Reviewed, UniProtKB/Swiss-Prot P24640 (LIP3_MORS1)

Names and origin

Protein names

Recommended name:
    Lipase 3
    EC=3.1.1.3
Alternative name(s):
    Triacylglycerol lipase

Gene names

Name:	lip3
Synonyms:	L3

Organism

Moraxella sp. (strain TA144)

Taxonomic identifier

77152 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Moraxella

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Sequence similarities	Belongs to the lipase/esterase LIP3/bchO family.
Biophysicochemical properties	Temperature dependence: Active at temperatures close to 0 degree Celsius.

Ontologies

Keywords
Biological process	Lipid degradation
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 315	288	Lipase 3		PRO_0000008547
Sites
	Active site	74	1	Potential
	Active site	142	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	P24640-1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: 9007D9741EE04DFB	FASTA	315	34,774
	10 20 30 40 50 60 MLLKRLGLAA LFSLSMVGCT TAPNTLAVNT TQKIIQYERS KSDLEVKSLT LASGDKMVYA 70 80 90 100 110 120 ENDNVTGEPL LLIHGFGGNK DNFTRIADKL EGYHLIIPDL LGFGNSSKPM TADYRADAQA 130 140 150 160 170 180 TRLHELMQAK GLASNTHVGG NSMGGAISVA YAAKYPKEIK SLWLVDTAGF WSAGVPKSLE 190 200 210 220 230 240 GATLENNPLL INSKEDFYKM YDFVMYKPPY IPKSVKAVFA QERINNKALD TKILEQIVTD 250 260 270 280 290 300 NVEERAKIIA KYNIPTLVVW GDKDQVIKPE TTELIKEIIP QAQVIMMNDV GHVPMVEAVK 310 DTANDYKAFR DGLKK

References

[1]	"Nucleotide sequence of the lipase gene lip3 from the antarctic psychotroph Moraxella TA144." Feller G., Thiry M., Gerday C. Biochim. Biophys. Acta 1088:323-324(1991) [PubMed: 2001407] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X53869 Genomic DNA. Translation: CAA37863.1.
PIR	S14276.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S33.010.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR000639. Epox_hydrolase-like. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PRINTS	PR00412. EPOXHYDRLASE.
ProtoNet	Search...

Entry information

Entry name

LIP3_MORS1

Accession

Primary (citable) accession number: P24640

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	July 28, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)