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Protein

Tyrosine-protein phosphatase

Gene

PTP

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation and processing of late viral mRNAs by displaying RNA 5'-triphosphatase and diphosphatase activities.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119Phosphocysteine intermediate1
Sitei124Essential for RNA triphosphatase activity1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase (EC:3.1.3.48)
Alternative name(s):
BVP
Gene namesi
Name:PTP
ORF Names:ORF1
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
Proteomesi
  • UP000008292 Componenti: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi119C → S: Loss of activity. 1 Publication1
Mutagenesisi124N → A: Abolishes triphosphatase activity. 1 Publication1
Mutagenesisi124N → D: Abolishes triphosphatase activity. 1 Publication1
Mutagenesisi124N → Q: Abolishes triphosphatase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948811 – 168Tyrosine-protein phosphataseAdd BLAST168

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Beta strandi19 – 24Combined sources6
Helixi30 – 33Combined sources4
Helixi39 – 41Combined sources3
Helixi45 – 51Combined sources7
Beta strandi55 – 60Combined sources6
Helixi71 – 75Combined sources5
Beta strandi79 – 82Combined sources4
Beta strandi87 – 89Combined sources3
Helixi93 – 109Combined sources17
Beta strandi113 – 118Combined sources6
Beta strandi120 – 123Combined sources4
Helixi124 – 138Combined sources15
Helixi142 – 153Combined sources12
Helixi160 – 167Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YN9X-ray1.50A/B/C1-168[»]
ProteinModelPortaliP24656.
SMRiP24656.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24656.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK14165.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPARWHNYL QCGQVIKDSN LICFKTPLRP ELFAYVTSEE DVWTAEQIVK
60 70 80 90 100
QNPSIGAIID LTNTSKYYDG VHFLRAGLLY KKIQVPGQTL PPESIVQEFI
110 120 130 140 150
DTVKEFTEKC PGMLVGVHCT HGINRTGYMV CRYLMHTLGI APQEAIDRFE
160
KARGHKIERQ NYVQDLLI
Length:168
Mass (Da):19,288
Last modified:November 1, 1995 - v2
Checksum:i2D4D85F11C52AB09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49V → I (PubMed:1993873).Curated1
Sequence conflicti167 – 168LI → F (PubMed:1993873).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22858 Genomic DNA. Translation: AAA66631.1.
M96763 Genomic DNA. Translation: AAA46753.1.
M75679 Genomic DNA. No translation available.
PIRiA40781.
RefSeqiNP_054030.1. NC_001623.1.

Genome annotation databases

GeneIDi1403833.
KEGGivg:1403833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22858 Genomic DNA. Translation: AAA66631.1.
M96763 Genomic DNA. Translation: AAA46753.1.
M75679 Genomic DNA. No translation available.
PIRiA40781.
RefSeqiNP_054030.1. NC_001623.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YN9X-ray1.50A/B/C1-168[»]
ProteinModelPortaliP24656.
SMRiP24656.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1403833.
KEGGivg:1403833.

Phylogenomic databases

KOiK14165.

Miscellaneous databases

EvolutionaryTraceiP24656.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTP_NPVAC
AccessioniPrimary (citable) accession number: P24656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably expressed late in infection.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.