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P24670

- AROD_SALTI

UniProt

P24670 - AROD_SALTI

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Protein

3-dehydroquinate dehydratase

Gene
aroD, STY1760, t1231
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate
Active sitei143 – 1431Proton donor/acceptor2 Publications
Active sitei170 – 1701Schiff-base intermediate with substrate2 Publications
Binding sitei213 – 2131Substrate
Binding sitei232 – 2321Substrate
Binding sitei236 – 2361Substrate

GO - Molecular functioni

  1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP24670.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase (EC:4.2.1.10)
Short name:
3-dehydroquinase
Alternative name(s):
Type I DHQase
Gene namesi
Name:aroD
Ordered Locus Names:STY1760, t1231
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522523-dehydroquinate dehydrataseUniRule annotationPRO_0000138805Add
BLAST

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi220341.STY1760.

Structurei

Secondary structure

1
252
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63
Beta strandi9 – 113
Beta strandi13 – 153
Beta strandi17 – 226
Helixi27 – 3711
Beta strandi43 – 486
Helixi49 – 513
Turni53 – 564
Helixi58 – 7114
Beta strandi77 – 804
Helixi84 – 863
Helixi94 – 10714
Beta strandi111 – 1166
Helixi117 – 1193
Helixi121 – 13313
Beta strandi137 – 14610
Helixi151 – 16313
Beta strandi167 – 1737
Helixi178 – 19417
Beta strandi201 – 2044
Turni206 – 2094
Helixi210 – 2145
Helixi216 – 2194
Beta strandi223 – 2253
Beta strandi227 – 2304
Helixi239 – 25012

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GQNX-ray1.78A1-252[»]
1L9WX-ray2.10A/B/C/D1-252[»]
1QFEX-ray2.10A/B1-252[»]
ProteinModelPortaliP24670.
SMRiP24670. Positions 1-252.

Miscellaneous databases

EvolutionaryTraceiP24670.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 483Substrate bindingUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0710.
HOGENOMiHOG000105514.
KOiK03785.
OMAiEGMPKII.
OrthoDBiEOG6P33BK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD.
InterProiIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.
PROSITEiPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24670-1 [UniParc]FASTAAdd to Basket

« Hide

MKTVTVKNLI IGEGMPKIIV SLMGRDINSV KAEALAYREA TFDILEWRVD    50
HFMDIASTQS VLTAARVIRD AMPDIPLLFT FRSAKEGGEQ TITTQHYLTL 100
NRAAIDSGLV DMIDLELFTG DADVKATVDY AHAHNVYVVM SNHDFHQTPS 150
AEEMVLRLRK MQALGADIPK IAVMPQSKHD VLTLLTATLE MQQHYADRPV 200
ITMSMAKEGV ISRLAGEVFG SAATFGAVKQ ASAPGQIAVN DLRSVLMILH 250
NA 252
Length:252
Mass (Da):27,649
Last modified:December 5, 2001 - v2
Checksum:iF9D4D4C86D18F17B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561L → S in CAA38418. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54546 Genomic DNA. Translation: CAA38418.1.
AL513382 Genomic DNA. Translation: CAD02002.1.
AE014613 Genomic DNA. Translation: AAO68886.1.
PIRiS15652.
RefSeqiNP_456161.1. NC_003198.1.
NP_805037.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68886; AAO68886; t1231.
CAD02002; CAD02002; CAD02002.
GeneIDi1248131.
KEGGisty:STY1760.
PATRICi18541418. VBISalEnt120419_1771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54546 Genomic DNA. Translation: CAA38418.1 .
AL513382 Genomic DNA. Translation: CAD02002.1 .
AE014613 Genomic DNA. Translation: AAO68886.1 .
PIRi S15652.
RefSeqi NP_456161.1. NC_003198.1.
NP_805037.1. NC_004631.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GQN X-ray 1.78 A 1-252 [» ]
1L9W X-ray 2.10 A/B/C/D 1-252 [» ]
1QFE X-ray 2.10 A/B 1-252 [» ]
ProteinModelPortali P24670.
SMRi P24670. Positions 1-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY1760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO68886 ; AAO68886 ; t1231 .
CAD02002 ; CAD02002 ; CAD02002 .
GeneIDi 1248131.
KEGGi sty:STY1760.
PATRICi 18541418. VBISalEnt120419_1771.

Phylogenomic databases

eggNOGi COG0710.
HOGENOMi HOG000105514.
KOi K03785.
OMAi EGMPKII.
OrthoDBi EOG6P33BK.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00086 .
SABIO-RK P24670.

Miscellaneous databases

EvolutionaryTracei P24670.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00214. AroD.
InterProi IPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view ]
Pfami PF01487. DHquinase_I. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01093. aroD. 1 hit.
PROSITEi PS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi."
    Servos S., Chatfield S., Hone D., Levine M., Dimitriadis G., Pickard D., Dougan G., Fairweather N., Charles I.G.
    J. Gen. Microbiol. 137:147-152(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  3. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.
  4. "The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction."
    Gourley D.G., Shrive A.K., Polikarpov I., Krell T., Coggins J.R., Hawkins A.R., Isaacs N.W., Sawyer L.
    Nat. Struct. Biol. 6:521-525(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH 3-DEHYDROQUINATE, SUBUNIT, ACTIVE SITE.
  5. "Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity."
    Lee W.H., Perles L.A., Nagem R.A., Shrive A.K., Hawkins A., Sawyer L., Polikarpov I.
    Acta Crystallogr. D 58:798-804(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) IN COMPLEX WITH 3-DEHYDROSHIKIMATE, ACTIVE SITE, SUBUNIT.

Entry informationi

Entry nameiAROD_SALTI
AccessioniPrimary (citable) accession number: P24670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 5, 2001
Last modified: May 14, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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