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P24670 (AROD_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase

Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:STY1760, t1231
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2522523-dehydroquinate dehydratase HAMAP-Rule MF_00214
PRO_0000138805

Regions

Region46 – 483Substrate binding HAMAP-Rule MF_00214

Sites

Active site1431Proton donor/acceptor Ref.4 Ref.5
Active site1701Schiff-base intermediate with substrate Ref.4 Ref.5
Binding site821Substrate
Binding site2131Substrate
Binding site2321Substrate
Binding site2361Substrate

Experimental info

Sequence conflict1561L → S in CAA38418. Ref.1

Secondary structure

.................................................. 252
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P24670 [UniParc].

Last modified December 5, 2001. Version 2.
Checksum: F9D4D4C86D18F17B

FASTA25227,649
        10         20         30         40         50         60 
MKTVTVKNLI IGEGMPKIIV SLMGRDINSV KAEALAYREA TFDILEWRVD HFMDIASTQS 

        70         80         90        100        110        120 
VLTAARVIRD AMPDIPLLFT FRSAKEGGEQ TITTQHYLTL NRAAIDSGLV DMIDLELFTG 

       130        140        150        160        170        180 
DADVKATVDY AHAHNVYVVM SNHDFHQTPS AEEMVLRLRK MQALGADIPK IAVMPQSKHD 

       190        200        210        220        230        240 
VLTLLTATLE MQQHYADRPV ITMSMAKEGV ISRLAGEVFG SAATFGAVKQ ASAPGQIAVN 

       250 
DLRSVLMILH NA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the aroD gene encoding 3-dehydroquinase from Salmonella typhi."
Servos S., Chatfield S., Hone D., Levine M., Dimitriadis G., Pickard D., Dougan G., Fairweather N., Charles I.G.
J. Gen. Microbiol. 137:147-152(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 700931 / Ty2.
[2]"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18."
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. expand/collapse author list , Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.
Nature 413:848-852(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT18.
[3]"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700931 / Ty2.
[4]"The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction."
Gourley D.G., Shrive A.K., Polikarpov I., Krell T., Coggins J.R., Hawkins A.R., Isaacs N.W., Sawyer L.
Nat. Struct. Biol. 6:521-525(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH 3-DEHYDROQUINATE, SUBUNIT, ACTIVE SITE.
[5]"Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity."
Lee W.H., Perles L.A., Nagem R.A., Shrive A.K., Hawkins A., Sawyer L., Polikarpov I.
Acta Crystallogr. D 58:798-804(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) IN COMPLEX WITH 3-DEHYDROSHIKIMATE, ACTIVE SITE, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54546 Genomic DNA. Translation: CAA38418.1.
AL513382 Genomic DNA. Translation: CAD02002.1.
AE014613 Genomic DNA. Translation: AAO68886.1.
PIRS15652.
RefSeqNP_456161.1. NC_003198.1.
NP_805037.1. NC_004631.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GQNX-ray1.78A1-252[»]
1L9WX-ray2.10A/B/C/D1-252[»]
1QFEX-ray2.10A/B1-252[»]
ProteinModelPortalP24670.
SMRP24670. Positions 1-252.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220341.STY1760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO68886; AAO68886; t1231.
CAD02002; CAD02002; CAD02002.
GeneID1248131.
KEGGsty:STY1760.
PATRIC18541418. VBISalEnt120419_1771.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0710.
HOGENOMHOG000105514.
KOK03785.
OMAEGMPKII.
OrthoDBEOG6P33BK.

Enzyme and pathway databases

SABIO-RKP24670.
UniPathwayUPA00053; UER00086.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00214. AroD.
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. aroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP24670.

Entry information

Entry nameAROD_SALTI
AccessionPrimary (citable) accession number: P24670
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 5, 2001
Last modified: May 14, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways