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P24656

- PTP_NPVAC

UniProt

P24656 - PTP_NPVAC

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Protein
Tyrosine-protein phosphatase
Gene
PTP
Organism
Autographa californica nuclear polyhedrosis virus (AcMNPV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Also dephosphorylates seryl and threonyl residues.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Phosphocysteine intermediate

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase (EC:3.1.3.48)
Alternative name(s):
BVP
Gene namesi
Name:PTP
OrganismiAutographa californica nuclear polyhedrosis virus (AcMNPV)
Taxonomic identifieri46015 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeAlphabaculovirus
Virus hostiLepidoptera (butterflies and moths) [TaxID: 7088]
ProteomesiUP000008292: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi119 – 1191C → S: Loss of activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Tyrosine-protein phosphatase
PRO_0000094881Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Beta strandi19 – 246
Helixi30 – 334
Helixi39 – 413
Helixi45 – 517
Beta strandi55 – 606
Helixi71 – 755
Beta strandi79 – 824
Beta strandi87 – 893
Helixi93 – 10917
Beta strandi113 – 1186
Beta strandi120 – 1234
Helixi124 – 13815
Helixi142 – 15312
Helixi160 – 1678

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YN9X-ray1.50A/B/C1-168[»]
ProteinModelPortaliP24656.
SMRiP24656. Positions 1-168.

Miscellaneous databases

EvolutionaryTraceiP24656.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24656-1 [UniParc]FASTAAdd to Basket

« Hide

MFPARWHNYL QCGQVIKDSN LICFKTPLRP ELFAYVTSEE DVWTAEQIVK    50
QNPSIGAIID LTNTSKYYDG VHFLRAGLLY KKIQVPGQTL PPESIVQEFI 100
DTVKEFTEKC PGMLVGVHCT HGINRTGYMV CRYLMHTLGI APQEAIDRFE 150
KARGHKIERQ NYVQDLLI 168
Length:168
Mass (Da):19,288
Last modified:November 1, 1995 - v2
Checksum:i2D4D85F11C52AB09
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491V → I1 Publication
Sequence conflicti167 – 1682LI → F1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22858 Genomic DNA. Translation: AAA66631.1.
M96763 Genomic DNA. Translation: AAA46753.1.
M75679 Genomic DNA. No translation available.
PIRiA40781.
RefSeqiNP_054030.1. NC_001623.1.

Genome annotation databases

GeneIDi1403833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22858 Genomic DNA. Translation: AAA66631.1 .
M96763 Genomic DNA. Translation: AAA46753.1 .
M75679 Genomic DNA. No translation available.
PIRi A40781.
RefSeqi NP_054030.1. NC_001623.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YN9 X-ray 1.50 A/B/C 1-168 [» ]
ProteinModelPortali P24656.
SMRi P24656. Positions 1-168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1403833.

Miscellaneous databases

EvolutionaryTracei P24656.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and transcript mapping of the HindIII F region of the Autographa californica nuclear polyhedrosis virus genome."
    Tilakaratne N., Hardin S.E., Weaver R.F.
    J. Gen. Virol. 72:285-291(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp EcoRI-I and -R (polyhedrin gene) region."
    Possee R.D., Sun T.P., Howard S.C., Ayres M.D., Hill-Perkins M., Gearing K.L.
    Virology 185:229-241(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C6.
  3. "The complete DNA sequence of Autographa californica nuclear polyhedrosis virus."
    Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.
    Virology 202:586-605(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C6.
  4. "The baculovirus Autographa californica encodes a protein tyrosine phosphatase."
    Sheng Z., Charbonneau H.
    J. Biol. Chem. 268:4728-4733(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiPTP_NPVAC
AccessioniPrimary (citable) accession number: P24656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably expressed late in infection.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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