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Protein

Superoxide dismutase [Cu-Zn] 1

Gene

CSD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Copper; catalyticBy similarity1
Metal bindingi47Copper; catalyticBy similarity1
Metal bindingi62Copper; catalyticBy similarity1
Metal bindingi62Zinc; structuralBy similarity1
Metal bindingi70Zinc; structuralBy similarity1
Metal bindingi79Zinc; structuralBy similarity1
Metal bindingi82Zinc; structuralBy similarity1
Metal bindingi119Copper; catalyticBy similarity1

GO - Molecular functioni

  • copper ion binding Source: GO_Central
  • superoxide dismutase activity Source: TAIR
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • cellular response to copper ion Source: TAIR
  • cellular response to light intensity Source: UniProtKB
  • cellular response to oxidative stress Source: UniProtKB
  • cellular response to ozone Source: UniProtKB
  • cellular response to salt stress Source: UniProtKB
  • cellular response to sucrose stimulus Source: UniProtKB
  • cellular response to UV-B Source: UniProtKB
  • defense response to bacterium Source: TAIR
  • gene silencing by miRNA Source: UniProtKB
  • response to copper ion Source: TAIR
  • response to iron ion Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to ozone Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G08830-MONOMER
MetaCyc:AT1G08830-MONOMER
ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] 1 (EC:1.15.1.1)
Alternative name(s):
Copper/zinc superoxide dismutase 1
Gene namesi
Name:CSD1
Synonyms:SODCC
Ordered Locus Names:At1g08830
ORF Names:F22O13.32
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G08830
TAIRilocus:2025595 AT1G08830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001641311 – 152Superoxide dismutase [Cu-Zn] 1Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 145By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP24704
PRIDEiP24704

Expressioni

Tissue specificityi

Expressed in leaves (at protein level). The spatial localization is regulated by miR398-mediated silencing. Mostly present in flowers, old rosette leaves and inflorescence, and, to a lower extent, in cauline leaves, stems and roots.2 Publications

Inductioni

Upon photosynthetically active radiation (PAR) (e.g. light fluence) increase and UV-B treatment. Accumulates in response to ozone fumigation. Induced in response to oxidative stress, via a reduction of miR398-mediated silencing. Repressed by sucrose in a miR398-mediated silencing-dependent manner. Induced by salt stress.4 Publications

Gene expression databases

ExpressionAtlasiP24704 differential
GenevisibleiP24704 AT

Interactioni

Subunit structurei

Homodimer. Interacts with DJ1A and CCS.2 Publications

Protein-protein interaction databases

BioGridi22646, 5 interactors
IntActiP24704, 1 interactor
STRINGi3702.AT1G08830.1

Structurei

3D structure databases

ProteinModelPortaliP24704
SMRiP24704
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
HOGENOMiHOG000263447
InParanoidiP24704
KOiK04565
OMAiHKGDIGN
OrthoDBiEOG09360P4O
PhylomeDBiP24704

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P24704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGVAVLNS SEGVTGTIFF TQEGDGVTTV SGTVSGLKPG LHGFHVHALG
60 70 80 90 100
DTTNGCMSTG PHFNPDGKTH GAPEDANRHA GDLGNITVGD DGTATFTITD
110 120 130 140 150
CQIPLTGPNS IVGRAVVVHA DPDDLGKGGH ELSLATGNAG GRVACGIIGL

QG
Length:152
Mass (Da):15,098
Last modified:January 23, 2007 - v2
Checksum:i59E01FF9794F34BD
GO

Sequence cautioni

The sequence AAF99769 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148I → F in ABN50366 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60935 mRNA Translation: CAA43270.1
EF408820 mRNA Translation: ABN50366.1
AC003981 Genomic DNA Translation: AAF99769.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28354.1
CP002684 Genomic DNA Translation: AEE28355.1
AY091168 mRNA Translation: AAM14107.1
AY050932 mRNA Translation: AAK93609.1
AY087273 mRNA Translation: AAM64826.1
PIRiS19117 DSMUZ
RefSeqiNP_001077494.1, NM_001084025.1
NP_172360.1, NM_100757.4
UniGeneiAt.25177

Genome annotation databases

EnsemblPlantsiAT1G08830.1; AT1G08830.1; AT1G08830
AT1G08830.2; AT1G08830.2; AT1G08830
GeneIDi837405
GrameneiAT1G08830.1; AT1G08830.1; AT1G08830
AT1G08830.2; AT1G08830.2; AT1G08830
KEGGiath:AT1G08830

Similar proteinsi

Entry informationi

Entry nameiSODC1_ARATH
AccessioniPrimary (citable) accession number: P24704
Secondary accession number(s): A3FMJ0, Q9FRQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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