Cation-dependent mannose-6-phosphate receptor precursor

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P24668 (MPRD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cation-dependent mannose-6-phosphate receptor
Short name=CD Man-6-P receptor
Short name=CD-MPR

Alternative name(s):
46 kDa mannose 6-phosphate receptor
Short name=MPR 46

Gene names

Name:	M6pr
Synonyms:	46mpr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subunit structure	Homodimer. Binds GGA1, GGA2 and GGA3 By similarity.
Subcellular location	Lysosome membrane; Single-pass type I membrane protein.
Domain	The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.
Miscellaneous	This receptor has optimal binding in the presence of divalent cations.

Ontologies

Keywords
Biological process	Transport
Cellular component	Lysosome Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Traceable author statement. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome Inferred from direct assay. Source: MGI lysosomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mannose binding Inferred from electronic annotation. Source: InterPro mannose transmembrane transporter activity Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

Chain

22 – 278

257

Cation-dependent mannose-6-phosphate receptor

PRO_0000019227

Regions

Topological domain

22 – 186

165

Lumenal Potential

Transmembrane

187 – 211

Helical; Potential

Topological domain

212 – 278

Cytoplasmic Potential

Amino acid modifications

Modified residue

268

Phosphoserine Ref.6

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Ref.7 Ref.8

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

108

N-linked (GlcNAc...) Potential

Glycosylation

114

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

196

I → T in AAA39482. Ref.5

Sequence conflict

221

M → T in AAA39482. Ref.5

Sequence conflict

226

H → P in AAA39482. Ref.5

Sequences

Sequence

Length

Mass (Da)

Tools

P24668 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 8E0E8727CE793E7D
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FASTA

278

31,172

        10         20         30         40         50         60 
MFPFSGCWRT ELLLLLLLAV AVRESWQIEE KSCDLVGEKD KESKNEVALL ERLRPLFNKS 

        70         80         90        100        110        120 
FESTVGQGSD TYSYIFRVCR EASNHSSGAG LVQINKSNDK ETVVGRINET HIFNGSNWIM 

       130        140        150        160        170        180 
LIYKGGDEYD NHCGKEQRRA VVMISCNRHT LAANFNPVSE ERGKVQDCFY LFEMDSSLAC 

       190        200        210        220        230        240 
SPEVSHLSVG SILLVIFASL VAVYIIGGFL YQRLVVGAKG MEQFPHLAFW QDLGNLVADG 

       250        260        270 
CDFVCRSKPR NVPAAYRGVG DDQLGEESEE RDDHLLPM

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization." Ludwig T., Ruether U., Metzger R., Copeland N.G., Jenkins N.A., Lobel P., Hoflack B. J. Biol. Chem. 267:12211-12219(1992) [PubMed: 1376319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Molecular cloning of the mouse 46-kDa mannose 6-phosphate receptor (MPR 46)." Koester A., Nagel G., von Figura K., Pohlmann R. Biol. Chem. Hoppe-Seyler 372:297-300(1991) [PubMed: 1647783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[3]	"Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor." Ma Z., Grubb J.H., Sly W.S. J. Biol. Chem. 266:10589-10595(1991) [PubMed: 1645352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland and Olfactory epithelium.
[5]	"Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells." Szebenyi G., Rotwein P. J. Biol. Chem. 266:5534-5539(1991) [PubMed: 1848553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-233.
[6]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, MASS SPECTROMETRY. Tissue: Macrophage.
[7]	"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation." Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B. Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed: 19656770] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84, MASS SPECTROMETRY. Tissue: Myoblast.
[8]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64068 mRNA. Translation: CAA45423.1. X64070 mRNA. Translation: CAA45426.1. X56831 mRNA. Translation: CAA40162.1. M63286 mRNA. Translation: AAA39735.1. BC027210 mRNA. Translation: AAH27210.1. BC046956 mRNA. Translation: AAH46956.1. BC080811 mRNA. Translation: AAH80811.1. M58585 mRNA. Translation: AAA39482.1.
IPI	IPI00108844.
PIR	A40399.
RefSeq	NP_034879.2. NM_010749.6.
UniGene	Mm.249225.
3D structure databases
ProteinModelPortal	P24668.
SMR	P24668. Positions 29-181.
ModBase	Search...
Protein-protein interaction databases
IntAct	P24668. 1 interaction.
STRING	P24668.
PTM databases
PhosphoSite	P24668.
Proteomic databases
PRIDE	P24668.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000007602; ENSMUSP00000007602; ENSMUSG00000007458. ENSMUST00000112610; ENSMUSP00000108229; ENSMUSG00000007458.
GeneID	17113.
KEGG	mmu:17113.
Organism-specific databases
CTD	4074.
MGI	MGI:96904. M6pr.
Phylogenomic databases
HOGENOM	HBG268550.
HOVERGEN	HBG006395.
InParanoid	P24668.
OMA	NETHVFN.
OrthoDB	EOG43FGXF.
PhylomeDB	P24668.
Gene expression databases
ArrayExpress	P24668.
Bgee	P24668.
CleanEx	MM_M6PR.
Genevestigator	P24668.
GermOnline	ENSMUSG00000007458. Mus musculus.
Family and domain databases
InterPro	IPR009011. Man6P_isomerase_rcpt-bd. IPR000296. Man_6_P_rcpt. [Graphical view]
KO	K10089.
PRINTS	PR00715. MAN6PRECEPTR.
SUPFAM	SSF50911. Man6php_recept. 1 hit.
ProtoNet	Search...
Other
NextBio	291264.
SOURCE	Search...

Entry information

Entry name

MPRD_MOUSE

Accession

Primary (citable) accession number: P24668

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	November 16, 2011
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents