta strandi21 – 26Combined sources6
Turni30 – 32Combined sources3
Beta strandi33 – 38Combined sources6
Turni39 – 41Combined sources3
Beta strandi42 – 52Combined sources11
Beta strandi55 – 60Combined sources6
Turni61 – 63Combined sources3
Beta strandi66 – 70Combined sources5
Helixi71 – 73Combined sources3
Helixi80 – 82Combined sources3
Helixi88 – 90Combined sources3
Beta strandi91 – 93Combined sources3
Helixi96 – 108Combined sources13
Beta strandi113 – 116Combined sources4
Beta strandi119 – 123Combined sources5
Helixi130 – 132Combined sources3
Helixi134 – 140Combined sources7
Helixi145 – 147Combined sources3
Helixi152 – 166Combined sources15
Beta strandi168 – 175Combined sources8
Beta strandi177 – 181Combined sources5
Helixi182 – 196Combined sources15
Turni206 – 208Combined sources3
Helixi215 – 230Combined sources16
Beta strandi231 – 234Combined sources4
Beta strandi240 – 251Combined sources12
Beta strandi255 – 265Combined sources11
Helixi269 – 272Combined sources4
Helixi283 – 288Combined sources6
Turni289 – 291Combined sources3
Helixi294 – 296Combined sources3
Helixi297 – 300Combined sources4
Helixi306 – 308Combined sources3
Turni310 – 312Combined sources3
Beta strandi313 – 315Combined sources3
Helixi324 – 337Combined sources14
Helixi342 – 358Combined sources17
Beta strandi367 – 369Combined sources3
Beta strandi373 – 375Combined sources3
Helixi378 – 387Combined sources10
Helixi391 – 399Combined sources9
Beta strandi405 – 407Combined sources3
Helixi416 – 446Combined sources31
Beta strandi454 – 460Combined sources7
Beta strandi468 – 470Combined sources3
Helixi472 – 502Combined sources31
Helixi514 – 524Combined sources11
Helixi529 – 536Combined sources8
Helixi544 – 555Combined sources12
Turni556 – 558Combined sources3
Beta strandi560 – 563Combined sources4
Beta strandi570 – 572Combined sources3
Beta strandi577 – 582Combined sources6
Beta strandi585 – 589Combined sources5
Helixi594 – 598Combined sources5
Helixi604 – 611Combined sources8
Helixi616 – 621Combined sources6
Helixi645 – 660Combined sources16
Beta strandi663 – 671Combined sources9
Helixi684 – 691Combined sources8
Beta strandi694 – 696Combined sources3
Helixi700 – 704Combined sources5
Beta strandi709 – 712Combined sources4
Helixi713 – 720Combined sources8
Helixi721 – 723Combined sources3
Helixi725 – 727Combined sources3
Helixi735 – 746Combined sources12
Helixi750 – 752Combined sources3
Beta strandi753 – 755Combined sources3
Beta strandi757 – 762Combined sources6
Helixi776 – 822Combined sources47
Helixi825 – 833Combined sources9
Turni834 – 836Combined sources3
Helixi841 – 885Combined sources45
Helixi913 – 921Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B7TX-ray2.50A1-835[»]
1DFKX-ray4.20A6-835[»]
1DFLX-ray4.20A/B5-835[»]
1KK7X-ray3.20A1-837[»]
1KK8X-ray2.30A1-837[»]
1KQMX-ray3.00A1-835[»]
1KWOX-ray3.80A1-835[»]
1L2OX-ray2.80A1-835[»]
1QVIX-ray2.54A1-840[»]
1S5GX-ray3.10A1-840[»]
1SCMX-ray2.80A777-836[»]
1SR6X-ray2.75A1-840[»]
1WDCX-ray2.00A774-837[»]
2W4Telectron microscopy35.00C5-835[»]
2W4Velectron microscopy35.00C5-835[»]
2W4Welectron microscopy35.00C5-835[»]
3BASX-ray2.30A/B835-885[»]
3BATX-ray2.30A/B/C/D835-885[»]
3JTDX-ray2.57A773-836[»]
3JVTX-ray2.10A773-837[»]
ProteinModelPortaliP24733.
SMRiP24733.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 775Myosin motorAdd BLAST693
Domaini778 – 805IQPROSITE-ProRule annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni836 – 1938Rodlike tail (S2 and LMM domains)Add BLAST1103

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili836 – 1938Sequence analysisAdd BLAST1103

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDFSDPDF QYLAVDRKKL MKEQTAAFDG KKNCWVPDEK EGFASAEIQS
60 70 80 90 100
SKGDEITVKI VADSSTRTVK KDDIQSMNPP KFEKLEDMAN MTYLNEASVL
110 120 130 140 150
YNLRSRYTSG LIYTYSGLFC IAVNPYRRLP IYTDSVIAKY RGKRKTEIPP
160 170 180 190 200
HLFSVADNAY QNMVTDRENQ SCLITGESGA GKTENTKKVI MYLAKVACAV
210 220 230 240 250
KKKDEEASDK KEGSLEDQII QANPVLEAYG NAKTTRNNNS SRFGKFIRIH
260 270 280 290 300
FGPTGKIAGA DIETYLLEKS RVTYQQSAER NYHIFYQICS NAIPELNDVM
310 320 330 340 350
LVTPDSGLYS FINQGCLTVD NIDDVEEFKL CDEAFDILGF TKEEKQSMFK
360 370 380 390 400
CTASILHMGE MKFKQRPREE QAESDGTAEA EKVAFLCGIN AGDLLKALLK
410 420 430 440 450
PKVKVGTEMV TKGQNMNQVV NSVGALAKSL YDRMFNWLVR RVNKTLDTKA
460 470 480 490 500
KRNYYIGVLD IAGFEIFDFN SFEQLCINYT NERLQQFFNH HMFILEQEEY
510 520 530 540 550
KKEGIAWEFI DFGMDLQMCI DLIEKPMGIL SILEEECMFP KADDKSFQDK
560 570 580 590 600
LYQNHMGKNR MFTKPGKPTR PNQGPAHFEL HHYAGNVPYS ITGWLEKNKD
610 620 630 640 650
PINENVVALL GASKEPLVAE LFKAPEEPAG GGKKKKGKSS AFQTISAVHR
660 670 680 690 700
ESLNKLMKNL YSTHPHFVRC IIPNELKQPG LVDAELVLHQ LQCNGVLEGI
710 720 730 740 750
RICRKGFPSR LIYSEFKQRY SILAPNAIPQ GFVDGKTVSE KILAGLQMDP
760 770 780 790 800
AEYRLGTTKV FFKAGVLGNL EEMRDERLSK IISMFQAHIR GYLIRKAYKK
810 820 830 840 850
LQDQRIGLSV IQRNIRKWLV LRNWQWWKLY SKVKPLLSIA RQEEEMKEQL
860 870 880 890 900
KQMDKMKEDL AKTERIKKEL EEQNVTLLEQ KNDLFLQLQT LEDSMGDQEE
910 920 930 940 950
RVEKLIMQKA DFESQIKELE ERLLDEEDAA ADLEGIKKKM EADNANLKKD
960 970 980 990 1000
IGDLENTLQK AEQDKAHKDN QISTLQGEIS QQDEHIGKLN KEKKALEEAN
1010 1020 1030 1040 1050
KKTSDSLQAE EDKCNHLNKL KAKLEQALDE LEDNLEREKK VRGDVEKAKR
1060 1070 1080 1090 1100
KVEQDLKSTQ ENVEDLERVK RELEENVRRK EAEISSLNSK LEDEQNLVSQ
1110 1120 1130 1140 1150
LQRKIKELQA RIEELEEELE AERNARAKVE KQRAELNREL EELGERLDEA
1160 1170 1180 1190 1200
GGATSAQIEL NKKREAELLK IRRDLEEASL QHEAQISALR KKHQDAANEM
1210 1220 1230 1240 1250
ADQVDQLQKV KSKLEKDKKD LKREMDDLES QMTHNMKNKG CSEKVMKQFE
1260 1270 1280 1290 1300
SQMSDLNARL EDSQRSINEL QSQKSRLQAE NSDLTRQLED AEHRVSVLSK
1310 1320 1330 1340 1350
EKSQLSSQLE DARRSLEEET RARSKLQNEV RNMHADMDAI REQLEEEQES
1360 1370 1380 1390 1400
KSDVQRQLSK ANNEIQQWRS KFESEGANRT EELEDQKRKL LGKLSEAEQT
1410 1420 1430 1440 1450
TEAANAKCSA LEKAKSRLQQ ELEDMSIEVD RANASVNQME KKQRAFDKTT
1460 1470 1480 1490 1500
AEWQAKVNSL QSELENSQKE SRGYSAELYR IKASIEEYQD SIGALRRENK
1510 1520 1530 1540 1550
NLADEIHDLT DQLSEGGRST HELDKARRRL EMEKEELQAA LEEAEGALEQ
1560 1570 1580 1590 1600
EEAKVMRAQL EIATVRNEID KRIQEKEEEF DNTRRNHQRA LESMQASLEA
1610 1620 1630 1640 1650
EAKGKADAMR IKKKLEQDIN ELEVALDASN RGKAEMEKTV KRYQQQIREM
1660 1670 1680 1690 1700
QTSIEEEQRQ RDEARESYNM AERRCTLMSG EVEELRAALE QAERARKASD
1710 1720 1730 1740 1750
NELADANDRV NELTSQVSSV QGQKRKLEGD INAMQTDLDE MHGELKGADE
1760 1770 1780 1790 1800
RCKKAMADAA RLADELRAEQ DHSNQVEKVR KNLESQVKEF QIRLDEAEAS
1810 1820 1830 1840 1850
SLKGGKKMIQ KLESRVHELE AELDNEQRRH AETQKNMRKA DRRLKELAFQ
1860 1870 1880 1890 1900
ADEDRKNQER LQELIDKLNA KIKTFKRQVE EAEEIAAINL AKYRKAQHEL
1910 1920 1930
EEAEERADTA DSTLQKFRAK SRSSVSVQRS SVSVSASN
Length:1,938
Mass (Da):222,822
Last modified:March 1, 1992 - v1
Checksum:iA5CCE4127D1A4896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55714 mRNA. Translation: CAA39247.1.
PIRiA40997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55714 mRNA. Translation: CAA39247.1.
PIRiA40997.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B7TX-ray2.50A1-835[»]
1DFKX-ray4.20A6-835[»]
1DFLX-ray4.20A/B5-835[»]
1KK7X-ray3.20A1-837[»]
1KK8X-ray2.30A1-837[»]
1KQMX-ray3.00A1-835[»]
1KWOX-ray3.80A1-835[»]
1L2OX-ray2.80A1-835[»]
1QVIX-ray2.54A1-840[»]
1S5GX-ray3.10A1-840[»]
1SCMX-ray2.80A777-836[»]
1SR6X-ray2.75A1-840[»]
1WDCX-ray2.00A774-837[»]
2W4Telectron microscopy35.00C5-835[»]
2W4Velectron microscopy35.00C5-835[»]
2W4Welectron microscopy35.00C5-835[»]
3BASX-ray2.30A/B835-885[»]
3BATX-ray2.30A/B/C/D835-885[»]
3JTDX-ray2.57A773-836[»]
3JVTX-ray2.10A773-837[»]
ProteinModelPortaliP24733.
SMRiP24733.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP24733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP24733.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYS_ARGIR
AccessioniPrimary (citable) accession number: P24733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.