P24656 (PTP_NPVAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase
EC=3.1.3.48

Alternative name(s):
BVP

Gene names

Name:

PTP

Organism

Autographa californica nuclear polyhedrosis virus (AcMNPV) [Complete proteome]

Taxonomic identifier

46015 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Alphabaculovirus › Autographa californica multiple nucleopolyhedrovirus

Virus host

Lepidoptera (butterflies and moths) [TaxID: 7088]

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Also dephosphorylates seryl and threonyl residues.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Miscellaneous	Probably expressed late in infection.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Ontologies

Keywords
Developmental stage	Late protein
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 168

168

Tyrosine-protein phosphatase

PRO_0000094881

Sites

Active site

119

1

Phosphocysteine intermediate

Experimental info

Mutagenesis

119

1

C → S: Loss of activity.

Sequence conflict

49

1

V → I Ref.1

Sequence conflict

167 – 168

2

LI → F Ref.1

Secondary structure

1

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168

Helix Strand Turn

Details...

Helix

6 – 8

3

Beta strand

19 – 24

6

Helix

30 – 33

4

Helix

39 – 41

3

Helix

45 – 51

7

Beta strand

55 – 60

6

Helix

71 – 75

5

Beta strand

79 – 82

4

Beta strand

87 – 89

3

Helix

93 – 109

17

Beta strand

113 – 118

6

Beta strand

120 – 123

4

Helix

124 – 138

15

Helix

142 – 153

12

Helix

160 – 167

8

Sequences

	Sequence		Length	Mass (Da)
	P24656 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 2D4D85F11C52AB09	FASTA	168	19,288
	10 20 30 40 50 60 MFPARWHNYL QCGQVIKDSN LICFKTPLRP ELFAYVTSEE DVWTAEQIVK QNPSIGAIID 70 80 90 100 110 120 LTNTSKYYDG VHFLRAGLLY KKIQVPGQTL PPESIVQEFI DTVKEFTEKC PGMLVGVHCT 130 140 150 160 HGINRTGYMV CRYLMHTLGI APQEAIDRFE KARGHKIERQ NYVQDLLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and transcript mapping of the HindIII F region of the Autographa californica nuclear polyhedrosis virus genome." Tilakaratne N., Hardin S.E., Weaver R.F. J. Gen. Virol. 72:285-291(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp EcoRI-I and -R (polyhedrin gene) region." Possee R.D., Sun T.P., Howard S.C., Ayres M.D., Hill-Perkins M., Gearing K.L. Virology 185:229-241(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C6.
[3]	"The complete DNA sequence of Autographa californica nuclear polyhedrosis virus." Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D. Virology 202:586-605(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C6.
[4]	"The baculovirus Autographa californica encodes a protein tyrosine phosphatase." Sheng Z., Charbonneau H. J. Biol. Chem. 268:4728-4733(1993) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L22858 Genomic DNA. Translation: AAA66631.1.
M96763 Genomic DNA. Translation: AAA46753.1.
M75679 Genomic DNA. No translation available.

PIR

A40781.

RefSeq

NP_054030.1. NC_001623.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YN9	X-ray	1.50	A/B/C	1-168	[»]

ProteinModelPortal

P24656.

SMR

P24656. Positions 1-168.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1403833.

Phylogenomic databases

ProtClustDB

CLSP2509865.

Family and domain databases

InterPro

IPR000340. Dual-sp_phosphatase_cat-dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]

Pfam

PF00782. DSPc. 1 hit.
[Graphical view]

PROSITE

PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P24656.

Entry information

Entry name

PTP_NPVAC

Accession

Primary (citable) accession number: P24656

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program