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P24656

- PTP_NPVAC

UniProt

P24656 - PTP_NPVAC

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Protein

Tyrosine-protein phosphatase

Gene

PTP

Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Also dephosphorylates seryl and threonyl residues.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Phosphocysteine intermediate

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase (EC:3.1.3.48)
Alternative name(s):
BVP
Gene namesi
Name:PTP
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
ProteomesiUP000008292: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi119 – 1191C → S: Loss of activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Tyrosine-protein phosphatasePRO_0000094881Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

Secondary structure

1
168
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Beta strandi19 – 246
Helixi30 – 334
Helixi39 – 413
Helixi45 – 517
Beta strandi55 – 606
Helixi71 – 755
Beta strandi79 – 824
Beta strandi87 – 893
Helixi93 – 10917
Beta strandi113 – 1186
Beta strandi120 – 1234
Helixi124 – 13815
Helixi142 – 15312
Helixi160 – 1678

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YN9X-ray1.50A/B/C1-168[»]
ProteinModelPortaliP24656.
SMRiP24656. Positions 1-168.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24656.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24656-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPARWHNYL QCGQVIKDSN LICFKTPLRP ELFAYVTSEE DVWTAEQIVK
60 70 80 90 100
QNPSIGAIID LTNTSKYYDG VHFLRAGLLY KKIQVPGQTL PPESIVQEFI
110 120 130 140 150
DTVKEFTEKC PGMLVGVHCT HGINRTGYMV CRYLMHTLGI APQEAIDRFE
160
KARGHKIERQ NYVQDLLI
Length:168
Mass (Da):19,288
Last modified:November 1, 1995 - v2
Checksum:i2D4D85F11C52AB09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491V → I(PubMed:1993873)Curated
Sequence conflicti167 – 1682LI → F(PubMed:1993873)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22858 Genomic DNA. Translation: AAA66631.1.
M96763 Genomic DNA. Translation: AAA46753.1.
M75679 Genomic DNA. No translation available.
PIRiA40781.
RefSeqiNP_054030.1. NC_001623.1.

Genome annotation databases

GeneIDi1403833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22858 Genomic DNA. Translation: AAA66631.1 .
M96763 Genomic DNA. Translation: AAA46753.1 .
M75679 Genomic DNA. No translation available.
PIRi A40781.
RefSeqi NP_054030.1. NC_001623.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YN9 X-ray 1.50 A/B/C 1-168 [» ]
ProteinModelPortali P24656.
SMRi P24656. Positions 1-168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1403833.

Miscellaneous databases

EvolutionaryTracei P24656.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and transcript mapping of the HindIII F region of the Autographa californica nuclear polyhedrosis virus genome."
    Tilakaratne N., Hardin S.E., Weaver R.F.
    J. Gen. Virol. 72:285-291(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp EcoRI-I and -R (polyhedrin gene) region."
    Possee R.D., Sun T.P., Howard S.C., Ayres M.D., Hill-Perkins M., Gearing K.L.
    Virology 185:229-241(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C6.
  3. "The complete DNA sequence of Autographa californica nuclear polyhedrosis virus."
    Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.
    Virology 202:586-605(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6.
  4. "The baculovirus Autographa californica encodes a protein tyrosine phosphatase."
    Sheng Z., Charbonneau H.
    J. Biol. Chem. 268:4728-4733(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiPTP_NPVAC
AccessioniPrimary (citable) accession number: P24656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably expressed late in infection.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3