SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P24722

- KCRT_ONCMY

UniProt

P24722 - KCRT_ONCMY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Creatine kinase, testis isozyme

Gene
tck1
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Catalytic activityi

ATP + creatine = ADP + phosphocreatine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei193 – 1931ATP By similarity
Binding sitei238 – 2381ATP By similarity
Binding sitei294 – 2941ATP By similarity
Binding sitei337 – 3371ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi130 – 1345ATP By similarity
Nucleotide bindingi322 – 3276ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. creatine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Creatine kinase, testis isozyme (EC:2.7.3.2)
Gene namesi
Name:tck1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Creatine kinase, testis isozymePRO_0000211984Add
BLAST

Proteomic databases

PRIDEiP24722.

Expressioni

Tissue specificityi

Exists in many tissues, but preferentially in testis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP24722.
SMRiP24722. Positions 15-383.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10087Phosphagen kinase N-terminalAdd
BLAST
Domaini127 – 369243Phosphagen kinase C-terminalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG001339.

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24722-1 [UniParc]FASTAAdd to Basket

« Hide

MEKINDKMAK LTIKRLSPEE EFPDLSQHNN HMAKVLTQDM YTKLRDRATP    50
NGFTIDGVIQ TGIDNPGHPF IMTVGCVAGD EETYEVFKEL LDPIIEDRHG 100
GYKPTDKHKT DLNPDNLKGG DDLDPNYVIS SRVRTGRSIR GFCLPPHCSR 150
GERRGVEKMS VEALDSLSGD LKGKYYALKN MTDAEQQQLI DDHFLFDKPV 200
SPLLLASGMA RDWPDGRGIW HNDTKTFLVW VNEEDHLRVI SMQKGGNMKE 250
VFNRFCTGLT KIETLFKDKG TSFMWNEHLG YVLTCPSNLG TGLRAGVHVK 300
IPNISKHAKF EEVLKRLRLQ KRGTGGVDTA AVGGTFDISN ADRLGFSEVE 350
LVQMVVDGVK LLVEMEKKLE KGQSIDDLMP AQK 383
Length:383
Mass (Da):43,004
Last modified:March 1, 1992 - v1
Checksum:i608BAAA115C7D1EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53859 mRNA. Translation: CAA37852.1.
PIRiS13164.
RefSeqiNP_001118187.1. NM_001124715.1.
UniGeneiOmy.35804.

Genome annotation databases

GeneIDi100136767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53859 mRNA. Translation: CAA37852.1 .
PIRi S13164.
RefSeqi NP_001118187.1. NM_001124715.1.
UniGenei Omy.35804.

3D structure databases

ProteinModelPortali P24722.
SMRi P24722. Positions 15-383.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P24722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136767.

Organism-specific databases

CTDi 1152.

Phylogenomic databases

HOVERGENi HBG001339.

Family and domain databases

Gene3Di 1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view ]
Pfami PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view ]
SUPFAMi SSF48034. SSF48034. 1 hit.
PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel creatine kinase cDNA whose transcript shows enhanced testicular expression."
    Garber A.T., Winkfein R.J., Dixon G.H.
    Biochim. Biophys. Acta 1087:256-258(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.

Entry informationi

Entry nameiKCRT_ONCMY
AccessioniPrimary (citable) accession number: P24722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi