Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P24699

- MYF5_MOUSE

UniProt

P24699 - MYF5_MOUSE

Protein

Myogenic factor 5

Gene

Myf5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.1 Publication

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    2. sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. camera-type eye development Source: MGI
    2. cartilage condensation Source: MGI
    3. embryonic skeletal system morphogenesis Source: MGI
    4. extracellular matrix organization Source: MGI
    5. muscle organ development Source: MGI
    6. muscle organ morphogenesis Source: MGI
    7. muscle tissue morphogenesis Source: MGI
    8. ossification Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. regulation of cell-matrix adhesion Source: MGI
    11. skeletal muscle cell differentiation Source: MGI
    12. skeletal muscle tissue development Source: MGI
    13. somitogenesis Source: MGI
    14. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myogenic factor 5
    Short name:
    Myf-5
    Gene namesi
    Name:Myf5
    Synonyms:Myf-5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:97252. Myf5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Myogenic factor 5PRO_0000127345Add
    BLAST

    Proteomic databases

    PRIDEiP24699.

    PTM databases

    PhosphoSiteiP24699.

    Expressioni

    Gene expression databases

    ArrayExpressiP24699.
    BgeeiP24699.
    CleanExiMM_MYF5.
    GenevestigatoriP24699.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    BioGridi201641. 1 interaction.
    MINTiMINT-1519267.
    STRINGi10090.ENSMUSP00000000445.

    Structurei

    3D structure databases

    ProteinModelPortaliP24699.
    SMRiP24699. Positions 76-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 13452bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG239177.
    GeneTreeiENSGT00530000063004.
    HOGENOMiHOG000234800.
    HOVERGENiHBG006429.
    InParanoidiP24699.
    OMAiMMDGCQF.
    OrthoDBiEOG76QFK1.
    PhylomeDBiP24699.
    TreeFamiTF316344.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR002546. Basic.
    IPR011598. bHLH_dom.
    IPR022032. Myf5.
    [Graphical view]
    PfamiPF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    PF12232. Myf5. 1 hit.
    [Graphical view]
    SMARTiSM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMTDGCQFS PSEYFYEGSC IPSPEDEFGD QFEPRVAAFG AHKAELQGSD    50
    DEEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN 100
    QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG 150
    QSCSEPTSPT SNCSDGMPEC NSPVWSRKNS SFDSIYCPDV SNACAADKSS 200
    VSSLDCLSSI VDRITSTEPS ELALQDTASL SPATSANSQP ATPGPSSSRL 250
    IYHVL 255
    Length:255
    Mass (Da):28,229
    Last modified:March 1, 1992 - v1
    Checksum:i0BDCBEDF2ABCAEC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56182 mRNA. Translation: CAA39643.1.
    AK044894 mRNA. Translation: BAC32132.1.
    AK083402 mRNA. Translation: BAC38902.1.
    CCDSiCCDS24161.1.
    PIRiS22825.
    RefSeqiNP_032682.1. NM_008656.5.
    XP_006513382.1. XM_006513319.1.
    UniGeneiMm.4984.

    Genome annotation databases

    EnsembliENSMUST00000000445; ENSMUSP00000000445; ENSMUSG00000000435.
    GeneIDi17877.
    KEGGimmu:17877.
    UCSCiuc007gyz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56182 mRNA. Translation: CAA39643.1 .
    AK044894 mRNA. Translation: BAC32132.1 .
    AK083402 mRNA. Translation: BAC38902.1 .
    CCDSi CCDS24161.1.
    PIRi S22825.
    RefSeqi NP_032682.1. NM_008656.5.
    XP_006513382.1. XM_006513319.1.
    UniGenei Mm.4984.

    3D structure databases

    ProteinModelPortali P24699.
    SMRi P24699. Positions 76-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201641. 1 interaction.
    MINTi MINT-1519267.
    STRINGi 10090.ENSMUSP00000000445.

    PTM databases

    PhosphoSitei P24699.

    Proteomic databases

    PRIDEi P24699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000445 ; ENSMUSP00000000445 ; ENSMUSG00000000435 .
    GeneIDi 17877.
    KEGGi mmu:17877.
    UCSCi uc007gyz.1. mouse.

    Organism-specific databases

    CTDi 4617.
    MGIi MGI:97252. Myf5.

    Phylogenomic databases

    eggNOGi NOG239177.
    GeneTreei ENSGT00530000063004.
    HOGENOMi HOG000234800.
    HOVERGENi HBG006429.
    InParanoidi P24699.
    OMAi MMDGCQF.
    OrthoDBi EOG76QFK1.
    PhylomeDBi P24699.
    TreeFami TF316344.

    Miscellaneous databases

    NextBioi 292665.
    PROi P24699.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P24699.
    Bgeei P24699.
    CleanExi MM_MYF5.
    Genevestigatori P24699.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR002546. Basic.
    IPR011598. bHLH_dom.
    IPR022032. Myf5.
    [Graphical view ]
    Pfami PF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    PF12232. Myf5. 1 hit.
    [Graphical view ]
    SMARTi SM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The MyoD family of myogenic factors is regulated by electrical activity: isolation and characterization of a mouse Myf-5 cDNA."
      Buonanno A., Apone L., Morasso M.I., Beers R., Brenner H.R., Eftimie R.
      Nucleic Acids Res. 20:539-544(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
      Tissue: Skeletal muscle and Smooth muscle.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "Sequential association of myogenic regulatory factors and E proteins at muscle-specific genes."
      Londhe P., Davie J.K.
      Skelet. Muscle 1:14-14(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PROMOTER BINDING.

    Entry informationi

    Entry nameiMYF5_MOUSE
    AccessioniPrimary (citable) accession number: P24699
    Secondary accession number(s): Q543W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3