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Reviewed, UniProtKB/Swiss-Prot P24663 (KAX13_MESTA)

Last modified November 24, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Potassium channel toxin alpha-KTx 1.3
Alternative name(s):
    Iberiotoxin
      Short name=IbTx
OrganismMesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Taxonomic identifier34647 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Blocks selectively the high conductance calcium-activated (maxi-K) potassium channels.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIonic channel inhibitor
Neurotoxin
Potassium channel inhibitor
Toxin
   PTMDisulfide bond
Pyrrolidone carboxylic acid
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpotassium channel inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Potassium channel toxin alpha-KTx 1.3
PRO_0000044899

Regions

Region26 – 338Interaction with Ca(2+)-activated K(+) channels Potential

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid Ref.1
Disulfide bond7 ↔ 28 Ref.2
Disulfide bond13 ↔ 33 Ref.2
Disulfide bond17 ↔ 35 Ref.2

Sequences

Sequence LengthMass (Da)Tools
P24663-1 [UniParc].

Last modified February 1, 1994. Version 2.
Checksum: 012D5EFA710C950E

FASTA374,254
        10         20         30 
QFTDVDCSVS KECWSVCKDL FGVDRGKCMG KKCRCYQ 

« Hide

References

[1]"Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus."
Galvez A., Gimenez-Gallego G., Reuben J.P., Roy-Contancin L., Feigenbaum P., Kaczorowski G.J., Garcia M.L.
J. Biol. Chem. 265:11083-11090(1990) [PubMed: 1694175] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Determination of the three-dimensional structure of iberiotoxin in solution by 1H nuclear magnetic resonance spectroscopy."
Johnson B.A., Sugg E.E.
Biochemistry 31:8151-8159(1992) [PubMed: 1381959] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

Sequence databases

PIRS32792.

3D structure databases

ModBaseSearch...

Family and domain databases

InterProIPR001947. Scorpion_toxinS.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX13_MESTA
AccessionPrimary (citable) accession number: P24663
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: February 1, 1994
Last modified: November 24, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectTox-Prot (Toxin Annotation Project)

Relevant documents

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents