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Protein

Cation-dependent mannose-6-phosphate receptor

Gene

M6pr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: MGI
  • secretion of lysosomal enzymes Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name:
CD Man-6-P receptor
Short name:
CD-MPR
Alternative name(s):
46 kDa mannose 6-phosphate receptor
Short name:
MPR 46
Gene namesi
Name:M6pr
Synonyms:46mpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96904. M6pr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 186LumenalSequence analysisAdd BLAST165
Transmembranei187 – 211HelicalSequence analysisAdd BLAST25
Topological domaini212 – 278CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001922722 – 278Cation-dependent mannose-6-phosphate receptorAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)2 Publications1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP24668.
PaxDbiP24668.
PeptideAtlasiP24668.
PRIDEiP24668.

PTM databases

iPTMnetiP24668.
PhosphoSitePlusiP24668.
SwissPalmiP24668.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007458.
CleanExiMM_M6PR.
ExpressionAtlasiP24668. baseline and differential.
GenevisibleiP24668. MM.

Interactioni

Subunit structurei

Homodimer. Binds GGA1, GGA2 and GGA3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201263. 7 interactors.
IntActiP24668. 9 interactors.
MINTiMINT-4102408.
STRINGi10090.ENSMUSP00000007602.

Structurei

3D structure databases

ProteinModelPortaliP24668.
SMRiP24668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK0D. Eukaryota.
ENOG4111GED. LUCA.
GeneTreeiENSGT00390000002109.
HOGENOMiHOG000013085.
HOVERGENiHBG006395.
InParanoidiP24668.
KOiK10089.
OMAiINETQVF.
OrthoDBiEOG091G0WP5.
PhylomeDBiP24668.
TreeFamiTF328910.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR028927. Man-6-P_rcpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR000296. Man_6_P_rcpt.
[Graphical view]
PfamiPF02157. Man-6-P_recep. 1 hit.
[Graphical view]
PRINTSiPR00715. MAN6PRECEPTR.
SUPFAMiSSF50911. SSF50911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPFSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL
60 70 80 90 100
ERLRPLFNKS FESTVGQGSD TYSYIFRVCR EASNHSSGAG LVQINKSNDK
110 120 130 140 150
ETVVGRINET HIFNGSNWIM LIYKGGDEYD NHCGKEQRRA VVMISCNRHT
160 170 180 190 200
LAANFNPVSE ERGKVQDCFY LFEMDSSLAC SPEVSHLSVG SILLVIFASL
210 220 230 240 250
VAVYIIGGFL YQRLVVGAKG MEQFPHLAFW QDLGNLVADG CDFVCRSKPR
260 270
NVPAAYRGVG DDQLGEESEE RDDHLLPM
Length:278
Mass (Da):31,172
Last modified:March 1, 1992 - v1
Checksum:i8E0E8727CE793E7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196I → T in AAA39482 (PubMed:1848553).Curated1
Sequence conflicti221M → T in AAA39482 (PubMed:1848553).Curated1
Sequence conflicti226H → P in AAA39482 (PubMed:1848553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64068 mRNA. Translation: CAA45423.1.
X64070 mRNA. Translation: CAA45426.1.
X56831 mRNA. Translation: CAA40162.1.
M63286 mRNA. Translation: AAA39735.1.
BC027210 mRNA. Translation: AAH27210.1.
BC046956 mRNA. Translation: AAH46956.1.
BC080811 mRNA. Translation: AAH80811.1.
M58585 mRNA. Translation: AAA39482.1.
CCDSiCCDS20493.1.
PIRiA40399.
RefSeqiNP_034879.2. NM_010749.6.
UniGeneiMm.249225.

Genome annotation databases

EnsembliENSMUST00000007602; ENSMUSP00000007602; ENSMUSG00000007458.
ENSMUST00000112610; ENSMUSP00000108229; ENSMUSG00000007458.
GeneIDi17113.
KEGGimmu:17113.
UCSCiuc009dow.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64068 mRNA. Translation: CAA45423.1.
X64070 mRNA. Translation: CAA45426.1.
X56831 mRNA. Translation: CAA40162.1.
M63286 mRNA. Translation: AAA39735.1.
BC027210 mRNA. Translation: AAH27210.1.
BC046956 mRNA. Translation: AAH46956.1.
BC080811 mRNA. Translation: AAH80811.1.
M58585 mRNA. Translation: AAA39482.1.
CCDSiCCDS20493.1.
PIRiA40399.
RefSeqiNP_034879.2. NM_010749.6.
UniGeneiMm.249225.

3D structure databases

ProteinModelPortaliP24668.
SMRiP24668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201263. 7 interactors.
IntActiP24668. 9 interactors.
MINTiMINT-4102408.
STRINGi10090.ENSMUSP00000007602.

PTM databases

iPTMnetiP24668.
PhosphoSitePlusiP24668.
SwissPalmiP24668.

Proteomic databases

EPDiP24668.
PaxDbiP24668.
PeptideAtlasiP24668.
PRIDEiP24668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007602; ENSMUSP00000007602; ENSMUSG00000007458.
ENSMUST00000112610; ENSMUSP00000108229; ENSMUSG00000007458.
GeneIDi17113.
KEGGimmu:17113.
UCSCiuc009dow.1. mouse.

Organism-specific databases

CTDi4074.
MGIiMGI:96904. M6pr.

Phylogenomic databases

eggNOGiENOG410IK0D. Eukaryota.
ENOG4111GED. LUCA.
GeneTreeiENSGT00390000002109.
HOGENOMiHOG000013085.
HOVERGENiHBG006395.
InParanoidiP24668.
KOiK10089.
OMAiINETQVF.
OrthoDBiEOG091G0WP5.
PhylomeDBiP24668.
TreeFamiTF328910.

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiP24668.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007458.
CleanExiMM_M6PR.
ExpressionAtlasiP24668. baseline and differential.
GenevisibleiP24668. MM.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR028927. Man-6-P_rcpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR000296. Man_6_P_rcpt.
[Graphical view]
PfamiPF02157. Man-6-P_recep. 1 hit.
[Graphical view]
PRINTSiPR00715. MAN6PRECEPTR.
SUPFAMiSSF50911. SSF50911. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPRD_MOUSE
AccessioniPrimary (citable) accession number: P24668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This receptor has optimal binding in the presence of divalent cations.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.