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P24699 (MYF5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myogenic factor 5

Short name=Myf-5
Gene names
Name:Myf5
Synonyms:Myf-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Ref.3

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processDifferentiation
Myogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcamera-type eye development

Inferred from mutant phenotype PubMed 19531352. Source: MGI

cartilage condensation

Inferred from mutant phenotype PubMed 8565825. Source: MGI

embryonic skeletal system morphogenesis

Inferred from mutant phenotype PubMed 10929709. Source: MGI

extracellular matrix organization

Inferred from mutant phenotype PubMed 16554364. Source: MGI

muscle organ development

Inferred from mutant phenotype PubMed 8587605. Source: MGI

muscle organ morphogenesis

Inferred from genetic interaction PubMed 19531352. Source: MGI

muscle tissue morphogenesis

Inferred from mutant phenotype PubMed 19531352. Source: MGI

ossification

Inferred from mutant phenotype PubMed 8587605. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17855775. Source: MGI

regulation of cell-matrix adhesion

Inferred from mutant phenotype PubMed 16554364. Source: MGI

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

skeletal muscle tissue development

Inferred from mutant phenotype PubMed 19531352. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 10929709PubMed 19531352PubMed 8565825. Source: MGI

transcription from RNA polymerase II promoter

Traceable author statement PubMed 1846704. Source: GOC

   Cellular_componentnucleus

Traceable author statement PubMed 1846704. Source: MGI

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 1846704. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 22638570. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Myogenic factor 5
PRO_0000127345

Regions

Domain83 – 13452bHLH

Sequences

Sequence LengthMass (Da)Tools
P24699 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 0BDCBEDF2ABCAEC9

FASTA25528,229
        10         20         30         40         50         60 
MDMTDGCQFS PSEYFYEGSC IPSPEDEFGD QFEPRVAAFG AHKAELQGSD DEEHVRAPTG 

        70         80         90        100        110        120 
HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN QAFETLKRCT TTNPNQRLPK 

       130        140        150        160        170        180 
VEILRNAIRY IESLQELLRE QVENYYSLPG QSCSEPTSPT SNCSDGMPEC NSPVWSRKNS 

       190        200        210        220        230        240 
SFDSIYCPDV SNACAADKSS VSSLDCLSSI VDRITSTEPS ELALQDTASL SPATSANSQP 

       250 
ATPGPSSSRL IYHVL 

« Hide

References

« Hide 'large scale' references
[1]"The MyoD family of myogenic factors is regulated by electrical activity: isolation and characterization of a mouse Myf-5 cDNA."
Buonanno A., Apone L., Morasso M.I., Beers R., Brenner H.R., Eftimie R.
Nucleic Acids Res. 20:539-544(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H.
Tissue: Skeletal muscle and Smooth muscle.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes."
Londhe P., Davie J.K.
Skelet. Muscle 1:14-14(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PROMOTER BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56182 mRNA. Translation: CAA39643.1.
AK044894 mRNA. Translation: BAC32132.1.
AK083402 mRNA. Translation: BAC38902.1.
CCDSCCDS24161.1.
PIRS22825.
RefSeqNP_032682.1. NM_008656.5.
XP_006513382.1. XM_006513319.1.
UniGeneMm.4984.

3D structure databases

ProteinModelPortalP24699.
SMRP24699. Positions 76-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201641. 1 interaction.
MINTMINT-1519267.
STRING10090.ENSMUSP00000000445.

PTM databases

PhosphoSiteP24699.

Proteomic databases

PRIDEP24699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000445; ENSMUSP00000000445; ENSMUSG00000000435.
GeneID17877.
KEGGmmu:17877.
UCSCuc007gyz.1. mouse.

Organism-specific databases

CTD4617.
MGIMGI:97252. Myf5.

Phylogenomic databases

eggNOGNOG239177.
GeneTreeENSGT00530000063004.
HOGENOMHOG000234800.
HOVERGENHBG006429.
InParanoidP24699.
OMAMMDGCQF.
OrthoDBEOG76QFK1.
PhylomeDBP24699.
TreeFamTF316344.

Gene expression databases

ArrayExpressP24699.
BgeeP24699.
CleanExMM_MYF5.
GenevestigatorP24699.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR002546. Basic.
IPR011598. bHLH_dom.
IPR022032. Myf5.
[Graphical view]
PfamPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
PF12232. Myf5. 1 hit.
[Graphical view]
SMARTSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292665.
PROP24699.
SOURCESearch...

Entry information

Entry nameMYF5_MOUSE
AccessionPrimary (citable) accession number: P24699
Secondary accession number(s): Q543W7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot