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P24722 (KCRT_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Creatine kinase, testis isozyme
EC=2.7.3.2
Gene names
Name:tck1
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Catalytic activity

ATP + creatine = ADP + phosphocreatine.

Tissue specificity

Exists in many tissues, but preferentially in testis. Ref.1

Sequence similarities

Belongs to the ATP:guanido phosphotransferase family.

Contains 1 phosphagen kinase C-terminal domain.

Contains 1 phosphagen kinase N-terminal domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

creatine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383Creatine kinase, testis isozyme
PRO_0000211984

Regions

Domain14 – 10087Phosphagen kinase N-terminal
Domain127 – 369243Phosphagen kinase C-terminal
Nucleotide binding130 – 1345ATP By similarity
Nucleotide binding322 – 3276ATP By similarity

Sites

Binding site1931ATP By similarity
Binding site2381ATP By similarity
Binding site2941ATP By similarity
Binding site3371ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P24722 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 608BAAA115C7D1EA

FASTA38343,004
        10         20         30         40         50         60 
MEKINDKMAK LTIKRLSPEE EFPDLSQHNN HMAKVLTQDM YTKLRDRATP NGFTIDGVIQ 

        70         80         90        100        110        120 
TGIDNPGHPF IMTVGCVAGD EETYEVFKEL LDPIIEDRHG GYKPTDKHKT DLNPDNLKGG 

       130        140        150        160        170        180 
DDLDPNYVIS SRVRTGRSIR GFCLPPHCSR GERRGVEKMS VEALDSLSGD LKGKYYALKN 

       190        200        210        220        230        240 
MTDAEQQQLI DDHFLFDKPV SPLLLASGMA RDWPDGRGIW HNDTKTFLVW VNEEDHLRVI 

       250        260        270        280        290        300 
SMQKGGNMKE VFNRFCTGLT KIETLFKDKG TSFMWNEHLG YVLTCPSNLG TGLRAGVHVK 

       310        320        330        340        350        360 
IPNISKHAKF EEVLKRLRLQ KRGTGGVDTA AVGGTFDISN ADRLGFSEVE LVQMVVDGVK 

       370        380 
LLVEMEKKLE KGQSIDDLMP AQK

« Hide

References

[1]"A novel creatine kinase cDNA whose transcript shows enhanced testicular expression."
Garber A.T., Winkfein R.J., Dixon G.H.
Biochim. Biophys. Acta 1087:256-258(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X53859 mRNA. Translation: CAA37852.1.
PIRS13164.
RefSeqNP_001118187.1. NM_001124715.1.
UniGeneOmy.35804.

3D structure databases

ProteinModelPortalP24722.
SMRP24722. Positions 15-383.
ModBaseSearch...

Proteomic databases

PRIDEP24722.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100136767.

Organism-specific databases

CTD1152.

Phylogenomic databases

HOVERGENHBG001339.

Family and domain databases

Gene3D1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProIPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERPTHR11547. PTHR11547. 1 hit.
PfamPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMSSF48034. ATP-gua_Ptrans. 1 hit.
PROSITEPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKCRT_ONCMY
AccessionPrimary (citable) accession number: P24722
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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