Reviewed,
UniProtKB/Swiss-Prot P24722 (KCRT_ONCMY)
Last modified
March 3, 2009.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Creatine kinase, testis isozyme EC=2.7.3.2 | ||
| Gene names |
| ||
| Organism | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) | ||
| Taxonomic identifier | 8022 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus |
Protein attributes
| Sequence length | 383 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
| Catalytic activity | ATP + creatine = ADP + phosphocreatine. |
| Tissue specificity | Exists in many tissues, but preferentially in testis. Ref.1 |
| Sequence similarities | Belongs to the ATP:guanido phosphotransferase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW creatine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 383 | 383 | Creatine kinase, testis isozyme | PRO_0000211984 | |||||
Regions | |||||||||
| Nucleotide binding | 130 – 134 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 322 – 327 | 6 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 193 | 1 | ATP By similarity | ||||||
| Binding site | 238 | 1 | ATP By similarity | ||||||
| Binding site | 294 | 1 | ATP By similarity | ||||||
| Binding site | 337 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "A novel creatine kinase cDNA whose transcript shows enhanced testicular expression." Garber A.T., Winkfein R.J., Dixon G.H. Biochim. Biophys. Acta 1087:256-258(1990) [PubMed: 2223887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| X53859 mRNA. Translation: CAA37852.1. | |
| PIR | S13164. |
| RefSeq | NP_001118187.1. |
| UniGene | Omy.35804 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2CRK based on UniProtKB P00563. |
| SMR | P24722. Positions 15-383. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 100136767. |
Phylogenomic databases | |
| HOVERGEN | P24722. |
Enzyme and pathway databases | |
| BRENDA | 2.7.3.2. 3435. |
Family and domain databases | |
| InterPro | IPR000749. ATP-guanido_PTrfase. IPR014746. Gln_synth/guanido_kin_cat. [Graphical view] |
| Gene3D | G3DSA:1.10.135.10. ATP-gua_Ptrans. 1 hit. G3DSA:3.30.590.10. ATP-gua_Ptrans. 1 hit. |
| PANTHER | PTHR11547. ATP-gua_Ptrans. 1 hit. |
| Pfam | PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit. [Graphical view] |
| PROSITE | PS00112. GUANIDO_KINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KCRT_ONCMY | ||||||||
| Accession | Primary (citable) accession number: P24722 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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