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P24656

- PTP_NPVAC

UniProt

P24656 - PTP_NPVAC

Protein

Tyrosine-protein phosphatase

Gene

PTP

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Also dephosphorylates seryl and threonyl residues.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei119 – 1191Phosphocysteine intermediate

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase (EC:3.1.3.48)
    Alternative name(s):
    BVP
    Gene namesi
    Name:PTP
    OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
    Taxonomic identifieri46015 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
    Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
    ProteomesiUP000008292: Genome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi119 – 1191C → S: Loss of activity.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Tyrosine-protein phosphatasePRO_0000094881Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Structurei

    Secondary structure

    1
    168
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Beta strandi19 – 246
    Helixi30 – 334
    Helixi39 – 413
    Helixi45 – 517
    Beta strandi55 – 606
    Helixi71 – 755
    Beta strandi79 – 824
    Beta strandi87 – 893
    Helixi93 – 10917
    Beta strandi113 – 1186
    Beta strandi120 – 1234
    Helixi124 – 13815
    Helixi142 – 15312
    Helixi160 – 1678

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YN9X-ray1.50A/B/C1-168[»]
    ProteinModelPortaliP24656.
    SMRiP24656. Positions 1-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24656.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P24656-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPARWHNYL QCGQVIKDSN LICFKTPLRP ELFAYVTSEE DVWTAEQIVK    50
    QNPSIGAIID LTNTSKYYDG VHFLRAGLLY KKIQVPGQTL PPESIVQEFI 100
    DTVKEFTEKC PGMLVGVHCT HGINRTGYMV CRYLMHTLGI APQEAIDRFE 150
    KARGHKIERQ NYVQDLLI 168
    Length:168
    Mass (Da):19,288
    Last modified:November 1, 1995 - v2
    Checksum:i2D4D85F11C52AB09
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491V → I(PubMed:1993873)Curated
    Sequence conflicti167 – 1682LI → F(PubMed:1993873)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22858 Genomic DNA. Translation: AAA66631.1.
    M96763 Genomic DNA. Translation: AAA46753.1.
    M75679 Genomic DNA. No translation available.
    PIRiA40781.
    RefSeqiNP_054030.1. NC_001623.1.

    Genome annotation databases

    GeneIDi1403833.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22858 Genomic DNA. Translation: AAA66631.1 .
    M96763 Genomic DNA. Translation: AAA46753.1 .
    M75679 Genomic DNA. No translation available.
    PIRi A40781.
    RefSeqi NP_054030.1. NC_001623.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YN9 X-ray 1.50 A/B/C 1-168 [» ]
    ProteinModelPortali P24656.
    SMRi P24656. Positions 1-168.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1403833.

    Miscellaneous databases

    EvolutionaryTracei P24656.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and transcript mapping of the HindIII F region of the Autographa californica nuclear polyhedrosis virus genome."
      Tilakaratne N., Hardin S.E., Weaver R.F.
      J. Gen. Virol. 72:285-291(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp EcoRI-I and -R (polyhedrin gene) region."
      Possee R.D., Sun T.P., Howard S.C., Ayres M.D., Hill-Perkins M., Gearing K.L.
      Virology 185:229-241(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C6.
    3. "The complete DNA sequence of Autographa californica nuclear polyhedrosis virus."
      Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.
      Virology 202:586-605(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C6.
    4. "The baculovirus Autographa californica encodes a protein tyrosine phosphatase."
      Sheng Z., Charbonneau H.
      J. Biol. Chem. 268:4728-4733(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiPTP_NPVAC
    AccessioniPrimary (citable) accession number: P24656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Probably expressed late in infection.

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3