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P24656 (PTP_NPVAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase

EC=3.1.3.48
Alternative name(s):
BVP
Gene names
Name:PTP
OrganismAutographa californica nuclear polyhedrosis virus (AcMNPV) [Complete proteome]
Taxonomic identifier46015 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostLepidoptera (butterflies and moths) [TaxID: 7088]

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Also dephosphorylates seryl and threonyl residues.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Miscellaneous

Probably expressed late in infection.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 168168Tyrosine-protein phosphatase
PRO_0000094881

Sites

Active site1191Phosphocysteine intermediate

Experimental info

Mutagenesis1191C → S: Loss of activity.
Sequence conflict491V → I Ref.1
Sequence conflict167 – 1682LI → F Ref.1

Secondary structure

.............................. 168
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P24656 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 2D4D85F11C52AB09

FASTA16819,288
        10         20         30         40         50         60 
MFPARWHNYL QCGQVIKDSN LICFKTPLRP ELFAYVTSEE DVWTAEQIVK QNPSIGAIID 

        70         80         90        100        110        120 
LTNTSKYYDG VHFLRAGLLY KKIQVPGQTL PPESIVQEFI DTVKEFTEKC PGMLVGVHCT 

       130        140        150        160 
HGINRTGYMV CRYLMHTLGI APQEAIDRFE KARGHKIERQ NYVQDLLI 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and transcript mapping of the HindIII F region of the Autographa californica nuclear polyhedrosis virus genome."
Tilakaratne N., Hardin S.E., Weaver R.F.
J. Gen. Virol. 72:285-291(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp EcoRI-I and -R (polyhedrin gene) region."
Possee R.D., Sun T.P., Howard S.C., Ayres M.D., Hill-Perkins M., Gearing K.L.
Virology 185:229-241(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C6.
[3]"The complete DNA sequence of Autographa californica nuclear polyhedrosis virus."
Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.
Virology 202:586-605(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C6.
[4]"The baculovirus Autographa californica encodes a protein tyrosine phosphatase."
Sheng Z., Charbonneau H.
J. Biol. Chem. 268:4728-4733(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22858 Genomic DNA. Translation: AAA66631.1.
M96763 Genomic DNA. Translation: AAA46753.1.
M75679 Genomic DNA. No translation available.
PIRA40781.
RefSeqNP_054030.1. NC_001623.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YN9X-ray1.50A/B/C1-168[»]
ProteinModelPortalP24656.
SMRP24656. Positions 1-168.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1403833.

Phylogenomic databases

ProtClustDBCLSP2509865.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP24656.

Entry information

Entry namePTP_NPVAC
AccessionPrimary (citable) accession number: P24656
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references